Methods for generating new hair follicles, treating baldness, and hair removal

ABSTRACT

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

FIELD OF INVENTION

The present invention provides methods of treating baldness in a subjectand generating new hair follicles, comprising epidermal disruption andadministration of a compound that promotes a differentiation of anuncommitted epidermal cell into a hair follicle cell. The presentinvention also provides methods for hair removal and inducing hairpigmentation.

BACKGROUND OF THE INVENTION

Follicular neogenesis is defined as the generation of new hair follicles(HF) after birth. Humans are born with a full complement of HF, whichcan change in size and growth characteristics as in early baldness orcan ultimately degenerate and disappear as in late stages of baldness orin permanent scarring (cicatricial) alopecias. Therefore, the generationof new HF is desirable in the treatment of common baldness as well asless common hair loss conditions, such as discoid lupus erythematosis,congenital hypotrichosis, lichen planopilaris and other scarringalopecias.

SUMMARY OF THE INVENTION

The present invention provides methods of treating baldness in a subjectand generating new hair follicles (HF), comprising epidermal disruptionand administration of a compound that promotes a differentiation of anuncommitted epidermal cell into a hair follicle cell. The presentinvention also provides methods for hair removal and inducing hairpigmentation.

In one embodiment, the present invention provides a method forgenerating a hair follicle in a scalp, eyebrow, or scarred region of asubject, comprising the steps of (a) disrupting the epidermis of thescalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with a compound that promotes adifferentiation of an uncommitted epidermal cell into a hair folliclecell, thereby generating a hair follicle in a scalp, eyebrow, or scarredregion of a subject.

In another embodiment, the present invention provides a method forgenerating a hair follicle in a scalp, eyebrow, or scarred region of asubject, comprising the steps of: (a) disrupting the epidermis of thescalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with a factor that promotes a differentiationof an uncommitted epidermal cell into a hair follicle cell, therebygenerating a hair follicle in a scalp, eyebrow, or scarred region of asubject.

In another embodiment, the present invention provides a method fortreating baldness in a scalp, eyebrow, or scarred region, comprising thesteps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarredregion; and (b) contacting the scalp, eyebrow, or scarred region with acompound that promotes a differentiation of an uncommitted epidermalcell into a hair follicle (HF) cell, thereby treating baldness in ascalp, eyebrow, or scarred region.

In another embodiment, the present invention provides a method fortreating baldness in a scalp, eyebrow, or scarred region, comprising thesteps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarredregion; and (b) contacting the scalp, eyebrow, or scarred region with afactor that promotes a differentiation of an uncommitted epidermal cellinto a HF cell, thereby treating baldness in a scalp, eyebrow, orscarred region. In another embodiment, the baldness is an androgeneticalopecia (AGA)-induced baldness. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the present invention provides a method forremoval of an HF from a skin or scalp of a subject, comprising the stepsof: (a) disrupting an epidermis of the skin or scalp; and (b) contactingthe skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor;(iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) acompound or factor that activates a EGF protein or EGF receptor, therebyremoving an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method forincreasing a size of a hair follicle in a scalp, eyebrow, or scarredregion of a subject, the method comprising the steps of: (a) disruptingan epidermis of the scalp, eyebrow, or scarred region; and (b)contacting the scalp, eyebrow, or scarred region with a compound orfactor that promotes a differentiation of an uncommitted epidermal cellinto a hair follicle cell, thereby increasing a size of a hair folliclein a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method forgenerating a hair follicle in a scalp, eyebrow, or scarred region of asubject, comprising the steps of: (a) disrupting an epidermis of saidscalp, eyebrow, or scarred region; and (b) contacting said scalp,eyebrow, or scarred region with a cell selected from (a) a precursorcell that is capable of differentiation into a hair follicle cell; (b)an inductive cell that is capable of inducing differentiation of anuncommitted epidermal cell into a hair follicle cell; or (c) a hairfollicle or portion thereof, thereby generating a hair follicle in ascalp, eyebrow, or scarred region of a subject. In another embodiment,step (b) is performed 3-12 days after step (a). Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method fortreating an AGA in a scalp, comprising the steps of: (a) disrupting anepidermis of said scalp; and (b) contacting said scalp with a cellselected from (a) a precursor cell that is capable of differentiationinto a hair follicle cell; (b) an inductive cell that is capable ofinducing differentiation of an uncommitted epidermal cell into a hairfollicle cell; or (c) a hair follicle or portion thereof, therebytreating an AGA in a scalp. In another embodiment, step (b) is performed3-12 days after step (a). Each possibility represents a separateembodiment of the present invention.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1: Epidermal abrasion results in de novo hair follicle (HF)formation. HF at progressive stages of development are depicted in theleft, center, and right panels. The arrow in the left panel indicates ahair germ. The dark stained cells are progeny of HF stem cells in thebulge.

FIG. 2: BrdU labeling of HF following epidermal abrasion. HF atprogressive stages of development are depicted in the left, center, andright panels.

FIG. 3. The wound site did not contain HF immediately afterre-epithelialization. Top view (left panel) and tissue section (rightpanel) of the site 10 days after wound induction.

FIG. 4. Appearance of hair germs 12 days after wound induction. Arrowindicates hair germ.

FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hairgerms express K17. Two different hair germs are depicted in the left andright panels.

FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, asevidenced by alkaline phosphatase (AP) staining. Arrows indicate DPcells. Left panel: hair germs. Right panel: HF at a furtherdevelopmental stage.

FIG. 7. Histological comparison between EDIHN-induced and embryonic HF.Top left, second from left, third from left, and right panels:Progressive stages of EDIHN-induced HF development. Bottom left, center,and right panels: Progressive stages of and embryonic HF development.

FIG. 8. Induction of several markers of embryonic HF development, Lef1(left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog(Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.

FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdUpulse-labeling. Progressive stages of HF development are depicted in theleft, center, and right panels.

FIG. 10. Induction of HF markers S100A3 (left panel; tissue sectionparallel to HF axis) and S100A6 (right panel; cross-sectional view offollicle) by EDIHN.

FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel)after wound induction.

FIG. 12. Schematic of whole-mount EDIHN assay.

FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, asevidenced by retention of BrdU label following a chase period. Leftpanel: lower magnification: 50×. Right panel: higher magnification:400×.

FIG. 14. A. Stem cells in EDIHN-induced HF express K15. Left top panel:Top view of wound site. Bottom, far left panel: epidermis whole mount;bottom, second from left panel: same as [bottom, far left] panel butviewed under white light; right panel: tissue sections. B. Neogenesis HFproceed to next hair cycle.

FIG. 15. Schematic of creation of new HF by EDIHN.

FIG. 16. No new HF are evident 11 days after wound induction in21-day-old mice. Top panel: macroscopic examination; bottom left panel:AP staining of the dermis; bottom right panel: K17 staining of theepidermis.

FIG. 17. 14 days after wound induction, new HF have begun to form asevidenced by AP staining of the dermis (left panel) and K17 staining ofthe epidermis (right panel). Main panels: 10× magnification. Inserts:80× magnification.

FIG. 18. 17 days after wound induction, new HF are more developed. Leftpanel: AP staining of the dermis; right panel: K17 staining of theepidermis. Main panels: 10× magnification. Inserts: 80× magnification.

FIG. 19. Wounds closed similar in mice subjected to depilation, thenwounding (left 3 mice in each panel) vs. wounding alone (right 4 mice ineach panel). Left panel: immediately following wounding. Right panel: 10days following wounding.

FIG. 20. Anagen induction by depilation prior to wounding enhances theefficiency of EDIHN. A. Top panel: lower left panel AP staining of thedermis; lower right panel: K17 staining of the epidermis. B. Graphicalrepresentation of enhancement of EDIHN by depilation.

FIG. 21. A. EDIHN in human skin grafted to immunodeficient (scid) mice,seven days after induction of an excisional wound. Arrows indicate newHF. B. Dermal abrasion of human skin grafts results in EDIHN. Humanadult skin (W) was grafted onto mice, abraded, and examined seven dayslater, by staining for S100A6 (first, second, and fourth rows) or S100A4(third row). Hair germs (HG) and dermal papilla (DP) are indicated.Human fetal skin (F) with normal developing hair follicles is shown forcomparison. Mouse skin 17d post wounding was included as a control (topleft panel).

FIG. 22. Transcripts up-regulated at least 2-fold in activated HF cells,as assessed by dChip analysis. (A). Mean values and standard errors ofthe up-regulated transcripts in non-activated (“bs-line”) and activated(“expt”) samples and fold-changes and differences between non-activatedand activated values are depicted. (B). Raw data for up-regulatedtranscripts in non-activated and activated cells. “Ctrl” denotesnon-activated and “High-dep” denotes activated cells. (C). Additionalinformation about up-regulated transcripts.

FIG. 23. Pigmented hair follicle neogenesis observed in the skin ofDkk1-expressing mice following EDIHN A. 3.2× magnification. B. 8×magnification.

FIG. 24. Control mice lacked pigmented HF.

FIG. 25. EGF inhibits HF formation by EDIHN. A. K17 staining of woundedskin of representative mouse treated with EGF. Magnification is 4×. B.High magnification view (10×) of skin depicted in (A). C. K17 stainingof wounded skin of representative control mouse that received no EGFafter wounding. Magnification is 4×. D. Higher magnification view (10×)of skin depicted in (D).

FIG. 26. Administration of an EGF receptor inhibitor (AG1478) leads togeneration of more and larger HF compared with controls. A. Top: skin of2 control mice. Outer dashed line indicates the extent of the woundedarea after contraction and healing; inner dashed line indicates the areaof neogenesis. Bottom: skin of 2 treated mice, in which the wounded areaand area of neogenesis largely coincide, with the exception of a smallarea on the left side of the encircled area in each panel. B. Large hairfollicles developed in the wounded area in the AG1478-injected mice.Left panel: epidermis stained for K17, with three large hair folliclesnext to each other. Right panel: dermis stained for AP with largecoalescing DP areas. Scale Bars: 200 μm.

FIG. 27. A. Increased hair follicle formation in K14-Wnt7a mice. Leftpanel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. B.Quantiation of experiment with 4 week old mice. C. Quantiation ofexperiment with 3 week old mice

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides methods of treating baldness in a subjectand generating new HF, comprising epidermal disruption andadministration of a compound that promotes a differentiation of anuncommitted epidermal cell into a hair follicle cell. The presentinvention also provides methods for hair removal and inducing hairpigmentation.

In one embodiment, the present invention provides a method forgenerating a hair follicle (HF) in a scalp, eyebrow, or scarred regionof a subject, comprising the steps of: (a) disrupting an epidermis ofthe scalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with a compound that promotes adifferentiation of an uncommitted epidermal cell into an HF cell,thereby generating an HF in a scalp, eyebrow, or scarred region of asubject.

In another embodiment, the present invention provides a method forgenerating an HF in a scalp, eyebrow, or scarred region of a subject,comprising the steps of: (a) disrupting an epidermis of the scalp,eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, orscarred region with a factor that promotes a differentiation of anuncommitted epidermal cell into an HF cell, thereby generating an HF ina scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method forgenerating a new HF in a scalp, eyebrow, or scarred region of a subject,comprising the steps of: (a) disrupting an epidermis of the scalp,eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, orscarred region with a compound or factor that promotes a differentiationof an uncommitted epidermal cell into a hair follicle cell, therebygenerating a new HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method forincreasing the number of HF in a scalp, eyebrow, or scarred region of asubject, comprising the steps of: (a) disrupting an epidermis of thescalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with a compound or factor that promotes adifferentiation of an uncommitted epidermal cell into an HF cell,thereby increasing the number of HF in a scalp, eyebrow, or scarredregion of a subject.

In another embodiment, the present invention provides a use of acompound or factor that promotes a differentiation of an uncommittedepidermal cell into an HF cell, for the preparation of a pharmaceuticalcomposition for use in a method for generating a hair follicle in ascalp, eyebrow, or scarred region of a subject, the method comprisingthe steps of: (a) disrupting an epidermis of the scalp, eyebrow, orscarred region; and (b) contacting the scalp, eyebrow, or scarred regionwith the compound or factor.

In another embodiment, the present invention provides a use of acompound or factor that promotes a differentiation of an uncommittedepidermal cell into an HF cell, for the preparation of a pharmaceuticalcomposition for use in a method for treating baldness in a scalp,eyebrow, or scarred region of a subject, the method comprising the stepsof: (a) disrupting an epidermis of the scalp, eyebrow, or scarredregion; and (b) contacting the scalp, eyebrow, or scarred region withthe compound or factor.

In another embodiment, the present invention provides a use of acompound or factor that promotes a differentiation of an uncommittedepidermal cell into an HF cell, for the preparation of a pharmaceuticalcomposition for use in a method for treating AGA in a scalp of asubject, the method comprising the steps of: (a) disrupting an epidermisof the scalp, eyebrow, or scarred region; and (b) contacting the scalpwith the compound or factor.

In another embodiment, the present invention provides a method forincreasing a size of a hair follicle in a scalp, eyebrow, or scarredregion of a subject, the method comprising the steps of: (a) disruptingan epidermis of the scalp, eyebrow, or scarred region; and (b)contacting the scalp, eyebrow, or scarred region with a compound orfactor that promotes a differentiation of an uncommitted epidermal cellinto an HF cell, thereby increasing a size of a hair follicle in ascalp, eyebrow, or scarred region of a subject. In another embodiment,the factor is an inhibitor of an EGF protein or an EGFR. In anotherembodiment, the factor is a Hedgehog protein, a nucleotide encoding sameor an activator of same. In another embodiment, the factor is anandrogen antagonist. In another embodiment, the factor is any othercompound or factor that promotes a differentiation of an uncommittedepidermal cell into an HF cell. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the present invention provides a method forgenerating a hair follicle in a scalp, eyebrow, or scarred region of asubject, comprising the steps of: (a) disrupting an epidermis of saidscalp, eyebrow, or scarred region; and (b) contacting said scalp,eyebrow, or scarred region with a cell selected from (a) a precursorcell that is capable of differentiation into a hair follicle cell; (b)an inductive cell that is capable of inducing differentiation of anuncommitted epidermal cell into a hair follicle cell; or (c) a hairfollicle or portion thereof, thereby generating a hair follicle in ascalp, eyebrow, or scarred region of a subject. In another embodiment,step (b) is performed 3-12 days after step (a). Each possibilityrepresents a separate embodiment of the present invention.

The precursor cell of methods and compositions of the present invention,is, in another embodiment, a HF stem cell. In another embodiment, theprecursor cell is an epidermal cell. In another embodiment, theprecursor cell is a dermal papilla cell. In another embodiment, theprecursor cell is a connective tissue sheath cell. In anotherembodiment, the precursor cell is any other type of cell known in theart that is capable of differentiation into a hair follicle cell. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method forgenerating a hair follicle in a scalp, eyebrow, or scarred region of asubject, comprising the steps of: (a) disrupting an epidermis of saidscalp, eyebrow, or scarred region; and (b) contacting said scalp,eyebrow, or scarred region with a precursor cell that is capable ofdifferentiation into a hair follicle cell, thereby generating a hairfollicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method fortreating an AGA in a scalp, comprising the steps of: (a) disrupting anepidermis of said scalp; and (b) contacting said scalp with a cellselected from (a) a precursor cell that is capable of differentiationinto a hair follicle cell; (b) an inductive cell that is capable ofinducing differentiation of an uncommitted epidermal cell into a hairfollicle cell; or (c) a hair follicle or portion thereof, therebytreating an AGA in a scalp. In another embodiment, step (b) is performed3-12 days after step (a). Each possibility represents a separateembodiment of the present invention.

In another embodiment, the present invention provides a method fortreating an AGA in a scalp, comprising the steps of: (a) disrupting anepidermis of said scalp; and (b) contacting said scalp with a precursorcell that is capable of differentiation into a hair follicle cell,thereby treating an AGA in a scalp.

In another embodiment, the inductive cell is a mesenchymal cell. Inanother embodiment, the inductive cell is any other type of inductivecell enumerated herein. In another embodiment, the inductive cell is anyother type of inductive cell known in the art. Each possibilityrepresents a separate embodiment of the present invention.

“Contacting” as used herein refers, in another embodiment, to bringingthe scalp, eyebrow, etc, into to contact with the compound, factor,cell, etc. In another embodiment, the term refers to embedding thecompound, factor, cell, etc into the scalp, eyebrow, etc. In anotherembodiment, the term refers to injecting the compound, factor, cell, etcinto the scalp, eyebrow, etc. In another embodiment, term refers to anyother type of contacting known in the art. Each possibility represents aseparate embodiment of the present invention.

“Promotes a differentiation” refers, in another embodiment, to the actof increasing the percentage of cells that will differentiate asindicated. In another embodiment, the term refers to increasing thenumber of cells per unit area of skin that will differentiate. Inanother embodiment, the promoter of differentiation is active in themilieu of the skin. Each possibility represents a separate embodiment ofthe present invention.

“Uncommitted epidermal cell” refers, in another embodiment, to anepidermal stem cell. In another embodiment, the epidermal cell is abulge cell. In another embodiment, the epidermal cell is a bulge-derivedcell. In another embodiment, the epidermal cell is any other type ofcell known in the art that can be induced to differentiate into an HFcell.

The “HF cell” that results from the differentiation is, in anotherembodiment, an HF stem cell. In another embodiment, the HF cell is adermal papilla cell. In another embodiment, the HF cell is a bulb cell.In another embodiment, the HF cell is a matrix cell. In anotherembodiment, the HF cell is a hair shaft cell. In another embodiment, theHF cell is an inner root sheath cell. In another embodiment, the HF cellis an outer root sheath cell. In another embodiment, the HF cell is amelanocyte stem cell. In another embodiment, the HF cell is amelanocyte. Each type of uncommitted epidermal cell and HF cellrepresents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method fortreating baldness in a scalp, eyebrow, or scarred region, comprising thesteps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarredregion; and (b) contacting the scalp, eyebrow, or scarred region with acompound that promotes a differentiation of an uncommitted epidermalcell into a hair follicle (HF) cell, thereby treating baldness in ascalp, eyebrow, or scarred region. In another embodiment, the baldnessis an androgenetic alopecia (AGA)-induced baldness. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method fortreating baldness in a scalp, eyebrow, or scarred region, comprising thesteps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarredregion; and (b) contacting the scalp, eyebrow, or scarred region with afactor that promotes a differentiation of an uncommitted epidermal cellinto a HF cell, thereby treating baldness in a scalp, eyebrow, orscarred region. In another embodiment, the baldness is an androgeneticalopecia (AGA)-induced baldness. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell isadministered in a solution. In another embodiment, the compound orfactor is administered in a cream. In another embodiment, the compoundor factor is administered in an ointment. In another embodiment, thecompound or factor is administered in a slow release formulation. Inanother embodiment, the compound or factor is administered in a liposomeencapsulated formulation. In another embodiment, the compound or factoris directly injected. In another embodiment, the compound or factor isadministered by any other method known in the art. Each possibilityrepresents a separate embodiment of the present invention.

The compound or factor that promotes a differentiation of an uncommittedepidermal cell into a HF cell is, in another embodiment, an inhibitor ofan Epidermal Growth Factor (EGF). In another embodiment, the compound orfactor is an inhibitor of an EGF receptor. Each possibility represents aseparate embodiment of the present invention.

As provided herein (Example 11), activating one or more pathways inwhich EGF is involved (by injection of EGF) blocks the formation of HF.Thus, antagonizing the pathway increases HF formation, as demonstratedin Example 12.

In another embodiment, the inhibitor of an EGF or an EGF receptor ispanitumumab. In another embodiment, the inhibitor is AG1478. In anotherembodiment, the inhibitor is nimotuzumab. In another embodiment, theinhibitor is an antibody that binds EGF or EGFR. In another embodiment,the inhibitor is HuMax-EGFR® (Genmab, Copenhagen, Denmark). In anotherembodiment, the inhibitor is cetuximab. In another embodiment, theinhibitor is IMC 11F8. In another embodiment, the inhibitor ismatuzumab. In another embodiment, the inhibitor is SC 100. In anotherembodiment, the inhibitor is ALT 110. In another embodiment, theinhibitor is PX 1032. In another embodiment, the inhibitor is BMS599626. In another embodiment, the inhibitor is MDX 214. In anotherembodiment, the inhibitor is PX 1041. In another embodiment, theinhibitor is any other inhibitor of an EGF or an EGF receptor known inthe art. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is aninhibitor of a tyrosine kinase activity of an EGF receptor. In anotherembodiment, the inhibitor is gefitinib. In another embodiment, theinhibitor is erlotinib. In another embodiment, the inhibitor iscanertinib. In another embodiment, the inhibitor is leflunomide. Inanother embodiment, the inhibitor is A77 1726. In another embodiment,the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD1839. In another embodiment, the inhibitor is CL 387785. In anotherembodiment, the inhibitor is EKI 785. In another embodiment, theinhibitor is vandetanib. In another embodiment, the inhibitor is anyother inhibitor of a tyrosine kinase activity of an EGF receptor knownin the art. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the EGF or EGFR antagonist is a carboxypeptidaseinhibitor from potato (PCI) protein or a homologue, fragment or mimeticthereof. In another embodiment, the EGF or EGFR antagonist is a sproutyprotein or a homologue, fragment or mimetic thereof. In anotherembodiment, the EGF or EGFR antagonist is an Argos protein or ahomologue, fragment or mimetic thereof. In another embodiment, the EGFor EGFR antagonist is a lefty protein or a homologue, fragment ormimetic thereof. In another embodiment, the EGF or EGFR antagonist is anantibody that recognizes EGF or EGFR, or a fragment or mimetic thereof.In another embodiment, the EGF or EGFR antagonist is small moleculeinhibitor that binds and reduces the activity of EGF or EGFR. In anotherembodiment, the EGF or EGFR antagonist is CRM197. In another embodiment,the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York,N.Y.). In another embodiment, the EGF or EGFR antagonist is any otherantagonist of EGF or EGFR known in the art. Each possibility representsa separate embodiment of the present invention.

In another embodiment, the present invention provides a use of aninhibitor of an EGF protein or an EGF receptor for the preparation of apharmaceutical composition for use in a method for generating a hairfollicle in a scalp, eyebrow, or scarred region of a subject, the methodcomprising the steps of: (a) disrupting an epidermis of the scalp,eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, orscarred region with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of aninhibitor of an EGF protein or an EGF receptor for the preparation of apharmaceutical composition for use in a method for treating baldness ina scalp, eyebrow, or scarred region of a subject, the method comprisingthe steps of: (a) disrupting an epidermis of the scalp, eyebrow, orscarred region; and (b) contacting the scalp, eyebrow, or scarred regionwith the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of aninhibitor of an EGF protein or an EGF receptor for the preparation of apharmaceutical composition for use in a method for treating AGA in ascalp of a subject, the method comprising the steps of: (a) disruptingan epidermis of the scalp, eyebrow, or scarred region; and (b)contacting the scalp with the inhibitor of an EGF protein or an EGFreceptor.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is aβ-catenin protein. In another embodiment, the compound or factor is anucleotide that encodes a β-catenin protein. In another embodiment, thecompound or factor is an activator of a β-catenin protein. In anotherembodiment, the compound or factor is an inhibitor of a protein thatsuppresses an activity of the β-catenin protein. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of (a) aβ-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c)a compound or factor that activates a β-catenin protein, for thepreparation of a pharmaceutical composition for use in a method forgenerating a hair follicle in a scalp, eyebrow, or scarred region of asubject, the method comprising the steps of: (a) disrupting an epidermisof the scalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with the β-catenin protein, nucleotide,compound or factor.

In another embodiment, the present invention provides a use of (a) aβ-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c)a compound or factor that activates a β-catenin protein, for thepreparation of a pharmaceutical composition for use in a method fortreating baldness in a scalp, eyebrow, or scarred region of a subject,the method comprising the steps of (a) disrupting an epidermis of thescalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with the β-catenin protein, nucleotide,compound or factor.

In another embodiment, the present invention provides a use of (a) aβ-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c)a compound or factor that activates a β-catenin protein, for thepreparation of a pharmaceutical composition for use in a method fortreating AGA in a scalp of a subject, the method comprising the stepsof: (a) disrupting an epidermis of the scalp, eyebrow, or scarredregion; and (b) contacting the scalp with the β-catenin protein,nucleotide, compound or factor.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is afibroblast growth factor (FGF) protein. In another embodiment, thecompound or factor is a nucleotide that encodes an FGF protein. Inanother embodiment, the compound or factor is an FGF receptor. Inanother embodiment, the compound or factor is a nucleotide that encodesan FGF receptor. In another embodiment, the compound or factor is anactivator of an FGF protein. In another embodiment, the compound orfactor is an activator of FGF receptor. In another embodiment, thecompound or factor is an inhibitor of a protein that suppresses anactivity of the FGF protein or FGF receptor. In another embodiment, theprotein that is inhibited is an FGF binding protein. In anotherembodiment, the protein that is inhibited is FGF-bp1. Each possibilityrepresents a separate embodiment of the present invention.

Is provided herein, FGF and its receptor are upregulated, under theconditions utilized herein, upon HF stem cell differentiation (Example9). Moreover, FGF-bp1 is downregulated, under the conditions utilizedherein, upon HF stem cell differentiation. Thus, FGF and its receptorpromote differentiation of uncommitted epidermal cells into HF cells.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is anectodysplasin protein (referred to, in another embodiment, as “eda”; inanother embodiment, as “ectodermodysplasin protein.”) In anotherembodiment, the ectodysplasin protein is Eda-A1. In another embodiment,the compound or factor is an ectodysplasin receptor (referred to, inanother embodiment, as “edar”). In another embodiment, the compound orfactor is an activator of an ectodysplasin protein. In anotherembodiment, the compound or factor is an activator of an ectodysplasinreceptor. In another embodiment, the compound or factor is an inhibitorof a protein that suppresses an activity of the ectodysplasin protein orectodysplasin receptor. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the eda protein of methods and compositions ofthe present invention has the sequence:

MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCCYLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAALHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_(—)001399; SEQ IDNo: 274). In another embodiment, the eda protein has a sequence selectedfrom the sequences set forth in GenBank entries NM_(—)001005609,NM_(—)001005610, NM_(—)001005611, NM_(—)001005612, NM_(—)001005613,NM_(—)001005614, NM_(—)001005615, AF040628, AF061194, AF061193,AF061192, AF061191, AF061190, AF061189, and AF060999. In anotherembodiment, the eda protein is encoded by a nucleic acid molecule havinga sequence set forth in the one of the above GenBank entries. In anotherembodiment, a biologically active fragment of an Eda protein is utilizedin a method of the present invention. Each possibility represents aseparate embodiment of the present invention.

In another embodiment, the edar protein of methods and compositions ofthe present invention has the sequence:

MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTWIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275).In another embodiment, the edar protein has a sequence selected from thesequences set forth in GenBank entries BC093870; BC034919; NM_(—)021783;NM⁻022336; AY152724; AF298812; AH008077; AF130996; AF130988. In anotherembodiment, the edar protein is encoded by a nucleic acid moleculehaving a sequence set forth in the one of the above GenBank entries. In,another embodiment, a biologically active fragment of an Edar protein isutilized in a method of the present invention. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is aNoggin protein. In another embodiment, the compound or factor is anucleotide encoding a Noggin protein. In another embodiment, thecompound or factor is an activator of a Noggin protein. In anotherembodiment, the compound or factor is an inhibitor of a protein thatsuppresses an activity of the Noggin protein. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the Noggin protein of methods and compositions ofthe present invention has the sequence:

MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLEEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No:NM_(—)005450; SEQ ID No: 276). In another embodiment, the Noggin proteinhas a sequence selected from the sequences set forth in GenBank entriesBC034027 and U31202. In another embodiment, the Noggin protein isencoded by a nucleic acid molecule having a sequence set forth in theone of the above GenBank entries. In another embodiment, a biologicallyactive fragment of a Noggin protein is utilized in a method of thepresent invention. Each possibility represents a separate embodiment ofthe present invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is aHedgehog protein. In another embodiment, the compound or factor is anucleotide encoding a Hedgehog protein. In another embodiment, thecompound or factor is an activator of a Hedgehog protein. In anotherembodiment, the compound or factor is a sonic Hedgehog protein. Inanother embodiment, the compound or factor is a nucleotide encoding asonic Hedgehog protein. In another embodiment, the compound or factor isan activator of a sonic Hedgehog protein. Each possibility represents aseparate embodiment of the present invention.

In another embodiment, the Hedgehog protein of methods and compositionsof the present invention has the sequence set forth in GenBank AccessionNo. NM_(—)000193. In another embodiment, the Hedgehog protein has asequence selected from those set forth in GenBank entries L38518 andNP_(—)000184. In another embodiment, the Hedgehog protein has any otherHedgehog sequence known in the art. In another embodiment, the Hedgehogprotein has any other sonic Hedgehog sequence known in the art. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is aTransforming Growth Factor (TGF)-beta1 protein. In another embodiment,the compound or factor is a nucleotide encoding a TGF-beta1 protein. Inanother embodiment, the compound or factor is an activator of aTGF-beta1 protein. In another embodiment, the compound or factor is aTGF-beta3 protein. In another embodiment, the compound or factor is anucleotide encoding a TGF-beta3 protein. In another embodiment, thecompound or factor is an activator of a TGF-beta3 protein. In anotherembodiment, the compound or factor is an antagonist of a TGF-beta1protein. In another embodiment, the compound or factor is an antagonistof a TGF-beta3 protein. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the TGF-beta1 protein of methods and compositionsof the present invention has the sequence set forth in GenBank AccessionNo. BC000125. In another embodiment, the Hedgehog protein has a sequenceselected from those set forth in GenBank entries BC001180, BC022242, andNM_(—)000660. In another embodiment, the TGF-beta1 protein has any otherTGF-beta1 sequence known in the art. Each possibility represents aseparate embodiment of the present invention.

In another embodiment, the TGF-beta3 protein of methods and compositionsof the present invention has the sequence set forth in GenBank AccessionNo. J03241. In another embodiment, the Hedgehog protein has a sequenceselected from those set forth in GenBank entries NM_(—)003239, BC018503,BT007287 and X14149. In another embodiment, the TGF-beta3 protein hasany other TGF-beta3 sequence known in the art. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell actsdirectly on the uncommitted epidermal cell. In another embodiment, thecompound or factor acts on the uncommitted epidermal cell via amesenchymal cell. Each possibility represents a separate embodiment ofthe present invention.

In another embodiment, the mesenchymal cell is a dermal condensate cell.In another embodiment, the mesenchymal cell is a DP cell. In anotherembodiment, the mesenchymal cell is another cell type or differentiationstage in the dermal condensate-DP lineage. In another embodiment, themesenchymal cell is any other type of mesenchymal cell known in the art.Each possibility represents a separate embodiment of the presentinvention.

The EGFR of methods and compositions of the present invention has, inanother embodiment, the sequence:

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKJICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank AccessionNo: NM_(—)005228; SEQ ID No: 277). In another embodiment, the EGFR has asequence selected from the sequences set forth in GenBank entriesNM_(—)201282, NM_(—)201283, NM_(—)201284, BC094761, AF288738, AY588246,AY573061, X17054, AF125253, U48722, K03193, and AY698024. In anotherembodiment, the EGFR is encoded by a nucleic acid molecule having asequence set forth in the one of the above GenBank entries. In anotherembodiment, a biologically active fragment of an EGFR is utilized in amethod of the present invention. Each possibility represents a separateembodiment of the present invention.

The EGF of methods and compositions of the present invention has, inanother embodiment, the sequence:

MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKClNTEGGYVCRCSEGYQGDGIHCLDIDECQLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No:NM_(—)001963; SEQ ID No: 278). In another embodiment, the EGF has asequence selected from the sequences set forth in GenBank entriesBC093731, AY548762, and X04571. In another embodiment, the EGF isencoded by a nucleic acid molecule having a sequence set forth in theone of the above GenBank entries. In another embodiment, a biologicallyactive fragment of an EGF is utilized in a method of the presentinvention. Each possibility represents a separate embodiment of thepresent invention.

The beta-catenin protein of methods and compositions of the presentinvention has, in another embodiment, the sequence:

MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEMEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank AccessionNo: NM_(—)001904; SEQ ID No: 279). In another embodiment, thebeta-catenin protein has a sequence selected from the sequences setforth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054,and NP_(—)001895. In another embodiment, the beta-catenin protein isencoded by a nucleic acid molecule having a sequence set forth in theone of the above GenBank entries. In another embodiment, a biologicallyactive fragment of a beta-catenin protein is utilized in a method of thepresent invention. Each possibility represents a separate embodiment ofthe present invention.

The Wnt protein of methods and compositions of the present inventionhas, in another embodiment, the sequence:

MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No:BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has asequence selected from the sequences set forth in GenBank entriesNM_(—)004625, D83175, U53476, and NP_(—)004616. In another embodiment,the Wnt protein is a Wnt7 protein. In another embodiment, the Wntprotein is a Wnt7a protein. In another embodiment, the Wnt protein isWnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein.In another embodiment, the Wnt protein is a Wnt3a protein. In anotherembodiment, the Wnt protein is a Wnt10 protein. In another embodiment,the Wnt protein is a Wnt10a protein. In another embodiment, the Wntprotein is a Wnt10b protein. In another embodiment, the Wnt protein isencoded by a nucleic acid molecule having a sequence set forth in theone of the above GenBank entries. In another embodiment, a biologicallyactive fragment of a Wnt protein is utilized in a method of the presentinvention. In another embodiment, a biologically active fragment of aWnt7 protein is utilized in a method of the present invention. Inanother embodiment, a biologically active fragment of a Wnt7a protein isutilized in a method of the present invention. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is aprotein encoded by a ribonucleic acid (RNA) molecule having a sequenceselected from the sequences set forth in SEQ ID No: 1-232. In anotherembodiment, the compound or factor is an RNA molecule having a sequenceselected from SEQ ID No: 1-232. In another embodiment, the RNA moleculeis homologous to a sequence selected from SEQ ID No: 1-232. In anotherembodiment, the RNA molecule is an isoform of a sequence selected fromSEQ ID No: 1-232. In another embodiment, the compound or factorincreases an activity of a protein encoded by an RNA molecule having asequence selected from SEQ ID No: 1-232. In another embodiment, thecompound or factor increases an expression or level of a protein encodedby an RNA molecule having a sequence selected from SEQ ID No: 1-232.Each possibility represents a separate embodiment of the presentinvention.

As provided herein, the transcripts depicted in Table 3 (Example 8; SEQID No: 1-232), the proteins they encode, and the pathways in which theproteins participate contribute significantly to HF stem cellactivation. Accordingly, under the conditions utilized herein, anagencan be induced by activation of these transcripts, proteins, andpathways. Activation of the transcripts, proteins, and pathways depictedin Table 3 is thus a method for enhancing EDIHN. In another embodiment,activation of these transcripts, proteins, and pathways represents amethod for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is aprotein encoded by an RNA molecule having a sequence selected from thesequences set forth in SEQ ID No: 233-257. In another embodiment, thecompound or factor is an RNA molecule having a sequence selected fromSEQ ID No: 233-257. In another embodiment, the RNA molecule ishomologous to a sequence selected from SEQ ID No: 233-257. In anotherembodiment, the RNA molecule is an isoform of a sequence selected fromSEQ ID No: 233-257. In another embodiment, the compound or factorincreases an activity of a protein encoded by an RNA molecule having asequence selected from SEQ ID No: 233-257. In another embodiment, thecompound or factor increases an expression or level of a protein encodedby an RNA molecule having a sequence selected from SEQ ID No: 233-257.Each possibility represents a separate embodiment of the presentinvention.

As provided herein, the transcripts depicted in Table 4 (Example 9; SEQID No: 233-257), the proteins they encode, and the pathways in which theproteins participate, contribute significantly, under the conditionsutilized herein, to induction of epidermal cells to differentiate intoHF stem cells. Activation of the transcripts, proteins, and pathwaysdepicted in Table 4 is thus a method for enhancing EDIHN. In anotherembodiment, activation of these transcripts, proteins, and pathwaysrepresents a method for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is acompound or factor that decreases an activity of a protein encoded by anRNA molecule having a sequence selected from the sequences set forth inSEQ ID No: 258-273. In another embodiment, the compound or factordecreases an expression or level of a protein encoded by an RNA moleculehaving a sequence selected from SEQ ID No: 258-273. Each possibilityrepresents a separate embodiment of the present invention.

As demonstrated by findings of the present invention, the transcriptsdepicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins theyencode, and the pathways in which the proteins participate, contributesignificantly, under the conditions utilized herein, to preventinginduction of epidermal cells to differentiate into HF stem cells.Inhibition of the transcripts, proteins, and pathways depicted in Table5 is thus a method for enhancing EDIHN. In another embodiment,inhibition of these transcripts, proteins, and pathways represents amethod for induction of hair growth in a subject.

In one embodiment, the compound that modulates a protein encoded by anRNA molecule having a sequence selected from the sequences set forth inSEQ ID No: 233-273 or the nucleic acid encoding same is administeredbefore the compound that modulates a protein encoded by an RNA moleculehaving a sequence selected from the sequences set forth in SEQ ID No:1-232 or the nucleic acid encoding same. In another embodiment, the twocompounds are administered simultaneously. Each possibility represents aseparate embodiment of the present invention.

In one embodiment, a protein encoded by an RNA sequence selected fromSEQ ID No: 1-273, or a compound that modulates the protein, isadministered before other proteins encoded by same or compounds thatmodulate them, in order to further enhance their effect in generating anHF or stimulating hair growth: In another embodiment, the wnt pathway isstimulated before the hedgehog pathway. In another embodiment, the twopathways are stimulated in an overlapping fashion. In anotherembodiment, the two pathways are stimulated simultaneously. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, activating or decreasing expression of an RNAtranscript in methods of the present invention occurs via atranscription mechanism (e.g. activation of expression of the RNA). Inanother embodiment, activating or decreasing expression of the RNAtranscript occurs via a translational mechanism. In another embodiment,activating or decreasing expression of the RNA transcript occurs via apost-translational mechanism. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the nucleic acid molecule utilized in methods ofthe present invention is a deoxyribonucleic acid (DNA) molecule thatencodes an RNA molecule having a sequence selected from the sequencesset forth in the present invention.

In one embodiment, an RNA molecule of the present invention encodes aprotein that plays a role in HF regeneration. In another embodiment, theRNA molecule is itself catalytically active, e.g., a ribozyme, etc. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes adifferentiation of an uncommitted epidermal cell into a HF cell is acompound or factor that promotes placodal cell fate. As provided herein,factors that promote placodal cell fate enhance EDIHN, as exemplified inthe Examples herein. In another embodiment, the compound or factor actsat the placode stage of HF development.

In another embodiment, the compound or factor inhibits a biologicalfactor that inhibits a differentiation of an uncommitted epithelial cellinto an HF cell.

In another embodiment of methods and compositions of the presentinvention, a composition comprising one of the above compounds orfactors is administered. Each of the above types of compounds, factors,and compositions represents a separate embodiment of the presentinvention.

In one embodiment, the present invention provides a method forgenerating an HF in a scalp, eyebrow, or scarred region of a subject,comprising the steps of: (a) disrupting an epidermis of the scalp,eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, orscarred region with minoxidil, thereby generating an HF in a scalp,eyebrow, or scarred region of a subject.

In one embodiment, the present invention provides a method for treatingbaldness in a scalp, eyebrow, or scarred region of a subject, comprisingthe steps of: (a) disrupting an epidermis of the scalp, eyebrow, orscarred region; and (b) contacting the scalp, eyebrow, or scarred regionwith minoxidil, thereby treating baldness in a scalp, eyebrow, orscarred region of a subject.

In another embodiment, the present invention provides a use of minoxidilfor the preparation of a pharmaceutical composition for use in a methodfor an HF in a scalp, eyebrow, or scarred region of a subject, themethod comprising the steps of: (a) disrupting an epidermis of thescalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a use of minoxidilfor the preparation of a pharmaceutical composition for use in a methodfor treating baldness in a scalp, eyebrow, or scarred region of asubject, the method comprising the steps of: (a) disrupting an epidermisof the scalp, eyebrow, or scarred region; and (b) contacting the scalp,eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a method forremoval of an HF from a skin or scalp of a subject, comprising the stepsof (a) disrupting an epidermis of the skin or scalp; and (b) contactingthe skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor;(iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) acompound or factor that activates a EGF protein or EGF receptor, therebyremoving an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method for hairremoval from a skin or scalp of a subject, comprising the steps of: (a)disrupting an epidermis of the skin or scalp; and (b) contacting theskin or scalp with either: (i) an EGF protein; (ii) an EGF receptor;(iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) acompound or factor that activates a EGF protein or EGF receptor, therebyremoving hair from a skin or scalp of a subject. In another embodiment,the epidermal disruption is light dermabrasion. In another embodiment,the epidermal disruption is a non-scarring method. In anotherembodiment, administration of the EGF protein, EGF receptor, nucleotide,compound, or factor suppresses HF formation. In another embodiment, theEGF protein, EGF receptor, nucleotide, compound, or factor isadministered within several days of healing. In another embodiment, theEGF protein, EGF receptor, nucleotide, compound, or factor isadministered within about 1 day of healing. In another embodiment, theEGF protein, EGF receptor, nucleotide, compound, or factor isadministered according to any of the timing embodiments enumeratedherein for Dkk1 protein. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the present invention provides a use of either:(i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding anEGF protein or EGF receptor; or (iv) a compound or factor that activatesa EGF protein or EGF receptor, for the preparation of a pharmaceuticalcomposition for use in a method for removal of an HF from a skin orscalp of a subject, the method comprising the steps of: (a) disruptingan epidermis of the scalp, eyebrow, or scarred region; and (b)contacting the scalp, eyebrow, or scarred region with the EGF protein,EGF receptor, nucleotide, compound, or factor.

In another embodiment, a composition or method of the present inventionis utilized on human skin. In another embodiment, the composition ormethod is utilized on an area of unwanted hair growth. In anotherembodiment, the area is the face. In another embodiment, the area is thebikini area. In another embodiment, the area is the legs. In anotherembodiment, the area is the arms. In another embodiment, the area is thechest.

An “inhibitor” utilized in methods and compositions of the presentinvention is, in another embodiment, an antibody that binds the proteinor biological factor that is the target of the inhibitor. In anotherembodiment, the inhibitor is a pharmacologic inhibitor. In anotherembodiment, the inhibitor is any other type of inhibitor known in theart. Each possibility represents a separate embodiment of the presentinvention.

The step of disrupting the epidermis in methods of the present inventionis performed, in another embodiment, by abrading the scalp, eyebrow, orscarred region. In another embodiment, the term “abrading” refers to anact of creating an abrasion. In another embodiment, “abrading” refers torubbing. In another embodiment, “abrading” refers to wearing away byfriction. As provided herein (Example 1), epidermal abrasion causes,under the conditions utilized herein, de novo HF neo-genesis. In anotherembodiment, the epidermal layer is disrupted.

In one embodiment, “abrasion” has the same meaning as “abrading.” Inanother embodiment, “abrasion” refers to an area of the scalp or skinfrom which the epidermis is removed. In another embodiment, “abrasion”refers to an area of the scalp or skin from which the epidermis anddermis are removed. Each definition of “abrading”, and “abrasion”represents a separate embodiment of the present invention.

As provided herein, under the conditions utilized, epidermal disruptionby a method of the present invention converts the skin back, in anotherembodiment, to an embryonic-like state, in which the follicleregenerates. In another embodiment, a subsequent window of opportunityis created, during which the number and size of new HF in the skin canbe manipulated. In another embodiment, the administration of a compoundor factor that promotes a differentiation of an uncommitted epidermalcell into a HF cell during this window causes regeneration of larger andmore numerous HF. The morphology of HF in abraded skin is similar tothat of embryonic HF (Example 1-2 and subsequent Examples), and themarkers expressed are similar as well.

In another embodiment, the present invention provides a method ofstimulating hair growth in a scalp, eyebrow, or scarred region of asubject, comprising performing a method of present invention, therebystimulating hair growth in a scalp, eyebrow, or scarred region of asubject. As demonstrated in Example 3, EDIHN-induced HF are capable ofgenerating hairs. Thus, methods of the present invention can be used tostimulate hair growth.

“EDIHN,” in another embodiment, refers to HF neogenesis induced bydisruption of the epithelial layer. In another embodiment, the termrefers to HF neogenesis induced by abrasion. In another embodiment, theterm refers to HF neogenesis induced by wounding. In another embodiment,the term refers to HF neogenesis induced by disruption of the epitheliallayer, followed by administration of a compound or factor that promotesa differentiation of an uncommitted epidermal cell into a HF cell. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method oftesting an ability of a compound to modulate HF generation in vivo,comprising (a) disrupting an epithelial layer of a first scalp, eyebrow,or scarred region, whereby the first scalp, eyebrow, or scarred regionhas been contacted with the compound; (b) measuring a first HFgeneration in the first scalp, eyebrow, or scarred region; (c)disrupting an epithelial layer of a second scalp, eyebrow, or scarredregion, wherein the second scalp, eyebrow, or scarred region is a scalp,eyebrow, or scarred region of the first subject or a second subject,whereby the second scalp, eyebrow, or scarred region has not beencontacted with the compound; (d) measuring a second. HF generation inthe second scalp, eyebrow, or scarred region; and (e) comparing thefirst HF generation to the second HF generation, whereby a differencebetween the first HF generation and the second HF generation indicatesthat the compound modulates an HF generation in vivo (Examples).

In another embodiment, the present invention provides a method oftesting an ability of a compound to stimulate hair growth in vivo,comprising disrupting an epithelial layer of a first scalp, eyebrow, orscarred region, whereby the first scalp, eyebrow, or scarred region hasbeen contacted with the compound; measuring a first HF generation in thefirst scalp, eyebrow, or scarred region; disrupting an epithelial layerof a second scalp, eyebrow, or scarred region, whereby the second scalp,eyebrow, or scarred region has not been contacted with the compound;measuring a second HF generation in the second scalp, eyebrow, orscarred region; and comparing the first HF generation to the second HFgeneration, whereby a difference between the first HF generation and thesecond HF generation indicates that the compound stimulates a hairgrowth in vivo.

In one embodiment, the methods of the present invention of testing acompound are repeated using a plurality of subjects, until astatistically significant sample has been tested.

In another embodiment of methods for testing compounds of the presentinvention, the first scalp, eyebrow, or scarred region is a scalp,eyebrow, or scarred region of a first subject. In another embodiment,the subject is a subject in need of generation of a new HF. The secondscalp, eyebrow, or scarred region, in another embodiment, is a scalp,eyebrow, or scarred region of the first subject.

In another embodiment, the second scalp, eyebrow, or scarred region is ascalp, eyebrow, or scarred region of a second subject. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the excisional wounds of methods of the presentinvention are created using a surgical tool. In one embodiment, thesurgical tool is a dermal biopsy punch (Example 2). In anotherembodiment, the excisional wounds are induced by freezing or cryoinjury.The use of freezing or cryoinjury is well known in the art, and is used,for example by dermatologists to injure skin. In one embodiment, thefreezing or cryoinjury results in a blister. In another embodiment, theblister is used as a “chamber” to introduce drugs and or cells into thereepithelialized area. Each possibility represents a separate embodimentof the present invention.

In another embodiment, the excisional wounds of methods of the presentinvention are not surgically closed. In another embodiment, theexcisional wounds are not contacted with a bandage or dressing beforethey heal or during a period of time after wound induction. In anotherembodiment, the excisional wounds are not contacted with an ointmentbefore they heal or during a period of time after wound induction. Inanother embodiment, the excisional wounds are allowed to heal bysecondary intention. Each possibility represents a separate embodimentof the present invention.

The subject of methods of the present invention, is, in anotherembodiment, a human. As provided herein (Example 7) human skin respondsto EDIHN in the same manner as mouse skin. In another embodiment, thesubject is a male. In another embodiment, the subject is a female. Inanother embodiment, the subject is any other type of subject known inthe art. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the subject is an adult. In one embodiment,“adult” refers to an age greater than about 18 years. In anotherembodiment, “adult” refers to an age greater than about 20 years. Inanother embodiment, “adult” refers to an age greater than about 25years. In another embodiment, “adult” refers to an age greater thanabout 30 years. In another embodiment, “adult” refers to an age greaterthan about 35 years. In another embodiment, “adult” refers to an agegreater than about 40 years. In another embodiment, “adult” refers to anage greater than about 45 years.

In another embodiment, the subject is elderly. In one embodiment,“elderly” refers to an age greater than about 45 years. In anotherembodiment, “elderly” refers to an age greater than about 50 years. Inanother embodiment, “elderly” refers to an age greater than about 55years. In another embodiment, “elderly” refers to an age greater thanabout 60 years. In another embodiment, “elderly” refers to an agegreater than about 65 years. In another embodiment, “elderly” refers toan age greater than about 70 years.

In another embodiment, the first subject, or, where applicable, both thefirst subject and the second subject, is a laboratory animal. In anotherembodiment, the subject(s) is/are mice. In another embodiment, thesubject(s) is/are rats. In another embodiment, the subject(s) is/aregerbils. In another embodiment, the subject(s) is/are hamsters. Inanother embodiment, the subject(s) is/are guinea pigs. In anotherembodiment, the subject(s) is/are rabbits. In another embodiment, thesubject(s) is/are pigs. In another embodiment, the subject(s) is/aredogs. In another embodiment, the subject(s) is/are cats. In anotherembodiment, the subject(s) is/are primates. In another embodiment, thesubject(s) is/are any other laboratory animal known in the art. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, the subject(s) has a disease or disordercomprising balding. In another embodiment, the subject(s) does not havea disease or disorder comprising balding. In another embodiment, thedisease or disorder is androgenetic alopecia (AGA). In anotherembodiment, the disease or disorder is male pattern baldness. In anotherembodiment, the disease or disorder is female pattern baldness. Inanother embodiment, the disease or disorder is a discoid lupuserythematosis. In another embodiment, the disease or disorder is acongenital hypotrichosis. In another embodiment, the disease or disorderis a lichen planopilaris. In another embodiment, the disease or disorderis a scarring alopecia. In another embodiment, the disease or disorderis any other disease or disorder comprising balding known in the art.

In another embodiment, the scalp, eyebrow, or scarred region(s) has amajority of HF in the telogen stage of the hair cycle. The findings ofExamples 5-6 show that (a) EDIHN can restore hair growth to the scalp,eyebrow, or scarred region at the telogen stage; and (b) the efficiencyof EDIHN at the telogen stage can be enhanced by depilation prior toabrasion or wound induction. In another embodiment, the scalp, eyebrow,or scarred region(s) has more than about 60% of HF in the telogen stageof the hair cycle. In another embodiment, the scalp, eyebrow, or scarredregion(s) has more than about 70% of HF in the telogen stage of the haircycle. In another embodiment, the scalp, eyebrow, or scarred region(s)has more than about 80% of HF in the telogen stage of the hair cycle. Inanother embodiment, the scalp, eyebrow, or scarred region(s) has morethan about 90% of HF in the telogen stage of the hair cycle. In anotherembodiment, the scalp, eyebrow, or scarred region(s) does not have amajority of HF in the telogen stage of the hair cycle. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment of methods and compositions of the presentinvention, the first step (e.g. epithelial disruption) is performed 3-12days prior to the second step (e.g. addition of an active compound,factor, cell, etc). In another embodiment, the interval is 4-12 days. Inanother embodiment, the interval is 5-12 days. In another embodiment,the interval is 4-11 days. In another embodiment, the interval is 6-11days. In another embodiment, the interval is 6-10 days. In anotherembodiment, the interval is 6-9 days. In another embodiment, theinterval is 6-8 days. In another embodiment, the interval is 7-8 days.In another embodiment, the interval is 5-11 days. In another embodiment,the interval is 5-10 days. In another embodiment, the interval is 7-10days. In another embodiment, the interval is about 1 week. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention furthercomprises the step of suppressing an activity or expression of a Wntprotein in the scalp, eyebrow, or scarred region. As provided herein,suppressing Wnt activity induces pigmentation in HF generated by methodsof the present invention. In another embodiment, the step of suppressingWnt activity or expression is performed within about 10 days ofepidermal disruption. In another embodiment, the step of suppressing Wntactivity or expression is performed prior to the second step (e.g priorto addition of a compound or factor that promotes HF celldifferentiation. Each possibility represents a separate embodiment ofthe present invention.

In another embodiment, the present invention provides a method forinducing pigmentation of a hair, comprising suppressing expression of aWnt protein in a follicle of the hair. In another embodiment, the Wntprotein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. Inanother embodiment, the Wnt protein is a Wnt7a. In another embodiment,the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is aWnt3a. In another embodiment, the Wnt protein is a Wnt10. In anotherembodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wntprotein is any other Wnt protein known in the art. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method forinducing growth of a pigmented scalp hair or eyebrow of a subject,comprising generating a hair follicle in the scalp, eyebrow, or scarredregion according to a method of the present invention and suppressingexpression of a Wnt protein in the hair follicle, thereby inducing agrowth of a pigmented scalp hair or eyebrow of a subject.

In another embodiment, the step of suppressing expression of a Wntprotein comprises inducing an expression of a Dkk1 protein. In anotherembodiment, the step of suppressing expression of a Wnt proteincomprises inducing an expression of any other Wnt inhibitor known in theart. In another embodiment, the step of suppressing expression of a Wntprotein is performed immediately or shortly after epidermal disruption.In another embodiment, the step of inducing expression of a Dkk1 proteinis performed immediately or shortly after epidermal disruption. Inanother embodiment, the step of suppressing expression of a Wnt proteinis performed at the time of epidermal disruption. In another embodiment,the step of inducing expression of a Dkk1 protein is performed at thetime of epidermal disruption. In another embodiment, the step ofsuppressing expression of a Wnt protein is performed several days beforegeneration of the follicle. In another embodiment, the step of inducingexpression of a Dkk1 protein several days before generation of thefollicle. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the step of suppressing expression of a Wntprotein is performed for about 8 days. In another embodiment, the stepof inducing expression of a Dkk1 protein is performed for about 8 days.In another embodiment, the step of suppressing expression of a Wntprotein is performed for about 9 days. In another embodiment, the stepof inducing expression of a Dkk1 protein is performed for about 9 days.In another embodiment, the step of suppressing expression of a Wntprotein is performed for about 10 days. In another embodiment, the stepof inducing expression of a Dkk1 protein is performed for about 10 days.In another embodiment, the step of suppressing expression of a Wntprotein is performed for about 12 days. In another embodiment, the stepof inducing expression of a Dkk1 protein is performed for about 12 days.In another embodiment, the step of suppressing expression of a Wntprotein is performed during the period of re-epithelialization. Inanother embodiment, the step of inducing expression of a Dkk1 protein isperformed during the period of re-epithelialization. In anotherembodiment, expression of a Dkk1 protein is halted after several days.In another embodiment, halting expression of Dkk1 protein after severaldays induces, or enables induction of Wnt protein expression. In anotherembodiment, the expression of a Wnt protein is induced about 9 daysafter the abrating or wounding. In another embodiment, the expression ofa Wnt protein is induced following the period of re-epithelialization.In another embodiment, induction of Wnt protein expression is necessaryfor formation of new HF. Each possibility represents a separateembodiment of the present invention.

In another embodiment, “several” refers to about 1 day. In anotherembodiment, “several” refers to about 2 days. In another embodiment,“several” refers to about 3 days. In another embodiment, “several”refers to about 5 days. In another embodiment, “several” refers to about7 days. In another embodiment, “several” refers to about 10 days. Inanother embodiment, “several” refers to about 12 days. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the step of contacting in methods of the presentinvention comprises directly contacting the scalp, eyebrow, or scarredregion with the compound, RNA, protein, etc. In another embodiment, thestep of contacting comprises indirectly contacting the scalp, eyebrow,or scarred region via contacting another site or tissue of the subject,after which the compound, RNA, or protein is transported to the scalp,eyebrow, or scarred region by a biological process; e.g, diffusion,active transport, or circulation in a fluid such as the blood, lymph,interstitial fluid, etc. Each possibility represents a separateembodiment of the present invention.

In another embodiment, the epidermal disruption in methods of thepresent invention further removes dermal tissue from the scalp, eyebrow,or scarred region. In another embodiment, the epidermal disruption doesnot remove dermal tissue from the scalp, eyebrow, or scarred region.Each possibility represents a separate embodiment of the presentinvention.

“Disrupting” an epidermis or epidermal layer refers, in anotherembodiment, to removing part of the epidermis or epidermal layer. Inanother embodiment, the term refers to disturbing the intactness of theepidermis or epidermal layer. In another embodiment, the term refers toperforating the epidermis or epidermal layer. In another embodiment,only part of the epidermal layer need be removed. In another embodiment,the entire epidermal layer is removed. In another embodiment, the termrefers to abrading the epidermis or epidermal layer (Examples). Inanother embodiment, the term refers to wounding the epidermis orepidermal layer (Examples). Each possibility represents a separateembodiment of the present invention.

In another embodiment, the epidermal disruption is performed with a toolthat comprises sandpaper. In another embodiment, the epidermaldisruption is performed with a laser. In another embodiment, the laseris a Fraxel laser. In another embodiment, the laser is a CO₂ laser. Inanother embodiment, the laser is an excimer laser. In anotherembodiment, the laser is any other type of laser capable of inducingtrans-epithelial injury. In another embodiment, the epidermal disruptionis performed with a felt wheel. In another embodiment, the epidermaldisruption is performed with a surgical tool. In another embodiment, theepidermal disruption is performed with any other tool known in the artthat is capable of epidermal disruption. In another embodiment, theepidermal disruption comprises use of a micro-dermabrasion device. Inanother embodiment, the epidermal disruption comprises a burn treatment.

In another embodiment, the epidermal disruption comprises a disruptionof a follicle of said epidermis and a disruption of an interfollicularregion of said epidermis. In another embodiment, the epidermaldisruption comprises a disruption of a follicle of said epidermis anddoes not comprise a disruption of an interfollicular region of saidepidermis. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the epidermal disruption comprises a light-basedmethod. In another embodiment, the epidermal disruption comprisesirradiation with visible light. In another embodiment, the epidermaldisruption comprises irradiation with infrared light. In anotherembodiment, the epidermal disruption comprises irradiation withultraviolet radiation. In another embodiment, the epidermal disruptioncomprises orthovoltage irradiation. In another embodiment, the epidermaldisruption comprises X-ray irradiation. In another embodiment, theepidermal disruption comprises any other type of irradiation known inthe art.

In another embodiment, the epidermal disruption is performed bymechanical means. In another embodiment, “mechanical means” refers toabrading. In another embodiment, the term refers to wounding. In anotherembodiment, the term refers to ultrasound. In another embodiment, theterm refers to radio-frequency. In another embodiment, the term refersto an electrical process or the use of an electrical current. In anotherembodiment, the term refers to electroporation. In another embodiment,the term refers to exision. In another embodiment, the term refers totape-stripping. In another embodiment, the term refers tomicrodermabrasion. In another embodiment, the term refers to the use ofpeels. In another embodiment, the term refers to any other type ofmechanical means known in the art. Each possibility represents aseparate embodiment of the present invention.

In another embodiment, the epidermal disruption comprises chemicaltreatment. In another embodiment, the chemical is phenol. In anotherembodiment, the chemical is trichloracetic acid. In another embodiment,the chemical is ascorbic acid. In another embodiment, the chemical isany other chemical capable of epidermal disruption that is known in theart.

Each method or type of method of epidermal disruption represents aseparate embodiment of the present invention.

In another embodiment, epidermal trauma is utilized in a method of thepresent invention.

Each type of epidermal abrasion and epidermal trauma represents aseparate embodiment of the present invention.

In another embodiment, the epidermal disruption of methods of thepresent invention creates an abrasion at least about 1-1.5 centimeters(cm) in width. In another embodiment, the abrasion is at least about 1cm in width. In another embodiment, the abrasion is at least about 1.5cm in width. In another embodiment, the abrasion is at least about 2 cmin width. Each type of abrasion represents a separate embodiment of thepresent invention.

In another embodiment, the scalp, eyebrow, or scarred region is notcontacted with a bandage or dressing following the epidermal disruption.In another embodiment, the scalp, eyebrow, or scarred region is notcontacted with an ointment following the epidermal disruption. Inanother embodiment, the scalp, eyebrow, or scarred region is allowed toheal for a period of time without being contacted by any substance,device, ointment, etc., that is ordinarily administered to an abrasionor wound to facilitate healing. In another embodiment, the scalp,eyebrow, or scarred region is allowed to heal for a period of timewithout being contacted by any substance, device, ointment, etc., thatis ordinarily administered to an abrasion or wound to prevent infection.In another embodiment, the period of time is the time it takes theepidermal disruption to heal. In another embodiment, the period of timeis any time or range of times between 2 days and 3 weeks. Eachpossibility represents a separate embodiment of the present invention.

In one embodiment, “following” refers to a period of time of about 2days. In another embodiment, “following” refers to a period of time ofabout 3 days. In another embodiment, “following” refers to a period oftime of about 4 days. In another embodiment, “following” refers to aperiod of time of about 5 days. In another embodiment, “following”refers to a period of time of about 7 days. In another embodiment,“following” refers to a period of time of about 10 days. In anotherembodiment, “following” refers to a period of time of about 2 weeks. Inanother embodiment, “following” refers to a period of time of about 3weeks. Each possibility represents a separate embodiment of the presentinvention.

In another embodiment, a method of the present invention furthercomprises the step of depilating the scalp, eyebrow, or scarred region.As provided herein, the findings of Example 6 show that the efficiencyof EDIHN can be enhanced by depilation prior to abrasion or woundinduction.

In another embodiment, the depilation is epilation. In anotherembodiment, the depilation comprises the step of waxing. In anotherembodiment, the depilation comprises the step of plucking. In anotherembodiment, the depilation comprises the use of an abrasive material. Inanother embodiment, the depilation comprises the use of a laser. Inanother embodiment, the depilation comprises the use of electrolysis. Inanother embodiment, the depilation comprises the use of a mechanicaldevice. In another embodiment, the depilation comprises the use ofthioglycolic acid. In another embodiment, the depilation comprises theuse of any other method of depilation or epilation known in the art.Each possibility represents a separate embodiment of the presentinvention.

In another embodiment, a method of the present invention furthercomprises the step of administering a topical retinoid to the scalp,eyebrow, or scarred region. In one embodiment, the topical retinoidinduces resting (telogen) BF in the scalp, eyebrow, or scarred region toenter anagen. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the additional step (depilation or administrationof a retinoid) is performed prior to the step of disrupting theepidermis. In another embodiment, the additional step is performedfollowing the step of disrupting the epidermis, but prior to theaddition of the compound or factor that promotes a differentiation of anuncommitted epidermal cell into a HF cell. In another embodiment, theadditional step is performed concurrently with the addition of thedifferentiation-promoting compound or factor. In another embodiment, theadditional step is performed following the addition of thedifferentiation-promoting compound or factor. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the additional step is performed between abouttwo days and about three weeks before the step of abrading. In anotherembodiment, the additional step is performed about two days before thestep of abrading. In another embodiment, the additional step isperformed about three days before the step of abrading. In anotherembodiment, the additional step is performed about four days before thestep of abrading. In another embodiment, the additional step isperformed about one week before the step of abrading. In anotherembodiment, the additional step is performed about ten days before thestep of abrading. In another embodiment, the additional step isperformed about two weeks before the step of abrading. In anotherembodiment, the additional step is performed about three weeks beforethe step of abrading. Each possibility represents a separate embodimentof the present invention.

In another embodiment, the methods of the present invention furthercomprise the step of contacting the scalp, eyebrow, or scarred regionwith an inductive cell, capable of inducing an epidermal cell todifferentiate into an HF cell. In another embodiment, the HF cell is anHF stem cell. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the inductive cell is a dermal papilla cell. Inanother embodiment, the inductive cell is a follicular papilla cell. Inanother embodiment, the inductive cell is a dermal sheath cell. Inanother embodiment, the inductive cell is a cell that has beengenetically modified; for example, with a gene encoding a factor thatactivates one of the proteins or pathways shown in the present inventionto be up-regulated in HF stem cells. In one embodiment, the factor ishedgehog. In another embodiment, the factor is a DP cell protein. Inanother embodiment, the factor is wingless/int (wnt). In anotherembodiment, the factor is a Noggin protein. In another embodiment, thefactor is a bone morphogenic protein (BMP). In another embodiment, thefactor is a fibroblast growth factor (FGF). In another embodiment, thefactor is a transforming growth factor beta (TGF-beta) protein. Inanother embodiment, the factor is sonic hedgehog protein. In anotherembodiment, the factor is a neurotropin. In another embodiment, thefactor is any other factor known in the art that can contribute toinduction of an epidermal cell to differentiate into an HF cell. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell has been genetically modifiedwith a gene encoding a factor that represses one of the proteins orpathways shown in the present invention to be down-regulated in HF stemcells. In another embodiment, the inductive cell has been geneticallymodified with a gene encoding a factor that activates one of theproteins or pathways shown in the present invention to be up-regulatedin HF stem cells upon their activation.

In another embodiment, the inductive cell is an autologous cell. Inanother embodiment, the inductive cell is an allogenic cell.

In another embodiment, the inductive cell is derived from a mesenchymalstem cell. In another embodiment, the inductive cell is derived from amesodermal progenitor cell. In another embodiment, the inductive cell isderived from a hematopoietic stem cell. In another embodiment, theinductive cell is derived from an embryonic stem cell. In anotherembodiment, the inductive cell is derived from an embryonic carcinomacell. In another embodiment, the inductive cell is one of the cell typesdisclosed in United States Patent Application No. 2003/0201815. Inanother embodiment, the inductive cell is any other type of cell knownin the art with inductive properties for an epidermal cell. Each type ofinductive cell represents a separate embodiment of the presentinvention.

In another embodiment, the epidermal cell (e.g. the epidermal cell thatis induced to differentiate into an HF cell) is an epidermal stem cell.In another embodiment, the epidermal cell is a bulge cell. In anotherembodiment, the epidermal cell is any other type of cell known in theart that can be induced to differentiate into an HF stem cell. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention furthercomprises the step of contacting the scalp, eyebrow, or scarred regionwith an anti-androgen compound. In one embodiment, the anti-androgencompound is finasteride. In another embodiment, the anti-androgencompound is Fluridil®. In another embodiment, the anti-androgen compoundis dutasteride. In another embodiment, the anti-androgen compound isspironolactone. In another embodiment, the anti-androgen compound iscyproterone acetate. In another embodiment, the anti-androgen compoundis bicalutamide. In another embodiment, the anti-androgen compound isflutamide. In another embodiment, the anti-androgen compound isnilutamide. In another embodiment, the anti-androgen compound is aninhibitor of an androgen receptor. In another embodiment, theanti-androgen compound is any other anti-androgen compound known in theart. Each possibility represents a separate embodiment of the presentinvention.

In another embodiment, a method of the present invention furthercomprises the step of contacting the scalp, eyebrow, or scarred regionwith an estrogen compound. In another embodiment, a method of thepresent invention further comprises the step of contacting the scalp,eyebrow, or scarred region, with an estrogen receptor agonist. Inanother embodiment, a method of the present invention further comprisesthe step of contacting the scalp, eyebrow, or scarred region with anestrogen analogue. In one embodiment, the estrogen analogue isestradiol. In another embodiment, the estrogen analogue is 17beta-estradiol. In another embodiment, the estrogen analogue is 17alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3.In another embodiment, the estrogen compound, estrogen receptor agonist,or estrogen analogue is any other estrogen compound, estrogen receptoragonist, or estrogen analogue known in the art. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, a method of the present invention furthercomprises the step of contacting the scalp, eyebrow, or scarred regionwith an inhibitor of an EGF protein. In another embodiment, a method ofthe present invention further comprises the step of contacting thescalp, eyebrow, or scarred region with an inhibitor of an EGFR. Inanother embodiment, a method of the present invention further comprisesthe step of contacting the scalp, eyebrow, or scarred region with acompound that reduces an expression of an EGF protein or an EGFR. Eachpossibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention furthercomprises the step of contacting the scalp, eyebrow, or scarred regionwith a Hedgehog protein. In another embodiment, a method of the presentinvention further comprises the step of contacting the scalp, eyebrow,or scarred region with a nucleotide encoding a Hedgehog protein. Inanother embodiment, a method of the present invention further comprisesthe step of contacting the scalp, eyebrow, or scarred region with anactivator of a Hedgehog protein. Each possibility represents a separateembodiment of the present invention.

In one embodiment, a scalp is treated by a method of the presentinvention. In another embodiment, an eyebrow is treated. In anotherembodiment, any other hair-bearing area or region of the skin istreated. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, a method of the present invention furthercomprises the step of contacting the scalp, eyebrow, or scarred regionwith a lithium compound. In one embodiment, the lithium compoundcontains a lithium ion. In another embodiment, the lithium compoundcontains a lithium atom.

In another embodiment, a method of the present invention furthercomprises the step of contacting the scalp, eyebrow, or scarred regionwith (2′Z,3′E)-6-bromoindirubin-3′-oxime (BIO). In another embodiment, amethod of the present invention further comprises the step of contactingthe scalp, eyebrow, or scarred region with any other compound known inthe art that is capable of inducing an epidermal cell to differentiateinto an HF stem cell. Each compound represents a separate embodiment ofthe present invention.

In one embodiment, the compound administered as part of methods of thepresent invention is administered systemically. In another embodiment,the compound is administered topically. In another embodiment, thecompound is administered to the site of the abrasion. In anotherembodiment, the compound is administered to the site of the woundinduction. In another embodiment, the compound is administered to thesite of the depilation. In another embodiment, the compound isadministered during wound healing. In another embodiment, the compoundis administered prior to HF neo-genesis. In another embodiment, thecompound is administered during HF neo-genesis. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method ofinducing formation of an HF stem cell, comprising performing a method ofthe present invention. In another embodiment, the present inventionprovides a method of inducing formation of a DP cell, comprisingperforming a method of the present invention. Each possibilityrepresents a separate embodiment of the present invention.

In another embodiment, homologues and variants of transcripts andproteins of the present invention are administered in methods of thepresent invention. In another embodiment, homologues and variants oftranscripts and proteins of the present invention are targeted inmethods of the present invention. Each possibility represents a separateembodiment of the present invention.

The terms “homology,” “homologous,” etc, when in reference to anyprotein or peptide, refer in one embodiment, to a percentage of aminoacid residues in the candidate sequence that are identical with theresidues of a corresponding native polypeptide, after aligning thesequences and introducing gaps, if necessary, to achieve the maximumpercent homology, and not considering any conservative substitutions aspart of the sequence identity. Methods and computer programs for thealignment are well known in the art.

In another embodiment, the term “homology,” when in reference to anynucleic acid sequence similarly indicates a percentage of nucleotides ina candidate sequence that are identical with the nucleotides of acorresponding native nucleic acid sequence.

In another embodiment, “homology” refers to identity of greater than70%. In another embodiment, “homology” refers to identity of greaterthan 75%. In another embodiment, “homology” refers to identity ofgreater than 80%. In another embodiment, “homology” refers to identityof greater than 82%. In another embodiment, “homology” refers toidentity of greater than 85%. In another embodiment, “homology” refersto identity of greater than 87%. In another embodiment, “homology”refers to identity of greater than 90%. In another embodiment,“homology” refers to identity of greater than 92%. In anotherembodiment, “homology” refers to identity of greater than 95%. Inanother embodiment, “homology” refers to identity of greater than 97%.In another embodiment, “homology” refers to identity of greater than98%. In another embodiment, “homology” refers to identity of greaterthan 99%. In another embodiment, “homology” refers to identity of 100%.

Protein and/or peptide homology for any amino acid sequence listedherein is determined, in one embodiment, by methods well described inthe art, including immunoblot analysis, or via computer algorithmanalysis of amino acid sequences, utilizing any of a number of softwarepackages available, via established methods. Some of these packages mayinclude the FASTA, BLAST, MPsrch or Scanps packages, and may employ theuse of the Smith and Waterman algorithms, and/or global/local or BLOCKSalignments for analysis, for example. Each method of determininghomology represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a kit, comprisinga tools and/or a compound suitable for performing a method of thepresent invention.

In another embodiment, the present invention provides a device,comprising a tool suitable for epidermal disruption and a means ofdelivering a compound or factor that promotes a differentiation of anuncommitted epidermal cell into a HF cell.

In other embodiments, the present invention provides a method oftreating any disease, disorder, or symptom associated with balding. Inother embodiments, the present invention provides a method of treatingany disease, disorder, or symptom associated with balding. In otherembodiments, the present invention provides a method of treating anydisease, disorder, or symptom associated with balding. Each disease,disorder, or symptom represents a separate embodiment of the presentinvention.

Pharmaceutical Compositions

In another embodiment, methods of the present invention compriseadministering a pharmaceutical composition comprising the HF stemcell-inducing or -activating compound and/or its analog, derivative,isomer, metabolite, pharmaceutically acceptable salt, pharmaceuticalproduct, hydrate, N-oxide, or any combination thereof; and apharmaceutically acceptable carrier. Each possibility represents aseparate embodiment of the present invention.

The pharmaceutical compositions containing the HF stem cell-inducing or-activating compound can, in another embodiment, be administered to asubject by any method known to a person skilled in the art, such astopically, parenterally, paracancerally, transmucosally, transdermally,intramuscularly, intravenously, intradermally, subcutaneously,intraperitonealy, intraventricularly, intracranially, intravaginally orintratumorally. Each possibility represents a separate embodiment of thepresent invention.

In another embodiment, the pharmaceutical compositions are administeredorally, and are thus formulated in a form suitable for oraladministration, i.e. as a solid or a liquid preparation. Suitable solidoral formulations include tablets, capsules, pills, granules, pelletsand the like. Suitable liquid oral formulations include solutions,suspensions, dispersions, emulsions, oils and the like. In oneembodiment of the present invention, the HF stem cell-inducing or-activating compounds are formulated in a capsule. In anotherembodiment, the compositions of the present invention comprise, inaddition to the HF stem cell-inducing or -activating compound activecompound and the inert carrier or diluent, a hard gelating capsule.

In another embodiment, the pharmaceutical compositions are administeredtopically to body surfaces and are thus formulated in a form suitablefor topical administration. Suitable topical formulations include gels,ointments, creams, lotions, drops and the like. For topicaladministration, the HF stem cell-inducing or -activating compound or itsphysiologically tolerated derivatives such as salts, esters, N-oxides,and the like are prepared and applied as solutions, suspensions, oremulsions in a physiologically acceptable diluent with or without apharmaceutical carrier.

In another embodiment, the pharmaceutical compositions are administeredby subcutaneous implantation of a pellet. In another embodiment, thepellet provides for controlled release of HF stem cell-inducing or-activating compound agent over a period of time.

For liquid formulations, pharmaceutically acceptable carriers are, inanother embodiment, aqueous or non-aqueous solutions, suspensions,emulsions or oils. Examples of non-aqueous solvents are propyleneglycol, polyethylene glycol, and injectable organic esters such as ethyloleate. Aqueous carriers include, in another embodiment, water,alcoholic/aqueous solutions, emulsions or suspensions, including salineand buffered media. Examples of oils are those of petroleum, animal,vegetable, or synthetic origin, for example, peanut oil, soybean oil,mineral oil, olive oil, sunflower oil, and fish-liver oil.

In one embodiment, the pharmaceutical compositions arecontrolled-release compositions, i.e. compositions in which the HF stemcell-inducing or -activating compound is released over a period of timeafter administration. Controlled- or sustained-release compositionsinclude, in another embodiment, formulation in lipophilic depots (e.g.fatty acids, waxes, oils). In another embodiment, the composition is animmediate-release composition, i.e. a composition in which all the HFstem cell-inducing or -activating compound is released immediately afteradministration.

EXPERIMENTAL DETAILS SECTION Example 1 Depilation and Epidermal AbrasionCauses De Novo Hair Follicle Formation Materials and ExperimentalMethods Depilation and Epidermal Abrasion

Mice were anesthetized with an injection of sodium pentobarbital beforethe hair on the back was clipped and depilated with Nair(Carter-Wallace, New York, N.Y.), then epidermis was removed using arotating felt wheel as described by Argyris T, J Invest Dermatol, 75:360-362, 1980). After scrubbing with 70% ethanol and drying under anincandescent lamp, the basal and supra-basal layers in an area of (1.5cm)² cm of the inter-follicular epidermis were removed by carefulabrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.).After abrasion, the skin was shiny and smooth, and there was no blood.One day later, the abraded area was covered by a fibrin crust, whichfell off after 3-7 days, exposing the newly regenerated epidermis. Agroup of control mice was sacrificed immediately after abrasion toconfirm microscopically the complete removal of the interfollicularepidermis.

Immunohistochemistry

Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thickparaffin sections were cut and stained, where applicable, withantibodies.

BrdU Labeling

The protocol described by Bickenbach and colleagues (Bickenbach et al,Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244,184-195, 1998) was used. Mice were injected with 50 milligrams perkilogram (mg/kg) bodyweight 5-bromo-2′-deoxyuridine (BrdU) every 12hours for a total of four injections.

Results

An area of the backs of 50-day old mice was subjected to depilation andremoval of the epidermis using a rotating felt wheel. Fifteen dayslater, HF placodes, hair germs and other signs of follicle neogenesiswere present (FIG. 1; arrow indicates a hair germ). Morphology of thefollicles was similar to embryonic follicle development. To furthercharacterize proliferation in the new follicles, the skin was labeledwith BrdU 60 minutes before sacrifice. As depicted in FIG. 2, theproliferation pattern was similar to developing follicles in the embryo.

These findings demonstrate that (a) disruption of the epidermis causesgeneration of new HF, and that this generation of new HF can occur (b)in adult subjects and (c) during telogen (50-day-old mice are in thesecond telogen stage of the hair cycle).

Example 2 Induction of a Large Excisional Wound, but not a Small PunchWound, Causes De Novo Hair Follicle Formation Materials and ExperimentalMethods Punch Wound and Excisional Wound Induction

The backs of 21-day-old mice were depilated as described for Example 1and sterilized with alcohol, followed by 1% iodine solution. Punchwounds, 4 mm in diameter, were induced using a dermal biopsy punch, downto, but not through, the muscle fascia. Excisional wounds were fullthickness and 1 cm in diameter; skin and panniculus carnosus was excisedusing fine surgical scissors.

Results

To test whether wounding could induce HF formation, punch wounds orexcisional wounds were induced in mice. Both types of wounds exhibitedcontraction and re-epithelialization following wound induction; however,unlike the mice receiving punch wounds, the mice receiving excisionalwounds also exhibited scar formation within 10 days of wound induction(FIG. 3, left panel). No follicles were evident at this time point (FIG.3, right panel). 12 days after wound induction, hair germs, with similarmorphology to fetal hair germs, were observed in the wound site,following BrdU pulse labeling (FIG. 4). Several markers were used toverify that the observed structures were HF. The structures exhibitedstaining with anti-keratin 17 (K 17), an HF marker (FIG. 5), andstaining with anti-alkaline phosphatase at the 12 day time pointverified that the structures had dermal papilli containing fibroblasts,as expected for HF (FIG. 6; HF at earlier and later stages are depictedin the left and right panels, respectively).

The HF generated by wound induction were further characterized bymorphological comparison to embryonic HF, following BrdU staining; aclear correspondence in morphology was observed at various stages (FIG.7). In addition, several markers of embryonic HF development, namelyLef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were alsoinduced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG.8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis;right panel: cross-sectional view of follicle) provided furtherverification that the development of the EDIHN follicles closelyparalleled embryonic HF development.

These findings provide further evidence that disruption of the epidermiscauses generation of new HF, and that this generation of new HF canoccur (b) in adult subjects and (c) during telogen (21-day-old mice arein the first telogen stage of the hair cycle).

Example 3 EDIHN-Induced Hair Follicles Generate Hairs

At 25 and 45 days after wound induction, wound sites contained new hairs(FIG. 11, left and right panels, respectively). New hairs appeared tolack pigmentation, except when the wnt pathway was inhibited, usingDkk-1 (Dickkopf-1) during the first nine days after wounding (seeExample 10).

These findings indicate that EDIHN-induced HF function normally; i.e.are capable of generating hairs.

Example 4 EDIHN Hair Follicles Retain the Ability to Enter into CyclicalHair Growth Materials and Experimental Methods BrdU Labeling

50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 daysbeginning 20 days after wounding. BrdU was detected 40 days afterwounding (17 day chase).

Whole Mounting and Immunofluorescence

HF whole mounts were obtained by incubating fresh skin with EDTA (20 mMin PBS) at 37° C. overnight, then separating the epidermis and dermis.Epidermis was then fixed in 10% formalin for 10 min, room temperature(RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS,whole mounts were stained with antibodies for immunohistochemistry(schematically depicted in FIG. 12) and were imaged using a Leicaconfocal microscope.

Results

To determine whether EDIHN-induced HF contain normal levels of HF stemcells, mouse skin was examined for the presence of label-retaining cellsat 21 days after wound induction. Retention of BrdU during a long chaseperiod is, under these conditions, one of the hallmarks of HF stemcells. Normal numbers and placement of label-retaining cells (in thebulge of the HF) were observed (FIG. 13). To verify that thelabel-retaining cells were HF stem cells, K15-eGFP mice were utilized.In these mice, eGFP (enhanced green fluorescent protein) is expressedfrom the K15 promoter; thus, expression of eGFP identifies HF stemcells. As depicted in FIG. 14A, eGFP-expressing cells were observed inin tissue sections (right side) of newly formed hair follicles 35 daysfollowing wound induction. eGFP-expressing cells were also seen in theepidermis whole mounts (bottom, far left panel) indicating theconversion of epidermal cells into cells with hair follicle stem cellcharacteristics. ([bottom, second from left] panel is same as [bottom,far left] panel but viewed under white light) This finding shows thatthe observed label-retaining cells exhibited HF stem cell properties.

To determine whether EDIHN-induced HF cycle normally, mounts wereprepared from additional mice at 35, 38 and 45 days after wounding. Asdepicted in FIG. 14B, the EDIHN-induced HF entered the resting phase,telogen, and then re-entered a new anagen stage.

In summary, the findings of this Example show that EDIHN-induced HFcontain HF stem cells, as do embryonically generated HF. The presence ofthe HF stem cells shows that EDIHN-induced HF retain the ability toenter into cyclical hair growth in the same manner as embryonicallygenerated HF. The findings also show that wounding induces epidermalcells to assume a hair follicle stem cell state (expressing K15-eGFP).This model is shown schematically in FIG. 15. The findings of Examples2, 3, and 4 show that EDIHN-induced HF are fully functional and thusable to restore hair growth to a subject in need.

Example 5 EDIHN-Induces New Hair Follicles in Mice at the Telogen Stageof the Hair Cycle

To determine whether EDIHN was induced new hair follicles in micewounded at the telogen stage of the hair cycle, 21-day-old mice weresubjected to EDIHN using a 1-cm excisional wound, as described inExample 2. Skin was then examined by whole-mount assay for indicationsof new HF. As depicted in FIG. 16, after 11 days, new HF were notevident by macroscopic examination (top panel), AP staining of thedermis (bottom left panel), or K17 staining of the epidermis (bottomright panel). After 14 days, as depicted in FIG. 17, dermal papillacells were detected in the dermis (left panel) and HF stem cells in theepidermis (right panel), demonstrating that new follicles were beingformed. After 17 days, the new follicles were more developed, as shownby examination of the dermis and epidermis (FIG. 18, left and rightpanels, respectively). This method induced formation of an average of 49new follicles in the wound, a number that was consistent over threeseparate experiments, as depicted in Table 1.

TABLE 1 Results of three separate experiments performed on 21-day-oldmice. Sample Expt 1 Expt 2 Expt 3 Avg of expts Std dev of expts 1 24 7055 2 29 52 25 3 27 85 53 4 102 25 80 5 53 27 23 Average 47 51.8 47.248.67 2.71 Std dev 32.8 26.3 23.7

The findings of this Example demonstrate that EDIHN is capable ofinducing formation of new HF in mice at the telogen stage of the haircycle, despite that fact that these mice do not contain HF at the anagenstage during wounding.

Example 6 In Adult Mice, Induction of Anagen Increases the Efficiency ofEDIHN

The experiment described in Example 5 was repeated with mice ofdifferent ages, and therefore at different stages of the hair cycle. Toensure that wound scarring occurred, larger wounds were in induced inthe older mice. As depicted in Table 2, adult mice at telogen, such as8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.

TABLE 2 Efficiency of HF formation by EDIHN in adult mice at variousstages of the hair cycle. Days after Mice exhibiting Age Wound sizewound EDIHN Hair cycle 3 wk 1 cm 20 25/25 (100%) Telogen 4 wk 1 cm 205/5 (100%) Early anagen 5 wk 1 cm 20 1/2 (50%) Anagen 8 wk 1.5 cm 3016/35 (46%) Telogen 14 wk 1.5 cm 30 1/2 (50%) N/A* 20 wk 1.5 cm 30 2/2(100%) N/A* *The second telogen lasts approximately 40 days in mice.Thus, 14-week-old and 20-week-old mice contained a mixture of telogenand anagen HF.

To determine whether experimental induction of anagen increased theefficiency of EDIHN, 8-week-old mice were depilated several days priorto wound induction. As depicted in FIG. 19, the wounds closed similarlywhether or not they were preceded by depilation. As depicted in FIG.20A-B, the depilated mice exhibited enhanced EDIHN relative to thenon-depilated mice depicted in the previous Example by a factor of11-fold.

The findings of this Example demonstrate that anagen induction enhancesEDIHN. In addition, these findings show that EDIHN is capable of notonly forming new HF, but also of activating anagen in pre-existing HF inthe telogen stage.

Example 7 EDIHN-Induces New Hair Follicles in Human Skin Materials andExperimental Methods Grafting

Discarded human adult scalp from the preauricular area obtained fromplastic surgery was grafted onto immunodeficient (scid) mice. The graftwas bandaged and allowed to heal, then was used in the wound healingstudy 3 months after grafting.

Results

To determine whether human skin responded to EDIHN as did mouse skin,human skin was grafted onto SCID (immuno-deficient) mice and subjectedto depilation by plucking and wound induction three days later. Sevendays following wound induction, formation of new HF was observed in thehuman skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosinstaining of paraffin embedded tissue sections.

In additional experiments, adult human skin was grafted onto mice,abraded, and examined at 7 days post-abrasion. New HF were generated inthe human skin, which mimicked normal hair follicle formation duringfetal development, as evidenced by staining for S100A6 or S100A4 (FIG.21B).

The results of this Example show that EDIHN can be used to generate hairgrowth in human skin as for mouse skin.

Example 8 Molecular Pathways Activated During HF Stem Cell ActivationMaterials and Experimental Methods Isolation and Activation of HF StemCells

K15-eGFP mice were depliated in order to induce formation of new HF.Activated hair follicle stem cells were isolated from K15-eGFP miceusing fluorescence-activated cell sorting (FACS) two days afterdepilation and 5 μg (micrograms) total RNA from the cell population wasisolated, reverse-transcribed and hybridized to an Affymetrix (SantaClara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzedusing Affymetrix Microarray Suite 5.0 and GeneSpring software (SiliconGenetics) to detect fold-change differences between activated HF stemcells (HFSCs) and non-activated (telogen) HFSCs. Values were normalizedbefore computing fold-changes and differences between non-activated“bs-line” and activated (“expt”) samples.

Results

To identify molecular pathways up-regulated during HF stem cellactivation, activated HF stem cells were isolated, and the geneexpression patterns of the cells were analyzed to detect up-regulatedtranscripts. The transcripts depicted in Table 3 were up-regulated atleast 2-fold in the activated HF stem cells relative to the cells priorto activation. In some cases, the sequence in Table 3 is a genomicsequence that contains the sequence of the transcript. Data pertainingto the up-regulation of the transcripts and further information aboutthem is provided in FIG. 22.

TABLE 3 RNA transcripts up-regulated during HF stem cell activation. SEQID No: Access. # Sequence 1 AW047343uuuuuuuuuuuuuuuuucuuaaaaauauaaauguauuugucugcaucaugacguucuucgggaccuagcuggccagaccacuggccaugggacaaggaggaagucagguguaagucugagcaagg

acaggacucugcccuggcaggguggagguggccucacagugucccaugcugggccugguagcggaaagcacagcacgguagugggacagcuccugccgcacagccaccaccuccugccgcaacaggg

guuuuccuucuccaggaaggcagcccgcacagauauccgguucuccuugagucuucuugcaucc 2AF053235 Sequence below.caguuccucagcauggccaccugcagccgccaguucaccuccuccagcuccaugaagggcuccuguggcaucggugguggcucuagccgcauguccuccauccuggcuggaggauccugccgggcucccagcaccugcgggggcaugucaguuaccuccucucgcuucuccucugggggagucugugggauuggagguggcuauggugggagcuucagcagcagcaguuuugguggaggacuugguaguggauuugguggucgauuugauggauuugguggugguuuuggugcuggucuuggugguggucuuggcggugguauuggugaugggcuccuggugggcagugagaaagugaccaugcagaaccucaaugaccgccuggccaccuaccuggacaaggugcgugcccuggaagaggccaacagagaccuggaggugaagauccgggacugguaccagaggcagcggcccacugagaucaaagacuacagccccuacuucaagaccauugaggaccugaagagcaagaucauuauugccacccaggagaaugcacaguucacuuugcagauugacaaugccaggcuggcagcugaugacuucaggaccaaguacgagaaugagcuguucuugcggcaguccguggagggugacaucaauggccugcgcaaggugcuagaugagcugacccuguccagagcugaccuggaaaugcagauugaaaaccucagagaagagcuggccuuccugaagaagaaccaugaggaggagaugcuugccuugaggggucagacugguggggacgucaauguggagauggacgcagcccccgguguggaccucagccgcauucugaaugagaugagggaccaguaugagcagauggcagagaagaaccgcagagauguggaggccugguuccugagaaagacugaggagcugaacaaagagguggccucuaacagugaucuaauccagagcaaccgcagcgagguggcugagcuccgcaggguguuccagggccuggagauugaacugcagucccagcucagcaugaaagcauccuuggagaacagccuagaagagaccaaaggcagauacuguaugcagcugucccagauccaggguuugaucagcaguguggaggagcagcuggcucagcuucgcugcgagauggagcagcagagccaggaguacaacaucuuguuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcuggauggcgagaauauccacuccuccucacagcacuccucuggacaguccuauucuucucgagaagucuucuccucauccucccgccagccccgguccauccucaaggagcaagguucaaccagcuucagccagagccaaagucagaguuccagggacuaauguuuugccuagagccuccucacccacaacugccucucaagcugagggcuuggggcaggacccuguuuucuuugcgcauuccccaucugucuccccuacccucucauggugguaggcuaauaaagcuuuuugguugaugcaaaaaaaaaaaaaaaaaa 3 M26005gcgccaguccuccgauagacugagucgcccggguacccguguucucaauaaagccucuugcuguuugcauccgaaucguggucucgcugguccuugagagggucuccucagauugauugacuacccacgucgggggucuuucauuuggaggccccagcgagauuuggagaccccugcccagggaccaccgaccccccgucgggagguaagcuggccagcggucguuucgugucugucucugucuucgugcguguuugugccggcauuuaauguuugcgccugcgucuguacuaguuagcuaacuagaucuguaucuggcgguuccgcggaagaacugacgaguucguauucccggccgcagccccugggagacgucccagcggccucgggggcccguuuuguggcccauucuguaucaguaaccacccgagucggacuuuuuggagcuccgccacuguacguggcuuuguugggggacgagagacagagacacuucccgcccccgucugaauuuuugcuuucgguuuuacgccgaaaccgcgccgcgcgucugauuuguuuguuguucuuuuguucuucguuaguuuucuucugucuuuaaguguuuuucgagaucaugggacagaccguaacuaccccucugaguuuaaccuugcagcacuggggagauguccagcgcauugcauccaaccagucuguggaugucaagaagaggcgcuggauuaccuucuguuccgcugaauggccaacuuucaaugugggauggccucaggaugguacuuucaauuuaaguauuaucucucagguuaagucuagaguguuuuguccugguccccacggacacccggaucaggucccauauaucgucaccugggaggcacuugccuaugaccccccuccgugggucaaaccguuugugucuccuaaacuuccucccucgccgacagcucccguccucccgcccgguccuucugcgcaaccuccgucccgaucugcccuuuacccugcccuuacccccucuauaaaguccaaaccuccuaagccccagguucucccugauagcggcggaccccucauugaccuucucacagaggaccucccgccguacggagcacaaccuuccuccucugccagagagaacgauaaagaagaggcggccaccaccuccgagguuucccccccuucucccauggugucucgacugcggggaaggagagacccucccgcagcggacuccaucaucucccaggcauucccacuccgcauggggggagauggccagcuucaguacuggccguuuuccuccucugauuuaacccuuccuuuucugaagauccagguaaauugacggccuuga 4 AA681998gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucugcgcgccggcaggauggcccacaagcagaucuacuacucagacaaguacuucgaugagcacuacgaguaccggcaugucauguuacccagagaacucucuaaacaaguacccaaaacucaucugauguccgaagaggaguggaggagacuugguguccaacagagucuaggauggguucauuacaugauucaugagccagaaccgcauauucuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagugcagcugggaucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucagugaauacuugaaaaguguacaaaccuuucauccauaccugugcaugcgcuguauucuucacagcaacagagcucagucaaaugcaacugcaaguagg 5 AF057156atuaaaaagccagcugcccaaugccugcacacagaauccacaccaacagagaaccugcucuucucugaguauuagguaagucucugcuugcaacugauuugaaauucuugcuuauuuuuuuacuaugaaaaacuguucaaagccaacucuauuacagaguugauguggggugcugccuacaguuagugaacaguagcauuguuugcuuaaauuauagcacauuuugggucuaggaacuugagaggugauucaguuggucacuguaguagacagccuuggaaucagagauuaaggcaaaaggaaaccuccauucaaauauucauggaaguucacagcuggagacagguuaaggcuucaguccagauagcuuucagaauuauugcaguucuuacugauaggcauaucaauagcgaaauuuaauuuauuagaggaaucuacuaaaguaaauuuuuaggccaauauagaacauaccauacuuguagucuggcagagaaggugacauaugaaauugaaaugcgauucauagacagugguagugaaagaaauaaugguggggangggcugugcangggaggcauggcucaaggacagcacuuagugguagcacacaccaugaacuaugauggaaaagcauuugauaggcagagacagaaauguaggaaauguguagggauccaugagagcauaaacuaaaagggcaaaagcauaugagcauggacuaacaugcagccacucugcaaguuauacuaugaucuauuucacaaggagguugguaugcugcugucuuugggugacaccgcuuucccagauguccugguguguagguucacaagccucucagaagccauacuuuauugcuuuuuaagacguauuauuaauauuuuggcuagcauaugguuuagugugagaguuuuauaugcauaugucauuauacuuugcucauuuaugucuuggaacuucuucaacuagguagaaaacaugaccagggagaaugagaguaaggaaagaacccacugagacagacaagagcaaaccauacuucugcuaaucauguuuaaaaguccagaaaugaucauaccauauuuuauuuucaaguguggaagucagcauggagaggggcucuuuuucucuaaaggggccugaaauuaaauugacuugauguugagguuaccuucucuuucaaugaaucacuaaauugucuuuucuguuucccaggacccaagugcuaucuaaccaugaguucccaccagcagaagcagcccugcacuguaccuccucagcugcaccagcagcaggugaagcagccuugccagccaccaccccaggaaccuugugcccccaaaaccaaggaucccugccacccuguuccugagcccugcaaccccaaggggccagagcccugccaccccaaggcacccgagcccugccaccccaaggcaccugagcccugcaaccccaaggugccagagcccugccagccuaaggugccagagcccugccagccuaaggugccagagcccugcaaccccaaggugccagagcccugccaaccuaaggcaccagagccuugccaccccaaggcgccugagcccugccacccuguuguucccgagcccugccccucaacugucacuccaucaccauaccagcagaagacaaagcagaaguaauauuguccagagccaugccugaagaccugaucaccagaugcugaggcugcugucuauccugcuuaugagucccauugccuugugcuaccaaugcugugaccuucagucuuaaucccucucuccuugcaccaccuaaaaaguugacucucauccucaucuucaagggcuccugagccucuuaacauugcccaaagucauauugaauggcuacacuuuucauggcucaggauucaucugaagggggugaggagugagacaaguguauggucaauauuuuccccccauuaaaugccauuuaacucc 6 AI845584uuuuuuuuuuuuuuuuuagccaaaauaguuauuuauuaauaauuuaagguuuuacauucuuauaauaaauuccagcucaaaacuuuacaccacgaacaucauggagcaaguuaauucucccuuccucucaaccuguugcauccaccaaaugggcgcucauacucgcacacauacacacacuuccaguuucguauuuuuuuuuaaaaggaaagaaaccaacccaaaguauugcauuugaggugacacuc ccugaa 7AA614971 aagaugcccuuuggauuggauuggauugaucauguuuaacucagcguauuuuauggaugaaagcuaaauacagauauuuggcaucucuaagguggaaugagcccacuccacacacugauaaaauucaugcauaguuu 8 AV374591aaccaaaugggaaugggguccccaacnuuncugugguaccagccggguuucucuugcauuggaaacaaacaccuuuguaggcauuugcguauucgugaagagacuguuuuaugaaucaccucuuagauuuaunuaauuaaccuaaguuguugaaguuucuguuucuccuuaagagaaauuacaaaaauucaacauugaagcauaguuucuuguuuucuguugucaaauaguaauaaugugcugugauguuuaugcuuauucauaaagauguuuuacuuuuuaguguaauguuaguucuuuuuaacauuauuuugcuuaaauuugauaaugcccgacaagaauauauuuugcuuugauuuauacacugauucuuugugacaaauaugacccauuaaaaaugccuuuuaauagacuaacuuaccuuuuguagcuagguacucauguucuuuuuuaaaagaugcccuuuggauuggauuggauugaucauguuuaacucagcguauuuuauggaugaaagcuaaauacagauauuuggcaucucuaagguggaaugagcccacuccacacacugauaaaauucaugcauaguuuuaaaugaacauuaauaaacucaug uugucuu9 U04443 gaauucaaggaggcuuuccagcuguuugaccgaacaggugauggcaagauccuguacagccaguguggggaugugaugcgggcccugggccagaacccuaccaacgccgaggugcucaagguucuaggaacccccaagagugaugagaugaaugugaagguacuggacuuugagcacuuccugcccaugcugcagaccguggcgaagaacaaggcccagggaaccuacgaggauuauguugaaggccuucguguguuugacaaggaaggaaauggcaccgucaugggugcugaaauccgucauguccuagucacacugggcgagaagaugacagaggaagaaguagagaugcuaguggcagggcaugaggacagcaaugguugcaucaacuaugaagcauuugugaggcauauccugucggggugacgggcccgauggggcggagcucguccggauggugcugaauggcugagacauucuguaucccgagucuguucccugcccagugugauuucuguguggcuccagacgcuccccugucacagcaccuugucccauuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuuugccc 10 Y07836caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugcccacauguaccaaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcugauugagaaaaagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacuuugggucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagcagcagcagaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaauguucugcucagguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuucccagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacucggcucccaaagccgucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugccagucauccagcggacuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggagaaaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacgugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacuucgcgggcagugaucugauggguuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggccacugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaacaccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagagagaucagcccacccugcagacccacagagaagauucagagugugugugagagugagugagugugcgugcgugcgugcuuguauguauguuuguauauguaggacaauaaguuccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggacuguagcacaucucugggcguuucccuacccagagaagagcc 11 M21285 Sequence below.uugcaggcgagggcuuccacaacuaccaccacaccuuccccuucgacuacucugccagugaguaccgcuggcacaucaacuucaccacguucuucaucgacugcauggcugcccugggccuggcuuacgaccggaagaaaguuucuaaggcuacugucuuagccaggauuaagagaacuggagacgggagucacaagaguagcugagcuuugggcuucugaguuccuguuucaaacguuuucuggcagagauuuaauauucuguugauuaacuaacaacuggauauugcuaucgggguguuaaugaugcauuuaaccuauuccgguacaguauucuuauaaaaugagaaagcuuugaucacguuuugagguaauaaauauuuuauuuagcuaggauuaaccaugccacaagacauuauauauuucuaagcacacaugauaaaugcauauacaauuuugcacaacagcuuuaauaauaacaauaaauuugaacauucuauacagagaggaucaaagccaaggaacaugcuguuuugaugcuagggugagcauggugcucagucccuguuuguuugcaugguguccagcuuuguuucuucucugucaucaccaccuucaggcaaauaguugaccaaccacuggccugugucuguccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucccuccuuguuccuagcuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggauggagaaauuaucuucauuugauacagagcaaguagauugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaagauggaagagagagagagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuaccaaagaccccaggccucucugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauuaaaucauuuucagagugaaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaacugaagauuuuuucauggaaaaagucuucguguucaaugugccuagaacugauaacuaaacagcugacauuugucggggacagauauggugugaaacuaugaaaauauaagcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgagguguugccuggguugccaguuucuuucguggcugggcaggaacuagugagguugaggggcagugucuguaaguagcugcuaagaggugcauuuccagaugaagcccuuggggaacaucugccagggauccgcaugguguuggcuccauccauugcuuuaguuuccuccuuggauuguguagaaacuuggcuucccaugguuuugaaccuuccaugccuucuuugcuuuguggccacccagccugccuagugcugccuaggaagcucuuacccaccugauuucuucugacauuucuuucuuuggccuuuuuuucuuucuccggacaugcagcuaguugccugaguguaucaagagcacccaggacuugcugcuguccaggccuguuccucccccaguauccguggguguggaagagcuguguagcuucaggaagcagagccaggugccaccuuucuguggcuuccagauccucccuaccuccaacucaugugccucugucacagugauuucaggaaagcuugguagacccucuagcaacaucucgguucagaaagucucucugguuugugaguuaacagcucagcuaagugcuguuuugucucagugaguuaaccacugaaugcgaggguugguuguugaucugucucggugugugucggaguagacagcauaugcacuucucccugugcgcuuugcaagguaauguggcuuuggcugauccaugcaggcagguagugguacagugcugcugaaaggaagaaguuccccauuuuaucuguuaaaacaccagagacaugggcaagugcuaauggaccucacuucaggaagagggucugcuuccugaagccagugugugaugaaaagugacugagaccugauaucuaaggugagaccugauaccuaacacucugucacacaguccagggccaacagugcuauaggaaagucuagaagaaaacaucacaucaguauuuuagaaccaucaaccaucucuugucccuauagcccaauccagaggccugguuuuuagaacuggcuguguaaggugccaaacacucaguucacuuguagaaucagagccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguugaaguagaaaaucucauagaaaaaucacuguagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacuuuucuaggucauagaugccugauuauaaagaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccagaucugauucaggccauguuccaaagcaaggcuacauugagguccuggugucuuuaaguaaaggacaucuuucagauccucucaaagaaggauuuauaacaguuuccagaugaauguacuaauagcuuugggugccuuaucucuuuccuaaucuguagugccugugagcucagucucacuccuucccuuagcccggagaccccuuagaucgagugggaaugaucaagaggcuggcuggagagucaucaguacauugguuugcagaaaucuuuuacaggcuacauuuuggaauuuuuuuuuuuuuaguaagugaucaaauuuggugggaaguaauucgaguguauucgauuguauugucguccucguuaucauugucaaacauguuauagacggcaguuggcacuggggcugcuaaucucuggguguagucucugaaacuguagcuccagugagguggugugaaagguuagcaaagccaccaucugcuggugcuccagccaaggugccucuuagccacugaauugcuauguuauccuuucucuuguaacaaacccaccccagagauaaagccuuuaaucaacccaagaaacuccugggcuaaguaucugacagucucacaucucaacagugugaauuaaguguccauagcaucagcucaggaggacacucugggagagugcugacaaaaaaggguuauuaauacugaccuacuacuucaagggcaguucugaggugauuagagcuuuuuuuaaaaaccaaguauuuggggauccucagcagagguauucauacagacucccaaagaacuauauauguuccugagaccaucguuuagucuacauugcucuucccagagacugacagauaugaccagucaaagugcaagacuaccuacccacugccaugaaaaccauugcaggaaaccuuucccuuccugaaugagauuuuuuuuuucccuuuuuaugugggguaauuauuugugacccaaguguaauuuggaugauuuccauuaauaucaacucuugaagccuacuuguacugauugagauuguauuuguuccuaauaaaaguggaucugguuguacuguc12 V00756 accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcuugaugcugcaacacuuaaaaccaugaagauuucucguuuugaaaggcauuuauauaacucugcagcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguuggagaauucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuauuuuugcuacuucuaauguauauaagcuuuuagagacaguuuuuuaucuuggucaacuuaaauaauuuuugauguagggguggguuguauuuuaauuuaauguacaguguuacaaauuaaugaguucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggucgu 13 Y14296auguccgcggccgccuacauggacuucguggcugcccagugucugguuuccaucuccaaccgcgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcgcgaggugaccaaggaacacggugacccgggggacaccuggaaggauuauugcacgcuggucacuaucgccaagagcuuguuggaccucaacaaauaccgacccauccagacccccucggugugcagcgacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaaucugggucgaguccuucccacagcccggaggagagacaggauucuggcagcgcgcccagcccacucucccuccuccacucuggaguggcuucgaaggggaaacacgccuccgaaaagaggcacaagugccccuacaguggcugugggaaagucuauggaaaauccucccaucuuaaagcccauuacagagugcauacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucucgcgcucggaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccguugcccacugugugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacaccguguuccaucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggugcuccccauggcagccaggcagagauggguccccggaaggacagagcucccaggaaacagacugacacauggaaaucugccacagcagaggcgcgcuggccacaggaggucacugcuucuuuggccaauauucugauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaagucaacauuugguccccuugcagaggcaacucugaaccgucucugacugaagauucagacuggugguguacauacgucunacugggugaguugaccccuggccucccacagugcagaaccacucucuugaaucacauuaacuuuugagauuuaaaaaaaacccaaacccaacccnncaaaacnccaganacaccgaaacucuggauccucgaugcuugcugacucucagaauugnuunuucuucucanuuaugcaagcnagagcacaccuacuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacanaaaguuacuuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucgaggggucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaacauaaacugcacuuuuauuuucuaauaccgagggugaauacgguaaauacaugcuuugaggguagaanccgacggucuguuuggcaccacguuauaaucugcunnuuuuaacgaguaccaccuuggagggcaggcaaauaaaugcuuuuggguauuuucuccuuuguuuuugacaaaugcugcggaugggggaucgggaucggaggggagugcuuuuaaagauaauaaaaaaugagguaaauaauuuuaacuuaugaauuuguuugaauuc 14 X16490gagauugaaacaauggaagaacuuuccauggcaaacaccauguuugcccucaaucuccuuaagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucucaucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaagugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuucaguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacaggcacaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacacaccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagauucaaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcaguggacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaaccaaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggugcuggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaaugggcuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccuccaugcaaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcauacuggaaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuuggaauugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacacuggaugaagaugauguuguggucuacauucccaaguucaaacuggcacaaagcuacgaacucaaguccauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucucaggaaugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcguggaugucaccgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacuggccaugguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaauuacccacacgauacuauuuguugguagauucuccucacccuaaaaggggaagaccuauuuccacaugagguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaaguuuaaauacuuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaauuguauagcagucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaagucagaugaugucuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuacaguguuauuuauuguuuauauaaugguuguuuuacaaauuguuguccucuguuuaaugaaacuguaacacuacagaagcagaaaauuagauaauuuucuauuuaaagaaaaucagccauuuaauuuaauaaugaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaaauguacuuaacaaaagacauguuauaucucuaucauuauauaucauauguacguaucugcaacucaucuauaauuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguuguauaaaacuuagcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccugagauaauaaaguucaaagauuuauuuugaaaaaaaaaaaa 15 AW120868uuuuuuuuuuuuuuunuaagaauuaacuuuuauuuuugcuuaguuuuauuaaaaaaauaaauaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaaucaaacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuauaacugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacaggaucaacuagggcaaaauaaauaauuguguggaagcccuga 16 C78850aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaauggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuucuggaaacugnauaaaaucauuuauucacgugauucuauuucuucuggaucuauugauuugaguuggugauacuguugggucanaaccagggccuguu 17 D67076 Sequence below.gcagcuccgagcuaggugcuaucgcaaggccagagcgcacagcccggcggagagagcagauccuugcucagaucgagucaaaucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucuagguccugcagcagccagcagugcggagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuuucuaagugacccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagcaggccagcgaagcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagccaaaagucccuuuuggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcucucuguccgcacacaugcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccacggaggaagaugaggagcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucuggacgccuuuggccagcagcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggggcgcagucccggguccgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacggugaucccggcucugccgcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuucauucagccagcgccuggaguggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguuccacauccugaggcgaaggcggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacucgcgacccgagagccagaacacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggaccaggaagcauaaggaagaagcgauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccgacuuccacggcagcggucuaaagcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuaggaauucaauuagccuggugguggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagcucucacccuucggaauuucugcagcuggcagaaacaacacaacagccccagugaccgggauccagagcacuaugacacugcaauucuguucaccagacaggauuuauguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugaccccagcaggagcugcucagucauagaagaugaugguuugcaagccgccuucaccacagcccaugaauugggccauguguuuaacaugccgcacgaugaugcuaagcacugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcucuccagcuuagaccauagccagcccuggucaccuugcagugccuacauggucacguccuuccuagauaauggacacggggaauguuugauggacaagccccagaauccaaucaagcucccuucugaucuucccgguaccuuguacgaugccaaccgccagugucaguuuacauucggagaggaauccaagcacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccuccgguggcuuacuggugugccaaacaaaacacuucccuugggcagauggcaccagcuguggagaagggaaguggugugucaguggcaagugcgugaacaagacagacaugaagcauuuugcuacuccuguucauggaagcuggggaccauggggaccguggggagacugcucaagaaccuguggugguggaguucaauacacaaugagagaaugugacaacccagucccaaagaacggagggaaguacugugaaggcaaacgaguccgcuacagguccuguaacaucgaggacuguccagacaauaacggaaaaacguucagagaggagcagugcgaggcgcacaaugaguuuuccaaagcuuccuuugggaaugagcccacuguagaguggacacccaaguacgccggcgucucgccaaaggacaggugcaagcucaccugugaagccaaaggcauuggcuacuuuuucgucuuacagcccaagguuguagauggcacucccuguaguccagacucuaccucugucugugugcaagggcagugugugaaagcuggcugugaucgcaucauagacuccaaaaagaaguuugauaaguguggcguuuguggaggaaacgguuccacaugcaagaagaugucaggaauagucacuaguacaagaccuggguaucaugacauugucacaauuccugcuggagccaccaacauugaagugaaacaucggaaucaaaggggguccagaaacaauggcagcuuucuggcuauuagagccgcugaugguaccuauauucugaauggaaacuucacucuguccacacuagagcaagaccucaccuacaaagguacugucuuaagguacagugguuccucggcugcgcuggaaagaauccgcagcuuuaguccacucaaagaacccuuaaccauccagguucuuaugguaggccaugcucuccgacccaaaauuaaauucaccuacuuuaugaagaagaagacagagucauucaacgccauucccacauuuucugagugggugauugaagaguggggggagugcuccaagacaugcggcucagguuggcagagaagaguagugcagugcagagacauuaacggacacccugcuuccgaaugugcaaaggaagugaagccagccaguaccagaccuugugcagaccuuccuugcccacacuggcaggugggggauuggucaccauguuccaaaacuugcgggaaggguuacaagaagagaaccuugaaaugugugucccacgaugggggcguguuaucaaaugagagcugugauccuuugaagaagccaaagcauuacauugacuuuugcacacugacacagugcaguuaagaggcguuagaggacaagguagcguggggaggggcugauacacugagugcaagaguacuggagggauccagugagucaaaccaguaagcagugagguguggcaaggagguguguguaggggauacauagcaaaggagguagaucaggacacuacccugccaguuacauucugauaagguaguuaaugaggcacaguagcaucugaaagaccauacagagcacuaaggagccccaaagcacuauuaguaucucuuuucuuauaucuaucgcccaaauaauuuucagagucuggcagaagcccuguugcacuguacuaacuagauacuucuuaucacaaagauugggaaaggcaaagcagaaagaugguaagacuggguuucaaacaaggcuugguuucaaucacuggaggcaaggaggaggggacaaacaagaucauuauucgaagucgcugguugcugugguuuuacggaagguugaugcaucauuccuaucaacagugaaaaguucagcuuguucaacgugacagaaaggcucaucuccgugaaagagcuccugauuucuucuuacaccaucucaguucuuaacuauaguucauguugagguagaaacaauucaucuauuuauaaaauguacauuggaaaaaaaaagugaaguuuaugagguacacauaaaaacugaaggaaacaaugagcaacaugccuccugcuuugcuuccuccugagguaaaccugccuggggauugagguuguuuaagauuauccauggcucacaagaggcagaaaauaauacauguugugccagaguuagaaugggguauagagaucagggucccaugagauggggaacauggugaucacucaucucacaugggaggcugcugcag 18 M61007ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgccgcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggccuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauuggcgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcggacuucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacuacggcgccaagccgagcaagaagccggccgacuacgguuacgugagccucggccgcgcgggcgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcggagccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgguuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcggcagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaaggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaagaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgcggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcuggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcucagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggccacugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgcgcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugcaccgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgcaccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacgggacuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuccugcgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuuuuuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaagaggcguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaaacuuuuuuggagaauguuuaaaagccaaaaaaaaaa 19 C85523aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucuggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauacaccuuagcacaggguagaggagucucgacggucanccagaauuuuucacaggcuuauauaguaaaacucaaagggggagaacugggcagggaaaguacaaguuuacaucacuagggaguucugccaaaggacaanggguucunucagaggaaucuacguaacuaaggngucauguccuaucaaggnaucuacguaacuaaggagucauguccuaucauuuggcaauguacccgnucuuuugagguuguuccggagggncuuauucucaaaauguuuuucagauuggaagggguggguunccgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucuccuguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacuggcuuuaacccnaucuuuaaaauggggg 20 AW122030uuuuuuuuuuuuuuuuuaugaaacaguuuuguucagcccaugacuuugugcaugacugucguccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaaggaucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucuuugcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaacugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucuauacauugcugaggucuuuuucugguuguucauguaucaguguuuucaaccucgugccg 21 U57524Sequence below.gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucaccaccccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaagucauuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcggugccccucuuugaccccuugguggagucagauguagcacggucgcccccaaagcguuucuaaauuaauagucacuuaguucuuaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugaggucuuuaugacccaccuagggccuccuguuugccugaucuccuaagagacaaaugggaggaucagauuccauagcgggaggugucugggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuuucuguuuccucuuccauuuguagacuccacuccacuuggcugugaucaccaaccagccaggaauugcugaggcacuucugaaagcuggcugugauccugagcuccgagacuuucgaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcacaccccagcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggagggagagagauggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuaaaaaguuuucuccucgaugccuauaugauauucacucagaacccagauucugaguucuucaaaacugaugauguuugugguuguccucaagacaauagacaugaguugugugaggauugaaacacguaguacaguuuuugucuuccuccuccaggccacacgugucugcaccuagccucuacucacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguacaucucccuuccaccuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccugauugcuuuugguuucaggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuucgcucuuguugaaauguggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcccaaguacccggauacagcagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggagagcuaugacacggagucagaauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugcuuuggaucagagggauuucaguuguuuaacuucucagacucggcuugcaaagcaggaucccaagaauuugucucugguuuguuuuaagagcuuacccuuuugguugaggaaugagggaauucuagaaauugaacccaggccuuagcacauggugauaagcacacguucaaccauuaagcuccacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuccuacagccuggugcccuuguucuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucuccccuuaucccaaugucuuggugaaguucuaggaauuuaauaugucuuuuuccccucucuuguuuuagcugcccuaugaugacuguguguuuggaggccagcgucugacauuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaauagaguuuuauuuuucuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccuagacccaggcauuuuacuggggugauucggcuguugucuuugugaaauccgggg 22 U05809cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagcguucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagcagaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccaccaccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcuguccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucgcuuugugcucucuaagggccaugcagcucccauuuuauaugcagucugggcugaagcuggcuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggcauccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccugggagcugcuugcgggauggcauacacaggcaaauacuuugacaaagccagcuaccgagucuauugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugcuggaauuuacaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagagcgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuuggcuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuuggucaggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagggauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagauuauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccucaggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaaagugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggccacgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcucuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggugagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgcggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacaucaaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggcccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcgauggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucauccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucggccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcugguguaacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccgggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccgagcaaccaaaggcaggauccucaccguggaggaccacuacuacgaagguggcauaggagaggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucagccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaaggacgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcugggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugaguggggagguaaauauauguuuug 23 AW212475uuaacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauagcucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacaug 24 V00835ugaguucucguaaacuccagagcagcgauaggccguaauaucggggaaagcacuauagggacaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcggucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucggcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggugcaaacccuuugcgcccggacucguccaacgacuauaaagagggcaggcuguccucuaagcgucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuucaccagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuuggucuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcgggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaaagccuucauuaguuacgaguauugucgaacggguccuuuggcgggguuggggcuaggauuuagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucccaggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuaugucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuaggcucccugcagcuccgaggaggacuuagugaacugagccgggacucgugguguuggccacugcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuugcaccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguugggacaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaaauguccuuugcuucccggaggccauuguauugucucggggacagaacuauacagagaacuauuuaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcugccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugugcccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacgaacagcgcugccaccacguguaaauaguaucggaccaacccagcgucuuccuauacaguuccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuugagucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauagucuggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagggguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug 25 AV374868gcggcacgaugugucuucggguggcuuuuuuuuuuuuguuuugaauaauguuuacaauuucccucaaucacuuuuauagaaauccaccuccaggccccccccuuuccccacuuaggccuucgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugcacauauauuuauauuuauaaucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuuaacg 26 M21285 See above (same Accession Number). 27 U74683acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgccgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuugggagucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcaccuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugauggaagcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcugggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaaugacuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacugccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuuguuggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggaggucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccaucaauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccugcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugccccgaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaacguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcuacucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucucagacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguugugaugguggauucccauaccucauugcagggaaguaugcccaagauuuuggggugguggaagaaagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccguuacuauucuucugacuacuacuaugugggugguuucuaugguggcugcaaugaagcccugaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgaugacuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccccuucgagcugacaaaucaugcuguuuugcuugugggcuauggaagagauccaguuacugggauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuuccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauaccgauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacagagugauuuagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagcaucuuuaaagaauuuugucuuugaacuuaaaaccauccuugauuuuuuucuuuuaauaucuuccccaucaacuacugaacuacuuuucuuuuuaaaguacuugguuaaguaauacuuuuaugagcagugguucaguuguccaauauuuuuugcaggucaucuacaaugcaaccagauguuucaguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaaaacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaaucaguaccauagucuuucuauguguguuuacaagaauuuuugucaccuacuucuucccuuagaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa 28 X61800gagcucgaucccuguuccgccuuugcuaugucugaaggcguccugcuuugcgcgugucggggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgcacaaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcaccccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagcuggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccagguccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcacacccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccgagggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgacgagagcgccaucgacuucagcgccuacauugacuccauggccgccgugcccacccuagagcugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcgggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcuagggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccugcugccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagcccacuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggcacaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccggcagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgcaaccaggagaugcagcagaagcugguggaguugucggccgagaacgagaagcugcaucagcgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugcccagcccgccuuuccugccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuugagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaaucgcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgagagaagcuauauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacgucuuauuaccauugcagcuaagguacauuuguagaaaagacauuuccgacagacuuuuguagauaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaagaauaagaauaagaauaaagaagcauuuaaaucgcaaaaaaaaa 29 U20735 Sequence below.uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaaagcaggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugccaacuggccgcugccgaccgucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagcccggggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuaucacgacgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaaacuccugaaacccaccuuggcgcucaaccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcaguggggcaggcagcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucguccccaacagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggcagcgguggagguacagggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaagcccuggacgaccugcacaagaugaaccacgugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucuaugcugguccggagccgccucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggaccgccgugcggacugggagcucauacccgacggccaccaucagcuaccucccacaugcaccacccuuugcgggcggccacccggcacagcuggguuugagucguggcgcuuccgccuuuaaagaggaaccgcagaccguaccggaggcacgcagccgcgacgccacgccgccugugucccccaucaacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcggccaccaagugccggaagcggaagcuggagcgcaucgcgcgccuggaggacaaggugaagacacucaaggcugagaacgcggggcugucgagugcugccggucuccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcugccaguugcugcuaggggucaagggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcugggcgccugccccccacuggggugaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacuggacuccggcccgcccgccugcgcccaguccuuccaccucgagguuuacauggcccccuuccagcguauuuuguauguuuuuuuuuucugcaaagagacugaauucauauugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcggagcuggccgccgcuugguacucagcugcggggauacuagggagggaccuccgcccccugcccucccccucugcauaguacuguggagaagaaacacgacuucgugucuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaaucuauuuaagua 30U19118 Sequence belowgaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagaguccuuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacuggagcaaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccuccugggucacugguauuugaggauuuugcuaaccugacacccuuugucaaggaagagcugagauucgccauccagaauaaacaccucugccaucggauguccucugcgcuggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucugaggcggccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaaaaaggagaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugaggagcugaagaaugagaaacagcauuugauauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacggacaccggaagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagagguggcacggaggcaauuggggaguucuuacugaauccuccuuuuccaccccacacccugaagccauuggaaaacuggcuuccugugcacuucuagaaucccagcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugcccccgagugaaccguggagcaggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucagaugaccuagcuggccccaggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuugauagguggggugggaccacauccucuacuguggcugacaacgcccuuccaagggaauauggaaugagaacauucauuauugagguuguccaauggccaggguaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuucagagccugguguugugcuauuuagauguuugucuugcacaacauuggcaugauuuuuccgggaguuucaucagaucugauuucugagagucuggggaucugccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcaccaggggagugaaacuggcugaugaccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacugcagaggaagaacccugggcacagcagcuuuguccuuggcuacaaacuguuacaacgucacacaaugaaggcacaaaguccaacuuucaaaggguguaggacuccauacucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagaccaggguuggaagccaggugcagggccaggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagaugugguccagagcauuucagcugggagaucucccucuggccaccaggacucuggcuacuguuaaaauccugauguuucuguggaauccucaguguuuaaucccacucaauaguaucauuacaguuuucuguaagagaaaauauuacuuauuuaucccaguauuccuagccugucaacauaauaaauaucggaacaaaaccuggua 31 AW049031uuuuuuuuuuuuuuuuugcugauaagaauucuuuuuauguuauucgaauaaaaaauacauucauacagaaauauaacaaucucgcaaaaaacaauuucaaauaaaaucuuguaaaacaaaauuuuacaaaaaucuuacaaagauucuuuagauaacagggugcuucaaaaaaaaagaaauaaagaaauuucacuaauagaaauuuuuuuuuuuaauuucaagcaaaaguuccugcuugauugaggcucaguugucaccugaccagaauggacugcuuaguauuaaaguuacagcaucgacacggacggcacccagccccagccagaccagcaacgucgcuguguuucauaagugagacgcgccagcacaaguuuccucucucuucuguuuaccuucuuacuuaauggaauugcuauggauaagcacacagcagggccaaaaaaggaguuuuccaaaauccagcaaaucaagug 32 M93275uaguggugaucuggaccgugcggacuugcucgucccucagcucuccuguuaggcgucucuuuucuccaggaggaaaaaauggcagcagcaguaguggauccgcaacagagcguggugaugagaguggccaaccugcccuuggugagcucuaccuacgaccuuguguccuccgcuuaugucaguacaaaggaucaguacccguauuugagauccgugugugagauggccgagaagggcgugaagaccgugaccucugcggccaugacaagugcccugcccaucauccagaagcuggagccacaaauugcgguugccaauaccuaugccugcaaggggcuagacaggauggaggaaagacugccuauucugaaccagccaacguccgagauuguugccagugccagaggugccguaacuggggcgaaggauguggugacgacuaccauggcuggagccaaggauucuguagccagcacagucucaggggugguggauaagaccaaaggagcagugacuggcagcguggaaaggaccaagucuguggucaauggcagcaucaauacaguuuuggggauggugcaguucaugaacaguggaguagauaaugccaucaccaagucggagaugcugguagaccaguacuucccucucacucaggaggagcuggagauggaagcaaaaaagguggaaggauuugauaugguucagaagccgagcaacuaugaacggcuggagucccugucuaccaagcucugcucucgggcuuaucaccaggcucucagcaggguuaaagaggccaaacaaaagagccaggagaccauuucucagcuccacuccacuguccaccugauugaauucgccaggaagaauaugcacagugccaaccagaaaauucagggugcucaggauaagcucuaugucucguggguggaguggaagagaagcaucggcuacgacgacaccgaugagucccacuguguugagcacaucgagucacguacucuggcuaucgcccgcaaccugacccagcagcuccagacuacaugccagacuguccuggucaacgcccaaggguuaccacagaacauucaagaucaggccaaacacuugggggugauggcaggcgacaucuacuccguauuccgcaaugcugccuccuuuaaggaaguguccgauggcguccucacaucuagcaaggggcagcugcagaaaaugaaggaauccuuagaugaaguuauggauuacuuuguuaacaacacgccucucaacuggcugguaggucccuuuuauccucagucuaccgaggugaacaaggccagccugaagguccagcagucugaggucaaagcucaguaaaccccuccuugucaccagagcaugauguugcuggccagaugaccccuuuugcuguauugaaauuaacuugguagauggcuuuagcuuagaaaagcagcuucuuagaaccaagggccucauuauggucacucacagcucaguuauggucuugccccagcuggcccuggcacaggaguucucuuaccuggcuggugaguggccuguguuagucuugugaggaccuggaggaaccuaaaagcucagaugcacuuacagucuugucuguggccuuuguauuguuauuggcuguaaacgucugucuggaccgaauaaagauucacguga 33 AB000713ggcacgagggagcugcaguguucgcgcuugguagcuggugcaucggacucagcuggcuuugugucccugaggcucaccgaaaaacacuuucucagcccucugacuccagagagagagagagagagguacuuuuuguggucaccgacuuugaccccugcagaggcugagcgauggcgucuaugggacuacagguccugggaaucuccuuggcaguccugggcuggcuggggaucauccugaguugugcgcuccccauguggcgggugaccgccuucaucggcagcaacaucgucacggcacagaccagcugggagggccucuggaugaacugcguggugcagagcacaggucagaugcagugcaagauguacgacucgaugcucgcccugccgcaggaccugcaggccgcccgagcccuuauggucaucagcaucaucgugggugcucuggggaugcuucucucagugguagggggcaagugcaccaacugcauggaggacgagaccgucaaggccaagaucaugaucaccgccggagccguguucaucguggcaagcaugcugauuauggugcccguguccuggaccgcucacaacgucauccgcgacuucuacaacccuaugguggcuuccgggcagaagagggaaaugggggccucgcuuuacgucggcugggcggccuccgggcugcugcuccugggaggaggccuccucugcugcaguugcccaccucguagcaacgacaagcccuacucggccaaguacuccgccgcccgcucuguccccgccagcaacuauguguaaggugggccacucuguccacauugccuuuguuauuuuuuuucggauugagcucauaacagccuguggccccucacauucuccaggaccugcccugcuaugggccacuaacugcuugcuggggacaggcaaacccggacugugcaaaguuacuagcccguagcucuugggcugcuccacauggcuccuuacggccggcaagaauggauguaaaaauaucuugcugcuuacauccaaauugcgguggauaugggcugaaggcagaagcagcugggaagggcaguagaggcgcaagcuggguccugcuggccgggguagcucagcugugacuuuggacucggaguggauguccucauguuagcaaacguccacuguccuuucucuaucccccucacucagccuacacguuacuccagcgcuacucuugccauuacgccccguguuuccgagcacagcugguccuaccccaagucauggugugcugagugacugaugaggggccauugagagccggugggcucugccauggaacccuuccguugauuagcaaugacugugcuugacccacccaccuacccuacuaaugaauuucuguagaguggauggacggguuugagggaagaaggguggagguggauuaaacugguuuggggagggcuggggaccuagaagcagcccaguguguccccaccccuuuuccgcacugucuugcuaauguucugaucacugugcgcccccucccucuucagaaggacccugggccucuugaguuggccccucugaguucccucccuuugcccauuucaaggacaccggccagucugcggaaggaagguacggggggggggggggggggugauggcauuguaccagggagucuccuggacuccccugccuucucugugguuucuuguuuuguaauuaaggucuguucacagcuguaauuauuauuauuuucuacaauaaauggcaccugcauacag 34 U20735 See above (sameAccession Number). 35 U83148augcagcugagaaaaaugcagaccaucaaaaaggagcccgcaccccuagauccuaccagcagcucagacaagaugcugcugcugaacucugccuuagcugagguggccgaggaccuagccucaggugaagauuugcuccugaacgaagggagcauggggaaaaacaaauccucggcgugucggagaaaacgggaauucauuccggacgagaagaaagacgccauguauugggagaaacggcggaaaaacaacgaagcugccaaaagaucucgggagaagcgccgccucaaugaccugguuuuggagaacaagcugauugcccugggagaagaaaaugccacuuuaaagcugagcugcucucccugaaauuaguuugguuuaauuagcuccacggcguaugcccaagaaauccagaaacucaguaauuccacagcugucuacuuucaggacuaccagacauccaaggcugccgugagcucuuuuguggacgagcaugagccugcgaugguagccggaaguugcaucucagucaucaagcacucuccccagagcucgcucuccgaugugucagagguguccucgguggagcacacucaggaaagccccgcacagggaggcugccggagcccugagaacaaguucccugugaucaagcaggagcccguggaguuggagagcuuugccagggaggccagggaggagcggggcacguauuccaccuccaucuaccagagcuacaugggaagcucuuucuccacuuacucccacuccccaccccucuugcagguccauggguccacuagcaacuccccaagaaccucagaggccgaugaggguguagugggcaagucuucugauggggaagacgaacaacaggucccuaagggccccauccauucuccaguggagcugcaacggguucacgccacgguggugaagguuccggaagugaacccuucugccuuaccgcacaagcuucggauuaaagccaaggccaugcaggucaaaguggaggcuuuggacagcgaguuugaaggcaugcagaaacucucuucacccgccgaugcgaucgccaaaagacauuuugaccuggagaaacauggaaccucggguauggcccauuccucccucccuccuuucucagugcaggugacgaacauucaagauuggucccucaaaucggaacacuggcaucacaaagaacugagcagcaaaacucagaguagcuucaaaacaggugugguggaagucaaagacgguggcuauaagguuuccgaagcugagaauuuguauuugaagcagggaauagcaaacuuaucugcagagguggucucgcucaagagauucauagccacacaaccgaucucggcuucggac uccagguaa36 L10244 gcucccgggaaacgaaugaggaaccaccuccuccugcuguucaaguacaggggccuggugcgcaaagggaagaaaagcaaaagacgaaaauggcuaaauuuaagauccguccagccacugccucugacugcagugacauccugcgacugaucaaggaacuggcuaaauaugaauacauggaagaucaagucauuuuaacugagaaagaucuccaagaggauggcuuuggagaacaccccuucuaccacugccugguugcagaagugccuaaagagcacuggaccccugaaggacauagcauuguuggguucgccauguacuauuuuaccuaugacccauggauuggcaaguugcuguaucuugaagacuucuucgugaugagugauuacagaggcuuugguauaggaucagaaauuuugaagaaucuaagccagguugccaugaagugucgcugcagcaguaugcacuucuugguagcagaauggaaugaaccaucuaucaacuucuacaaaagaagaggugcuucggaucuguccagugaagagggauggaggcucuucaagauugacaaagaguacuugcuaaaaauggcagcagaggagugaggcgugccgguguagacaaugacaaccuccauugugcuuuagaauaauucucagcuucccuugcuuucuaucuuguguguagugaaauaauagagcgagcacccauuccaaagcuuuauuaccagugacguuguugcauguuugaaauucggucuguuuaaaguggcagucauguaugugguuuggaggcagaauucuugaacaucuuuugaugaagaacaaggugguaugaucuuacuauauaagaaaaacaaaacuucauucuugugagucauuuaaauguguacaauguacacacugguacuuagaguuucuguuuugauucuuuuuuuuuaaauaaacucgcucuuugau uu 37 U88328cgcuggcuccgugcgccauggucacccacagcaaguuucccgccgccgggaugagccgcccccuggacaccagccugcgccucaagaccuucagcuccaaaagcgaguaccagcugguggugaacgccgugcgcaagcugcaggagagcggauucuacuggagcgccgugaccggcggcgaggcgaaccugcugcucagcgccgagcccgcgggcaccuuucuuauccgcgacagcucggaccagcgccacuucuucacguugagcgucaagacccagucggggaccaagaaccuacgcauccagugugaggggggcagcuuuucgcugcagagugacccccgaagcacgcagccaguuccccgcuucgacuguguacucaagcuggugcaccacuacaugccgccuccagggacccccuccuuuucuuugccacccacggaacccucguccgaaguuccggagcagccaccugcccaggcacuccccgggaguacccccaagagagcuuacuacaucuauucugggggcgagaagauuccgcugguacugagccgaccucucuccuccaacguggccacccuccagcaucuuugucggaagacugucaacggccaccuggacuccuaugagaaagugacccagcugccuggacccauucgggaguuccuggaucaguaugaugcuccacuuuaaggagcaaaagggucagaggggggccugggucggucggucgccucuccuccgaggcacauggcacaagcacaaaaauccagccccaacggucgguagcucccagugagccaggggcagauuggcuucuuccucaggcccuccacucccgcagaguagagcuggcaggaccuggaauucgucugaggggagggggagcugccaccugcuuuccccccucccccagcuccagcuucuuucaaguggagccagccggccuggccuggugggacaauaccuuugacaagcggacucuccccuccccuuccuccacacccccucugcuucccaagggagguggggacaccuccaaguguugaacuuagaacugcaaggggaaucuucaaacuuucccgcuggaacuuguuugcgcuuugauuugguuugaucaagagcaggcaccugggggaaggauggaagagaaaagggugugugaaggguuuuuaugcuggccaaagaaauaaccacucccacugcccaaccuaggugaggagugguggcuccuggcucuggggagaguggcaaggggugaccugaagagagcuauacuggugccaggcuccucuccauggggcagcuaaugaaaccucgcagaucccuugcaccccagaacccuccccguugugaagaggcaguagcauuuagaagggagacagaugaggcuggugagcuggccgccuuuuccaacaccgaagggaggcagaucaacagaugagccaucuuggagcccagguuuccccuggagcagauggaggguucugcuuugucucuccuauguggggcuaggagacucgccuuaaaugcccucugucccagggauggggauuggcacacaaggagccaaacacagccaauaggcagagaguugagggauucacccagguggcuacaggccaggggaaguggcugcaggggagagacccagucacuccaggagacuccugaguuaacacugggaagacauuggccaguccuagucaucucucggucaguagguccgagagcuuccaggcccugcacagcccuccuuucucaccuggggggaggcaggaggugauggagaagccuucccaugccgcucacaggggccucacgggaaugcagcagccaugcaauuaccuggaacugguccuguguuggggagaaacaaguuuucugaagucagguauggggcuggguggggcagcuguguguugggguggcuuuuuucucucuguuuugaauaauguuuacaauuugccucaaucacuuuuauaaaaauccaccuccagcccgccccucuccccacucaggccuucgaggcugucugaagaugcuugaaaaacucaaccaaaucccaguucaacucagacuuugcacauauauuuauauuuauacucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuuaaugaaaaaaaaaaaaaaaaaaaaaaaaaa 38 X82786 Sequence below.aaggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaaggagaaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaaccggaagagaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagcccacagcacagagaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguugaagagguuaagaagucuacaaagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggaggguacccaaggaaaaggcacaggcccuagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaaucagcaagugauaaaggacccacacagaugcccuguaauucucuacaaccagagcaaguugacagcuuccaaagcucaccaaggcgacccaggacaagacgugggaaaguagaggcagaugaagagccuucagcaguaagaaagacaguaucaacaucaaggcaaacuaugcgaucccgcaaggucccugaaauugguaacaaugguacccaaguuucaaaggccuccauaaagcagacauuagauacaguagccaaaguaacuggcagcaggaggcagcuaaggacacauaaaggaugggguucaacccucuugaaguuguuaggugacuccaaagaaauaacccaaauaucagaucacucugagaaacuagcacaugacaccaguauccuuaagagcacucaacagcaaaagccagacucaguaaaaccucugagaacaugcagaagagugcugagggccucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaagcaacccuuugcuguccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcaccaaagcaggaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagccugugaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguuaugaaaacagaagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaacagccaaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccucccaggagacagagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaacaugcuugaggucuagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuugauaaagccucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuuggacagugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggaugaagacauuguaugcaccaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuauguagcaaagacauuuaagaaggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccaguguaaagaugaacuguaaauacuacugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucuucagacgccaauggaggucaugaggaagaucaccagggaucucagcgcaauuacaguuuaggggugagcaggcagaaauguggcccucuguccuauccaauaaagcucugaaauucgcugccaaaa 39 AW122523uuuuuuuuuuuuuuuuuaaaucaaaaguuaugaugacuuuauuuuaaaucuuaauacaccaaaaauauuuuucaauguugugagauaagcacuugaaaauaagaauuccaacacugcugugauuucgcugugaggcuugauagugaauuuucccucugaauauggguuuagggccuaggaagcagaaugccagucauuuuccaaguagcagugagcuaagcccagcccggucaugcucagacccacacuuaacugaaauauucacacuaggaggcggcaccaccaggcaacaccuugaucaaccaggagaacaaaagucugaagugccaccaagcauuggggaaaugauauuguuuagaugcuagugagucagguucuuucaaauguguccuaacuggguugcaaacauaguugcauccu uau 40AI642048 gucuguaaaaaucuguuuaauaaauauacaucuuagaaguaccaaaauaauuaccaacaaaauacaacauauacaacauuuacaagaaggcgacacagaccuuaguugggggcgacuuuuaagcacaugccacugaacaccuggcucuuacaugggaggacacacugggcucacuuacuaggucuauggugguucaaucaaaagcacaauaaauaaaacgugguccuuucauuagguucuggaaaaucaccucccccccccccaaaaaaaaucccacaaacaugaaccuuaagagacauuuucuuugaauuucagugaucuguuuccccggauuucacaaagacaacagccgaaucaccccaguaaaaugccugggucuaggcgcugugugguguggugcuaaguauacccuuucucauuuuuuuucuuuuucu 41 L07264cggccgccagaccuucaagggcuggaguggacgcgcggaccgacucugaacagacagacgaaccgcggccgcaagguucccagacaggaucucacccagaggcaggcagcggacagugccuuaguggaaccucgcuguccuccaccgccuggccccggugcaggcguccaguggccgccgcauccaaagugaucgcugccuccccgucuccgccagcucgggaccaugaagcugcugccgucggugaugcugaagcucuuucuggccgcaguguuguccgcguuggugaccggugagagucuggagcggcuucggagaggucuggcggcagcaaccagcaacccugacccucccacuggauccacaaaccagcugcuacccacgggaggugaucgugcucaggggguccaggacuuggaagggacagaucugaaccuuuucaaaguugcuuucuccuccaagccacaaggccuggccaccccaagcaaagaaaggaaugggaaaaagaagaagaaaggaaagggguuagggaagaagagagacccaugccucaggaaauacaaggacuacugcauccacggggagugcagauaccugcaggaguuccguacucccucuugcaaaugccucccugguuaccacggacacaggugucaugggcugacucuaccaguggagaauccccuauacacauaugaccacacuacagucuuggcugugguggcuguaguacugucguccgucugucuucuugucaucgugggacuucucauguuuagguaccacaggagaggagguuaugacuuggaaagugaagagaaagugaaguugggcguggcuagcucccacugaggaggaccugagcuauaggaaccuucagaggcuacuucugagacagugguucguuacacguucuacauagaggagaaauauuucaccagcagccaugaaaacgucuucauucauuuccaguugcuacccugacugggccuccuguaau 42 M15668ucgaccucacggucuugccaaaaugucgcuuuccaacaagcugacuuuggacaagcuggacgugaaggggaagcgggucgugaugaggguggacuucaacguuccuaugaagaacaaccagauaacaaacaaccaaaggaucaaggcugcuguuccaagcaucaaauucugcuuggacaauggagccaacuccguuguccuuaugagccaccugggccggccugaugguguucccaugccugacaaguacuccuuagagccaguugcugcugaacucaaaucucugcugggcaaggauguucuguucuugaaggauugugugggcccagaagucgagaaugccugugccaacccagcggcugggacugucauccugcuggaaaaccuccgcuuucauguagaggaagaagggaagggaaaagaugcuucugggaacaagguuaaagcugagccggccaaaauugaugcuuuccgagccucacuguccaaacuaggagaugucuaugucaaugaugcuuuugggacugcacaccgagcccauagcuccauggugggugugaaucugccacagaaggcugguggauuuuugaugaagaaggagcugaacuacuuugccaaggcuuuggagaguccugagcgacccuuccuggcuaucuugggaggcgcuaaaguugcagacaagauccagcugaucaauaauaugcuagacaaagucaaugagaugaucauuggugguggaauggccuuuaccuuccuuaagguccucaacaacauggagauuggcacaucucuguaugaugaagaaggagccaagauugucaaagaucucauguccaaagcugagaaaaauggugugaagauuaccuugccuguugacuuugucacugcugacaaauuugaugagaaugccaagacuggccaagcuacuguggccucugguauaccugcuggcuggaugggcuuggacugugguacugagagcagcaagaaauaugccgaggcugugggucgagcuaagcagauuguuuggaaugguccuguugggguauuugaaugggaagccuuugccaggggaaccaagucacucauggaugagguggugaaagccacuucuagggguugcaucacuaucauaggugguggagacacugccacuugcugugccaaauggaacacagaggauaaagucagccaugugagcacugggggcggugccagucuagagcuccuggaagguaaaguccuuccugggguggaugcucucagcaauguuuaguauuuucuuuccugccuuugguuccugugcuccuaagcuaaccugcuguuuuccacaucuccauuugguguuagcgcaagauucagcuaguggcugagauguggcacagaccuuaacagugcaagcaucucagcucgucuuacugcaucagaugcugguucuucaagaucccauuuaaauuccuuagugacuaaaaccauugugcauuguagagggcgucuauuuauauucugccugagaaaggaagugagcuguaaaggcugagcucucucucugacguauguagccucugguuagcuucgucacucacuguucuugacucagcauggcaaucugaugaaauucccagcuguaagucugcagaaauuuccgaauuc 43 AI047508uuuuuuuuuuuuuuuucauguuuaauaguuuauuucuuauuuuguugcuuauaucuucaauaaaucauuuugcagguuuuguuacagauuuuugauaagccaacucaaguacugauuuuucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuuccacauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccaucaucucuuaggacaucauacuggcaagugaugauauaggucuuagguaaaugaugcaauauauugucauuggccaacagagggcaugccuucacaucuaugaacccuggauacuuuugagccagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagggagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug guuga 44AJ001418 Sequence below.gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaacccuacggauccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgcugagcagcgccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugcuggacuuugguucagaaaaugccugugaaagaacguccuuugcuuuucugcggcaagagcugcccguccgccuggccaauauccugaaggagauugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccagagccugauggauuugguggaguuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcuggucaaaguucgaaacagacaucauaauguggucccuacaauggcucaaggcauccuggaguauaaagacaccugcacaguggaccccguuaccaaucaaaaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagcacauccucauauucagugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcaguaguccaagaugccuuugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagucaauggaaaauuuccaggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucuucgaacucuucaagaaugccaugagggccacggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaagaagaccuuacaaucaagauuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguacuccacugcuccaacaccugugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgucucuacgccaaguauuuucaaggagaucugaaucucuacucuaugucagguuaugggacagacgcuaucaucuacuuaaaggcuuuaucuucugagucuguagaaaagcucccagucuuuaacaagucagccuucaaacauuaucagaugagcuccgaagcugaugacugguguaucccaagcagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugacauuuuacgggaucaaagugggucuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaacacaaaaccaagcaagcaaaacacaaacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccgggagaagucagggcagggcuccaggggauaacagguguccugcuucuccuuuggcaaugcaaaaugacuccugacuguuccaaauacugaaaagaagucugccucugaguuacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggauguuuggugguucuugcugccagccaaauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuuggcgccuugggagaaauguguguaaauguacauuguauagguauuagugugcucuagaaaggacaggauggaaggaaucaaagcacuuuaucgagcuuguggcugagcauugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcuccaguaucaugcagcuuuuuauguuugcacucaaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaauaugcacugaccucagaaagucgaguucaaaagggagauaaaauugccaaagugauccaaggauugugcauguugggaaacccauaugagagaaaggauucucauacuuagaacuuuccuaugaagaaauggugguaaacuuucucuaccuagaaguaguggaaauuucaaggucaucuuaaaaaagaugugcguuguauauuuuaacuacauucucuacacucuaacauuaacauaucuauucaaauuugucuaguugccaauugucuucagagugugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguauggaaguaaaacguucucauaucaggaggaugucauuugugaagcauggggacaucaugaacuagugaugugcgugaggcuugggaggcugaaggguaaggaucagcgggaggccauccauguaggagagagaauuaaaacgaggagcgagggaagcaauggagagagggaagcaagaaaggaaccagaaggcuggcaucauccuauuucccacaggcuaacccaagggaugcucugugccuuuccuggggagggaagggggugaacugguagauuugaaagcaguauggcuucuucugugggucucccucuuacuagacaaggugaaaugauaauucgugucaaauuaaugugaaauuuuuuuccugcauuguaauauuaugaggccugagucgcaguugaguuugaaauuuguauuuaauuucacagugaccuagagcuaaggugcucccgguuguggcaauaggagccacaaguauuuucuuucuuucuuucguucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuuccuuccuuccuuccuuccuuccuuccuuccuuccuuccuuccuucuuccuuuccuuuucuuuucucuucucuucuuuucuuuuuucuguuucuuuuucuuuuuuugcauuguagauguuguccuuaaaagaucagggcagugacuuucacagcaggacuuugacucccacauugguugaucacacaaaacugucagcauuuggguaaucugauguauaguuguuuuguugcugauguuuccauugaaauuucagcucugaguuugugcacaugaauacuuacuuguguuuaccaaaggucuaaggcauuugguuacuuaacccaaauauccugaacugugcguaaaguaauagagaaaagcuuuagggucucaauagugucaccuguguaaaucaaaucaaaauagccuucccuauuauuuaugaacccaugggagacuuuaaacucuuguagauagaugcuaaaugcccaggcccacuuaacuuauuaaugugugaauuacauuuauguuuuuaguuuauaugcaaagaauugugauaauuuuauaauaaauauuuuuauuauaauagu 45 AI838080uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauuaaccauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaaguggauagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuuccacagucaauacagaacuagccauuaucccagcacaccgauuugugc 46 AF072127agccaggagccucgccccgcagcugcacagagagcaaggguauaggcacuaacuuguuugcagagaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcaucugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugcuggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugccccaguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucuacgagggacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacuccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcauccugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccuggaagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauuucaggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucuaugaccccuugacccccaucaaugccagguaugaauuuggccaggcccucuuuacuggcugggccgcugccucccucugccuucugggagguguccuacuuuccugcuccuguccccggaaaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaagacuaugugugacagaggcaaaggaagagaucuuccuggagcaaauacaaaauggacauugaaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguagaacagaaggaagcauauuuuuauacauccccauggcuaugcaggccuuggcug 47 X80417 Sequencebelow.cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagaccccgggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguuaccaugucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaagaacggucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacguguguggacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcaucaucuucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcugcagguccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugugugacugaagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuuaaugaauggugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccgugguggcucugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggcccaugugcgggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacaucgaugucggcuuugacaagggccuagaccguaucuuccugguaucacccaucaccaucuugcacgagauugaugaggccagcccacuguuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucauccuggagggcaugguagaggccacagccaugaccacacaggcucgcaguuccuaccuggcuaacgagauccuguggggccaccgcuuugagccagugcucuucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccaucuacaccccgcugcagcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugagaacgagcuggccuuccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgagcaugacuuugacagacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugcccuuggcuuagaugcagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcaggccgaaagccucgggucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguuggcgggagcguggauggcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugacuucuugggguaggguugcucaggaguuagggacucugcuggaggccuuaggugcaggucccaaccccggugggaggaggcuguguauguacacuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaauccaaaaaaaaaaaaaaaaaaaaaaaaaaaa 48 AI847051uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaauuaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccaguucaaccccagccugguccaaacaccauuacugucacugggcccugucauuucacc 49 U09504uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaaucccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauuguccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugacaaaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauuccacuauggaguucaugcuugugaaggcuguaaggguuucuuucggaggagcauucagcaaaacauccaguauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaaccggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcuguucgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugcaaugaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaacagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggagcaagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggugaccagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugagagcaugccaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaaucaagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacaucucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuuguauugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauagaauuccaguagguggauguucucagacugagaacagaaauaguuaccugugcaacacuggagggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucuggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagaggugguggaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucuguuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuauuugaugcaaaggaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaugggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccagcucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgaucuggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaaggaccuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaaguugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu cauccuuaa50 U22033 auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccuggaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccggagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuugguggugaccaggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuccagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcuccuuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugugcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucuucggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcugcaguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaagggaccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacuggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucaguccugaagaggccuacgaccuuggccgcagagcuauugcuuaugcuacccacagagacaacuauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggagaguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga 51 AF033034 Sequencebelow.auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuagaugggagcagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacuaguccagacucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauuggaccaagagagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagccucucagccccuagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucaccugugagggcaaaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuuucgugaccacuauuagggugcauuuaaaaaucaaucucucucuuuucugcuccucuuucuccaccuucccucaugugugugucuguguguguguguuucugugugugugugcgugcaccauacagguauaugugccaugacaugugugcaggucaguagacagccuugguugucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguacaccaagacaguuggccugugagguuccagggagucuccugucucuggcccccaucuuauagcaggaguugugagauuucagaaaugugcacccacaucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuucacccacugaaccaucucaccagcuccacuauggcgguuuucugaaacugaagggaguggggagaaggcgcugagugugaacgggucuggaaggcggguauaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccaggugcagcaucaaauguggcuccacccaacggucaguaacuccgcagacagcaccgugguuaacugccucacagagggggcccagggaccuaguuccuuaaagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauucacacgaggcccuucuccuccgaggacccuaccuuuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuaucaggaaggaccuggcccaccggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaaggaaaggggcguggcauguccagauuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggugaggguggugguggaaagaaucugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuuauaugggggugaggcuuggggagcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauaucauauggugcuggaccaaccaucucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaacggcuucuugggaagagagaggaagugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugcacaaagaugcaauagacauucaggaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacugcagcugggguguaguguggcuguagaagcacguuuaugauguacagguuccgggagagggaggaagagagagggagggaaggaggaauggaggaagagagggagagggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaagagagggagggaagaaggaauggaggaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaagagagaggugugagggauggagggacagagagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagagagaaaagucaccaauuauuuuucuccccagucgcccccugcccucacaccaaggguacccccacuuuucuuucacucaugcacacacacuacacccaauguuuagguaacacauguagggcaggcagagccuuugugaaugugcuugguaguuuucugccuuacuucuaaauaaccaaucacacggaugccacaggguuccuuuagacuguccagggcuccggggcucuuagacuguucccaaugugggugucacaugcaaacaguaagcaccuucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcacagaccuuugcuacuucuacacagacuuacccuuuaaaacauuuaauuauauguuuuuuucagcauaaagaucuauuuugauuauuuuuaguugcguguaugggugugugccugugugugauuguguaauugucuguaugggaguguaagugccuacagaggcaucggauccccuggagcugccguuacaaguaagggacugggacucagaccugagugguuuggaugagcagugaaugagcguggugagccaucccaccaugcccuauaaacacuuucaagaggacuuugcuggguauggucaaguugucccccugcgacagccaccccaacuugccauccucauuuacuguacuggaagcagcaaccaccucugcaauuuugcacaagaaccugagagucugaaagacuuuuguuggcacuggccuguguuccacugggguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugccaggcaaccagcacguuugagcacaacgguguagccaggaagggugugugggaauuuugaugcuaguuuuucuuuaauuagguugagagugaaaucauggucuguaugcauccaacaacuuaauccaaaaaguugguugcacggcuccuggaagguuuaccggcaaggaaccugucccauuuuguaaguaggugggacuggagaguugccaagaagccccccucccugcccccuuccuccuggcagauucugcuuaaaaugagugugguucacugcagaauagugucaccugucuucagaugucuaaagacauaagaaaggccuagccagcuaagucagaaaaggggacuuuccggugggaaugcauuuuccagucucuaggagaagucuuuauccaaauaaaauuagcauagugguggagucacugccagggcgcuggugcggaagcacagcccagagccgaggacguggccauccuccuuccucugaugcaaaguguucucuauccccaguuaccaugagcaauaucaguagcaucgugaaccgggcccgugaugccuuuaacucaggcaagacucgaccgcugcaguuccggguugagcagcuggaggcguugcagcgcaugauc 52 AA960603uuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuuacagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaaucuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcuccaacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccggagacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaacaaggcauauucauguaccaccaacauuuc 53 U47737 Sequence below.ggugauccuccaggaccuaagguuucgguauuaucuucggggccucuucacccggaggugagucugcugagcccgaccucagguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgcagcguguaggaucuggggucccggcgcucugcucccgggugcagagugguuggagcaugcgaggcccucugcagcgugcucuguuccuaccaucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucacuggguaccccuaucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcugggggguggggguagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugucuuauccaggauuuugcauaucaaugcugagguucuggugauuaaguagggucccuggcuagcggggguaaccugaacaaccuuccuccgcuggccgcuagccaauagacaccuggcuuccgcggaugagcccuuugaguuuguggagguguuccucagguccccagggcccugccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuuccuucgcuaguccuccgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagacagcucagggcuccaucguuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaaaacaaaaccagaaaugaggacaggcccagcugggcuuggcacugaacuuggccaccuggagcuuuggcuacccacuacaagaugucagcaagucucaggauagaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccucuaggagaacuguaagccaccuuugucucugggacgccccucucccacucaacagauggcaccagucaucuuccuccucaagaggccagugguauucaaaauaggauauugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaagggcccagaaaagucccauagccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguaguggaguggaggugucuucuuguggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccuccagcccgugucucugccacaagagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgguucaugcaugcucauuuaucugaccacugucuuaaccccaggacaaccacuuaacuguccacuuccauaucagaguucuugguuccccuuuacuucgucuauggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuuggagaaagauuuguaggugccacgggagauuucagguaaaagcucuuuuaauaauuggcuacaauagcagcaggaggaggccaggaauucugagguagagauuugauuagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaaguggggagaggcucucagaugaauggcuuggacugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauuguccgucugauuggugcauugggccagguagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccccagggcagcagggagucaauacugcucuccugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauauuggggagguguagagugggccaggcccagggucugcugguaucuaugccaggauccugaguggugguggcguagccugucuuuuaaccaacugccucucucacaguaggcuuacuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagagucuuccugccugugcuguuggcagcccuucugggcauggagcaagguauggagcucugagauaacccugcagccugguccuccuccugaucucucauucuuucuccugaguagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuucccaccuccuacucucuagccaacugaccuaguuccccugaugcugugcuggcccagcuacaccuuugucaccucguguugacuuuagccacuccaguaccaaagucugaagucaguugucauuggcuggcuuuuuucccugacccagggcugagcaugcuguugcuucuugucaguggguuggggaucaagggccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauaggcaggugucaccuacagcauugucccuuuugcaguucauucccugaugugcuucucauguaccgaucagaagaacaauauaaacugccuguggccaguuucaugccaggagaaagaccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagcugccuguuucccuagccagggccagggaccugcggggcuuuccccauuuccugcucccugucugucuguccccucauccucacuuuccaugcagggaugucaaccuuggcuacacccugaacaagggcugcuccccgaucugccccagugaaaaugucaaucucaaucucgguguggcguccgugaacagcuacugcugccaaagcuccuucugcaacuucagcgcagcuggccucggacuucgugccaguaucccacuacugggccuuggacuccugcuuagcuuguuggcucugcugcagcugagccccugaccaucccccauguguucuccauauccccccagcucaggaaaagcccagcuccuuuuaggucccaggggacccuaggaaccuucagcuccuccugggugugucuaguucccccuccacacucucucaacgucagggcuaaguaccaaacucacccauaccugcucuguugaagugguacuggcuacccuugcuuccagagccaauccuauaaccucccuuggggaaccagcgaaggggugaagaucuccuuggagucucaagaguaccagagucagcgccgaaucuuguggacacacugacaaggaugucuaauccaaauagauguauaucugugugcucaguguaucccugugugaaugaagccacuuggauucuggggugggcaaagaagaccugaaaagauucuacagcagaaggccugugucgccaccaaaaccccucccccugguaucauuguacccaccuuguacucuguucaggaggcugcccauggaggacugccaccccuccagaugaaggcucccacuacccgaugcaguugagucccauccugcccucucugcccacacuggcuuccugcugcuauucuagugccucaaauaaaccguucacacccuu54 L00039 cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucuguggagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccacagcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcacaacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguuggacaguggcaggguccugaagcagaucagcaacaaccgcaagugcuccagccccagguccucagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggaggaacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaacgaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaagcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguugaaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggaggagcuggaaucucucgugagagcuaaggagaacgguuccuucugacagaacugaugcgcuggaauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaagcuucagccauaauuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuucccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaaucguuaaaaucuauccaauuuuccauguaaauagggccuugaaauguaaacaacuuuaauaaaacguuuauaacaguuacaaaagauuuuaagacauguaccauaauuuuuuuu 55 D21099gugggacgggccccccucgaggucgacccacgcguccgggaguacccccgaccuuggcugcgugcugacucgcuuccuucugccugcccaggcuugcacuccccggggaucugccucugcaucucuugccuucgcuguuguuucccucucuguccagcuccccucccgcucucgcccuggagaauggcucagaaggagaacgccuacccguggcccuacggcucaaagacgucucagucuggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuugcucucgugaacugguccaacagccaguccacagcugccccuggccagaaguuggcugagaacaagagucagggcuccacugccucgcaaggaucccagaacaagcagccuuucacuauugacaacuuugagauugggcguccuuugggcaaaggcaaauuuggaaacguguacuuggcucgggagaagaagagccguuucaucguggcacucaagauccucuucaagucucagauugagaaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacaucccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccuggaauacgccccucgcggggaacucuacaaggaacugcagaagagucggaccuucgaugagcagcggacugccacgaucauggaggaacugucagaugcccugaccuacugccacaagaagaagguaauucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacugaagauugcagacuuuggcuggucggugcaugccccaucccugaggaggaagaccaugugcggcacgcuggacuaucugcccccagagaugauugaggggcgcaugcauaaugaaaugguagaucuauggugcaucggggugcucugcuaugaacugaugguggggaacccccccuucgagagcccuagccacagugagacguaucgucggauugucaagguggaccugaaguuccccucuucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaacggcugccccuggcggagguugcagcucacccuuggguccgggccaacucaaggaggguucugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucaguguucuuuguaugucuguguauguguucugagaaggggugggaacuggaaacuauuccuagcuccaguucuaggggaucugaucucucuucugaccucuacaggcaaaauuaggcaccccuguggugcacauauaugcacgccaaacacaugaaguuacaaacaaacaacaaacacacagauagugcuggagagauggcucggcaguuaaaagcacuggcugcucuucccaggaaccuagaacucaauucuagcacuacauggugcucacggccacugucuguaacacccaguccuggggaaucuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggcaaaacacccaugcacugacuuuuaagaaacccucuagucugauuccuuucaauuugucaaauguugaauguuauuuuuaaaauauuauaagccauuuaauacaauuuuucuuugaaacaugguauagccuagucugucuuaaauucagaaaaauuaugaagaacaacauuuuauaauaaagucuuaaauguuucauguuuuug 56 AF026481 Sequence below.uugccuaggaagggcgcgucgucucucugcucguccggcugugacggggaagggucccgcugcguuuuggucacugugaguaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccggugguagagagcuuucuaguuggcaggagguuucguauguggaggaggccagcuuaggcagaaagcacauguucucagagaugaggacaagacuaagaccgucuaaucccugaucuuuaccuuccggcccgcugaccugggccuggaugcuaaagcccucugcuuucgucuaaacagcgcuaaauaguaaacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggcagcuaggagagagcggcuggcacgugguaagcacacgguaaguuucgguuaaauuaaaacaaccauccguugagcaucucuuagcaagcuccuuccacccuucaaacaaucagugauagugcgucuguuucacugauuagggagcuaaggcuccaacagcagcaaaggaacuaauccgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaaucggguguucccggguuuuguuuuguuguuguuguuuuuguuuuguuuucuuagugaaagaggcagggugggcuccaggccgcugaggauuaauaaagagauucuaugaggaggaaauaacaggcaggugguaugaucgaggcaaggcccugaggaaggcuuggguggggugaguagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuggggcaaaugguaaggcggcguaaggucacauuccuuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaaccgagguacuauuuuguagcucucagaagccaggacucugcaacacuguuugcugccuguggaucuucuauauucacagugucccaguugcuucugaucuaccacuguuagauacuucugccacccauccuaagaguauaguuguucuuggaaaggagucucagcugcugucagcaggagucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggcaaaaacaggcgcagagguaaaaaugaaaaugaaucugagaaaagagaguugguguuuaaagaggaugggcaggaguaugcucaggugaucaaaaugcugggaaauggacgguuggaagcaaugugcuuugacggugugaggaggcuggccauauaagagggaagcugagaaagaagguuuggauaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugauguaaucuuaaaguauaaugcagaugaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaaacggacacauuugguccuggggaugaugaugaaauccaauuugaugauauuggagaugaugaugaagacauugaugacaucuagccugaccuaagcaugcuaccuuccaaguucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaaguaaaacuucauggcauguguaugacuuguuaaugcaagcuaaugaauuuuauuuuuugaaguacuauauuucuuugaaaaccaaagauguugaguuaucaucuuaagugacauguuaacacuuugugcuuuugaauauaauugaaccuagcgcacagcagugagcacuguuaagagacugccuuuccauuuguagcuucauuucuggcacgggaguguuuugugucagcaguucugccagguggccaucgaugagcugaaguaaguccuaguccagcacaucugcuucaggccuuuguacucuagucaucuggcugcguucgagacuucucagcagaacuuauagauguguacggcugcacuuggagucagacaagauauggcuacuuuuguacuuauggagccaugccauuuuauacuuucacguuguauacauucguuugacccuuuaaguuguugccacccauaaaaaggcaucuuacagugcaguuuuuaaauuacauggguagcaauuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaauccauuaucuugauuuuaggaauauaauaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauagaaaaugaaaaagagcagugagucuguucugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacacauaaaauauguuuuacuuugcaaaguagguuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaauuacuauguguugauuaaaguuaguuacagaauuguacaagcuaagauuuuccuuaaacuaagcuuagguuaaagggagaggagccacagcucaaugaaaacacgguuccuguuuucuaaauggaggcgcccagaaacacaauaaaacauguugguacaaaaaaaaaaaaaaa 57 J04596caugaucccagccacccgcucgcuucucugugcagcgcugcugcugcuggccaccagccgccuggccacaggggcgccuaucgccaaugagcugcgcugucagugccugcagaccauggcugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcacccaaaccgaagucauagccacacucaagaauggucgcgaggcuugccuugacccugaagcucccuugguucagaaaauuguccaaaagaugcuaaaagguguccccaaguaacggagaaagaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauacaauuucuuuugaggguccuauuuauuuauguauuuauuuauuccacaaagugugugguuuuuauuuuacauuaauauuuaacaguguggauacauuucaucgaugguaguucaguucugcuuguucaguuuaaagaugguaggcuuaaaauauuucauuaaaacuaauauuuauugggagaccacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagagagauagaguuuaguauuauguuuuguauguauuagggugaggacaugugugggaggcuguguuuguaugucuugaaaagaaugucaguuauuuauugaaagucgucuuucauauuguauggucaacacgcacguguugacgcuucccuuggacauuuugugucuaguugguagcccauaaugggcuuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagacguucaaaggacuguuacaaaugaaguaaaaauaaaaguuuuauuaag 58 X81580cgucucccgcauucgucugggccgugcaccugcccgcuagcucgcugcacuaccguugcccacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucguugcucuugcugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggugcuguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacgcgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccgugugcgcacggcaggagggcgaagcaugcggcgucuacaucccgcgcugcgcccagacgcuacgcugcuaucccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaaagagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagggaggccugguggagaaccacguggaugggaccaugaacauguugggaggugguagcagugcuggccggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaaggucaaugaacagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaagaaguugcgcccgccucccgccaggaccccuugccagcaggaguuggaccagguccuggagcggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugcacauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucugaacggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggagcucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacugguggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccaucccgaacaccagcagaaauggagggcgucagggugacggguguggaggaguucccaguuuugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugaccccccccagcggcuguuaacugaaccucccuugcuucuguuagagaggggaagggugguauggagggcacuggguacaggccugggaauggggaaagaaauuuuuauuuuugaaucccugugucucuuuuacuuaagauuaaaggaaggaaaaauaaaaaaaaaaaaaaaa 59 AI314958gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaaucauugguacaauaaauauggaaaugcugagcagacaauuaucacaguggccuaugggcugagggacagggacccaggaauacuguuacccuggauacuuccucagggccaaucaggaggucuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaacuuuuagaaugucuauuaaagccauggauacaggauuuacgauaacagaagauggauacuaaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccagugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuccaccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc ucgcacg 60AF058798 gaauucugcgcgguuuugcauuuuuugggucagauuggcuuuuuacaugauuacgaagcuccaacgacuagaccacagggaccgucgccuuggcggccgagcagucguauccaacuuggagacagccaguucgccgugugucugucuguccuucaucgcagucauggagagagccagucugauccagaaggccaaguuggcugaacaggccgaacgguaugaagacauggcagcuuucaugaagagcgccguggaaaagggcgaggagcucuccugcgaggagcgaaaccugcuuuccguagccuacaagaacguggugggcggccagagagcggccuggaggguccuguccagcaucgagcagaagagcaacgaggaggggucagaagagaagggccccgaggugaaagaguaccgggagaagguagagaccgagcucagaggugugugcgacaccguacucggccugcuggacucgcaccucaucaaaggggcuggagaugcagagagccgcgucuucuaccugaagaugaagggugacuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauucugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaaccccauccgccugggccuggcccugaacuuuucagucuuccacuacgagauagccaacagccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugcacacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaaccugacgcuguggacagccgacagugcuggggaagaggguggugaggcuccggaugacccccacaucugaagcagcggaaaaacaacccggguuggcuuggccuuccaguccccagccuggcauagaggauuaaaagggagugggauuuugccuuucccaaacccugaauguucagcaacaccuugggaaggucuuucgaagggggcgcagccaagcugaagccaccagggcagggaauuuaauuuuucguguagcuguuuggguggguguuucccaaaaccaucccaccccuguuuuuugaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggauccgaauaauccaggagguuccccacccuguggcugagaaauggacuguggcaagggcugugugugugugagagagagggaaacucugugugugugugugugagagagagagagagagugaaugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccugugagacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 61 AW046627uuuuuuuuuuuuuuuuuaaauaccaaaacauuuaauugaaauaccuguauaaaaaauaugaucuucagacauuucacacuuuugaacuuauacaaccccaccccugaugcuuagucacaccagggucacagaaacacagcugcuaaaauaaauuaagggcuugagacucugucccccaaccccagcuuucagagccagcaagcagacuguacaaggucaauaauuuaaaccccuccccagcgcagagugcucagggugacagggucuc 62 AI848050uuuuuuuuuuuuuuuuuaauguaacgaccggugugcuucaguuuguuuagcagaaccacucucuugaaucacauuaacuuuugagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaacaacaaaaaaaaaaccaacccuccauagcacagcugucuuuuaugcaagcaagagcacaccuacuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuacuuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucgaggggucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaacauaaacugcacuuuuauuuuc 63 AF065441augagacuccacagccucauccugcucuccuuccuucuccuggcuacucaggcguucucagaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagaggguucagcucccucguuagggaaggcccagaauaagcagagaagcaggacaucuaaaucucugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacugaggaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuuguguuuuugcuggugacccaacugacugccuuaaacacgacaaagaccagaucuacuggaaacagguugcccgcacgcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuugaagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaacgcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaacaagguccaagaagcugucuccacggagccaaacagggucaaagaagacaucacacucaauccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugugcucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcacauucuuccucaacauguuacaggcgacaucaugcuaa 64 AF022992 Sequence belowcgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggauggagggcgcucgaacggccaggugucgugauuaaauuagucagcccucagagacaggcguccuaccuccuuuauccagaccucaaaagccccguugugcacccgugguggcuucuucaccuucccuguuucguccuccacuguauggcccagacaugagugguccccuagaaggggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggccccgcagcaccggccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaacggacccgaguccaggggcgcaucucagcggaguucucauaguuccucuucuggcaauggcaaggacucagcucugcuggagaccacugagagcagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugcgagcucagagcaggacaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaugacugcacuucgggagcucaaacuucgacugccaccagagcgucggggcaagggccgcucugggaccuuggccacacugcaguacgcucuggccugugucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugugccauggacaugucuacuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuucucuguggcuguguccuuccugacaggccggauugucuauauuucggagcaggcagguguccugcugcguugcaaacgggauguguuucggggugcccgcuucucagagcuccuggcuccccaggaugugggugucuucuauggcucuacuacaccaucucgacugcccaccuggggcacuggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaaucagaggagguccugaccgggauccagggccucgguaccagccauuccgccuaaccccauaugugaccaagauucgggucucagauggagccccugcacagccgugcugccuacucauugccgagcgcauccacucugguuaugaagcuccccggaucccuccugacaagaggaucuucaccacccgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguuaccuuccccaggaucuccugggggcuccaguacuucucuuucuacauccugaggaccgaccccucaugcuggccauucauaagaagauacugcagcuggcaggccagcccuuugaccauuccccuauucgcuucugugcucggaacggggaauaugucaccauggacaccagcugggccgguuuugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggcaccccugaaugaggacgucuucacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucagagcagauccaucgauugcugcugcagccugugcacagcuccagccccacggggcucuguggaguuggcccucugauguccccugguccucuacacagcccuggcuccuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugacuuuccagcagaucuguaaggaugugcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagcccccaccccggccccgccuccuugcuacagguacauucaaagccaaaguccuucccugccaguccccaaaccccgaacuggagguggccccaguuccugaccaagccucguuagccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagcagaucaacugccuggacagcauccucagguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccuccuccuccuacacugccucuucagccucugaugaugacaagcagagggcagguccaguuccugugggggccaagaaagauccgucgucagcaaugcugucuggggagggggcaacuccucggaaggagccaguggugggaggcacccugagcccgcucgcccuggccaauaaggcagagagcgugguguccgucaccagucaguguagcuucagcuccaccaucguccaugugggagacaagaagcccccggagucggacaucaucaugauggaagaccugccuggccuggccccuggcccagcccccaguccggcccccagccccacaguagccccugacccaaccccagaugcuuaucgcccagugggucugaccaaggccgugcugucccugcacacacagaaggaagagcaagccuuccucaaccgcuucagagaucuuggcaggcuucguggacuugacaccucuucuguggcccccucagccccuggcugccaccauggccccauucccccuggucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccaccaccagacccccggcccgaaacucccugcuaugucucccauccuucaccugugcccucuucuggacccuggccacccccaccagccacgacccccuucccagcaaugguccagcccuacccacucccaguauucuccccucgaggaggaccccagccccuucccccugccccuacaucuguguccccugcuaccuucccuucucccuuagugaccccaaugguggccuuggugcucccuaacuaucuauucccuaccccaccuaguuauccauauggggugucccaggccccuguugaggggccacccacgccugcuucccacucgcccucuccaucccugcccccaccaccucucagccccccccaccgcccagacuccccacuguucaacucgagaugcagcuccccacuccagcucaaucugcugcagcuugaggaguccccccgcacggaggggggcgcugcugcaggaggcccaggaagcagugcugggccccugccucccagugaggagacugcugagccagaggccagauugguggagguuacugagucguccaaucaggaugcacuuucaggcuccagcgaccugcuggagcuacugcuccaagaagacucucgcucgggcacaggcuccgcagccucaggcucccugggcucuggccugggcucugggucugguucaggaucccacgaagggggaagcaccucagccagcaucacccgcagcagucagagcagccauacaagcaaguacuuuggcagcaucgacucuuccgaggcugaagcuggggcugcucgggccaggacugagccuggggaccaggucauuaagugugugcuccaggaccccaucuggcugcucauggccaaugccgaccagcgugucaugaugacauaccaggugccguccagggaugcagccucugugcugaagcaagaccgggagaggcuccgggccaugcagaaacagcagccacgguucucagaggaccagaggcgggaacugggugcugugcacuccuggguccggaagggccagcugccucgggcccuugaugugauggcguguguggacuguggcagcagcguucaagauccuggccacucugaugacccgcucuucucagaacuggauggauuggggcuggagcccauggaagaggguggaggcgaggguggugggugugguguuggcgguggugggggugaugguggugaggaggcccagacccaaauuggggcuaaggguucaagcucucaggacucugccauggaggaagaagagcaaggugggggcucauccagcccagcuuuaccugcagaagaaaacagcaccagcuagauccauuuuggggccgcuuacagcagucuaaugagaggcuuccuuucgaccauguugggguucuuauaacucaagauacagcuggaccaaccaauaggaaacugccccagcuucucccaacauagggggcuggacccccauuaccagcccaggcacaggagcugccucuagcuucuuagcagaguggaaguucucagccccauuuggaggauuguccacgcccgucccacugaggagacgggcgggucuucgguuaagguugcugacaagcugcugaaguggucuguccaaaucccagcugagccugagucccagucgcaggguuggggcugcacuuauuuauuugggagagacagcucacucucccaccucaccccaagaugggaggaggggaaccugggaucuguguaggauccagguccgugaaccccuagcugcuccagggugggggagguugguggaccauggagucccuggugcugccccucaggugggacccagguguucucagcucuacccucuaccaaugacauuuguguuuuugauauugugucuguuauuuuuuuuuuaauacaaaaugacaaaaugaaaaaccaaaaa 65 AF064088 Sequence below.gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagccaggcagcucgcgaccugcggccaggcagccaaccaugcucaacuucggcgcuucucuccagcaagcuucggaggggaaaauggaacuaauuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaagcgcucauguccaugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugauaccuccgaggaugacagcuugcuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagccccucugacuucgaacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaugcugccaagccuccaggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagccaccagugucauccgucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaacuaucaggacaauucuuuccggagaagaacccacggaaauguugaggcuacucgaaagaacauacccugugcugcagugucaccaaacagauccaagccugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugccuuccucagagacaguaauuuguaggucuagccagcuccuucguccccagugcagaagucaguacuggugucuucaccuacaguauccacugggggagugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcacaguuguccccagcacuccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugagggcaccgucguguuugugguaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacugucucccauugccccugcuccuggauucucuccuucagcagcaagggucacuccucagauugacucguccagaguaagaagucacaucuguagccacccaggguguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacaggggaaaaaccuuucagcugcagcuggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacacacaggugagaagaaguuugccugucccaugugugaccgucgguuuaugaggagcgaccauuuaaccaagcaugcccgacgccaccuaucagccaagaagcugccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcuuccgcacagugacggccagaagauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuucugcaaggcuguggcccuccaaaagggccuaaaguagaagcccuggccugggggaggccccgccugggugaaaugacaagaagugcuucagccacaggcaggucacagaggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucccuuauuuuagucuggaaaguuucggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuugccauuuauacuugagaccagcuuugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuacgguacagaaauggagcuagaaaaugaguuuguguuacacagagaugucaucuucuccagaguuaucuuguuucuuauuccuagucuuuccagucaaauccguggauguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguugaacagcuguacauugcugugggggagccaaaggauuggaacccucauuaauuuaauugcuuggaaaugcagcuaaaauucuucuuuggcauuuuguuuugaaaguuuaggcauuuuacucuacuuuagauuuuaguuugcuugcaguuuuuuguguagauuugaaaauuguauaccaauguguuuucuguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaaauauguauuauaaagaagagaugucaagaauuugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacacuuaacgucaagcauacacugugguuuuuuuguuuuuuuguuuuuuuuuuucaaauuagaaaguuuaaugaccguuacagauggacagugucuuuuuauuuauaggaguuuuucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcuucuaccuugaaaaggauguuaauguggucauguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuuuaaagugucaugaugugaucacaccugcaguuuggggcaucgaauccagggccuugcaugucuucuguaagagcucucaucgcugaccuguaucccccgcaagagcaaugacuuuugcuaacaguauuucuuuucuguuguaaaguggacagaugauacacuuggucgcaaagguaaauuauucaaaauccacagugaaaaccucaccacacuuucccauuuaaacuauuuccauaucucagagguuucugacaugcaaacuugaacccuugaaagaagaguuuucuuaaaaauuauaaaaaucacgaguuacaauuugcacaauauuuuuuguugaacuuuauaccuuguuuacaauaaagacuuuucuuug 66 AI787713uugucanuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgcaggaggguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauugaaagggacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccaccagcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggaguaugaccagugucguauacagguuaggcugccugaugggacuucacugacccagacuuuccgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggaggagccuggacaggaccaggacccugugcaguugcucaguggcuuccccagacgggcuuucucagaggcugauauggaacggccucugcaggaacugggacucgugccuucugcuguccucauuguggccaagaagugucccagcugaggguucuccaucccaccaucuc 67 AI853531uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauagcucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacauggcagcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaaucagaggauguaaaaacugaacacaaacugcgugucucacugaaucucagggcagugaagcagccagcgugaguuuucaaagcaggaagaugcugaagugaccucuggcauuaagacguucug ugcua 68X14678 Sequence below.uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugaauuuuuuccuuuugcgucguuauuucagcaauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccaggguaaggaacucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuuaacuucaucauguucagucuggccuuuggguuucaucauagcaaucuguucaacuucacccugcaagauuaaaaaucgauuauggucuaagucaaugccauggcuucuaaggagauuuccaacaucuuuaaacgucuucuucuucccacuuaugugguagacagaagugcuaucucuguaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuaucuuuugaaaaugaacuucuacaguacaacucugaauauccuuguguucaucagaauuauguaucaguaccgauagcuuuuuagaccuuauuuuuugugcucgauagccaaacacaaaaagcauggaaucaauaacauuggauuuuccacugccauuugguccaauaauacaggaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaugaguuaucaugagacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccucuaaacuucuguuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacugcaacucccaccaccuccucucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugccaguuugcucacggccugggugaacuuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccuccagggccgcugccccuauggcucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccaugugcugcgacaaagcaucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuucccuguccucuuguuccuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugcugccccugggaccccugugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcaccaucugggggcccuuggguggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagcggcagcagccugggggggucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaaggcgucuccccaucuucaaucguaucucugucucugagugacaagugccuaccuacccaguauggaucagcuagaucucaaagagagggcagggacugcucauugcuguggggaccuggggcacuccucuaaguuaauaagucccaucuucuggacauuccaagaugcaauaacccauuucccuggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccuaggguaccuaagauguuugagggagacaguugacaguuggucuuccaggccccaagucuucuguuguuuuugagauaggagcuuauuaugguaccccaggcuggcuuugaacucaauauaauccugccuuagccuuuuccaaguucugggguuacagguaugcaccagccccucugcaacucuggucuccuggaaucuuaagugcugugaagagccggcucccacaauacuauccuaauuuuuacuagacccugaaguucaguguccgguggucgaagccucuccugagaauccuggugcucaaauuucccuccuaaagcaaauagccaaagccauugccaaaucccuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuaagauuuuauaguauuuauauauauugggucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaugcuauaauauauuaauauauugcu69 AI854358 cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucgcgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcgcagcagcgccagcgucagcgacagcagcggcuucagcgacucggagagugcagacucaguguacagggacagcuucaccuucagugaugagaagcugaauucuccaaccaacuccucuccagcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcucgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg gguc 70X67668 ccgggccgaggagaagucugcaaaacaagaggcuggggauugccuuagcgagaaaucaguucucuuaggagguuagggaaggaagucuuucucuggaggucugagggaagcgcucgugucagaugccggguugucauggguaagggugaccccaucaagccgcugggcaaaauguccucuuacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucggucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaaggaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacagggagaugaagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccgaagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauugaauacccgggccugucuauuggagauacugcgaagaaacugggugagauguggucugagcagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguaugaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccugguaggccagcaggcucaaagaagaaugacucagaagaugaggaagaagaagaggaggaagaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauaugugcucaggcaguuauuuugcuaagaauguaaauucaagcgcagcucaacauuagcucca guaggaa 71K02236 aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaaccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugcugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuuaaggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacuaguccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagcguucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagauggauccugcuccugcgcuggcgccugcaaaugcaaacaaugcaaauguacuuccugcaagaaaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgccgcgccgcgccuucccucccgggagcguucagguggugugccucugacaagguuucucgcucacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcgaagugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaaggggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuuuguacaacccugacucguucuccauaacuuuuucuauaaagcauguaacugacaauaaaagccguugacuugauu 72 X51829 Sequence below.gcucugaguuuguggaagauuacaugcgauaucccgcgcgaccccgcaucccuuugccggccgggacagccuuugcuacagccugugaaacauugcguccccgagccccacgccugagggcgacaugaacccgcuggcuucgcgagcaguccggacccacgaucgcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccgagcccaagaccccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacugaugggcuugcucagucgggccuggagccgccugaggggcccagaagucccagaggcauggcuggcaaaaacaguaacaggagcagaucagauagaagcugcggcucugcugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaacagagucaagcagcccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaugaguacaaugcaaagccaggacaagaugaccuuagagagaaggaaauggaacgcacagcuggcaaggccacacuacagcccgcuggccugcaaggggcugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacaucacagcuggagggugguccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauagcuccgggauacaaacccagcaccccugugccuuucuugggggaggcagaacaucaagccacggaagaaaaaggaacagaaaacaaggcugaccccuccaacucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagcaggagggagaagccaagguagaggcacacagggcagggcagggucacccuugucggaaugcugaggcugaggaaggaggaccugagacaacuuuugucuguacuggaaaugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaagacaacagcgauucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaagacagcgauucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagcgauuuggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagcgauuuggauucagcugaggaagacacagcucagaccggugccaccccacauacaagucccuuccugaaggccuggguguaucgcccaggagaggacacagaagaugacacagaagaggaagaggacagugagaauguggccccaggugacucagaaacagcugacucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaagggacguggggaagagcccccucucuuccagguggccuucuauuuacccggagagaagccagaaucaccuugggcugcaccuaagcugccccuucgacugcagaggcggcucagauuguucaaagcccccacccgggaucaggaccccgagauuccucuaaaagcucggaagguacacuucgcugagaaagucacaguccauuuccuugcugucugggcaggaccagcccaagcugcccgucgaggucccugggagcaguuugcacgagaucgaagccgcuuugcucgacgcauugcccaggcagaggagaagcugggucccuaccuuaccccugauuccagggccagagcaugggcacgccuuagaaacccaucucuuccacaguccgagccucgcucuuccucugaggccacucccuugacccaagaugugaccacacccucuccccuucccagugaaaccccuucgcccagccuguacuugggagggaggcggggcuaagccugaguaguuuccuauuauuuauuuauuuauuuauuugaauaagaaauaaagccuuuuaauuuguagugau 73 AW048937uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuuggggucgggugugaggacucgggacaaugcagggugcugucccuucucgugagacgcuuacaaucugaguggagacagggagggagccacaauacauguucuuggggugcgggcuaaggguagacaguccagaccaggauguuacagaaacagggauguuuggggcuggagucagacccacuaagugcuuugacacccacgguauucaacacugagaaaggaucagccauugcucaguguccugugagcucccuuagcccccaagacaccaucuuggccuggcuccuuguacaacugcuacuaa 74 AV139913cccaaaacccauucagcaaaguucccaaccucgacgggcuagcaguauuuaaccagugauggguucacuguuguauuuggugaauacuguauuuuguuucaguucuuucucccagauaauuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuuuuuuuuaauauaugacaguuauuugagaacccauuucuacuuugaauucauuuucguugaaagugauguuucuucaccuaccauuuuccuauuaaaguucuguauucaaau 75 M32490 Sequencebelow.agaccgugagcgagagcgccccagagaagcgccugcaaucucugcgccuccuccgccagcaccucgagagaaggacacccgccgccucggcccucgccucaccgcacuccgggcgcauuugaucccgcugcucgccggcuuguugguucugugucgccgcgcucgccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuccacuugaccagacuggcgcucuccaccugccccgccgccugccacugcccucuggaggcacccaagugcgccccgggagucggguugguccgggacggcugcggcugcuguaaggucugcgcuaaacaacucaacgaggacugcagcaaaacucagcccugcgaccacaccaagggguuggaaugcaauuucggcgccagcuccaccgcucugaaagggaucugcagagcucagucagaaggcagacccugugaauauaacuccagaaucuaccaaaacggggaaagcuuccagcccaacuguaaacaccagugcacauguauugauggcgccgugggcugcauuccucuguguccccaagaacugucucuccccaaucugggcugucccaacccccggcuggugaaagucagcgggcagugcugugaagaguggguuugugaugaagacagcauuaaggacucccuggacgaccaggaugaccuccucggacucgaugccucggagguggaguuaacgagaaacaaugaguuaaucgcaauuggaaaaggcagcucacugaagaggcuuccugucuuuggcaccgaaccgcgaguucuuuucaacccucugcacgcccauggccagaaaugcaucguucagaccacgucuuggucccagugcuccaagagcugcggaacuggcaucuccacacgaguuaccaaugacaacccagagugccgccuggugaaagagacccggaucugugaagugcguccuuguggacaaccaguguacagcagccuaaaaaagggcaagaaaugcagcaagaccaagaaauccccagaaccagucagauuuacuuaugcaggaugcuccagugucaagaaauaccggcccaaauacugcggcuccugcguagauggccggugcugcacaccucugcagaccagaacugugaagaugcgguuccgaugcgaagauggagagauguuuuccaagaaugucaugaugauccaguccugcaaauguaacuacaacugcccgcaucccaacgaggcaucguuccgacuguacagccuauucaaugacauccacaaguucagggacuaagugccuccaggguuccuagugugggcuggacagaggagaagcgcaagcaucauggagacgugggugggcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugccaaggggcugauguggacggacagcagcgcagccgcaguuggagaaugccaaggggcugauguggacggacagcagcgcagccgcaguuggagaagacuucgcuucauaguacuggagcgggcauuauugcuccauauuggagcauguuuacggaugacguucuguuuucuguuuguaaauuauuugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauuguaauagagacaaaauaagauuaguugggccaagugaaagcccugcuuguccuuugacagaaguaaaugaaagcgccucucauuccuucccgagcggagggggacacucugugaguguccuuggggcagcuaccugcacucuaaaacugcaaacagaaaccagguguuuuaagauugaauguuuuuuuauuuaucaaaguguagcuuuuggggagggaggggaaauguaauacuggaauaauuuguaaaugauuuuaauuuuauaucagugaagagaauuuauuuauaaaauuaaucauuuaauaaagaaauauuuaccuaaa 76 AI121305ccaauaccacagccgugaccacagccaagaccacagccaaaagccuggccauccgcacucucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccucuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauuucaggccagugcuuaaacauacccgaaugaagguuuuauguccucaguccgcagcuccaccaccuuggaccacagaccugcaacacuagugcacuugagggauacaaaugcuugccuggaucuuucagggcacaaauuccgcuucuuguaaauacuuaguccauccauccugcgugua 77 U35374auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacacacugaauaucgaccucaaguggcagugaucugugguuccggcuuaggagggcugacugcucacuuaaaggaggcucagaucuuugacuacaaugagauacccaacuuuccccaaagcacagugcaaggucacgcaggccgacugguguuuggauugcugaauggcagaugcugugugaugaugcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagugagaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacucaaccccaauuuugaaguuggagauauuaugcugauccgugaucacaucaaccuaccugguuucuguggccagaacccucuccggggccccaacgaugaaagguuuggaguucguuuuccugccaugucugaugcuuaugaccgggauaugaggcagaaggcuuucagugccuggaaacaaaugggggagcaacgaaagcuacaagaaggcaccuacgugauguuggcaggccccaacuuugagacuguggcagagagucgucugcuaaagaugcugggggcagaugcuguuggcaugagcacagucccagaaguuaucgucgcaaggcacugugggcuccgugucuuugguuucucacucauuacgaacaagguugucauggauuaugagaacuuggagaaggccaaucacauggaaguucuggaugccgggaaagcagcugcacagacauuggaaagguuugucuccauucuuauggagagcauuccacucccggaucguggcagcuga 78 X15643 Sequence below.uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccaaaguucacugacaaacucacauuugucugauauuuagcuauguaacagcacuuacgguagcaauagaauuugauucucacucaucacaaugaaaauggcuggcgcucucucucucccucucuccccauuucaaaucugcaagcacaccccuuagagauggagagaauuugauccauuggagaaucgagcuaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugugcccuaaaugucagccauuguuaugguauuauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagucuaucaaacauaauacaugugaaaucaaaccuugaaaauuaauuuuuuucccaacagucaagacauuugccagcugcagagauuagcauuucaugaaucuuagucuugucugauuuuuuuaaugggaaggaacaacuauccucaacuauccuuuuuuuuuuucuguaguuuuaaaaugaacuccacaaaacauguuuuuaauauagggaauuauaugaaauuguggggugggcagcgagguuaaaggcagaaauagcccaaugguggcacauucacugacacagccuaaaagauuagcaaauuacccagccaacacauacaauuaauacaauuaauauuuuuauaguuaaaacagaguuacuaaagaaauuguuugaaaagaaaauuaugaagacuggaaagacggcucagugcuuaagagcuuuggcuagucuuccagagaaccagggucauccagcacucacaaggcagcuugugagcugauacuaucuguauauucaguccuagggaaucugaugcuuuguccugaccuccaaaacaggcacaaauguggugcacaggcaaauguagagauaagacucccaugcacagaacauaaauaacguaguuuaauuuuuuaaauuguaaaacugaaaaugguugcacuugcauuuuuauuuucagcacauccccagauauccgccauauaacaagaaaaugaugccacacucccaagaauuaagaauuacaccucccaacccuacccaaauguguauacucuaggucuaaagaaaugcaaaggaugaaguuacugccuugugcgguucucaaggagggaggaugccaaaaaaauauuuuuucacaaagugugcugagaaacucuguagcuguuggagucaucuccugugcucuugccaaauaacugaaaggggauacacuggaugucugugaauggggugucacuuaugagugcuagaagcggguaccuggauguggacacggugucugagugguccgcacuccaugucuccacaggagcgcuuauguguguuucuuuccuccugcuucuggguguuccuggguuuguuuacagccaccucucuguuggaccaggagacagcugucgucuccagaaugagcgggcacgggugugucucgguggcuguggcugugguucggcauaagucugagcauguccuggucgucagggugcguuugugcugugugugcguguccgggugagcuugcucuuucuguuccuaaaagaaaaugcacccugcgcuaccggcguccagagacucucagcccgcagaggugaccugaacggacagguagcaccuccagacagcgccugguuggcggguugcacagcagccccagauuucucucucuggugccccagcuaggguagcuggaagggagcgguggccuggccuccggggagccgcugggccccgccgggcuaacccaggaggaggccggcuaggcugggaggguuagcccuuggugcccuacgccugcccgggccagucgcggccgccggccauuggcccaaagaauuguugcacgucacuggcaauuccccuagaagucugugcacauaacgggcagggcgcacugcaaggcugcuucucccgcauuuaggcugcggcugcaggcaccgcgagcccggagcacccacgagcuuagugugcaggacgcaccccagcacagccaccuacggccgcugaaugaagcuuccaggaguccgcccccggccgucgccccgucggaggugcacccgcugagagcgccuggaccgaaaggccggugcgcucaccugcuaaccugccagccauggggccacacgggaacgacagcgacuucuugcuggcacccaacggaagccgagcgccacaccacgacgucacucaggaacgggacgaagcguggguugugggcauggccauccucaugucgguuaucguccuggccaucguguuuggcaacgugcuggucaucacagccauugccaaguucgagcgacuacaaaccgucaccaacuacuucauaaucuccuuggcgugugcugaucuagucaugggccuagcgguggugccguuuggggccgucacaccucuaugaaaauguggaauuuuggcaacuucuggugcgaguucuggacuuccauugauguguugugcgucacagccagcaucgagacccugugcgugauugcaguggaucgcuauguugcuaucacaucgcccuucaaguaccagagccugcugaccaagaauaaggcccgaguggucauccugaugguauggauuguaucuggccuuaccuccuuuuugccuauccagaugcacugguaccgugccacccacaagaaagcuaucgauuguuacaccgaggagacuugcugugacuucuucacgaaccaggccuacgccaucgcguccucgauugugucuuucuacgugccccugguggugauggucuuugucuauucccgggucuuccagguggccaaaaggcagcugcagaagauagacaaaucugaaggaagauuccacgcccaaaaccucagccagguggagcaggaugggcggacgggccacggacuccgaagguccuccaaguucugcuugaaagagcacaaagcccucaagacuuuaggcaucaucaugggcacauucacccucugcuggcugcccuucuucauugucaauaucgugcacguuaucagggacaaccucaucccuaaggaaguuuacauucuccuuaacugguugggcuacgucaacucugccuucaauccucuuaucuacugucggaguccagauuucaggauugccuuucaagagcuucugugccuucgcaggucuuccuucgaaaccuaugggaacggcuacucuagcaauagcaacggcagaacggacuacacaggggagccaaacacuugucagcuggggcaggagagagaacaggaacugcugugugaggaucccccaggcauggaaggcuuugugaacugucaagguacugugccuagccuuagcguugacucccaaggaaggaacuguaguacaaaugacucgccacuguaauacaggcuuucuacucucuaagaccccuccuugacaggacacuaaccagacuauuuaacuugaguguaauaacuuuagaauaaaauuguauagagauuugcagaagggggggcacauccuucucgccuuuuuuuaauuuuuauuuuauuuuuuagcugcaaacaagagagagaacuguauuugagugcuuauuguucuuguauaguucaguuccucuuguauggaacuuaaagguuucugucugaagaguguugguucugaggacugagucugucugucugucugucugucugucugucuggaugauguuuucauguaucuaccucacuggucaaguauuaagaaugauauauugcugcuggaaauccauaucuaaaggagagaguuuucuuccuguacccuuggacuugaaauauccugugucuuggaccuuucugcugugacaaugggcccuuucucucucacuccacuuauuuacucaaauggauucgaggcagggauuugagggacaacacuaguuguuuuguuuuuguuuuuguuuuuuuguuuguuugguucguuuuugguuuguuguuguuuuuugggguuuguuuuuguuuuuguuuuuuuggguuuuuuuuuuuugcugagaaaagucuaaaguuuacaguaaauaaauuguuuaaccaugacuucauugcacccguuucuucaaaaccucuugacucuggaguguccuugucucucccacuggaaaccacagguaaacuaugugucgugaccgaugaguggcuuaauguguaagaguaccagaauggcaugcuugcaugcaccgugccuagcccuuccgugugugucuucagagcuccagaugcaaaccugugccuucccuaacuucacucgugucccaaagcaguccugccuguucacagcauaacccaguauguccuacaguugcucuucugugcugucacuccagaaacccugacucacggaaacagaguuauggacauauguuuuuguccccauaugcucugacaccaccuucagccuuacuugcuuaauaacuguguauauuuacaucacugcgucucuuacaguagugccuuuguacugcaucagggcuugguguguucaggaugaggaagauguucuguguaauagcuguucaagcaucuagaaauucugagggaaaucaaaggccucggucagagagagagagagagagcaaagcuuuaaaaaacauagcuggugaaugcuucacgcccuucagccucuccucgcuccgucugcugucccgugucuucuguucccaauucucugcacuucuguguaaaccaggcuucccaugucuggcauuccgugcauuauaugauauuuggcggcacgucuguaccaguaaauucugguagcacccccuaguuacaauaauugcagacacucagcgcguacgacccccuaguuacauaugcagacacu 79 AI849109uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggccccagaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaauacagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaaaucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucagcuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaaccagagccacggaggggagaggcuugcguugacuucccacaugugcugucccauagcagcugagugaccccacca 80 U70132agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgaggacccguccaagaagaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaagccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaaucgccguguggaccaaccuuacggaagcccgaguccggguuugguucaagaaucgccgggccaaauggagaaagcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacgggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugccaagggccucacgucagcgucucuguccaccaagagcuuccccuucuucaacuccaugaacgucaauccccuguccucucagaguauguuuuccccgcccaacuccaucucaucuaugaguaugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagccugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccuguccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccuggccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacccggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgcccagggcgcggggauccgaggacugucggagugggcaacucugccccagaaagacugagaauugugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaagaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucuacgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuugacuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguuaacauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagcaguuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuauacagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacacuguauguuucuaacauauuauuauu 81 M13805cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggaccugagccgcauccugucagagaugcgugaucaguacgagaagauggcggagaagaaccgcaaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccaccaacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcaggcccuggagauugagcugcagucccagcucagcaugaaagcaucucuggagggcagccuggcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcaguguggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaagauccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcuggagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccaggugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggugcaccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagaggcagcuucccucuccgcuccggcauuacccuccugcuacagccucuccccagcauuccuaugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacugaaauaaaugaccauggugac 82 AV138783ccccaggggugaaaugaggauuccccacccugcggaacagugaaauguguauaauuaagaggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuacagcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauuuuuacuacagagacauuccaauaaauucguuaagcc 83 K02927 Sequence below.cugacagucgucucugucccuucuucgccucggagcugcuaacuggucucgaaccucucagcacuucagcuucuagcggcgaugcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaauuacaucacgaauccagaaacucuguuauggacucaacauggacuuuguugauccugcugcagaucaccaugaaaguaauccaaggccuauaguggggucaccacaguggaacuggacacccuggcugcugagacagccgcgaccuugaccacgaagcacccugacuaugccauccuggcagcaaggauagccgucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaauccgcacaacggcagacacucucccaugguggccagcucaacacucgacauuguuauggccaauaaggaucgccugaauucugccauuaucuaugaccgagauuucucuuauaacuacuuuggcuuuaagacacuggaacggucauauuuguugaagaucaaugguaaaguggcugaaagaccacagcauauguugaugaggguuucuguggggauucacaaagaagauauugaugcugcaauugaaaccuacaaccuacuuucugagaagugguucacucaugccccuccuacucucuucaaugcugggaccaaccgcccacagcugucuagcuguuuccucuugaguaugaaagaugacagcauugaaggaauuuaugauacucugaagcagugugccuugauuucuaaguccgcugggggaauugguguugcugugaguuguauucgggccacugguagcuacaucgcugggacuaauggcaauucuaauggccuugugccaaugcugagaguauauaacaacacagcucgcuauguggaucaagguggaaacaagcgcccaggcgcguuugcuauuuaccuggagccuuggcacuuagacaucuuugaguuccuugacuugaagaagaacacaggcaaggaagaacagcgagcacgcgaucucuucuuugcacuuuggaucccagaucucuucaugaagcgagugggagacuaaccaggacuggucauugaugugucccaaugaguguccuggucuggacgaggucuggggagaggaguuugagaaguuauaugaaaguuacgagaagcagggucguguccgaaaaguuguaaaagcucagcagcuuugguaugccaucauugagucccagacggagaccgguaccccauacaugcucuacaaagauuccuguaaccggaagagcaaccagcagaaccugggaaccaucaaaugcagcaaccuguguacagaaauaguagaguacaccaguaaagaugagguugcaguuuguaacuuggcuucucuggcucugaauauguaugucacaccggaacauacguaugacuuugagaaacuggcagaagucacuaaagucauuguccgaaaucugaauaaaauaauugauauaaacuacuacccuauuccagaggcacacuuaucaaacaaacgccaucggcccauuggaauugggguacaagguuuagcagaugcuuucauccugaugagauaccccuuugagagcccagaagcccaguuauuaaauaagcagaucuuugaaaccauuuacuauggagcccuggaagccagcugugaacuagccaaggaguauggccccuaugaaacguaugagggaucuccagucagcaaggguauucuucaguaugacauguggaauguugcuccuacagaccugugggacuggaagccucucaaggagaagauugcaaaguaugguauaaggaacaguuuacuuauugccccaaugccuacugcuucaacugcccagauucuggggaauaaugaguccauugagccuuauaccaguaacaucuacacucgaagagucuugucaggggaauuucagauugugaauccucacuuacugaaagaucuuacugagcggggcuuguggaaugagagaugaaaaucagauuauugcaugcaauggcuccauucagagcauaccagaaauuccugaugaccugaagcaacucuauaagaccgugugggaaaucucucagaagacuguucucaagauggcagccgagagaggugcuuucaucgaucagagccagucuuuaaacauccauauugcugagcccaacuauggcaaacucacuaguaugcacuucuacgguuggaagcaggguuuaaagacuggaauguauuacuuaaggacgaggccugccgcuaauccaauccaguucacucugaacaaggaaaaacugaaagauaaggaaaaggcacugaaggaggaggaggagaaggagaggaacacagcagccauggugugcucuuuggagaacagagaggagugccugauguguggauccugagaaaagcggggccugggagacgcagcgggcucuccugcccgagaggcagacgauuugagcauagauaggauaguggguuugcuugguuaucagcagcucugcuuggacgugccugccaggacagggagccacgacuuacaguacuguuucuacacaguguaaauaucauuuuuaacaaacagaaaaccaaagccagcuuugauauuaggaaucaagguagaggcuuugggaauacuaaagagccuuccugcaaauagugaggagacuuaggaagucucgucucuccagcuuucccugccuggccauucucaguuugggcaaagagauuuaguuugauuugacugauugccuagaaguaaaaucaagcaauuacucaucagcuaaagaccuuugucuagacaaacuucuauaagucauuuugaaauaaacauuucuaagugau 84 X07699 Sequence below.uugccucagacgcuagcuguagcuggcaggcgguuguacgugcuccagagucgucgguacccgcuacugcagucgcuuucguguggcuuccgcugagcucuuccgagcugcucgcucuccacacgcgccgccgccguaauccgccaccauggugaagcucgcaaagguaagaggccuuggcgcgccgacgcggacgacuaggccccugcuuucggagggacgcgcgcgcgcccgcccguccgucgcggaggggaggagggcuugcgcgcaaucccgggcgcguucgagggcgccaugcugggggggaaagucucgcgcgacuagcgggaggucucgcggugcuugcccucugacuuagggggaugagaagagcggaggcagguuuccgggagggcgauaucgaggguucggauguagcgggcgggaggggacggugugaggagagaucggaggagcugagagcggauaggggcacggcgugggaagagagggccaaccuuaggcggcgagcggucccggggccccgccuccccgcgcacgugcucuggugcgcgcccgccacgugcucugcggagccccgcacgugucgcgcgacccggggcagugggggagugucuguaguaccccggaaagggggacggcagcguggggauggauggguggcccggcgaucugcugucucugccggugaccgggauggacacgugguggaccccugagguggcggcguggugacuccacgugguggggcuggaagcgagagaaagugggaagcaguuggguuacguggugcugcuuuaagaggugauuucgagauacccccuuccccagcaaauaacuuaaagggaucccuuuaacuggguuuuuuuuuuuuuuuuuuuuuuuuuuuuuguggaagaugccagaaaauagauggccaggauuaggagacuuuauaaccuguggcuguuucuugguguagaguucugucugcucaguuaucugugagaaggaaaaaaaaauuaugcgcgguucgcagaaaaaacugccaggagaaugccaugccuggccaagaagaagucuuuaugcuuguguccuuuaguaagaaaaaggugguggccaaaggcaaagugacugaaaaugcgugcaauuuuugugugcguuuguaggcuggcaaaacccacggugaggccaagaaaauggcuccuccuccaaaggagguggaagaggauagugaagaugaagaaaugucagaagaugaagaugacagcaguggagaagaggagguaagaagcuauuugcagcgaagaauuaaaccgguggaauugaaugcuggaagucuuagaaauacaggauauguaguaaaugguugaauggcaagccccuuccucccucccucccucccucccucccucccucccucccucccuuccuuccuuccuuccuuccuuccuuccuuccuucugcaagacagucggcaaaacaggggacagaaacaggcagaauuuugaguuccaggcaagcagggaguagacauaugaaaccuugucucaagaccguuguuauggucaugcucaaucagauuucuuagaaaagcucaggugcugaguccaguuuuuuuuuuuuuaaaguauugaaagccaugucuccuuauuucaggguuuaauguuuaucuuugugugugcgcgcacccauuaagcaugcuugguacccucauacuagaauguacuuggauccccuggaacuggaguuaaagccacaugugaauguuacauguuacaagaguaacacaugugcuuaacuuuugagucaucucuccaguucuugguuguuuguuuuuuuuuuuuuaagccuaucuaauguccauuuucuugugcucaaaguuagucucuuaauguagcauuggguauaaaggaaugcuuaugauuuguuugcuuucaagguugucaucccucagaaaaaaggcaaaaaggcuaccacaaccccagcaagaaggugguuguuucacaaacaaaaaaggcugcaguucccacaccagcuaagaaagcagcugugaccccaggcaaaaaggcaguagccacaccagcuaagaaaaacauuacaccagccaaagucauuccaacaccggguaagaagggagcugcacaagcaaaagcguugguaccaacuccugguaaaaagggagcugccacuccagcuaagggggcuaagaacgguaagaaugccaagaaggaagacagugaugaggaugaagaugaagaggaugaagaugauagcgaugaggaugaagaugaugaggaagaggaugaguuugagccaccaauaguaaaaggagugaagccagcaaaagcagcuccugcugcuccugccucagaggaugaggaagaugaugaggaugaagaugaugaggaagaugaugaugaagaggaggaagauggugaguuagaucuuaggauauuuaggguacugcauguacauucccucacuguuucauuagauuaaaaacucauuuugugcucuuaguucuuuccauaacuuaauagguuuucauuugcuaaguaguuuuuguuuuuuuuaaguauuuguagcauuuaucuugucuggauugguagguagcaaauacauuugccugauuugccaucuuucuuccagacucugaggaagaaguuauggagaucacaacagccaaaggaaagaaaacuccugcaaaaguuguuccuaugaaagccaagaguguggcugaggaggaggaugaugaggaagaggaugaagaugacgaggaugaggaugaugaggaagaggaugacgaagaugaugaugaggaagaagaggaggaagguaaccauauuaacuuuuaaaguaugcugaccuaaguaaggcuuacuggcuaugcuaaagugucugcuuacucaugaauggcauuuuaaaacaucuagaaccuguuaaagcagcaccuggaaaacggaagaaggagaugaccaagcagaaagaagccccugaagccaagaaacagaaaguagaagguaagccugcaaaacuggggaaacagaucagaguagcacuagcacaagugaugagugacaaagggacuuaauacugaaccaugggguugaaaugaaauaugcugaugugcuuuauaguuuaugaugaaauuuguugugugcuuaagugggcugaaaguucauuuuuugugugugcaggcucagaaccaacuacaccuuucaaucuguucauuggaaaccuuaauccaaacaagucuguuaaugaauuaaaauuugccaucagugaacuuuuugcuaaaaaugaucuugcuguuguggaugucagaacugguacaaauagguaaguuuuaauugaauguuacauguguaucagcuagaauuuuuaguuuccaguuguauucuucccugccuuuaaacauggggcuauaucuaacuauguuaguaaaagucaguugucuccucucguggccuuaaguacaguuaaggagcugcaguaagaaagacuauaguauugaacuaaaugaucgagucauagggccugcaauuugaaguuccuguguuugacuugauaaagauaaaauaaaauuuaaagaagaaaagauauuaaacacauaaaauuuugugcaguaucuacaacuauggaucugcauagucauaugcuuuuagcuaaaaguauucucuguacuuuuagcgggguccaugcuagcuacugcuguuaguuacaauauacugaaugaagaaaucgaggugaauuuguuguaaugucuugguacauggacuuguuuuguuuuuuguuuuuuuuucuuuaagauuuguuuauguauaugagcacacuguagcuguccagaugguuuugagccuucaugugguuguugggaauugaauuuuuaggaucucagcucgcucugcucucaguccuugcuugcucuggcccaaagauuuauuuguuguuauacauaaguacacuguagcugacuuaagaugcaucagaagagggcauuaggucucauuaugggugguggugagccaccaugugguugcugggauuugaacucaggaccuucagaagagcagucaaugugcuuacccgcugagccaucucuccagccuuuggacuugguuuuauggaagauaagggugaucuaguuuuauuuuuguuagugcuguagaugcucugugugugugccacaugguauaagugcagaucaccuucucauaccuguaaucuuguuuuuuccaucuucaaggaaauuugguuauguggacuuugagucugcugaagaccuagaaaaggccuuggagcucacugguuuaaaaguguuuggcaaugaaauuaaacuagaaaaaccaaaaggaagagauaguaagaaagguauguaagggggucugggugacuggauacuaacagacuuaggcagucuggugccucuuccuuaguuucauccucauugugaaccaaugagaugucauaggucaugugcuuguugacagguuugauuccugggauauauaaugucagggcugacaggaggaauagcuuagugaguaaagaugcuugcugcaaaauguuugaucucuagaagccacaugaagagagaagaaccuuuaaucccagcauuugggagacagaggcaggcagauuucagaguucgaggccagccuggucuacagagugaguuccaggacauccagggcuacacagagaaacccugucucggaaaaaaaguuuuagcuuauccucugaccacauguguaucgugacaugcuugaagcuuaccuaucucuuaaaugaauucuugaucccuauauuuugaguuucagaauuuggauuuuaaguguuuguuucuuaguugugcugaaaauugaacgugggcuuuucacaugcuaggcaaauuuguuggguuuuuuuguuuguuuuuuucucaagacaggguuuuucuguguagcccuggcuguccuggagaccaagcuagccuugaacucagaaaucugccugccucccaagugcugggauuaaaggcgugagucaccacugcccugcuaggcaaucacucuuaaaacugcuacauauccucuguccccuuuugcucauuuuacaagguugcugugugcucaaucugcagucuauguuauaugcuuacuggaucuaggcuuuugauguagaaugaaccauaugagugaugagguaucuuagagauggaaacuaagucuaaauagacuuguuccauauacaacuuaauacauauggucuaaggaacaugauauacauguaaacaaguaggaaggagauaagucugguguccagggaagccaggagagccucaucugaaacuggacagggguuugugagucaucaggugacaauugaacauaggguacucuucaugcaaaugguuaguaaccauugagccaccucuccaucccuuuauaccauuuuuuuuuuuagcauauauccuuguacuuuauaggaauuauuugcuuuauucucuugugacuuguaaauugauguacuuaauuaaaucuuuuuccaacauaguucgagcugcaagaacacuucuagccaaaaaccucucuuucaacaucacugaggaugaauuaaaggaaguguuugaagacgccauggagaucagauuagucagccaggaugggaaaaguaaaggguaguuuugugucuuugaguguuaaaguuuuauuaaguuuagugucuucuuccccucuccuuguccuugcagucucuagucugcugcuucaaacuuaacuucauaaccagaaaauugaauaucugguccucuggccucuaccucccaaguucugacauuaaaaaugcucaacugauggguuuugaaggugugaucaauuuucaggcucaauccaaauuggcaucuuuugccacaaguacuauccuucccuauuuuaugagagaaaugugauucuaggcaguucagucuauuguguuggcucuuuuuccuccucaccaguuuaaaggaugaagaugagcuaauacauaguaaaagaacaguaaaagcacaugugacuaaguccuucaugucugaugcuugaguaauauuuucucuaacguaguaacugaauugucuuguacucuuucaggauugcuuauauugaauuuaagucugaagcugaugcagagaaaaauuuggaagaaaagcagggggcagaaauugauggacgaucuguuucacucuacuauacuggagagaaaggucaaaggcaagagagaacuggaaagaccagcacuuggagugguaaguuaaaggguuuauuguguagugggaacaggaaucauuuguaucuuuguauuuuaaguaauugguuaccuacaauuaguucaccuuuguucauauagcugauguuuagucuucaugagugaaagcuauuugaaaucauuuccuuuggaguauaguaggcaaauaaagcuuuuuguuggguauguuuuguacuuuaaauggcuuaaacuauuuuagaaaauaguguaagacaacaaagaacaguuaucuaauuagaaugaaaaugaaaggagcaaagaaggcauuacuguauauaauggauauacacuggugguucuagaauuaugguauaugguacaugguugaagugccauuguuucaguuaacauuccaguaaccuuguggauuagguuggagacaugcuuuauaggugacccacuuacugaguguuuaaauauacacagacauacucuaacauaccuugcuaauguguuaucuuuguauuugcaggugaaucaaagacuuugguuuuaaguaaccuuuccuacagugcaacaaaagaaacucuugaggaaguauuugagaaagcaacuuuuaucaaagugccccagaacccacauggcaaaccuaaaggguaaaauaauuuuuacguuagaugugggcuggacauacauacucuuacguauaagaguaagacuguccuguuagcuuaaaaaaaaacuaaaguuuuagcuauacaaagggcaguaaauauugauaguaaauuacaugcugaugccaaguguuucuaagcuuuauucugagaacugacuuucaaccuucagguaugcauuuauagaauuugcuucauuugaagaugcuaaagaagcuuuaaauuccuguaauaaaauggaaauugagggcagaacaaucaggcuggaguugcaaggauccaauucgagaagucguaaguccuuugacaugauaugacuugguugggugauuuuuuuuuuuauuuuuaugugccuauaugcucauuuggggcugucuuuauguuguugcugagaaaaugacaacuggauaugaugacugauuaccugagaaauaauugaugaaaucucaagaaaauuccucuagauagucaaguucugauccagcuaugucaacucaaagcagcaaccuugauugcccucugaguacgcuuuuuuuuugauccaguguagucuuuuuuuuuuuaaccuuaauuucuuguguuaauugcuuuuucugguaaaagggggaaaaaaagacauaacaaaaucaguguaagggaaggcucagugguugagcacugagaggaccuggguucaaaucccagcacucacauggcaccuaucgagacaggauuucucuguguaguccugccugucguggaacucacucuguagaccaggcuggccucaaacucagaaaucugccugccucugccuccuaggugcugggauuaaaggugugcgccaccacugcccaacccugucuguaacucuuaagaucugacauagauugcagacaaaacacuaaugcacauaaaaaaauuuuuuuuuuuaaaaaaggaaucuacuucagcugaauguggcaguauggcaguauucaccaaggguucauagugaaacaggaauuuuucucuuccagaaccauccaaaacucuguuugucaaaggucugucugaggauaccacugaagagaccuuaaaagaaucauuugagggcucuguucgugcaagaauagucacugaucgggaaacugguucuuccaaaggguaagaaggcguaguaguguugcugcuuuuuagugaauucugcauggagaacuugggucugcaguaucuucucauugagcuccuuucuguccaucagugauagauuauggauucgcacgagaagaagagagaauucacagaacuggcacuuaucuucuguuuuugcagaaguauauuuggcuguugugugagacauuaugagauacuggcgauuuucucgaccugaagaguacuuuggucacucuacuugggugacuugguacuuauuguguuacuuuaaaauguguuuacuuaaugggugagguuuuuuuguuuuucuuuucuguuuuagguuugguuuuguagacuuuaauagugaggaagaugccaaagcugccaaggaggccauggaagauggagaaauugacggaaacaaaguuaccuuggacugggccaaaccuaagggugaagguggcuuugguggucgagguggaggcagaggagguuucggaggcagagguggaggcagagguggaagagguggauuuggaggaagaggccggggaggcuuuggagguaaggaagggaaaggaacuggaaacggauuccuaaaccuguguccuaaccaaccaccuuaaugggaaggucaguccuaauuguaucacccuuugauguuuuuccuuccuauagguagaggaggcuuccgaggcggcagaggaggagggggagacuucaagccacaaggaaagaagacgaaguuugaauag 85X57800 Sequence below.uuagacgguugcgcgcgcagaggguugguaguugucgcuguaggccuucgcugccgcuucugcaucgugaaucgggggaccuuggcagccagaccucguuccucuuagaguagcucucaucuagucgccacaacuccgccaccauguuugaggcacgccugauccagggcuccauccugaagaaggugcuggaggcucucaaagaccucaucaaugaggccugcugggacgucagcucgggcggcgugaaccugcagagcauggacucgucucacgucuccuugguacagcuuacucugcgcuccgaaggcuucgacacauaccgcugcgaccgcaaccuagccaugggcgugaaccucaccaggugagcggguggcgggagcggggccccacucuucccgcuuccgcucuuggcggggcugugacucugcacgcucauuggcuggcuuggccauccgcgcuuucugauuggucuauggugucgggggcagcccucaccaaagcgcgcgguuccgaaaagcccgcgcuggcaguggcgcccacucuguuuccgcgccaaagccacaaagcgggaguccgcgggaaaaugagugcuccggagcugugcucauuaaaugccugcagcuuugaguggcuggucuuagcgccuaauaaacgagucuuagugcaaauguaaugucgacuuagagugacaauagaccuuuucuugacuuccagagucucacugcgcaucauggauuugaggggaaucugucaguuuuagcuuuuaacuuugcuacagcuaccuagguuagugccuccuguauacguguucaaggacagugugugacuuauuuuaguacagauacauggauuagugccacuuguauacauuuugaaagauuuacgaaaaggccagacgugauggggcacauucuccaguacacuagaaaccaaggacaccccgcucaaaaagaugcuuucucgaauguuggcuuuuagugcauuuuacuaagucgguuuuaagaaucacauauacccgguaauuugcuucaccccugagagaguuugggguacccuuagccccuuuaacaguucuccaaccgugagugugaaaugguacaacuuguaauugcuuuuuaaaauauagauguggauuacauguugauaaagccugucuuuuuuuuuuugggggguagcauguccaaaauucuaaaaugugcugguaaugaagacaucauuacauuaagggcugaagauaaugcagacaccuuagcacuaguauucgaagcaccaaguaaguuaaacaccuuuaaaacucggaguuacguguuguuucuguuucucaaaaccaaaaaaaauauuaacaauauuguaaauuccaucauagauaggaccguguggugugcuugguaacauuuuccuucuuuugguagaucaagagaaaguuucagacuaugaaaugaaguuaauggacuuagauguggagcaacuuggaaucccagugaguuaccuuguuucugauuguguguuacccugcugugauaccagcugaugcguguucugaguggaguggugguauuggggaugaauggcacacugccauuucacuaaaccacagcagucuaaaguugauugaguuuuaaagaaaccagaagucuugcauucugaguucugguuaagaugcuaaaucuugagaacaugaagcugagccuucccccuuuucuagacugaccuuuaacuuguggguuuacaggaacaggaguacagcuguguaauaaagaugccgucgggugaauuugcacguauaugccgagaccuuagccacauuggagaugcuguugugauauccugugcaaagaauggggugaaguuuucugcaaguggagagcuuggcaaugggaacauuaaguugucacaaacaaguaauguggauaaagaagaggaggcggugaguaguaagggggcguccaguuaggugucugaagcagggauggagccucggcuuuuguuuuuauuuauucauucauuuugagauggagucuugaguagaccaagcuaucuuagagcucagagacgacuccauaagcuuuuacagguagcauuuggaaagcuaaguguacagccuuuugcuuccuggaaauacucuuggcaaauaagugaggguuggcaagugagcaaaagaaaaugguuggggguguauguagcuuuauguguugcagguucaagaguauuugcagucccaagggaaauaagaaagacuucacaaaauguggaaagaguuguauuaaaugcucuugacaguuacauccauagagaaagcugggcaugaugucucaaacccacaacugauguacucaaagcuacagcaggaagauucucagcuuaaagucaaccuggcagaaaaucuagcucaaaagaaugaggaagaaauugggaaggcaaaggaagauguucuccgaguccuccucauucaaguagaacauacuaggccucuuuaauuucuaaguaucccugaaucgaggcuuuuucucaggaauccaauguauauuucauggcuacacuuuuuuuuuucuuuuuuaaguuuugcuagcuagccugagcaucagaauuacacacagaagucugaacuaaauaggauuuuuaggguuuaguauagugaaauucagagugcuucugcaaguauuuaagguaaauauaagguguuacuuggccucugcaugaauuuaaaguaaaugaaaguguaagaauucgaacauagauaaacacacaacccaagaacuaguucuuaaccuuaaucugcugaauuauuucuacuuccauaucaacuucagcuccucaguucucaaauacugacauguaauucaucaguauuugucugaugugcaagcauuuccacaacaaaagaaauuaaggaauuuuucaguauccacauguucaaggauugggaauugaauaaaauugauaaucauacaaugaagacugguuuacugucccuuagcuugcauucagcuguugguucuuguuuuuggaagugguuauguguuaucuuccucucuucaugcauucuuugcaagagaaguauguacaaucugaauaggaacaacuuucuccuuuguuuugauugcuugggguguggcucuacaggaugggcaagcuagacuuuuuucuucuuuagucaagguuuucaucaacccuuccaaaaugauaacuauuuguuuugcuuugugguauaauaccgugaucuaauagugugaguuucugaugucuacagugagccuguuuucuccucuagguaaccauagagaugaaugagccuguucaccuaacguuugcucugagguaccugaacuuuuucacaaaagccacuccacugucuccuacaguaacacucaguaugucugcagaugugccccuugguaagaugauaaguuugaacauuguuuuguaaugugguauuuauaguauucggugguuuaauuuuuccugucuuucaguuguagaguauaaaauugcugacaugggacacuuaaaguauuauuuggcucccaagauugaagaugaggaagcaucuuaggcauugcuagaaauugagaaaacuaaaccuuugaagauugcuccugagaugccagcguguccugaggucuuuucugucaccaaguuuguaccugaguauucuuaaauauuaauaaaauauguagauaucuucuguaaauaaccuacuuucuuuucucuccauucuccauaauuugcuuaaagaauaagcuccaaaguaaaaacuaguuuuguuaacaugaauguuucugcuuuacaaauacuggugauuuuccaucaaugaucuugacgcuaaaugcaguuuuaagaaauauuguucaauuuaaauaaaguuaacaauuugaaaaguca 86M35247 Sequence below.ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucauuugguuacuuuuaaaauucagauugucugguguuuuccaaucacucgcgacuguaauuugaaguuggguucugagauaauacaaucgcugucgcucuaguuuauaaagcuguccaagaucugcccagucccagauguccuggguccucagggccgcuguggucugccaacuucugcagcuggaugccagaccauccuggacucggaucccuuuggguauuucuacaccgcugugucccggccuggccuuggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccgaggauggcacccuggcuggagcaggaggaagcaggugacugggagcagcagacucguauagucacaauucaaggacagcugucugaaaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaaggcugcgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugaacgaaaacccaaguuccuguacagugggaaacagcacuguaccucacaucucucaggaccugaagagccacugcucagaucugcugcagaaauaccuggaaaaagggaaggagaggcugcugcguucagacccuccaaaggcacaugugacccgucaccccagaccugaaggugaugucacccugagguguugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugguggugccucuugggaaagagcagaguuacacaugccauguguaccaugaggggcugccugagccccucauccugagaugggagccugcaugguaccaaaagccuuggauuuggauuguugccaugguuuucauuuuguucaucauuugucucugugugguuugcauaugcaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacucuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccacuccccaggaacuucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugggagaugccccuuugaguggcugggcugugaggacagcaggccaguucuugccacccuggacagaaacacaucucaccuuucuggcucaaggaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacacaaagcucccuccucucacccacagcacucuggguccuacccucagugcuucagggacauuuaaucaggucaaauugggaucaauggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu 87 AI553024cuggcacggacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcgcacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugcaaccgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuuuucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauuuuuuacauccuacuaacaguagauuuuuuuguagugaacauuuuuuguauuuuuauuuauaagucucauaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagaauaaag uuaacuc 88X16995 Sequence below.ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcgggaccaggcugcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuucuguuucuagggacagugcaugaaagagaugggguguacgcgcgggcgaaaaggaaggguguuuucgggucggcuuacgaggagggguguguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagcgggcgaagggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccagugugaggcacucuguacucuggguuuggguguugauugccggguaggggguugucugagcauggacugggaaaagguacucagagcuucggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccuucccggcucucagcccccuuucccaguguuuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaaccgugcuggaagaccuggggguugcugaaggaaauggccagcuagguuggcuggguaaugguuguguuagacuaaguugucagaguaucuagaaaccuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcucacgauagagucucgauguaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuugaaucuguuagguagggugcagccugcgggcuuggucaccuaacagguguugccaggaccugccccaagccggauucucccacucccucuuucaaccccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucuuguguugcugacuaucggccugaagcuggguagauugguggggguugauccggauguaggauguccaaguggagaaacaggauuugaauggagcuggaacaaacgcccaguccugacugcugccacccuucuuccuccacccccaacccaucccuucccaggcuucuugcaaacagaggcagaaguggccauauuucuuucuuucucccaggugcuguaugcccuagggacuugacacggggcaggcggggugggaacugguuggggggggacgugcuguuuuaugggaagucguaugccuagccagcgguggagcuguccuggcuaggcacccaggggugguguggggaaugggagaaauacugggacuagagggucucaagggccagcagguggugauagucuuuuucuccaccccacccucugcuccaccaccccucugccucagcaccccucugcccucagcaccccucugccucagcacccucugccuccagccacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucaguguuccugugugaccugucuuuucaacuagaaagucuagaacuguacagaccccagaguuggagguggaaagggacacuagguccuggagccuccucugugggcuuuuuugaccagaugagaacguaagggccuccuccagcuaucccuggucauucaggugcuucagguuugugaccuuugcugagacccuggaugcugcagcaaacagacaucugcuuuagcagagggacagcuugucucugugcauccgcugguaggauccuccacucuguccaauuagcuugcgcugcugcuggguucugaguguucucuuacaaaaugacaagguuagggggcuggagagauggcucaggggcuaagagcacccauguggcaguuugcaacugucuguaacuccuguuccaggggggaucugacacccucacacggacaaacaugcaggcaaaacaccuauuggcauggaaaaugaaaauaaaugaccggguuagcugagaaauuccuuuugagaguugucuuuucuccaguccaggacugcucucuggaucuuccugcucaguuccucgccucccuuccauauaugguauuuaagguuuuacuuuuuuuugcguuuucaauuguuuuuaauuguauuuauaugugucucugugugugcacaugagcauggguguccuacaaggcuagagacaucagauguccuggagcuagaguuacagaugguugugagccaccugauguaguugcugggaacuggauuuaguuccuguggaagagcagugcaugcucuuaaccacugagcaacuucuccacgcggcccccccccaguauacgguauuuaaaacucuauagcaaugcuacccaacccauuguggagcuggggauggugagguggccuaguuccccccaacuccuggaaacaugucagaaaguacagagugggugccugugggaucagcaugcgggggguggugguggugagguguggggcugcuuucucccgaggcuaccgugauagacaguuguaccuugcuggcagccucuaccccauuuccaggaugucagucucugcagacguaugggggacgguggggaagggguauacagagccaugggugugccugggaauguacucccaggaagugacugguugaaaagucagcagaucuccugggggauagaggggugggcugaagcucuguggguugccucucucagcccugaccugugaacagggaggcuggggguuggaggaacacagcuucccccuguuccuggggggacaugcuggacagccuuuccuagcucccccggcccacugggguguggcuggucgucggacugagcucuuuuggaccuggucucugccugugagcuuugugacucguugagauagcauuugggcugagggauugggagucuucuguucuuugguccugacacccgcuuccuugucuaggccugccaccuggcuccccccaccccccuccccggccuaccaaguuucuugcuucccuuacugaccccuccuccucccuccuuugugucuccucccucuccagagaugcccuguauucaagcucaauauggaacaccagcaacgagcccaggaccgcgugaccaccugaccggugauccccuggcccuugaguucggcaagccuaccauggaccuggccagccccgagacagcaccugccgcaccugcuacacugcccagcuucagcaccuucauggacggguacaccggagaguuugacaccuuccucuaccagcugccggggacgacccagccgugcuccucagcuuguuccucugccuccuccacgucuucuuccucauccucggccaccucccccgcuucggcguccuucaaguuugaggacuuccagguguacggcugcuacccgggcacccugagcggcccauuagaugagacccuauccuccagcggcucugaguacuauggcagucccugcucagcccccucgccaucuacacccaacuuccagccgucccagcuuucucccugggacggcucauuuggccacuucuccccgagccagacuuaugaaggccucugggcauggacagagcaguugccuaaggcuucuucagggccuccgccaccuccaaccuucuucuccuucaguccucccacuggccccagccccagccuggcccagaguucucugaaauuguucccaccaccagccacccaccagcuuggggagggggagagcuauuccaugccagcagcuuuccccggcuuggcacccaccucuccgaaccgugacacuuccggcauucuggacgcacccgugaccuccaccaagucccggagcggggcuucagguggcagcgagggccgcugugcagucuguggugacaaugcuucgugucagcacuaugggguccgcaccugugagggcugcaagggcuucuucaagguauuuuguugguucugggggacgaugauaucauguuggagguggggguggagugggucauccguugggaucuguagugaccucuccugagguuucuucccagcugguucuguccugcaggacgagggacaggugugugccaucuuagaggcugggacuuuuuauucagcagggcacacaucucucuagggcugcagaaagcuggggaagggggcagaagguguguguguguguggccugcaguggugcucagaaacagaaaaccuagugggcagccucugguucuccacagaacuuguguuucuggcacuggaugaaaggacacaggcagaggguuugguucuugcuggggguggacuugggaacaggcuguguguuugucccagugcugggugccugcuuggcnnnncccaccuccanccccuuaguccucuccucugcgccaggaaaagggcagguggacacaugcagacaccuguuagaacaggugucuggacggccgugggaguuccuagacccuggucuuggguucugggaucuucccugugagguugaaaccuucuccaguaucucccagacuccucucugcgcucuggcccuccguuucucccucccccuacauccaaauguuaggaaaauagcuaugaacagagggcgcuuuugucugcgucggccacaggaucuggacgguccccuccccugggcucuccaccccccccccaaaccccaugcucugacagccuguuccguguccccccuuccuccagcgcacaguacagaaaagcgccaaguacaucugccuggcaaacaaggauugcccuguggacaagaggcggcggaaccgcugccaguucugccgcuuccagaagugccuggcugugggcauggugaaggaagguggguggcaagauggugcccucggcauaggcgaccugauggggug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89AF038562 ggcacgaggcugugcccgccaugucugcuacccaucacaagaccucccugccucagggcguccgcgugggcacugucaugagaauucgaggcuuggucccugaccaggcuggcagguuccauguaaaccugcuaugcggugaggagcaaggagcagaugccgccuugcacuuuaacccgaggcuggacacuuccgagguugucuucaacaccaaacaacaaggcaaauggggccgugaggagcgaggcaccggcauccccuuccagcgugggcagcccuuugaagugcuccucaucgccacagaggaggcuucaaggcuguggucggggaugacgaauaucuccacuuccaccaccggcugccgcccgcccgcguucgcuugguggaagugggcggagacgugcagcugcauucauugaauaucuucuaagcaaaggacccaagggccuuugcccgguuacggguuggggguuuuuugaucccacaagaaagguuuuggaucggccaauaacauuuuucuguuguucugaaaaauuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 90 Y11666gccacauuguugcaccaacuccagugcuggagucucaggacaccacaggcuacccggaguuguucugcuuuggagauccgagggcaggagcaucacgccagugacucugauaggugcgaucgccggauuggaacagaacugucauuuuuuuccgaaguugagccuuagugacccagugagugaaguuagcgacgggacgcuaagcagcuagaccggucggcaggagugagacuuaggguaccuucuaguaguugugauuaaaaaaauugaaaaaaagaaaaaaaaaaacccuguuucuggaaacuugaggcccucagcuggugagccaucgugguuaagcuucuuuguguggcuccuggagucuucgaucccagccggacacccgggccugguuucaaagcggucggacagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacucgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaaaaccaagugcaga 91 U40930 Sequence below.cccagcuguuucguccguaccuagaccgcgguuauggcgucguucacggugaaggccuaucuucugggcggaggaggcgacccgcgagauccgccgcuucagcuucugcuucagcccggagccggaggcggaagcccaagccgcggccggcccggggcccugcgagaggcugcugagccgaguggcugugcuguuccccacgcugaggccuggcggcuuccaggcgcacuaccgcgaugaggauggggacuugguugccuuuuccagugaugaggagcugacaauggcuauguccuaugugaaagaugacaucuuccgcaucuacauuaaagagaagaaggagugccggcgggaacaucgcccaccaugugcucaggaggcaccccgaaacauggugcacccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccagacuacgaccugugcagcgugugcgaggggaagggccugcacagggaacacagcaagcucaucuuucccaaccccuuuggccaccucucugauagcuucucucauagccgcuggcuucggaagcugaaacauggacacuuuggcuggccuggcugggagaugggcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuucugcuccaccagaagaucccaaugucaauuuccugaagaaugugggggagaguguggcagcugcccucagcccucuaggcauugagguugacauugauguggaacauggagggaagagaagccgccugacacccacuaccccagaaaguuccagcacaggcacagaagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcccugucagucucugacagagcaaaugaaaaagauagccuuggagucggugggacagccagaggaacagauggagucgggaaacugcucaggaggagacgaugacuggacacauuugucuucaaaagaaguggacccaucuacaggugaacuccagucucuacagaugccagaaucggaagggccaagcucucuagaccccucacaggaaggacccacagggcugaaggaagcugcccuauacccacaucucccaccagaggcugauccccggcugauugagcccucucccagaugcuguccauggguuucucggaugaaggcggcuggcucaccaggcuccuacagaccagaauuacgacaucggggcugcucuggacacgauccaguauucgaagcacccuccaccauugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagcagggcuucuauagauaggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucaggcaauaggaaagugcaugaggagaguuuugaaugugcauaugcugacgccugagaacagacccagguacccguggcugagcugagcuuccucugcuuccccuaggccuggccucugcagggaacugcagcacacacugcacucccaccugcucuugccgccagcauugcaccagcaguccagaauuccugccgacaacccguguuuccuuuauuaaaagugauuaguacaacugcuaguuauuuucaacaaauaaagccauuauguuaagaggggacuguccauagugagugaaagguggcaggcaggggccuacagcuccuagggaauggagaauucaugugaagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccacucuuuaguguuugugucuaauguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaaguaaccuguaauaaaaugccauaugcacuuuaacca 92 D26090 Sequence below.gagggaauugcgggaccccgucuggggaagcucccgccgccccggggugcucagcucucugucucccuugacccagguacagucaugucgggcuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggccaggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccgagugggcaccgaucgcacgggcuucaccuucaaguacagagaugaacucaagcggcauuacaaccugggugaauacuggaucgagguggagauggaggaccuggccaguuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaaggagguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaagacauccaggucaugcucaagucagaugccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagccucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauaucgccaugcccaggccuagagggcuaugccuucccaggaagugcaauauggaucaggcugggcgcccaaagugcccacuggauccauacuucaucaugccugacaagugcaaguguguggacuuccagacucugaaacugcaggagcugccugaugcagucccucauggugagaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacagggucaccaucaugggcauuuauuccaucaagaaguuuggcuugaaccccagcaagggccgggacaggguaggugugggcauccggagcucguacauccgagugcugggcauccagguggacacagauggcucuggccgaagcuuugcugggucugucagcccacaggaagaggaggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuucccccuccaucuuugggggcauggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagauggacucacucgccgaggugauaucaacuugcugauguugggagacccugguacagccaagucucagcuucugaaguuuguggagaagugcucucccauugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauacgggaccccucaucucgaaacuucaucauggaagguggagccaugguucuggccgauggugggguugucuguauugaugaguuugacaagaugcgggaagaugaccguguugcaauccaugaggcuauggagcagcagaccaucuccauugcuaaagcugggaucacuaccaccuugaacucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagacaaaaggggaggacaauauugacuucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcacaaugaggagagggacaugaugcuagccaaacaugugaugacucugcaugugagugcacugacacagacacaggcuguggagggugagaucgaccuggccaagaugaagaaguucauugccuacugccgagcgagguguggaccucggcuaucagcagaggcagcagagaagcugaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcguuccagcauccccaucacugugcggcagcuggaggcuauugugcgcauugcugaggcccucaguaagaugaaacugcagcccuuugccacugaggcugauguagaggaggcauugagacuguuccagguguccacacuggaugcugcuuugucuggcaaucugucggggguggagggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgccguuuugccauuggcucucaggugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcuauccgaaaggugcugcagcucaugcuacgcaggggugagauccaacaccguaugcagcgcaaggugcucuaucgccucaagugagcccauugcccaucaacccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuuuugcccugccucuccaccucagacugcugucugcagcacaucugcagccccuggaaauguacuuuggucuguuggcucauacuguguuugagugucugaggacucucugcucugggugucuauccccugucaugccuucucaacaagaugagucuggagcaggaacaggcccuggaauguagaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguauguacagagguaauaaagcaauugagucccuggcugcuaaggucaguggacccagu 93 AI787627ggaugcagccggaagugcagcgugcgugcgguuuggugggucgcugugugcgcuccgcgugugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgcagccugagggcgaggaagacgccagcgacggcggcagaaagcgaggccaggcgggcugggaagguggcuaucccgagaucguaaaggagaacaagcucuucgagcacuacuaucaggaacucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucccagccacacugagaaucacuggguacaaaagccaugccaaagagauucuccauugcuugaagaacaaguacuuuaaggaguuggagganccugaaguagauggacagaaaguugaguuccacaaccacuaagcugguacccugaagaacu 94 M33988gagcucaaauucuggcuuucuauuggguacgauauauuaaccaaugggagaaacacaaacagaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucuuuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaagcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguuccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgccggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcuggcgggcaaugcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcuggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaaggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaacaaaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacguucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuuaguaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuugagucaaaaguguguaagagaugaaaccuuuagaacauacuauaaauuuuuaguagaaauuuggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaagggccauuaaaucccacuuccauaguuuc 95 AI845182uuuuuuuuuuuuuuuuuggaaaugaagguaauuuauugaaacugguuuugggacaggcgaguggacaacuguugaaaggagcuagcgcacagccgggugggagcgggugcuuagccacagauccuaucugaggcccaacuuuuucuuuuccuucugcuucuuacggaccacauccagguuccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauucaucucucgcauggcgcgcacauagucacuggggucuuugaagcugacaaagccauagcccuugguuuugccugugcgcuuguca 96 AA619207uucggauccuugccaauauauguaucccauuuggaauggugaucuuaaaaugugagugcaugcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccgaagcuggaacacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauucuucaugaaaauccaaacacguuaagggaccagggagaugccacugccccccugaauuuucaucaaaaauagacacguuuauguaaacagaacuauuuuccauauucauagugacuuuuuaaguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu auuacau 97AW125783 cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcgccucgcuuuucgugguggcucggauccuagcggaccucaaccagcaggcgccggcgcccgcccccgcggaacgcagagaaggggccgcugcgcgcaaggcgaggacccccugccgccugccgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcgcgccggccgcgccccccagccccgcguggagcgagccggaggcggcauuggagcaggagcccggccccgcggggagcggcgagccuggccucagacaaaggggucggggaggccggagccgcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa 98 J04103Sequence below.cgucaguccccgccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccggccuugcgcgccgggaccgccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacauggaccaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucuguuugcugugcucccuucucucagugaagaucagacacuccaagaagugcccacgggccuggauucugucucccaugacucggccagcugcgagcugccuuugcucacucccugcagcaaggcagugaugagccaagccuuaaaagccaccuucaguggcuuccaaaaggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucugggccaccaacgaguucagccuggugaaugugaaccugcaccaguuuggcaugaacggccagaugcuguguaaccucggcaaggagcgcuuccuggagcuggcgccugacuuugugggugacauccucugggaacaucuagagcagaugaucaaagagaaccaagaaaagacagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuucagcauggaacaggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucggccacgccugcagcucugggcucugagcuccagauguugcccaagucucggcucaacaccgucaaugucaauuacuguuccaucagccaggacuuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaacgguggggacagcuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggguaccuuccuucgagagcuuugaggaggacuguagccagucucugugccucaguaagcugaccauguccuucaaggacuacauccaagagaggagcgacccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggaccaauccaguuguggcaguuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggauggaugggaguucaagcuugcugaccccgaugagguugcccgccggugggggaagaggaaaaauaaaccaaagaugaacuacgagaagcugagccggggcuuacguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuucguaugugaccugcagaacuugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagacugagggccuca99 D90146 Sequence below.auggcucuaacaacgcugcucuuggugguggcggccgcccugacccugaucgagacccgcgcgggugagugcggggucgggagggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcuccacucccggcccgcguacccgaccggggucccgggaggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugcgguauuuccacaccgcugugucccggcccggacucggggagccccgguucaucaucgucggcuacguggacgacacgcaguucgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggaguauugggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuacaaccagagcaagggcggugagugaccccgggucggaggucacuaccucuccacgucccgaaacagaggccggugaggucccgggugcaaaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcgguggggggguggggggggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugacaugggguccgacgggcgccuccuccgcggguaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagaccugaaaacguggacggcggcggacauggaggcacagaucacccgacgcaagugggagcaggcugguauugcagagagagaccgggccuaccuggaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcaggggccgcgggcagcuccucccucugcccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguggugccccuggcucagaggggagagagugacccugggucuccugaucccucaucacagugacugcacugacucucccagggcucagccuucucccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguuccccuguagccucugucagccauggccucucccaggccaggguucucagccuacacccacugucuguagacacugacuccuguccugcugagugugucagcccuuacaccucaugaccugaagucuccuuuacccgaugggagacauggacaucuacacuaggcugguucccccaguuucuagaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugacacccaauucuaucuauuccugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuuguguuuuuccccucucguuuucuuuuuaucuuuacuuuuuuuuuaaggguauuauguugcuuauaaucgguuuuucuucggcacuggaaugauauugcucucucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucguggaacucacucuguagaccaggcuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcugggauuaaaggcuugggccaccaccacugggcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccauccagaucacuccugauaucccugugccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagggucuucugcaauccaggccugagugagagggaagaccacacacccugugagcccacuguguuccagugagugcugcacugggguccacagcacauuccagggauccugugugacacaucuguaccuugucccccagagucaggggcugggagucauuuucucuggcugagugucagagguucaccacauuucugcuacacacucccugauggcuguuuacuuggacugacaguuaauguuggucagcaagaugaccacagugguuuagucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagauacgaacucaaacacauaugaaauuucuuauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacaucacauaaggaugaccauguugacccacuggcucauguggauucccucuuagcuucugaguccccucaggaaaaugugcaguccugugcugagggggccagcucugccugcaggucacuagugccaugacaguuaaaguguucauacagacacauaguucauuguaauuacugauuuagcguugucuuggcaguuuucaguuugcaugcauuuauuuauuuauuuauuuauuuauuuauuuauuuaaugcauggaaguacacuguugcuguacugaugguuguuugccuuugugugguuguugggaauugaauuuuuuuuuuuaggaccucucuuugcucuggucgacccugcucacuccggucaacuccuaugggucaacucugcucauucagucccugcuuguucuggcccaaagauuuauuuauuauuuauuauacauaaauacacuguagcugacuucagaugcaccagaagagggcgucagaucucauuacagaugguugugagccaccaugugguugcuggaguuugaacucaggaccuucaaaagagcagucagugcucuuacccucugagccaucuccccaguccucaguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucccccaaagacacaugugacccaucaccccauaucuuaugaugcugucacccugaggugcugggcccugggcuucuacccuguugacaucacccugacuuggcaguugaauggggaggagcugacccaggacacggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugauggugccuuuuggggaggagcagaauuacacaugccaugugcaccaugaggggcugccugagccccucacccugagaugggguaaggagggugugggugcagagcuguggucagggaaagcuggagcauucugcagacucugagcuggucagggcugagagcugggaucaugacccucaccuucauuuccuguaccuguccuucccagagccuccuccauacacugucuccaacauggcgaccauugcuauugugguugaccuuggagcuguggccaucauuggagcugugguggcuuuugugaugaauaggaggugaaacacagguaggaaagggcagggucugaguucucucucagucuccuuuagaagugugcucuaaucauuaaugggaaacccaucuacaccccacauugcuaccuucuccaacuggguccucugucaguucugggaacuuccaagaucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacugugcuccagcuccagguuaguguggggacaggauuguccuguggacauugcagugaagcuggagauguuggggagcucugggaacccauaguaacucuuccagagaaaucuuccagggccgcaguuguccaauaugaauacauauauguacauaugcauauacauuuuuuacccuuggcagggacagcuccuagagcucugauagaucucucccaggugguaaaggugacacucugggaccugauuggggaggggcaauguggauaugauuggguuucagggacuccacgaauccccucugagugagugguggguuguuggaauguugucuucacagugaugggucgugucccuc 100 AI563854uuaaaucuggagggauuuuucacacagccuaucuuuuuaggugugccuuucccauauuuuauuaaacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaaacauuuuacaaaagagaacucucuaggaucagcuacaucaaggacaagcagaaaaauagaugcaguccaacaaagacauugaaaaugacuu 101 AF017128 Sequence below.ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagagguucaucuggagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaagugguucagcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacccuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggucgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcaggugagacuggccgaaucgucggggggggggggaccugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagcagcaucugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggacgagcgcagcgggaagcgcgaauaucugcgaauuccccuucucgcucgcccguaucucccuagcugacugucuuucugccccuccgucuccguuacggucuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccugccuggacaggaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagagacgggguccaucagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguccgugucccuuuauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccuggagaccacgaaguguugggaugugcgcggggucaccugcccggccacacucgcgcuccacauucucggcacccgacgucucucacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccaggggagggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccugggugccccucccuuccuggccccaaacggccccuaaggaccgacgaccugggagcgagagaugccccuggcagugcuucuagcccagaacgggggucacugagaugcugggucccccaguauugggcuggggacauagcuguccagacuugccuaagcaugugaggugcuuccuggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccacccccaccgacacucaaucccaacacaugccucagauuucugcaagaaaaggaaggaaaggaugccagaccccuuauaggaggcuuuuacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuugaacuuucaaguuuuuaagucgacagcuaggcaugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaagugacuuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagccgauuaaaacucugauuucugagcuaugagagcuggcuucucaacagcaauggaacguugaaugauguuaauaacagggaaacugagacuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucuggugcuacaugucuauagucuuggugccugggagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugagauccugcccaccccacccccggcccccaaacaacaaauucucauccugauucucagaauugccuugggagcuagaagcugaaaguaugcccaucugugaggacugggucucaaaucuuaguuucuacuuacuagcugugggucuaugggcaacugcucuccugucugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauacuugauuuaaaacaaaaaaccaaacuaucucugguggggaaacagacagacgaagagagacauuuugugaccugcccaaaaucacacagcuccugaacaaguaaguuucugguugccaaauguugcuccuuguggucucccaaaacugguaucuacacugaggugaagggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuaucucucagaaguuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugggacccacuggcuauccccgaccucuggccuauccccaguacagucccccucagccccggccaggagucauacgagcccuagggccaccuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguagggguccuacuagacagggacaggaucuugcuacgagggaauuucuuauucagcauugaaguuccugagaggccaagaaggagguaaaaggucaccuuugagucaaggaaggcuuccuggagaaggcuacacguuaaccuaaaccacggauaggauuugcguauggaagcugaaaagaaucuucugggaggaggguuggaggcacagaauugaggugaaggggacagaguguuaagugagcaugucuccacugucugacgugcacaggguggaaggaagccugaugcuggcuuuguaccucggggugacucuucuuuucaacagucacggaaucucagccuauuucuuuuaauuaucacaaaaagugagugggcagugguggcucacaccuuaaauuucagcacuggggaggcagaggcagguggaucucuggguucaaggccagccugguuuacagagugaguuccaggacagccaaggcuacagagaaacccugucucaagaaagggaaaaaaaaagugaaugggaaauguauuucaauuuuuccaucuuccaucagaggaagugaagcauagagggguacucacuuguccagauucauacaaaugugaguaaugagacaggacugguccuggccugaggucuacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagugagcugagaacuuuugccucccugaaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagagguggggucuugagagccuccugccuucccaagugcuaggaguauagguguaugcuagauacccgacagggaugacggaucuuuuaggccauagcacuuucuuuccucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcuggguguacccguaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaaggucagccugggauauauaaacccuaucuccgauaaccaaacaacaaucaaagcaaaccugacuuaaguguuaaguaggaaagaauaugcuguaagucaucagccuggcugggggacugaccgccucugagggacugaagaaccugcuucaagcccggagcccugcacucaaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauaugugagauuggccagagaagagccagcaacaggcuucccagcaagggaacagcuuaccucugugaucagcuggggcgugagcaagaggcaagcccagggugaauccuuccuuuagcccuguccugaggagacaccuuuugaccacggguacuaguggguuggagcugugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuccucacaugugagugugcagagaucuggaugggugacucagcagcggcucuggcugcuccuuagaggauccggguuccaaucucagcacccacguggcaacucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcacugaaugcacaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuuucuuuugagacaggguuucucuguauagcccuggcuguccuagaacucacucuacagaccaggcuggccucaaacucacagaggcaucugccugccucccaaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagugcuuccauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcugggauuugaacucaggaccucugaaagaggagcucuuaacugcuaaaacaucucucuagccccagucuacauauuuuaaaucuuuuuuuaagauugauuuauuuauuauacauaaguacauuguagcugucuucagacacuccagaagagggcgucagaucuuguuauggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuuacccgcugagccaucucaccagccccuuuuuuaaucuuuaaaaaaaaaagggggggggccugga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102 X67644 Sequence below.ccguggguuccuaauggugcuauugacgacgggcacaaagucucauaauuuuagaaacuucacuuauuuugugacccaccuaguauggggcaaaggcaggagcuucggacuuccugucuucccucuaucccuuugaauagcgucucgggagugucccuaaguaaccauugcaguuuuguguccgugugcucuguugaaaucucugugauguguguaugguuuucacgugaacggaggcaggcagagcccggucuguggguucuaguguguucuuuaucuucuuggaaguuugugcaaugacuucccuccuguuuccugcgcauaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggaggguggcuggaccaucugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuuacccacaagcauucacuacucccaggaaagaacgugcacuggggcaccuagagaauaaccaaucaacgcuccgccuacauuuugcuuccuccuuggaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggccccuucuuuggcucuauaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugccacucgcgcaaccaucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcggggcucuggucccgaaauuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcgggcaccgaaaacgcagccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcccuggaacuuguagguaacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccagcuaccaaccgaggaacccaacauugccaagaggguccucuuucuccuguucgccagcaucuucugccagauuuugauggcugaagagggugugucgcagccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacugcgcccccgguccucgagccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaacauccggcggccuucuaaacgcgaugggucacaguccgaagaaacaaaggcaccauggauggguaccuggugcgagagaacguaucccaaacugggauuucuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggcccacuggggacggacagagacuuucuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggagggguguauguaauauuuauucuaacuuaugcaggggugcgagauaugccucccugcuguaacacagauauuuauuacgauuuauagggucgguaagacagaguugugggagggaggacccgggugguaggacucccagcuuggggauuagucuggggggguguaauaagauuagggguaacacuccgucuuccagcacuucaacucuguagucuguuguaaggcuuuggaagacccuugggaauccggccuuugaugucuucugguugcuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcugucuggggucgccuaguauguauguucugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaaguguaucauucag 103AF064088 See above (same Accession Number). 104 AI843085uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauagauguuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcuucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacugagagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaacaucacuaaccccuuuuuacauaccgaauucaagucacuac 105 AW124932cggccgccgguauuuuuuugcaaguauugagaguucuguauguuuugaaaagaguaauuuuaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagccuggcgguacuccucgugccgaau 106 X58609 auggcgcugggaacgcugcuccugcugcuggcggccgcccuggcccggacccagaaccgagccggugagugcagggucgggagggaaacagaacuuuccaaacagucugcggggaggggcgggugcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgcgucccuagccccgcgcccugcuccccuccugucccgcgcauccgcccggggucccgggagaaggucggggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagaccgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacgacacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcgguggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggccaugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcgggcggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugacguccugguucccaagucugagguucgggaacagaacggacccgggaccgguuucccuuucaguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacacacuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccggcaguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacugcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagaguauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcucgggaaggagacgcugcugcgcacag 107 M18837 Sequence below.auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccggguccggagggaaauggccucugaggaaaggggagggggcggcacgggggaagccgcgucccggcgucgcccaccugacccuccgccccuucuccacccuagccccgcgcccugcuccccucccggcccgcucacccgcgggggucccggaaggaguucggggucucaccgcgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagccccgguucaucucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacgcggagaauccgagauaugagccgcgggcaccguggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuuccgagugaaccugaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgaccccuccacgucccaaaacaggggcccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuucccuuucaguuuggaggagccgcgggugggcggggccggggcgugugggcggggcugaccgcggggucccgcaggcucucacacuauucaggugaucucuggcugugaagugggguccgacgggcgccuccuccgcggguaccagcaguucgccuacgacggccgcgauuacaucgcccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaagugggagcaggcuggugcuacagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagcucgggaaggagacgcugcugcgcacaggugcaggggccgcgggcagcuccucccucugcccucgggcuggggcucaguccuggggaagaagaaacccucagcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucaucacagugacugcacugacucucccagggcucagccuucucccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguuccccuguagccucugucagccauggccucucccaggccggguucucagcccacugucuguagacacugacuccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacugaucggagacauggacuacccuacacuaggcugauugccucaguuuccugaauuuucaaaagaauacauucucccagaucccucccugucugugggguuuccaccccuucgacaaccuaauucucucuauuccuauagugguggucacaucagcccuuaugggguacccuggaggaauaucaauaguggaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucucucucucucucucucucucucucucucuucuucaguuuuugagauaggguuucucuguaugcccuggcuguccuggaacucacuuguagaccaggauggccucgaccucagaaauccgccugccucugccucccagugcugggauuaaaggcguguggccaccuugcccagccuuucuuauuuucuuuacuuuuuuuuuuuuuuuuggaggggguaauuuuguuucuagucaucuuuugucuuuugucugcacuggagugauccuguuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaaguuaagacaaguuaaaucaggguucucuuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacauccagaagccuccugcucuuccucugucccacaaguuacagugcuccccccccccccccagugaaucuggacuuggacucugagagacagggucuucugcaauccagggcuggagugagagggaagaccacacacccugugagcccacuguguugcagugagugcugcacugggguccacagcauacuccagggauccugugugacacaccuguaccuugucccccagagucaggggcuggaagucauuuucucuggcugagugucagagguugacaccauuucugcuacacacucugugauggcugcucacuuggacuggcgguuaugcuaguuagcaagaugaacacagugguuuacgucucaguugucacacccuuccaguggcauauggcucuaauuucuacuuuugauacgaacucaaacacuuauuaaauuaguuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaacaucacauaaggacugccaggaugacccacuggcucauguggauucccucuuagcuucugagucccccagaaaaugugcagcugaggaaaccagcucugccugcaggucaccagugccaugacaguugaagugucaaacagacacauuguucagugucaucagugauuuaacugugccuuguguagauuucagagggucuuguuaauugugguacuuuuuuuuguuuuuuguuuuuuuuuuuuuuuguuuuguuuucaagacaggauuuuucuguauagcccuggcuguccuggaacucacauuguggaccaggcugaccacgaacucagaaaucugccugccucugccucccgagugcugggauuaaaggcgugugccaccaccaaccagcuaaucgugagauuucuuucuuuuuucuuuucuuuucuucuuuuuuuuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguucucuguguaucccuggcuguccuugaacucacuuuguagaccaggcuggccuugaacuuagaaauuugccugccucugcuccggagugcugggauuaaaggcaugugccacuaccaaccagcuaauugugggauuucuuaaaucuuccacacagauccuccaaaggcacaugugacaugucaccacagaucugacggugaugucacccugaggugcugggcccugggcuucuacccugcuaacaucauccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccuucaggggauggaaccuuccagaagugggcaucugugguggugccucuugggaaggagcagaauuacacaugccaugugcaccaugaggggcugccugagccccucacccugagaugggguaaggagggugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcucagggcugagagcuggggucaugaccucaccuucauuuccuguaccuguccuucccagagccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcuuggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguaggaaagggcagagucugaguuuucucucagccuccuuuagagugugcucugcucaucaauggggaacacaggcacaccccacauugcuacugucuguaacugugucugcucucaguucugggaacuuccuagugucaagcucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacuaugcucuggcuccagguuagugugggggacagaguuguccugaggucauuggagugaagcuggaguuguugggugcucugggaacccauaauagcuucucuguuguaauccucugguggccugugucagaucuugcuauagauauaucuuuguauauauuuuucccuaggcagggacagcucccagagcucugauauguuucucucaagauuguaaaggugacauucuauggccugauugcagaggggcacuguggacaugguuguuuucagggacucccacaauccccugugagugguggguuguugggauauugucuucauuguggugguuccugacccucauucucuaucaugaagacagcugccuggaguggacuuagugacagccagugugaccuugggucuucauuuuucuuuagagaacagcgccugauguucccugugagccuaugggcucaaugugaagaauuguggagcccagccuucgccuacacaccaggaccugucucuugcauugcccuguguucccuuccaccgccaaccuuccgggucugcag 108 AW124268uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaaccucauuaucuaaaauuuauacagccucacauuccuaaaccaccucuggcacuuuucuugaauuaagucaaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggccaugaggacucgcagauaugucuccucggaccuggaagcgugucagccaugggauccacuaauccaccauccgguacacagggucacccacucucaggcucccaagcuucuccaccgagaaauacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcgauagcucuucagggucuccaguggc 109 AF090738 Sequence below.cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcguccucucccaaaguggccuacaacccuuacccagaggacuauggagacauugagauugguucucacaagaguuccgcaguaaccugggggcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagcgaugacuacaugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugcccccuuccggagcagccgugccagcacccccuucaggggugggcaggaccuucccaguaaacggagguggcuacaaagccagcuccccagcggagagcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagacccuaagcuacuccccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagcagcuuugcguggaggcagugaaggccucaaaggcaucccgggccacugcuacagcucuuugccccgcucuuauaaggcucccuguuccugcagcggagacaaugaccaguaugugcucaugagcuccccugugggccggaucuuggaagaggagagacuggagccccaggccaccccaggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuuccuccaugaggccgagugccaucgguggccgcccugagggcuuccugggccagcgaugucgggcagugcggccuacacgccuaucgcuagagggacugcagacccuucccagcaugcaagaguacccucuacccacagagcccaagagcccuggcgaguacaucaacauugacuuuggugaggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuucacugcucucagcuaguaguccugcuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucuccacucucugacuauaugaaccuggacuucaguucucccaagucccccaagccuagcacccgcaguggggacacaguaggcuccauggauggccuucucucuccagaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuacagcagccucugccaccugccccgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcuggcuccucaauguccuccgagccuggggauaauggugacuauaccgagauggccuuugguguggcugcaaccccgccacaaccuaucguggcaccuccaaagccagaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucagguaucugggguggaggcuuuccuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagacccacaggggggacgucgucgccacaguucagagaccuuuuccucuaccaccaccgucaccccaguguccccauccuuugcccacaauuccaagcgccacaauucggccucuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggaggugaugagccgcccacauccccaggacaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaaccccggucagcccggagcuuugauuggcuguccuggaggcagcaguucucccaugcgcagagagaccuccguggguuuccagaacggccucaacuauaucgccaucgaugugagaggcgagcagggguccuuggcgcagucucagccgcagccaggagacaagaacuccuggagccggacccguagccuuggggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccaggcacuggagcuuugcccucugccagcaccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucgugaaaggugaggcccuuugaccuugaggaugggggagggagaguggaguauuggguggcu 110 AI834950uuuuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucgacgggccagaggaggguggagagagcacgagugguuuaaauaggggaggaugggagcauggcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuuggaauauuuuauaacaauauauauaagauucugguuugcuuuuccuuuucgucucguaaaggagagagaauugcauaguucgauucuguccaagggggcagcugcauauggucggccgggcgggucacuggucgu 111 AI851365uuuuuuuuuuuuuuuuuaagugucaccacuugugacagucagcauguuacuaucagcuccagccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaagaaacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaacagugcucuuguugacauucagacaguucugagggccacucugagaggcgccuuccuguucucaccugacaaggauauuguuugguuugguuugguuugguuuugccuuacuauggcuuuucuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuuacuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccuagagacgccacaagagccacugccgugacauaccucacaagcuacaucccuguccucaaaau 112AW047339 cggccgcggccaccggccugcgccaagcugcugcugcggcagccaguaccucggugaagcccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuugguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaaggacgggauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagugguugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaagcagcggacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuucuuauccaaguucuauaugg 113 U06834 Sequence below.gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauucagccaaagugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuagaagagacccuguugaacacaaaacuggaaacggcggaucugaaaugggugacuuacccucaggcagagggccagugggaggagcuaagcggccuggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcguccagggggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacguguaugccacgauacgcuucaccaugauggaaugccugucccugccgagggccagucgcuccugcaaggagacauucacugucuucuauuacgagacgaacgugauacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaacaucugacucggaagcgcccuggagcugaagccacagggaaaguuaauaucaagacgcugcgccuggguccucucagcaaagcuggcuucuaccuggcuuuccaggaccaaggagccugcauggcucugcucucccugcaucucuuuuacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugccgguggcagguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaugggcugagcagcaggucacgggcugcagcugcgcgccaggguacgaggcugcggaaagcaacaaaguaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccgccgugcccagccaacagccacucgaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguucaccuugcacuaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuggaguggagugcuccccuugaguccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugcccugugggggcgacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccugaugucaccuauaccuuugagguugcugcuuugaauggugugucuaccuuagccacuggaccaccuccuuuugagccugucaaugucaccacugaccgugaggugccuccugcagugucugacauccgagugacucggucgucacccagcagcuugauccugucaugggcuauccccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggccccagcaguguucguuuccugaagacaucagaaaaccgagcugagcuccgggggcugaagcggggagccagcuaucugguccagguacgcgcacgguccgaggcuggcuacggucccuucggccaggagcaucacagucagacucaacuggaugagagcgagagcuggcgggagcagcuggcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguucucugccucaggaagcagagcaaugggagggaaguugaguacucggauaagcaugggcaguaucucaucgggcacgguaccaaggucuacauugauccuuuuacuuacgaagacccuaaugaggcagugagggaauuugccaaagagaucgaugucuccuaugucaagauugaagagguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaaggagagcuguguggccaucaagacucugaaggguggcuacaccgagcgccagagggcugaguuccugagcgaggccuccaucaugggccaguucgagcaucccaacaucauccgccucgagggcguggcaccaacagugugccgguuaugauccucacggaauucauggagaacggagcccuggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcugaggggcaucgccucgggcaugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacaguaaccuggucugcaagguguccgacuuuggccucuccagauucuuggaggagaacuccucugaucccaccuacacaaguucccugggaggcaagauucccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggcgcuaugggaucgucaugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaaugccauugaacaggacuaccggcugccuccuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcagaaggaccggaaugcccggccccgcuuuccccagguggucagcgcucuggacaagaugauccggaaucccgcuagccucaaaaucguggccagggagaauggcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguucuguggucgaguggcuucgagccaucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugagauggucagucagaucucugccgaggaccuucuccgaauuggagucacucuggcaggacaccagaagaaaaucuuggccagugugcagcauaugaagugggaagcuaagccaggagccccuggugggacagggggaccagcccagcaguucugaccuccaaggacucaccaccguggcagauucuucuuuccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucacagccuucccauuggauugcacuuugaacagagggggucggagacacagauuuggggaaccgugccauaugggaucauacaugcccuccaggcggggaaccccaacucagagugagucuuucccucaagacugggcaaagaaacaucccuacgucucuaaccucccaucuucccagaggcucucuccccaagcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggugaccagccugccaacuugggaguggaaaaugccgucccaggaggcaggaaggggcugucaggacccggugauguaaucauuggguuuugauguccugacuugcugucaccaccaaaggcaaucauuuuucccuuguaaaugccccuccccucaucugccuucauauugaagguucugaaguuuuacuguuuuuuauuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccagauuuuguguguuaaagggcaccugguuccacuaucuccuguugggaacaaggacccaucgauauguucuagaacagugccuuggaaaugcca 114 AA980204ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccggagccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagccggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgagaggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuagagacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcgaggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgagcuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggagucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcgugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcuggagaagagagcagcacaucu 115 AI843232ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccggagccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagccggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgagaggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuagagacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcgaggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgagcuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggagucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcgugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcuggagaagagagcagcacaucu 116 U59807 Sequence below.augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggcccaggucaggccagucugagccaggccugcggagacccggcggccucagggaccggccugcccagacuggucagguccugcagcggguuuccggggcggccacaagugugacugggagcugggggcucuggaucugguuggaagauucagggccgggaacuggggcgagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccgguggucccagagaauucaggaaggcaguguuagaaccuagacggcaccuuuuugacuuacacccaggccuaaacaagagaaagccagacugggcuacugugcuugucuccucaaaagaaagagcuaggacuguuuagcucaguggcaggaauucaacugauaccaccaccaccaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacuugcuugugccuagucugaaacgaggggguggaccuugggccugggcugcccuuccugugacuguuagcagagcagagauucaguacaagguagggggagguucaggguauuagcaagagaagaaaaguuaaacaaauccucucuucagcucuccugccacgccccaagcccaggacccuguccacuaagccuagcugaucuugggagguguuugcucugaacugaaguggccaagaaggaagugagucagcuccaugagacccuagaaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucaggaggcagagacaggcgagucucucugaauuugaagccagcccaguuugcuuaguuccaugccagccauagcuacauagugagacccugucccccccccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaaugaggaguauugaaggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccauccaggugaagucccagcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauaguggcuggcaccaaccucuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcagaguguccugcaacuuccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuaggguucccggccuuaaaggaggagacaaggguuaucacuggcuaaguuaguggcugguggccuguucuggcucaguuucuaaggcuggguuaagccuggaacuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguugguggagauaaaugcgugcacuugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaacaaagaaaggcacgaugagcucuccuacuucuga 117 AI152659gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacuuauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauuauacugugcacccugugaugcaugaagugauuuuauguauggucugcuaugugggcagaggucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggauuuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacaccacuguguggaauuauaaauacaucccaugugca 118 AI850090uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugacaguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuuuguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacucugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaauuaucaagucagccaucagcuuuucuuaggagagagagagagagugugugugugugugugugugugugugugugugugucugucugucugucugucuggguaucccacuuagggccaugugcauguuagguaaaugcuccaccacugagcuguuucuuagccgcacuuuucucagauuucagguuuguuuguuuguuuguuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaau 119AF064635 See above sequence (AI850090). 120 AI843106uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacagacuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaaccuguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacuaaaauauuuuccagcuuuauucuuuaaggagcuguauaaccuucaaagucagggucccgaggucagcagggcauggggcagaaugcaccuggcacucccugugcagcagacugcaaccaca uu 121AF033186 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggggaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguugcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuugucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaauucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccugagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguuccagaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucagcuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacaggaaaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcuccagaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccugaaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugugcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuuuggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguuguagcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucguguguaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucgcccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagucaugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaaucgaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucuacugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacuccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugauguccacccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc gguuag 122Z50159 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggggaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguugcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuugucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaauucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccugagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguuccagaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucagcuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacaggaaaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcuccagaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccugaaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugugcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuuuggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguuguagcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucguguguaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucgcccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagucaugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaaucgaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucuacugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacuccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugauguccacccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc gguuag 123X78683 Sequence below.gaauuccgugugcaaggcgaggucuguaagcuggagcggggcagaggcuggcgggcaccccuuccugaccgcuggugccgccgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggcaugggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaaggcggucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggauccccugguuccaguaccccaucaucuaugacauucgggccagaccucggaaaaucuccucccccacaggcuccaaagaccugcagauggugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcuggacuaugaggagcgagugcugccguccauuguuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcugaucacccagcgggcucaggugucccuguugauccgaagagagcugacagagcgcgccaaggacuucagccucauccuggaugauguagcuaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcaggaagcccagcgggcccaguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcggaggcugccaagaugcuuggagaagcacugagcaagaauccuggcuauaucaagcuccgaaagauccgggccgcccagaacaucucuaaaacgaucgccacaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguuuuacucggggaagugacagccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcacacuuguccagcuuggaggagccagcucggggucaagcacagcccacccugccccaggcaucaugugauggacuuuucuguaucugcccucuuggauuaaggaagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcgggguggacaaugugauuucuccgugauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc 124 X68193acccaccggcuuucggaccauggccaaccucgagcguaccuucauugccaucaagccagauggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccgccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucgaccugaaagaccguccuuucuucccggggcuggugaaguacaugaacucggggcccgugguggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggagaccaauccagcugauucaaaaccaggcaccauccguggggauuucugcauucaaguuggcaggaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguuuaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagacaugaagaaaccagaauccuuuucagcacuacugauggguuucuggacagagcucuucaucccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaaaaaaaaaaaaaa 125 AA062013uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugcaggugcacaugccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucguauccccaaggaacagggagugcucugguccuuugggcgugggaaccgggccaaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaagcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcagggaaccuggcaucaggugguugccgcuggggcuacauccuugggcuuuguguacccucuugauuuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaagggccuugggacugccugguaagacuucaaucugaugggauaagggcuguac 126 AI465965auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauacuuccgccaauguguguaugacaugugugcccauaagggugacaaagccuaucucugccguagccuggcugcuuauacugcagccugucaggcagcuggggcagcagugaagcccuggaggacagacagcgucugcccucuccaguguccugcccacagccacuacuccaucugcacccgcuccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac 127 U50413 Sequencebelow.ggcacgagccgaguuggaggaagcagcggcagcggcagcggcagcgguagcggugaggacggcugugcagccaaggaaccgggacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcugaagcccaggcugggcagaggaaggaagcgagccgacccggaggugaagcugagaguggagcguggcaguaaaaucagacgacagauggacagugugacaggaacgucagagaggauugggccucgcugcgagagucagccuggagucaagguguugacaaguugcugagaaggacacgugggaggacgguggcgcgcggagggagagcccugucuucagucaccccguugauggaggacagauggacagcagccggacggccagucaccucucuuaaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuuagcccauucucugaacucacuuucucuuaaaacguaaacucggacggcagugugcgagccagcuccucuguggcagggcacuagagcugcagacaugagugcagagggcuaccaguacagagcacuguacgacuacaagaaggagcgagaggaagacauugaccuacaccugggggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagcccggccugaagauauuggcugguuaaauggcuacaaugaaaccacuggggagaggggagacuuuccaggaacuuacguugaauacauuggaaggaaaagaauuucacccccuacucccaagccucggcccccucgaccgcuuccuguugcuccggguucuucaaaaacugaagcugacacggagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgccucuccuuauaaagcuccuggaagccauugagaagaaaggacuggaauguucgacucuauacagaacacaaagcuccagcaacccugcagaauuacgacagcuucuugauugugaugccgcgucaguggacuuggagaugaucgacguacacgucuuagcagaugcuuucaaacgcuaucucgccgacuuaccaaauccugucauuccuguagcuguuuacaaugagaugaugucuuuagcccaagaacuacagagcccugaagacugcauccagcuguugaagaagcucauuagauugccuaauauaccucaucaguguuggcuuacgcuucaguauuugcucaagcauuuuuucaagcucucucaagccuccagcaaaaaccuuuugaaugcaagaguccucucugagauuuucagccccgugcuuuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagagauuuuaaucucaacggaauggaaugagagacagccagcaccagcacugccccccaaaccacccaagcccacuacuguagccaacaacagcaugaacaacaauauguccuugcaggaugcugaaugguacuggggagacaucucaagggaagaagugaaugaaaaacuccgagacacugcugaugggaccuuuuugguacgagacgcaucuacuaaaaugcacggcgauuacacucuuacaccuaggaaaggaggaaauaacaaauuaaucaaaaucuuucaccgugauggaaaauauggcuucucugauccauuaaccuucaacucugugguugaguuaauaaaccacuaccggaaugagucuuuagcucaguacaaccccaagcuggaugugaaguugcucuacccaguguccaaauaccagcaggaucaaguugucaaagaagauaauauugaagcuguagggaaaaaauuacaugaauauaauacucaauuucaagaaaaaagucgggaauaugauagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaacggcuaucgaagcauuuaaugaaaccauaaaaauauuugaagaacaaugccaaacccaggagcgguacagcaaagaauacauagagaaguuuaaacgcgaaggcaacgagaaagaaauucaaaggauuaugcauaaccaugauaagcugaagucgcguaucagugagaucauugacaguaggaggagguuggaagaagacuugaagaagcaggcagcugaguaccgagagaucgacaaacgcaugaacaguauuaagccggaccucauccaguugagaaagacaagagaccaauacuugauguggcugacgcagaaaggugugcggcagaagaagcugaacgaguggcuggggaaugaaaauaccgaagaucaauacucccugguagaagaugaugaggauuugccccaccaugacgagaagacguggaaugucgggagcagcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggcacuuuccuuguccgggagagcaguaagcagggcugcuaugccugcuccguagugguagacggcgaagucaagcauugcgucauuaacaagacugccaccggcuauggcuuugccgagcccuacaaccuguacagcucccugaaggagcuggugcuacauuaucaacacaccucccucgugcagcacaaugacucccucaaugucacacuagcauacccaguauaugcacaacagaggcgaugaagcgcugcccucggauccaguuccucaccuucaagccacccaaggccucugagaagcaaagggcuccucuccagcccgaccugugaacugagcugcagaaaugaagccggcugucugcacaugggacuagagcuuucuuggacaaaaagaagucggggaagacacgcagccucggacuguuggaugaccagacguuucuaaccuuauccucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuaauuuaaagccacaacacacaaccaacacacagagagaaagaaaugcaaaaaucucuccgugcagggacaaagaggccuuuaaccauggugcuuguuaacgcuuucugaagcuuuaccagcuacaaguugggacuuuggagaccagaagguagacagggccgaagagccugcgccuggggccgcuugguccagccugguguagccugggugucgcuggguguggugaacccagacacaucacacuguggauuauuuccuuuuuaaaagagcgaaugauauguaucagagagccgcgucugcucacgcaggacacuuugagagaacauugaugcagucuguucggaggaaaaaugaaacaccagaaaacguuuuuguuuaaacuuaucaagucagcaaccaacaacccaccaacagaaaaaaaaaaaaaa 128 AW120502uuuuuuuuuuuuguuuuaauuuggcuccaaugaucgcauucucaaacuccuuugggagggcauuagaugacccaguauccgacgacuuagauucacacguguuuuucuccucugagcucuuuucuccaggcucacngucuuuguuuuucaagcuuucuugggccuuugaacaauuuucuuccuuugaagauucuccugg 129 X62940 Sequence below.agccgaguaggaccgagcugcugcagacgcgccgggucacucgagccagcaccaccguucucacgcccugagcugcagacagcuaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacggggcuguuuuuuuaauuuggcugcaauugcaugaaaucccaaugguguagaccaguggcgauggaucuaggaguuuaccaacugagacauuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucuggugcaagugugguagcuaucgacaacaaaauagagcaagcuauggaucuggugaaaagccauuugauguaugcggugagggaggaaguggaaguucugaaggagcagaucaaagaacuaauagagaaaaacucccagcuggagcaggagaacaaucugcugaagacgcuggccaguccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagccacaggggaccacacagcccccugcacagccagcaucccagggcucaggaucaaccgcauagccuccuaggccccaacagaacuggcugcugcugcugcugucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauugcugucuacgaaagagacgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuugaagaaauguacuaguugagugaauuaaagguuaaucagagagugagcagggaugugcccugugcaacguggcagaugucugaggaaugguuuaauugaccccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucgggcggcucgccuucguggggcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccuucaaagaacucggagaggccagaaacaagacugcaauggggggcggggggagggaugaugcaguccuuauacaaaaccgacaacugucaccaaagcuuauaaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugacacaacggugacagguagcugggaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguaguguaacgaauuuguaccauagaggacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugucugaaaagguguggcuuguccuuccuagagagaucuacuuaaaaacugcuuuguggcaaaaaccacaccugaagaaauuuuaagaauuuggcccaguuagucacucuguguaaucccggaaucuagcugcugaagucuugcgaaguaaacuccccgugaccgaugucaguuaagcuggugauaccuggagaaguggucaguugcuaaggaaguggauuucccaguagggguuucugcaccucaccuguauagucguucugcgcaugucccccacacaguccccaccuguauuuaccuguucuacuugucaccuuucaauaaagcauaucaaauguugau130 U60020 Sequence below.auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcucccgggaaucuucucccuguugguucccgaggugccgcugcuccgggucuggguggugggccugagucgcugggccauccuaggacuagggguccgcgggguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgcacugaguuuggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcuggauuacuguacuggaacagucguccagaugccuucgcuaucaguuauguggcagcauugcccgcagccgcccuguggcacaaguuggggagccucugggcgcccagcggcaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccuaagaagagacgucucuaccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggccgcaucacugacuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauuuucucaccauagccagcacagcgcuggaguuugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagagguguuucgggccguccuucgccaggagacaggguuuuuccugaagaacccagcagguuccaucacaucucgggugacugaggacacagccaacgugugcgaguccauuagugacacgcugagccugcugcugugguaccuggggcgagcccugugucucuugguguucauguuuugggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaagaagcugggaaaagugcaccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccuuaucggcgaugccuaccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaaugaagacgcuaaacaagaaggaggccuuggcuuacgucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugggaauucuguaccugggcgggcagcuggugaucagagggacugucagcagcggcaaccuugucucauucguucucuaccagcuucaguucacccaggcuguucagguccugcucucccucuaccccuccaugcagaaggcugugggcuccucagagaaaauauucgaauacuuggaccggacuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuuguggaguuccaagaugucucuuuugccuacccaaaccagcccaaaguccaggugcuucaggggcugacguucacccugcauccuggaacggugacagcguuggugggacccaauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggccagcugcugcuggauggccagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagccgcugcuauuuggaagaaguuuucgagaaaauauugcguauggccugaaccggacuccaaccauggaggaaaucacagcuguggccguggagucuggagcccacgauuucaucucuggguucccucagggcuaugacacagagguaggugagacugggaaccagcugucaggaggucagcgacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuuggaugaugccaccagugcccuggaugcuggcaaccagcuacggguccagcggcuccuguaugagagccccaagcgggcuucucggacgguucuucuuaucacccagcagcucagccuggcagagcaggcccaccacauccucuuucucagagaaggcucugucggcgagcagggcacccaccugcagcucaugaagagaggagggugcuaccgggccaugguagaggcucuugcggcuccugcagacuga 131 L32752gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgcagguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauugaugaagcgccacuugaccggagaguuugagaaggaguauguagccacccugggcguggaggugcacacauuagucuuccauaccaacagaggaccuaucaaguucaaugugugggacacagccggucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuauaauguuugacguaacaucaagaguuacuuacaagaaugugccuagcuggcauaaagaucuagugcgugugugugaaaacauccccauuguauuguguggcaacaaaguggauguuaaagacaugaaagugaaggcaaaaccuauucucuuccaccgaaagaagaaucuucaguacuaugacauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcucauuggagauccuaacuuggaguucguugccaugccugcucuugccccaccugagguagucauggacccagcuuuggcagcacaguacgagcaugauuuagagguugcucagacgacugcucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaagucuauuuuaggcaacuguccugugaugccagccagcggugcagugugugugccaccuuauuuagcuaaaggagaucgugcaauucauugggaugcugaaggagaugaaugggcuucggagugaauguggcaguuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaacagaguuguucuggauuucaaagauaagacugcuaccguagcaucacaauagucaguggug accggaauuc132 AI840013uuuuuuuuuuuuuuuuugauuuaugaaaaguuuuauuuaucaguacugugaagaauucucaucauaauugcuacguuaaucaaggaaaaggcacagagaagcaugugucguuugaguccucgauacuggaccucccagcccaugcucccuaugaggagucuagcugcugugguggucuucacagcuuugguuuucuggagacgaagcucaugauugcguucaugcacuccucugacagccaccuugcuugcagaguagugcacucuucagcguugacugggcguagagcuuuucuuucucauuuuuucugauuaacucuuuggaaauucucauuggguuuggcgggagcuucgcauau 133 AB020424ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcguuaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguguuucgggaaugauuugcgguggaugaacgaaaccccgguacguccugugccaaggagcauaugucaggacggacgcucguuaaugccucagugguggggcaacguucgcucucuaucuauacgacucucgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggugugaauugcagaauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuuucgguugagggcacgccugccugggcgucacgccuuguuuugcucugugcccgugcucuuucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaagcgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggauguuguggucccccgucaccuuaaggggcucaagagacccggacuaggcgagccgcgcuucguaagaggagggcgagcugucucgcaau 134 AI848453uuuuuuuuuuuuuuuuugaaguugcugccccuuuauuggugacccgggcaaguuuaaggagaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagggucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuacuuuccaaguuaacgaaccgauaagaaaagauucucccuuaaacugacaaguacaauguacauguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaagaccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguugguuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgaugccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggccaaucanacgguggguu 135 AU040563cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucaccccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggcagauuguuguaguugucuuccuggcccuccagcaggcuucgggagguggcuaucuccugcuccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugcggcacgcaggugcngcg 136 X89749 Sequence below.ggacugacuccuugggcagauugccucuccuccuucucaugccagaggcugcugaugaggaaagguccaggggacuguccaugcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaacacucucuuguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcuccuagaaaccccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuguugcagcaucaggcagugacucugaggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagaggcaaucugcccaaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagcacugcugucccagcagacacaccuguccacacuacaggucuguaacugguucaucaacgcccgccgcaggcuccuuccugacaugcugagaaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauugaagcugcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaacccuagggagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccgucagugaucugccauaccacugugacugcauugaaggaugggccuuucucucucugucagccgauuggugugggacagaguacagauguaccgcaaauagcacccagcaacuuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucuuuucaacacuccucccccuacuccaccagaccucaaccaggauuuuaguggauuccagcuucuaguggauguugcacucaaacgagcggcagagauggagcuucaggccaaacucacagcuuaaccguuuuuucaaacaaaacaguucuccaaaauacgguccugauugccgggggugauggcaagagaugcauuauuuuauauauuuuuuc 137 AW125390uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauugaauccacuguggauagauaaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggagggugaagcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaagaacaaugaugaugacacuaacaauggugauaacaaccaucaggaugcugaggaccaaggugcugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccaccaucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaaguucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucugggcauguugaucacaguaguucugacagaagccga 138 X05862 Sequence below.aagcuucaggauacagugcacacucguaaauaaaaacuacaggcugcugcgaauuauauuucaacugaccggagaggcaaagccugacuguccauuaacccuuaacuuccaaacgcaaacugcuuacugcaucuuuuggcauuuuaccuuaugccuuguuagguccaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaagagccuuugaguuaggagugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgacaccgcgugcuuggccagcuccccgggcagcagcaggcgcacggccgucuggaucucccgggacgugauggucgagcgcuuguuguaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucguucacgaacgaguucaugaugcccauggccuuggaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcugcgcuugcgcuucuugccguccuucuucugggccuuggugacggccuucuuggagcccuucuucggggcgggagcggacuuggcgggcucaggcauacugagaggaugaagugaacuaaguugaaaaaggauaacuaaaaguuaaugacuguucuggcugcaauuuuaaacaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuucaaaccagggcgccauugguaaccaauguguaaccaaugaaaucucuccguuuucgcguccagccuugacuauauauacuaugcguauacguuuuugcuucuuacugcggugguuaucuacagcugaguuaugucuggacguggcaagcaaggacguggcaagcaaggaggcaaggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccugacggccgagauccuggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcuggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuuuucagagccacucacuuucucaaagagaccuaacacuacugggauagugcauugugggaaauacguguauuaaccuuccuccuauuuucccugcuugugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuuggaaggcaggcacccaaccucggaccuaguacauaaaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacagaccggacugcacaaagaauugucuugaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucacuugaauccuguuuauguggcaugauugacaaguccugccauuuggcaaagucaaaaucagcaaaggauguuaaagcauuuggugguaucacagcuaaaac139 AW046181uuuuuuuuuuuuuuuaugcaaauaguuuucaagauuuuauugcaaaccaaaauugguuuaucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccauguuaauuacaguacauuaaaaugaugguuuacaaauaagccuguaaguuuaaauaucuaguguuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaagaauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuuaaacaauugaaaacaccaaccggcuuugacugacaacuggggcauugguccauaaaaacccuuucuaaaaauagaaauau 140 U10118 Sequence below.gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugcuguucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcucuucuuaaggagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauagaagagcuaaagcaagagcugauucuggcagaaauucauaacggaguggagcaagugcguguucgauugaguacuccacugcagacgaacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagaucaaagcgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagcaaguacugacuccaagccuaucgacgcaucgcgucuggaucuucgaauugguuguauuguuacugccaagaagcacccugaugcagauucacuguauguggaggaaguagaugugggagaagcagccccgcgcacggucgucagcgggcuggugaaucauguuccucuagaacagaugcaaaaucguauggugguuuuacucuguaaucugaagccugcaaagaugcggggaguucugucucaagccauggugaugugugccaguucaccagagaaaguggagauucuggccccucccaacggguccguuccuggggacagaauuacuuuugaugcuuuuccuggagagccugacaaggagcuaaacccuaagaagaagaucugggagcagauccagccugaccugcacaccaaugcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuugcagagcccaaaccauggccaauaguggaauuaaauaagugcucuguaacugaaagacauuggcgaaaacuuaauaacaauaaagagaaguguguuuaucacuuacauau 141 AW212775ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauaggcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagcaaagcagcccuuagccuccccgacccccuuucccucccucccagca 142 AI846302uuuuuuuuuuuuuuuuuaaacaaugacgccguuuauuuaaaauguuuacucccagaaauauagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaaucccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucaggagccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuguccuagagcuucccgugggaaagcuugggugagaauuuuagccuaaagggagggggcuguggccgggcacuuugcgcucauccacugcagg 143 M22998 Sequence below.acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuacagcgcguccguucuccgucucgcagccggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaaggugacgggccgccucauguuggcugugggaggagcagugcucggaucacugcaguucggcuauaacacuggugucaucaacgccccccagaagguuauugaggaguucuacaaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggccaucuucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugcugaugaugaaccuguuggccuuuguggcugcugugcuuaugggcuucuccaaacugggcaaguccuuugagaugcugauccugggccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagaggugucaccuacagcucuacguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuagacuccaucaugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccuguugcccuucugccccgagagcccccgcuuccugcucaucaaucguaacgaggagaaccgggccaagagugugcugaagaagcuucgagggacagccgaugugacccgagaccugcaggagaugaaagaagagggucggcagaugaugcgggagaagaaggucaccaucuuggagcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggugcugcagcugucccagcagcugucggguaucaaugcuguguucuacuacucaacgagcaucuucgagaaggcaggugugcagcagccuguguacgccaccaucggcuccgguaucgucaacacggccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccucauuggccuggcuggcauggcaggcugugcugugcucaugaccaucgcccuggccuugcuggaacggcugccuuggauguccuaucugagcaucguggccaucuuuggcuuuguggccuucuuugaaguaggcccugguccuauuccaugguucauuguggccgagcuguucagccaggggccccguccugcugcuauugcuguggcuggcuucuccaacuggaccucaaacuucauugugggcaugugcuuccaguauguggagcaacugugcggccccuacgucuucaucaucuucacggugcuccucgugcucuucuucaucuucaccuacuucaaagucccugagaccaaaggccgaaccuucgaugagaucgcuuccggcuuccggcaggggggugccagccaaagugacaagacacccgaggagcucuuccacccucugggggcggacucccaagugugaggagccccacacccagcccggccugcucccugcagcccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgggcaagccgggccugggcgccuuuccucagccagcagugaaguccaggaggauauucaggacuuugauggcuccagaauuuuuaaugaaagcaagacugcugcucagaucuauucagauaagcagcagguuuuauaauuuuuuuauuacugauuuuguuauuuuuuuuuuuuaucagccacucuccuaucuccacacuguagucuucaccuugauuggcccagugccugaggguggggaccacgcccuguccagacacuugccuucuuugccaagcuaaucuguagggcuggaccuauggccaaggacacacuaauaccgaacucugagcuaggaggcuuuacgcuggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauagggguccggacuccauuuuaggauucgcccauuccugucucuuccuacccaaccacucaauuaucuuuccuugccugagaccaguuggaagcacuggagugcagggaggagagggaagggccaggcugggcugccagguucuagucuccugugcacugagggccacacaaacaccaugagaaggaccucggaggcugagaacuuaacugcugaagacacggacacuccugcccugcuguguauagauggaagauauuuauauauuuuuugguugucaauauuaaauacagacacuaaguuauaguauaucuggacaaacccacuuguaaauacaccaacaaacuccuguaacuuuaccuaagcagauauaaau ggcugguuuuuag 144 X64837 Sequence below.gcuuucuaaacuagcaagcaucguguggguccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacacugacuguacuuccacuccugaaggacccacacgaugcuuucuaaacuagcaagucugcagaccauugcugcucugcgccgaggaguccacaccucagucgccucugccacgucuguugccacaaagaagacagagcaaggcccaccauccuccgaguacauuuuugaacgggaaucuaaauauggugcacacaauuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauaugugggauguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagaucauagaugccaugaagagucagguggacaagcugacauuaacaucucgggcuuucuauaacaauguccuuggugaauacgaggaguacaucaccaagcuuuucaacuacaacaaaguucucccuaugaauacaggaguggaggcuggagagacugcauguaagcucgcucgucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuuggggucgaacacuaucugcaaucuccaguuccacagauccgaccaguuaugauggcuuuggacccuucaugccaggcuuugaaaccaucccauauaacgaucugcccgcacuggagcgugcucuucaggauccaaauguugcugccuucaugguggagcccauccagggugaagcaggcguuaucguuccggauccaggauaccugacaggaguucgggaacucugcaccaggcaccagguccuguuuauugcugaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugagaaugucagaccugauaugguucuucuugggaaggcccuuucuggcgguuuauacccugugucugcagugcugugugacgaugagauaaugcugaccauuaaaccaggcgagcacggcuccacauacggcggaaacccacuaggcugccgaauugccauugcggcucuugagguuuuagaagaggagaaucuugcugagaaugcagacaagaugggcgcuauccugaggaaggagcucaugaagcugcccucugacguugugaccucagugagagggaaaggguugcuaaaugccauugucaucagagaaaccaaagacugugaugcuuggaaggugugccugcgacuucgagauaacgggcuucuggccaagccaacccacggugauaucaucaggcuugccccuccccuugugaucaaggaggaugagauccgggaguccguggagaucaucaacaagacuaucuuguccuucugagaguaggaacucuggggagccaucuucagacagggcucuugugaaacucugcuugcaguggccagagccugucuccugaaaggcauauauuucaguugaugcauaauagagugacaccuaggaaccugcagguggcugcgugacagaaaagugagagcgagaggcgaggcgucucuuuguugagguuugacugugugggaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugcagucauuuacgugcgucuuuacaguuuccuugcugaugugaaugguuuguauuuagaaguuauuucugagauacuacagaacaguuaaaucauuauaaucaaugaauguuaaguugauugaagguuaagcauauguaaaauacuaguuuaaaguaaacuuuucauuggccaacaccagaauguauuauauagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacauuuauuuucaguauuucuuugaauaaagcuuaauguuucuuuuuacgccaacagaguauuuuguauuuccauuuugguaauaaucaguguauuauuucauccugaugacuggcauuucaucaccuauugagaucacuggguguguuucaggccuuuuauucuaaauaaagcuaugaccaguuucugucugu 145 AI843119uuuuuuuuuuuucuuuuccgacgcccacaagaggaauaagagauuuaaugauggaaaguauggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauauccaaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacuguuaggaccauuagaucagau 146 AI837786uuuuuuuuuuuuuuuuuacaguuuuaaaacaauacacagcuuucucgggcugaagcaauugcaagaacguauugguauugguauauuacagcuacauacaagguuuaugaauagcaauggagaaaaauaaguuauuuaaauauugacuucauaaagagaaagugcaauguuguuaguugucauaucacuugcuugacaguuugugggguuucuucccuaucaauuuuaacaaucaagauaacauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuugggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucauuucucagagaagaaucaauucgaguuccauccacaccuggggucgggacaca 147 U41465 Sequencebelow.ccgggcucgaauucucuagacucgaguuuagagaauucgagcucucccaguuuuaaagcaaaauuuuggacugugaagcaaggcacugggcaaacacaacauggccuccccggcugacagcuguauccaguuuacccggcacgcuagugauguucuucucaaccuuaaucgccuccggagucgggacaucuugacggacguugucaucguggugagccgugagcaguuuagagcccauaagacagugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugaaaugcaaccuuaguguaaucaaucuagauccugaaaucagcccugagggguuuugcauccuccuggacuucauguacacaucuaggcucaaccugagggaaggcaauaucauggcggugaugaccacagccauguaccugcagauggagcauguugucgacacaugcaggaaguucaucaaggccagugaagcagaaauggccccugcacuuaaaccuccccgugaagaguuccugaacagccggaugcugaugccccaugacaucauggccuaccgaggucgugaggucguggagaacaauaugccacugagaaauacucccgggugugagagcagagcuuuugcuccuccucuguacaguggccugucaacaccaccagccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugaugaggagcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccaggcaagucccuaaugaguauagcaggccagccauggaggugucccccaguuugugucacagcaacaucuacucgcccaaggaggcagucccagaggaggcucggagugacauacacuacagugugccugagggccccaagccugcugucccuucugcucggaaugcuccauacuuccccugugacaaagccagcaaagaagaagagagaccuucuucggaggaugagauugcccugcauuucgagccccccaaugcacccuugaaccggaagggucugguuaguccccagaguccccagaaauccgacugccagcccaacucacccacagaguccugcagcagcaagaacgccugcauccuucaggccucuggcucuccgccagccaagagccccacugacccgaaagccugcaacuggaagaaguauaaguucaucguucucaacagccucaaucagaaugccaaacccgagggcucugagcaggcagagcugggucgccucuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucuccaguccccgaccaagcucagugccaguggggaggacucuaccaucccccaagccagccggcucaauaaucucgugaacaggucccugggaggcuccccccgaagcagcagugagagucacucaccacucuacaugcaccccccaaagugcacauccugcggcucucaguccccacagcauacagagaugugccuccauacugcugggcccacguucccggaggagaugggggaaacccagucagaguauucggauucuagcugugagaaugggaccuucuucugcaacgaaugugacugccguuucucugaggaggccucgcucaagaggcacacgcugcagacgcacagugacaaaccauacaaaugugaucgcugccaggccuccuuccgcuacaagggcaaccucgccagccacaagacuguccacacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucaaucggccagccaaccugaagacccacacucgaauucacucuggagaaaagcccuacaaaugugaaaccuguggggccagguuuguucagguggcccaccuccgugcccacgugcucauccacacuggagagaagccguaccccugugaaaucuguggcacucgcuuccggcaccuucagacucugaagagccaucugcgcauccacacaggagagaaaccuuaccauugugagaaguguaaccugcacuuucgucacaaaagccaacugcgacuucauuugcgccagaagcacggcgccaucaccaacaccaaggugcaauaccgcgugucggccgcugaccugccuccggagcuccccaaagccugcugaaugaagcauggaguguuccucgcccuuuccucuccagccccuucucagaaucuacccaaaggaugcuguaacacuuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucauaguugggguggggguggg148 U70494 ucgcgguccgacggaggagugggcgcugggaucucgcugagcguccgccuggccucgucucuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaaggacuccggaaaggccaagacaaaggcgguuucccgcucgcagcgagccggcuugcaguucccugugggccguauucaucgacaccugaaaucuaggacaaccagccacggacgugugggcgcgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugaguuggcaggaaaugcgucaaaagacuuaaagguaaagcguaucaccccucgucacuugcagcuugcuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcuggugguggugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuuaaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccaguguuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucuauuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgagucuuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguaguggguuuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguuauaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaauaaaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucucacucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 149 D17666 Sequence below.caccaccgugcacgcagcuccgggcccgugggguguugguucuugcccucguaacccccucuguccagccaccaugauaagcgccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaagcugccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaauccggagcgaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugagucacaauccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugugccuggacuuaggcaguggacguaguuuacuggaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuacauacuaaggacuaaagcuugcauguguuccucagaauaugaaaagcccaaguucuuguguaguugauggcugaugcaacuuuuuuccccccaggauggcuggaauggccuuagccaugaggcuuuuagauuuguuucaagaagagauuaugcguaaguacaaccucaguuucucugagaaaaaaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauucaauaugccacugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuucuuacagaucagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggagggcaaacaagcaaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaaguacauaggaaugcugagucggagcccagguuaguggugggcacuuuaauccuaguaaaggcagagggaucucugaguucaggaccagccuagaguacaaagugagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuuuaaucagugucuuugggaauuuuagguccuggagaaugcugaaggugccagaacuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguaugccagcaaaacggcaagcugucaccaauccaaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaagacacgugaguaauaggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggaucaccuuggaucacuuuuucauuauuucugcuugggaagaaaucacaccaccaucagaggcauauagguuuuuuuuuuguuauuucuuuguuguuguuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaacucauucuguagaccaggcuggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucaugugauauaugaugaacuuagagugguuaaguuucacagggauaguuuacuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaauggugaugcuuggguugaggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaagagacugcagguaaguggauuuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaacuucauauucuguagauaauggagucugaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaauucaugcuccuccugcugccuccugggugcuaaguugcaaggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggccucucuacauauuaagccacaaaggagucuguugccccucaagaggaugagauguggaauauuaggcuacaguuuuguugccuuuuuuuuauuuuccuaacaugguaccacaauugaauuuuauucuuuguuucccagaaaauuacuugggccacacagcaaaaaaugcugugaucacagucccugcuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggaguggaggugggguaccugaguuaaaggauggaaagauagauuuauuucuacuuucucuaggccacuaaggaugcuggccagauaucugggcuaaaugugcuucgagugaucaaugagccuacagcugcugcucuagcuuacggucuggacaaaucugaagauaaaguguaaguuggucagaugacguagcauuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacuacaauuuguguggguccguguguugugguacauuuguacauuuguacauggcauggauauggaugucaaagauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaaccaguaguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugauacguuaacaggcaugccacuuagguugauaacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaaacuuuuggucuuuuaauucguuccuuuguuuuguuccuuggaacuuaacuuacuuauuuauuuuuuagcauugcuguguaugauuuaggugguggaaccuuugacauuucuauccuggaaauucagaaaggaguguuugaggugaaaucuaccaauggggacacuuucuuaggaggggaagacuuugaccaagcuuuguugcggcacauugucaaggaguucaagagagagguuaguuaccacugcuuagucaccacugguuaagguguaggcguuggguuguugagaauuuuuguuuguuugcauugcuuuuagcuuuguuaauagcuuuuuuauacuaagguaacuaacuauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucuuagauugggaacaaaagaccaagugacaguguuauaguagggagaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuacucucucgcagucuauauaugucuccuaauccuauuuauagacagggguugauuugaccaaagacaacauggcgcuucagaggguucgggaagcugcugagaaggcuaaaugugaacuuuccucaucugugcaggugagggauggaaaaaucccaguacugagcauauuugaauaguguauucuaauuuaccuaaugucaguguagcucuuuacaguuuucuguuggcugaaaacuuggggcaugagcaaaggaacaacuugaugaucaguucuuuucauuugaaugaaugaaguagauuuauggauguguguaucuuuugccugcaugugugucuguacuacauuugugcuugguuucuguggcggccagaagaggguaucagaacugacaugucaguguuggggannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncacacugagucuaaauucugaucaugucuuucagucguguuauguuacuuugagugaguaucaaagaucacgucucccaucugacgugugguccugugcagacugacaucaacuugccauaccuuaccauggaugcuucuggaccaaagcauuugaauaugaagcugacucgagcucaguuugaaggcauugucacagaucuaaucaagagaacuauugcuccgugucagaaagcuaugcaggaugcagaagucagcaagagugacauaggagaagugauucugguugguggcaugacaaggaugcccaagguauggacucaugguauuucuccuagaggaaaaaaauaacaaugcauucuugaggcaaauggcuuguguuguguguggaaacaaaugugauccauucuucuaguguucuuuaaagaguggugagaccagacucaccaaaaagugcuuuuagucgccugugauggcucauguaggaggauggccuugaguucuggguaagaugcagcuacagaauucuaccuugcacacacacuuaaacccagucugguaaagagaaguuguuaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagauguaaaauugauaauacuucuuccuaagauugggcgauuguguagaauaugagaacuguauuuuauaaccccuugucaugugccuucuauuucaaaugauauccucugggaagcuagauaauuaaauucuucucucauuuaaguggacaguggaugagaugcucugaaguugucaaauacaaacaagucugcagucuuggauaugaaucucucugacuugcugucuggcaggcguauucuguuuggcuccaucagucgcccuggguguuggcuaacagguucuuucucccugaugcuuagguucagcagacuguacaagaucuuuuuggcagagccccgaguaaagcuguuaauccugaugaggcuguagccaucggagcugccauccagggagguguguuggcuggugacguuacagacgugcugcuccuggaugucacuccccucucucuggguauugagacucugggaggcgucuuuaccaaacuuauuaauaggaacaccacuauuccaaccaaaaagagccagguaagagccauucuuuuuuccugccuauuaacagucccaaguuguacaagugcuguuuacaaucacuuuaugaacucuuuaaaacuuuguuucuaagacuauacuaacuggacugggugnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnccuagguguuuucuacugcugcugauggacaaacucaaguagagauuaaagugugucagggggaacgagagauggcuggagacaacaaacuucuaggacaguucacuuugguaaguguuuuugagucugaguaucaugcuuuuggggucuauagcuugcaaagcuccaaacugcugacauuacaggcauauuguguuauuuuuuaaaaagaacguuauguacaugaguuaugaaacccaugauuuuaguuuuuuaccuaaagugcuuuguguuuucagaauuugaaauuuucaaagccugggaaauguucagacucagaagcaaugcuaacucagaaguuaguuuuauccugauuacucauuuuaaaaaacuuaauagcuacugguucuggucagcauugcuacaguagagaaguuuauuugcuguaaauucugggcacauauaaccaucaugguuauuaacuucuugaagcccagugauuucagaaagcacuaaaacuaccaccaucacuuaaaaucucaagguuuugaacauucagugaagauacuuguuuuaggaaacaagugguuaguuggccugauuuggaaaugagaauacaugggccuuucaaaggagcucacucuggauauuuauuuuagauuggaauucccccagccccucguggagugccccagauugaaguuacauuugacauugaugccaaugggauugugcacguuucugccaaagauaaaggcacuggucgugagcaacaga150 X14897 Sequence below.auaaauucuuauuuugacacucaccaaaauagucaccuggaaaacccgcuuuuugugacaaaguacagaaggcuuggucacauuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuuccccaguccuuauuguaauauugcacagugcaauugcuacauggcaaacuaguguagcauagaagucaaagcaaaaacaaaccaaagaaaggagccacaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauugggaucguuaaaaugaaucuuccuacaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaaaaugaaaagguuugcuaauagaguaacauuaaauacccugaaggaaaaaaaaccuaaauaucaaaauaacugauuaaaauucacuugcaaauuagcacacgaauaugcaacuuggaaaucaugcaguguuuuauuuaagaaaacauaaaacaaaacuauuaaaauaguuuuagaggggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuugaaaccuauuaaaaagcccaugauuacaguuaauuaagagcagugcacgcaacagugacacgccuuuagagagcauuacuguguaugaacauguuggcugcuaccagccacagucaauuuaacaaggcugcucagucaugaacuuaauacagagagagcacgccuaggcagcaagcacagcuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucugaagcgcacgcugcaccgcggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagccuggacuuucaggagguacagcggcggucugaaggggaucugggaucuugcagagggaacuugcaucgaaacuugggcaguucuccgaaccggagacuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuccacucggccauagccuuggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcuuuucccggagacuacgacuccggcucccgguguagcucaucacccuccgccgagucucaguaccugucuucgguggacuccuucggcaguccacccaccgccgccgccucccaggagugcgccggucucggggaaaugcccggcuccuucgugccaacggucaccgcaaucacaaccagccaggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagccacuggccucccagccuccagcuguugacccuuaugacaugccaggaaccagcuacucaaccccaggccugagugccuacagcacuggcggggcaagcggaaguggugggccuucaaccagcacaaccaccaguggaccugugucugcccguccagccagagccaggccuagaagaccccgagaagagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcuggcugcagcuaagugcaggaaccgucggagggagcugacagaucgacuucaggcggaaacugaucagcuugaagaggaaaaggcagagcuggagucggagaucgccgagcugcaaaaagagaaggaacgccuggaguuuguccugguggcccacaaaccgggcugcaagauccccuacgaagaggggccggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaaggaagacggcuucggcuggcugcugccgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaaccugacggcuucucucuuuacacacagugaaguucaaguccucggcgaccccuuccccguuguuagcccuucguacacuuccucguuuguccucaccugcccggaggucuccgcguucgccggcgcccaacgcaccagcggcagcgagcagccguccgacccgcugaacucgcccucccuucuugcucuguaaacucuuuagacaacaaaacaaacaaacccgcaaggaacaaggaggaggaagaugaggaggagaggggaggaagcaguccggggguguguguguggacccuuugacucuucugucugaccaccugccgccucugccaucggacaugacggaaggaccuccuuuguguuuugugcuccgucucugguuuucugugccccggcgagaccggagagcuggugacuuuggggacaggggguggggcggggauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucuggggauagauggcuggcuggguggguaggguggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaagggugcugaguguggggugcaggguggguugaggucgagcuggcaugcaccuccagagagacccaacgaggaaaugacagcaccguccuguccuucuuuucccccacccacccauccacccucaagggugcagggugaccaagauagcucuguuuugcucccucgggccuuagcugauuaacuuaacauuuccaagagguuacaaccuccuccuggacgaauugagcccccgacugagggaagucgaugcccccuuugggagucugcuaaccccacuucccgcugauuccaaaaugugaaccccuaucugacugcucagucuuucccuccugggaaaacuggcucagguuggauuuuuuuccucgucugcuacagagcccccucccaacucaggcccgcucccaccccugugcaguauuaugcuaugucccucucacccucacccccaccccaggcgcccuuggccguccucguugggccuuacugguuuugggcagcagggggcgcugcgacgcccaucuugcuggagcgcuuuauacugugaaugaguggucggauugcugggugcgccggaugggauugacccccagcccuccaaaacuuucccugggccuccccuucuuccacuugcuuccucccuccccuugacagggaguuagacucgaaaggaugaccacgacgcaucccgguggccuucuugcucaggccccagacuuuuucucuuuaaguccuucgccuuccccagccuaggacgccaacuucuccccacccugggagccccgcauccucucacagaggucgaggcaauuuucagagaaguuuucagggcugaggcuuuggcuccccuauccucgauauuugaauccccaaauauuuuuggacuagcauacuuaagagggggcugaguucccacuaucccacuccauccaauuccuucagucccaaagacgaguucugucccuucccuccagcuuucaccucgugaaucccacgagucagauuucuauuuuuuaauauuggggagaugggcccuaccgcccgucccccgugcugcauggaacauuccauacccuguccugggcccuagguuccaaaccuaaucccaaaccccacccccagcuauuuaucccuuuccugguucccaaaaagcacuuauaucuauuauguauaaauaaauauauuauauaugagugugcgugugugugcgugugcgugcgugcgugcgugcgugcgagcuuccuuguuuucaagugugcuguggaguucaaaaucgcuucuggggauuugagucagacuuucuggcugucccuuuuugucaccuuuuuguuguugucucggcuccucuggcuguuggagacagucccggccucucccuuuauccuuucucaagucugucucgcucagaccacuuccaacaugucuccacucucaaugacucugaucuccggunugucuguuaauucuggauuugucggggacaugcaauuuuacuucuguaaguaagugugacugggugguagauuuuuuacaaucuauaucguugagaauuc 151 AJ006289Sequence below.caccugauucccggaggcccgagcccuuagucugggcgggguggcgcgggccggaaggacgccaucccggccugggccauggaggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacguguuuaccugugugagaaaaucauagcugagagacauuuugaucaucuacgugcaaaaaaaauacuaaguagagaagacacugaagaaauuucuugccgaacuucaaguagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccaggggccuggacacccugguggaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucggaauauaaaacuggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucucuaggugcaauuccgaugagagcaaucucucugagaaacagagagcauccacugucauguaccacccggagggagaguccagcacggcucccuucuucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuucagccacucuuccucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguuguggaaacucaagugagauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuacuagugaugcaaaaugcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuuuaaaaucaguguacacauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucaugguggucgugacuuuuccauaauguccuuucuuuuuuauuauuuuuagguguuugcguauuuugaacuuuucauaagauuaauuuuaucggaauauuucucaauuugagaaaacaacuuguggauugggaauaauguuuuuagcacauuuaugcuacaaauuuucagucugauuguuuuucccacugaucuggcaguauauuuuagcaguaagcuguugugugucaggaaagcuggacacgggaaagcugccgacacacucagcagugucccacuccuuaguucugagaagccgucggguucugaggagacaccugguggcacugagccuggugaccucagugggccaaaauuuguuuuauacucacccugccagcgugagugucuuacuuucacaggccuuguguccucagucuuaucuuaaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguaauugacuaaaguccucgcucugagccguuuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacaggauguggccguggccaguguggcuuuaguguuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaaguuugacuaacuuuacacauuuuaaaaaugcugauugucuucguuuaaauuauaauuuuaccuauuucuugacaucuaacuccuauuuauuucuauuauuuaaaaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu 152 X12944 Sequencebelow.ggggggggggggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaaggagacaaaaccaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcccaaaccuaaaaaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcgaauaauccugcagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugugugcauuuuugauaacuguguacuucuggugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaauuucguuuuacuuuuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucauuacugggugggggaaggaucaugugucaguaacaaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguuggcucccaggagagagauccuggucuugaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaauucacuuuuauauccucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggcccccaaaauugguuucccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuccuuuuauaaaagauuguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguuguuaaaacaacauccuuaaugugaaaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguuuuauaguggcuuucugauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccauguccugccugaauaccaugauuguuuaugaaagaaucuuaauaaagcugguuacaguuaggcuggaaaa 153 AW061302uuuuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacaguguggauuccucucccagagaagggucuuucagaggcaggggacugucacccaggugcaggccgucuacuugucauuuucauacauggcuggauucuuccuuuucgacugcucaaacuccugguugccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcucgcgagugcggcgcaacacguuggggaugccuuugcugaaauagcuugggaaggcgcgcugcucaaagggcgacaagcugua 154 U67328 Sequence below.caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauuccaacaucucugucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugcauccuaacuuugguggagcgaauggaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaagaguauguggagcaccugaaggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugaggagaucugccagaucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacuccuccugaaggauccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugugcaaguacaucuaugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcuccacucccgcugguaucaggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugcagauccuguauaaccguacuauggugcaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucuggauauucagucaagugguggugccaaggagcuucuaggucaggguugcugcugcgcgcuugcaggagcgaaaucaggaacaggaaaagguagagcgacgccggcaggugcccuuucaccugcacaucaaccuggagcugcuggagugugucuaucuggugucagcuaugcuccuggagauccccuacauggcugcccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccaccaccaacugcgggugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcauguggucgcugccuccaaggccaugaagaugggcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuucccugaggcugacaaaguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcagugucuaugacucaaucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaagaugaucauuaacgaagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugcccagcaagaaacuuggcucugcaagcuggcugagaaaacuuggcacccuaguggagaauaauggacggguguuugaccaaaaacagggaaccuaugguggcuauuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcuacccccagcaacagucucagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccuaacucaccccaaucauuaaagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa155 AI604314uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugcagcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaacuagguaaguucugauguaagauuucuaugggauuauuuuagaauauauagauuuguguaguuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaaaacaucuuugcaugauuacuuuacacacacaaauauaguaaaacuuacauaguacaaauucacauaagacuccauucugucuauaacuucauccaugugguuuuaccaugaauuauaauucuuaaccucuccuauaacugucagcuuccauuuaauuuugaaaguaucacuucacaaagagcacuucauuugcuuuuagaguauacauagacu 156 AI845121cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggcaugggguauggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccgugguaucagugggaccacucagaacucaggaugaacuggggugaaccgauacacugggaccuagacauguacaucaggaaucguguggacacgucaccuaccccuguguccugngaugucauguguaaacaucucuucggcuuuguggcuuucaugguuuucauguucuggguagggcacguguucccuuccuaccagccuguggguccgaagcaguacccuuacaaaaaucuguaccuggagcg 157AW047756 uuuuuuuuuuuuuuuuugaugcaaaugucuuuauuuuccacuuaaacaaguuucccuuuugcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuagugagaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgccaugcagcccaguuacaccuuuaggucagaaaggcugaugcgugaccagccucuauugccucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaacucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuuuuuacaacuccauaagcccuuuggccaaagucccugcaguguuuggggaggaccuucccacccuucaccagucagugucugaucugguggag 158 AI838021uuuuuuuuuuuuuuuuuaauaucuguaauaguuuauuucaaagauuugacauuuacaaguagaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagagauccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcuuuguucccaacucaggacaguacuuuagugcuugcuucauuuacuggaaaaguucacuggacauaguuuccacuucuucccccacagcuuccagcucagcaaacuuaagcuacuacuccucgaugcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggcuuucagugucggugucagaaguccguuuucaa 159 AW122893uuuuuuuuuuuuuuuuucugagguauuaaaauaucuagacugaauuuugccaaauguaagagggagaaaguuccugaagacucugacuacuugcuuauuuuugauugaccuucuaugcuuaugucauuacugccucacaacguguuugauguccuuuaaugauacaaagugagccugugccuucauuuucuugcccauuuugguaccccucgugccg 160 M59821 Sequence below.gcgcccgaacgucuagcagaguaccugcugcuguaagcuugucgucugggcugcaccgcccgucuuaacccauucucgacuuaacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguaccacucucgcaugcagcgagguggcuugcgacuccaccggagucugcagcuaucccucguuaugcgcagcgcucgagagcucuaccucucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcgggaagccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcugcgaguccaggagaccccugcgcucugugacccgccccccgcuagagucagccgcaagcgccggagcagcagcgauuugagcgacaguagugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucccgaucgccugcagcuuccuccggcacaaagcgaaggugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccagucuccugaacuguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaauaugcucaacgugcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggagaacgcacacccgaggcgaaggccggcgggggccgugaagaagagccgcggcccgagcugccgagaggccagggcaaggacugaggagcgaggggcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuuggagaagggacaccuagaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccauucgcguuucggccccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccuguugccuugcguggguguggggccugggaggaggccaggguguggacccgcccuagggacugggaagugacuugagucaccucgcccccacaggcugcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccgggacuggucaaccuagaugaucgccuggcguggaccaccgcgggacgggugggccgcuggucguaguugcugccguagacacagcuucuucgggcaggaaagaaaauuuuuuuuuuaccagcguguuuaagaaagucuguuuacuuuucccacgguggguuguuuaauuagcaacuaccuggaguuuuacaaugucagcuaggaaaauaaagaccaucggugu 161 M13805 See above (sameAccession Number). 162 AI845886uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagcaauagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagggagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccuccacacuggugacugcccagagugcccuggccccaguguguuggcacucagucugacuuuacaacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagcucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacaguuccaauauuucacauauauuucuucuugugcagucuaagccgagaaugccauguaaaugggucacugcgaaaugcagcaauuuagu 163 X53157gucucgggcgagauggcuucaagguuacuucgcggagugggcgcuuuggcggcgcaggcccugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguccccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaagggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccuaaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaacuguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacuguggaacccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucagaauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc 164 U19118 Seeabove (same Accession Number). 165 AF062071 Sequence below.gcgcaccgccygyguygcgcgscagcgucgucuaggugcaucgcgggcccccgcagrwagaaaaauauggcucaggagacuaaccagaccccagggcccaugcuguguaguacaggauguggcuuuuaugggaauccuaggacaaauggaauguguucuguuugcuacaaagaacaucuucagagacagcagaauaguggcagaaugagcccaauggggacagcuagugguuccaacaguccuaccucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaaaucaagaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaacuaccccgaaaacagaggugucagagccaguugucacucagcccaguccaucaguuucucagcccaguucuucucaaagugaagaaaaagcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuugacugccgauguggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagcugcagcaaaaaucagaaaagaaaauccaguuguuguggcugaaaaaauccagagaauauaaaauuacuacaugugaagagacugaaacuuuguuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucuccagaguuuugcuuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggauagauacagcccuacaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauugaaauacacauauacuaggaacaaaauuuaguuccacgugccaaacuaaaggaaugaaaucucugcauguuugcagcauaucugccuuuugggaauguaaucaagguauaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggcagucuacuaccauagucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaagcuacaaaacugguauuugguaccaugugugagccugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacaacugguucuaagucaaaccaucaagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagauaucugcauucucauuacuaaaauuguagcacagaacugcacuaggauuuguuuacaaggagaaauuaaacucuguuugguuuucacauauagcagcucuguuaaauaacaugcaucugaauuuuaaguugcaaagguaucugaacaguuaauuuuucaugugcaucuuuuguugaauguuuugguucaagaaagaauguuuaaagcuuuuuaaagacuucaguucuuaauguaacuguacccuucugcauggaaaaucauaaccaacauggcugcaguagacuucuuuagugguauccagcaccacuugcagagggcugcuuuaucauauuguacuuggguguaggacucuaguguucuuggguguauugcaugggcugcauuaucuacagcauuguacaauaacaacuagaaaaggcgguauacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugugauguaugaaacuuguguuuuuuauauauaaaugaguauaguuagauuaguguugugguaaugccuguuuucaucuguaaauaguuaaguauguacacaacaaggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuauuaaaacauugaguuuugcuucaauuuuauguaccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauugcacauaaucaugcuauucagcauugaugcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa 166 U10404augacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagccaucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcaugccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucguauccccaaggaacagggaguccuguccuucuggcgugggaaccuggccaaugucaucagauacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucugggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucagguggugccgcuggggcuacauccuugugcuuuguguacccucuugauuuugcccguacccgucuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugccugguuaagaucuacaaaucugaugggauuaagggccuguaccaaggcuuuaaugugucaguacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaagggaaugcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucugucacugcugucgcuggccugacuuccuauccuuuugacacgguucgccgucguaugaugaugcagucuggacgcaaaggaacugauaucauguacacaggcacgcuugacugcuggcggaagaucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccaacguucucagaggcauggguggcgccuuugugcuugucuuguaugaugagaucaagaaauacacauaa 167 U07634Sequence below.cguagaaguugucucugucggcgggcgggcgggcaggauuggggcaccgagaccggcgugcggacagcagggaucgcggggagcgaggggugcggcauggagcuccgggcagucgguuucugccuggcgcugcugugggguugcgcgcuggcggccgcggcggcacagggaaaggaaguuguuuuguuggacuucgcagcaaugaagggagagcucggcuggcucacgcaccccuauggcaaagggugggaccugaugcagaacaucauggacgacaugccuaucuacauguacucggugugcaacgugguauccggcgaccaggacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcgagacuguaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacuauggcaccaacuuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgaggcucgcaacgucaagcugaacguagaggagcgcaugguggggccccuuacccggaagggcuucuaccuggccuuccaggacaucggcgccugcgugcggcugcucuccguucgcgucuacuacaagaagugucccgagaugcugcagagcuuggccugcuuccccgagaccauugcugucgcuguuuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggugccuuaugggggcgagggggcucucaugcacugcacgguggauggcgaguggcuggugccauccgagugccugugccaggaaggcuacgagaaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuucccuggaguguccagagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuucagggcaccugaggacccacuguccaugucuugcacacguccacccucugccccuaacuaccucacggcaugcaugggugccaaaguagaacugcguuggacagcucccaaggacacugguggccgccaggacauugucuacagugucacuugugaacagugcugcgcagagucuggcgagugugggcccugugaggccacggugcgcuauucagaaccuccucacgcccugacccgcacgagugugacagucagugaccuggagccccacaugaacuauaccuucgcugucgaagcacgcaauggcgucucaggccuggugacuagccgaagcuuccggacugccagcgucaguauuaaccaaacagagccccccaaagugaggcuggaggaccgaagcaccaccucccugagugucaccaggagcaucccggugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggaugccaacagcuauaauggccgccgcacggaaggcuucuccgugacccuggaugaccuugcuccggauaccacguaccuggugcaggugcaggcauggacgcaggagggccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaggaucucgcaacauggcggugaucggcgguguggcuguagguguuguuuugcuucugguacuggcaggaguuggccucuucauccaucgaaggaggaggaaccugcgggcucgccaguccucugaggauguccguuuuuccaagucagaacaacuaaagccccugaagaccuauguggauccucacacuuacgaagaccccaaccaggcuguacucaaguuuaccaccgagauccacccauccuguguggcaaggcagaaggucauuggagcaggagaguuuggagaggucuauaaagggacgcugaaggcauccucggggaagaaggagauaccgguggccaucaagacacugaaagcgggcuacacugagaagcagcggguggacuuccugagcgaggccagcaucaugggccaguuuagccaccacaauaucauccgccuggaggcgguggucucuaaauacaaacccaugaugauuaucacagaguacauggagaauggagcgcuagacaaguuccuuagggagaaggauggugaguucagcguacuucaguuggugggcaugcugagggguaucgcauccggcaugaaguaccuggccaacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaacagcaaccuggugugcaagguguccgauuuuggccugucgcgugugcuggaggaugaccccgaggccaccuacaccacaaguggcggcaagaucccuauucgauggacagccccagaggccauuuccuaccgcaaguucaccucagccagcgauguguggagcuacggcauugucaugugggaagugaugacuuauggcgaacggcccuuacuggaacugucaaaccacgaggucaugaaagccaucaacgacggcuuccggcuccccacgcccauggacugcccuucagccauuuaccagcucaugaugcagugcuggcagcaagagcgcucccgccggcccaaguuugccgacaucguuagcauccuggacaagcucauccgacgccccgacucccucaagacgcuggcugacuucgauccccgaguguccauccggcugcccagcaccagcggcucggagggaguccccuuccguacgguguccgaguggcuggagagcaucaagaucgaacaguacacggaacacuucaugguggcuggcuacacggccaucgagaaggugguacagauguccaacgaagacaucaaaaggaucggagugcgucuuccuggccaccagaagcgcauugccuacagccugcugggacucaaggaccaggucaacacaguggggauuccuaucugaguccauuggggcugucacacaauacuugaagagccacaguggucucccugccgaucuggugcuggcccacuggaacuuuauuuauuucuguuuccucgucuaugccucccuaggacucugcaggggcuuuuugaaugacaccugccugagccugggaaacuuggauugcuggucagggcucucuuuccccugaaaaggacccagcuaagaacuuagcaguuugccauggccuucccagcauccccugaggcuaaaguuccaccaagagucgauaucgacgagggacauuuccaaacggaccuccccaucuucauuuggccuccugagaagccacucuggagcugaggcuaagcacuaagcccaggaccauaugacuagcacuguaccgcccgccccuaguuagaggguagguuuuggacuuggcuggguuguggucacaagcaaucucccagugccuuuuacagaccccagucugcccucccgucgagggccagcuucuugcuuuccuagggcccucucaggaugcuuggcugugcugagguuuuuauuaaauauauauuuuauacuugcggaaagaaugaguguguggcagggacuugccagggcuggagacagaggauccccugcaacaagacauucccgggcugggggcuggcggaccugcaggagacuuuccgccaccaccccgucuccagccccuuuggacaaaugucgcugucaguguuacagauuucuuuuauuggguuguuuuuuuguuguauuuuuuugaaccuuaacuuauuauuuuuuuuauauuuauuguuagaaaaugacuuauuucugcucuggaauaaaguugcagaugguuca 168 X04663 Sequence below.ccaaaaaccuuaauuuucuuucuuguucgguaccuacauuggaaccaccaaaaacaauuauuucaguaaaccguagccaugagggaaaucgugcacauccaggccggacaguguggcaaccagaucggugcuaaguucugggaggucauaagcgaugaacauggcaucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugaagccacagguggcaaguaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcucagguccuuuuggccagaucuucagaccagacaacuucguuuucggucagucuggggcaggcaacaacugggcuaaaggccacuacacagagggagcugaguugguugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugacccacucacuggguggaggcacuggcucuggcaugggcacccugcucaucagcaagauccgggaagaauauccugaccguaucaugaauaccuucaguguggugcccucgcccaaagucucugauaccguggucgagcccuacaaugccacccugucuguccaucaguugguugagaacacggaugagaccuacugcaucgacaacgaggcccucuacgacaucugcuuccguacccucaagcucaccacgccaaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggccagcuuaaugcugaccuucgaaagcuggcugucaacauggugccauucccacgucuccacuucuucaugccuggcuuugccccucucaccagccguggaagccagcaguaccgggcccucacugugccugaacuuacccagcaggucuucgaugccaagaacaugauggccgccugcgacccgcgccacggccgguaccucacaguugccgccgucuuccguggacggauguccaugaaggagguggaugagcagaugcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcugucugugacaucccaccgcguggccucaagauggcagucaccuucauuggaaacagcacagccauccaggagcuguucaagcgcaucucugagcaguuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagauggaguucaccgaggcugagagcaacaugaacgaccuggugucugaguaccagcaguaccaggaugccaccgcggaagaggaagaggauuucggagaggaggcagaagaggaggccuaacggcagagagcccugcaucagcucaggcugcuuagaucccucagccuuucuccaacugcccuuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauuggggguaaauggugccuggcacauggcaggcacucaauaaauauuuguuugugg 169 X61232 Sequence below.ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugccgcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgccggcggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcugcgcgaggcgcuggugucgguauggcugcagugcaccgccaucagcagaaucuacacagugggcgccagcuucgagggccgggagcuccuggucaucgagcugucugacaaccccgggguccaugagccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacgggaauugcucauuuucuuggcccaguaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagcacccgaauucauaucaugcccuccuugaaccccgacggcuuugagaaagccgcauggcagcccgggcagcugaaggacugguuugugggccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaggaucguauauguuaaugagaaagaaggcggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaaggcugucauucacuggaucauggacauucccauuugugcuuucugccaaucugcacggaggagaccuuguggcuaauuacccauaugaugagacacggagcgguacugcucacgaauacaguuccugcccugaugacgcaauuuuccaaagcuuggcucgcgcguacucuucuuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaugauggaacgaccaaugguggugcaugguacagcguccccgguggaaugcaagacuucaauuaccugagcagcagcaacugcuuugagaucacuguggagcuuacgugugagaaguucccaccugaagagacucucaaaagcuacugggaagauaacaaaaacucccucaucaacuaccuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacgcaaccaucucuguggaugggauagaccaugaugucaccucggcuaaggauggggauuacuggcgauugcuugcuccuggaaacuauaaacuuacagccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguugggguggacuuugagcuugagucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugaugucagaaacuuugaauuuuuaagaaaggcuucuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaauguggcucuuuucuuuuagguugugugcaguugauauuuaacauugauuuauuuuugaucauuaaguaauaguuacuaaucacguaaauacacccggacagaaauauaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucgaagccucuuuuaacguaaugggugacaaugucacuugacagaugcaugagagucacgauauagcugacugugacccugcacugcaaucacauaguuccauauaaguuguccuuagucucuugugcugauucacuguauaagcaugauccugguaaugcacuuuggaugggaagaaaauguacgugcuuuucagaggggcucugaacagaaugaaaaccuaguucuugcguguacuuugaagaauggaauuguauuagucagcuguuaaugccacuucagaaguuugggguuuugucuugauuguagauugg 170 X14309 Sequence below.gccacggacgccucucugaacggggauccaggcaggauuagagcugccucacugacuacaggccgugucgugucaccguuucugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaagcagcccaugaaugcagcggacggggcggcggccggggagaagaacggucuggugaagaucaagguggcggaggacgagacggaggccggggucaaguucaccggcuuauccaaggaggagcuacugaagguagcgggcagcccuggcugggugcgcacccgcugggcgcugcugcugcucuucuggcucgguuggcugggcaugcuggcgggcgccgugguuaucaucguucgggcgccgcgcugccgugagcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggccgggaugcgggaggcauagcuggucugaagagccaucuggaguacuugagcacccugaaggugaagggccugguguuaggcccaauucacaagaaccagaaggaugaaaucaaugaaaccgaccugaaacagauuaaucccacuuugggcucccaggaagauuuuaagaccuucuacaaagugccaagaaaaagagcauucacaucauuuuggaccucacucccaacuaccagggccagaaugcgugguuccucccugcucaggcugacauuguagccaccaaaaugaaggaagcucugaguucuuggcugcaggacgguguggaugguuuccaauuccgggaugugggaaagcugaugaaugcacccuuguacuuggcugaguggcagaauaucaccaagaacuuaagugaggacaggcuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccagcgaccugcuguugaccagcuccuaccugucaaauuccacuuucacuggggagcguacugaaucccuagucacuagguuuuugaaugccacuggcagccaauggugcagcuggagugugucgcaagcaggacuccucgcagacuuuauaccggaccaucuucuccgacucuaccagcugcugcucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugcccuuccuggacagccugcgaaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagccucaacaugacagugaagggccagaaugaagacccuggcucccuccuuacccaguuccggcggcugagugaccuucgggguaaggagcgcucucuguugcacggugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggaccagaaugagcguuaccugguggugcucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcuggcauaagccugccagccagcgcuaaacuuuugcuuaguaccgacagugcccggcaaagccgugaggaggacaccucccugaagcuggaaaaccugagccugaauccuuaugagggcuugcuguuacaguuccccuuuguggccugauccuuccuaugcagaaccuaccacccuccuuuguucuccccaggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagauuacauacgaauucuuauacuggguguuuuugucuucaaauaaaaacaucaccccugccucaug 171 U42386 Sequence below.gncuuaagccncguuuauuuugaugnccuguuggcucagunaugnccaagaugccnauuguuuuugcccnuaaauaaauuuacugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccauaaauaauauaaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaacgucuugaagcauauuaauggaauuaguuucuaauguggcaaacuguauuaaguuaaaaguucugauuugcucacucuauccuggauagguauuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcauacauucaaagcacuguucucaaaguuaaugcaaguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuaugagcuagccaaaugugggcauguuauuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucuacuuagacuuuuuaaaugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuagggcucuggaugauuuuuggucuaauaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauuaugcagcaggcuuuauuuuaaaugccgauucacauuacucuguucaagcugcguugagauguuaaacuggcuuacuauagacuuuguaaaaaaaaaaaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuggaaauauguacauaacugaacaaggugucaauucugcucuacagugcaguuuagucaguuuuaguugcauagguuuccauuguuuuuauagucuguuuaugcuaaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacugggaauucuggguuaauuuugugaccagaaugcagugaucaaaauguucaaucuuuuuacaguggcauaggaagauggcaaaaauuuccuaaagugcaauagauuuucaaguguauugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguuauggugcuauuucaauuagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuauugcacauucagagaauuuuauauauaugucuugugugcguguccuuaaacuuccaaucuuauuuugucucuuggagauuguugaacgcagcuugucuaggaaagggaugggacuagauucuaaaauuuauuugggaccaugggaaugauaguugggaagaaacuuugcacacgacagauuucuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuauuuuuguaagccuaaaagugauucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaauguugaaugucaccguaugcgugaaauuauauauuucgggguagugugagcuuuuaauguuaagucauaauaaacucuuaagucaaauuaagcagacccggcauuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaaaucaugccaagguuugauacacuugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucucagauguuuguugugugaguuuuguuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacaugugguuaucuuuguuguauuggcauauucagugacuuguacauucagcaauagcauuugagcaaguuuuaucagcaagcaauauuuucaguuauguuuccaaauuaagaauggguuuaaacuugcugaauguaaagauugacccucaagucacuguagcuuuaguaguugcuuauuguauuaguuuagaugcuagcacugcaugugcugugcauauucugguuuuauuaaaauaaaaaguugaacugcacagucuccuuuguuguugucaauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaauauguacauaacugnacaaggugucaauncugcucuacagngnaguuuagncaguuuuagungnauagguucccaunguuuuuaungncuguuuaugcuaaaucuggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccuggguuanuuuggngaccagaaugaagugancaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaaagugnaauagauuuccaaguguuungugccugguncuaaaacuuuunuuaaguagggugcacunganaguauugaggncauugguuauggugcuauuuccanuuagucuagguuuaggcccu 172 U51126 Sequence below.cucggucuccaagaugguggcuaacaaaacgugaggccuagagguugauccuaggucacuggaagcauguccuugaagaggacuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucaccucuacaaucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuuggaaggcgauuccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccugccgagacacaucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccacggcaaugugcgggagacguaccgauaccugacggacaucuucaccacccugguggaccugaaguggagauucaaccuguugaucuuugucauggucuacacagugacguggcuuuucuuugggaugaucugguggcugauugcguacauccggggagauauggaccacauagaggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuuauucuccauagagacagaaaccaccaucgguuauggcuaccgggucaucacggacaagugcccugaggggauuauucuccucuuaauccaguccguguugggguccauugucaacgccuucaugguaggauguauguuugugaaaauaucccaacccaagaagagggcagagacccuggucuuuuccacccacgcggugaucuccaugcgggaugggaaacugugcuugauguuccgggugggggacuugaggaauucucacauuguggaggcauccaucagagccaaguugaucaaguccaaacagacuucagagggggaguuuauuccccucaaccagacugauaucaacgugggguacuacacaggggacgaccggcucuuucuggugucaccauugauuauuagccaugaaauuaaccaacagagucccuucugggagaucuccaaagcgcagcugccuaaagaggaacuggagauuguggucauccuggagggaaugguggaagccacagggcaguucugaaaucgaaaucaagcagaggucuauaagaacacccuggagacccccaugcugcuggaucuuggguccaugaacugcuuuuauuugcugcaaucaaaaaugcuagucgcugaucugauaggagaggaaacgagacucagagccugaaggauaacacgcugagggcugauuucauacacucuucccggcuggaucaucccagcccccacagcguccaggcuuaguuucuuccuuuguuuuaacaaucuauacuuccuccagccugggcgagcuaguauacccagaguuugguuuuguuucuuuucagagcuguaagcccagugcccagugaccucaucugggaggagaguuaagcaauaagaccugaaugcuaacucugggguagaaaaccucugcagagacagcgucucugggaagucucuacagagacagaguagggaagucucacgaaggucagagucuuacuuccauaccuggagaaauccgcccguccguucagugccgguuucaacuccucugccaaagacuucuuuccaagacacugguaucagcuaucccagcaguaacuuuggcaguauauaaaucaauggcacugccccauaaaaccccguugaguaaaaccuauggucuucaacagcuggggagccuguagcccagcuccugugugaggcuaaggcuguggagaccaugccugcucaccuccucguugaaaagcaaaacacuguaagaaaccuaacaugacuuuuuccaacauuucucaggcuggggagaagacuugguccacaaagagcuugaggucuugaucuggaucccuagcauccauggaagaaggugggcaugaucacccacacuccucaucccauagcucugaaugagguaggcagauuccuggggcucaccagcucauccuaacagccaggucccaaugagggacugucuacaaaagaacaagagguggauccugagaagcgacacccaagcuugaccucuagccccuguacacaccuguuaagcaccugggcaucgggacacacacucgcaauuugcaaacaaggcaaauucucacacuucagaaggcacugagagaaucccauaagcucaaaaaguuaggagccaagauugaccauuaaugacuuggguugaaaagacuaaaccacuggauagaauguuucauuacuaaaacaccuuaccugaaaaguauuacugcucuucuuucugcaacuggaccaugcagagauccacaaagagaugcccagagauuauuagugauggucauaugauauacacaauguggacucuaagccaaggccccaucaacucagauccagaggcugacagugugcuuaucuuagagauaccacaguggcugccuaaucaccacguccuuaagucaggggaguuugauuauuuccuaugaacaccgaguggggacagcggauuaccaaugaagcaauccaaccugacaauccuaaccacccagaagaggaucgcugggggaaagcaugaauuauuuacgugucaacaugugcacacuccggccacgcagcucaacagccaggagugcuucuccacuuagcccugcccuggcauccauuuaugaucucgucuguuguguuaauuacccagcuagcuuuuuucucaaaaauaauaucucccagccauagaccuacucaucuguguccucuuuaauuucaacccacaguuacaucauucacuggcuugcucaguuucuucaacucugaaaugggaaugaugaugaugaugccucuuccccccaagccaccauccucccccgugaccuuccuagguacagacucaaaccagggaagauuauuuccuucucauaggccacagggugaaaugcaauaaagaacaaagccuuguagggaggcagagggaaagaccaguccucacaagaggcuccauuguuuccagggacuuugaagcuuggacagaaugucagaugauccccuuugaaggugcuccaaagagucaaugugaaaaauauugacugaugugugcccuccacaagccaaggugccucugcccuggucaccuaccaugaauuauaaacugaugauauuugaaauaauaaggaacacuggagccggccagaaaggauucugcagucccauaaauagcaacauucaucacuacaaugccugccaacgguggccgugaauguagauuacccccggcucuucugaggccacugaggacagggcaaacuaccucugagaauggaggcucacuguucugcaucccacuucuaaauguuccaugaauuuuuugagacaucucccauaucccuguuagaaagauucaaccuugugcuauuaaccaaaucauuuugaauuccauaaaccucuacucuaaaguauacacuuaauucuacaauacagacaacaaauaugacuuuuuccuaugaaagagugauaaagauacuguaucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 173 AF093853Sequence below.uggaaugggugcuaggugaaggcuuuguugaaucaggaugcugagcugguguuuuuacagguccagauaugaugagcuggaguuuugguaggcccagguaccuccuccaaaauugaccacauaauuggucacaaaucaggccuccacagauacaaaaauauugaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaagccagguucacugcugcggcugcgccuccuuguucucagcgucaccacugccgccaugcccggaggguugcuucucggggacgaagcccccaacuuugaggccaauaccaccaucggccgcauccgcuuccacgauuuccugggagauucauggggcauucucuuuucccacccacgggacuuuaccccagugugcaccacagaacuuggcagagcugcaaagcuggcgccagaguucgccaagaggaauguuaaguugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaauggugaaacacccacggaaaaguugccauuucccaucauugaugauaagggcagggaccuugccauccuuuugggcauguuggauccagucgagaaggacgauaacaacaugccugugacggcccgugugguguucauuuuuggcccugacaagaaacugaagcugucuauccucuacccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacaggcacaaagccgguugccaccccaguugacuggaagaagggagagagcgugaugguaguccccacccucuccgaagaggaagccaaacaauguuucccuaaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccagccuuaagucuuugcggaaauuggggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugcagcagguccguagaaagaucguggcaugaucacagccggccuguagaucgcucgcuauacuacugggucauuaaauggaaauggcaccaaaaccuucucgggauucuuuacucugugccuucgccagcauucugccccucugccugucacagugcccuacugacuggcucucuuugaaacgaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagcagugugggcucugugcuagaaugaugaaacaccuuuuguagcuuuccgaacggaaucuucuguuacccauuuuggagagcacugacauggggagaagcuuucaauucuguauuuuuaguaaauaaaguggggacagccgggagaauucuuacagggaaucuauuguaaguuucuaucgaagugggcucagaaagccuuucgccucccaagagugcgcauguaccuccuagaguuuccacaucugcucucuggugaugucugccugugaacgcaccuuauaagacgggcggugacaguguuuuaccacucagugccuaguaguggguggccauuucugaauucugcuuuuugagguucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaaagccaacauucauguggaaacugaacaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaagacuuuuuagaguuuaaugaaaaugaagccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacucauagcccugagugcauccaaaggaaaaaaaaaaaaaccuagagagaguguacacuagcagccugacugcacacuuagaagcucugcaaaaaaaggaaucaaauucacccaagaggaauagacagcaggaaauaaucaaacuuagggcugaaaucaaccaaauggaaacaaaaagaacuauucaaagagugggccaaaccaggagcuaguucuuugagaaaaucaacaagauagauaaacccuuagccagacucacuagagggcacagggacagcauccuaauuaacaaaaucagaacugaaaagggagacauaacaacagauccugaagaaauccaaaacaccaccagauccucuacaaaaggcuauacucaacaaaacuggaaccuggaugaaaggaaaagcuucuagacaga 174 Z19521Sequence below.augagcaccgcggaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguugcaguagaagacucaggcagcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauggcagccccgagugcccggauggcuccgaugaguccccaaagacaugcaugucugucaccugucaguccaaucaauucagcuguggaggccgugucagccgaugcauuccugacuccuggagaugugauggacagguagacugugaaaaugacucagacgaacaaggcuguccccccaagacgugcucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgagauugccuagauggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcugcaaaucauccauaugcauccccagucuuugggccugcgacggggaugucgacuguguugacggcucccaugaguggccacagaacugccaggccgaagacacggccuccaaaggcguuagcagccccugcuccucccuggaguuccacugugguagcagugaguguauccaucgcagcuggucugugacggcgaggcgacugcaaggacaagucagaugaggagcacugcgcgguggccaccugccgaccugaugaauuccagugugcagauggcuccugcauucacgguagccgccagugugaccgugaacaugacugcaaggacaugagcgacgagcucggcugcgucaaugugacacagugugauggccccaacaaguucaagugucacaguggggagugcaucagcuuggacaaggugugcgacuccgcccgcgacugccaggacuggucggaugagcccaucaaggagugcaagaccaacgaguguuuggacaacaaugguggcuguucccacaucugcaaggaccucaagauuggcucugagugccugugucccagcggcuuccgguugguggaccuccacaggugugaagauauugacgagugucaggagccagacaccugcagccagcucugugugaaccuggaaggcagcuacaagugugagugccaggccggcuuccacauggacccacacaccagggucugcaaggcugugggcuccauaggcuaucugcucuucaccaaccgccacgagguccggaagaugacccuggaccgcagcgaguacaccagucugcuccccaaccugaagaaugugguggcucucgacacggaggugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcgcccugauggaccaggccccuaacuuguccuacgacaccaucaucagugaggaccugcaugccccugacgggcuggcgguagacuggauccaccgcaacaucuacuggacagauucagucccaggcagcguaucuguggcugacaccaagggcguaaagaggaggacacuguuccaagaggcaggguccagacccagagccaucguaguggacccugugcauggcuucauguacuggacagauuggggaacacccgccaagaucaagaaaggggguuugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaauggcaucacacuagaucuuuccaguggccgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaugggggcaaucggaaaaccauuuuggaggaugagaaccggcuggcccaccccuucuccuuggccaucuaugaggacaaaguguauuggacagaugucauaaacgaagccauuuucagugccaaucgacucacggguucagaugugaauuugguggcugaaaaccucuuguccccggaggacauuguccuguuccacaaggucacacagccuagaggggugaacuggugugagacaacagcccuccuccccaauggugguugccaguaccugugccugcccgccccacagaucgguccccacucgcccaaauucaccugcgccugcccugauggcaugcugcuggccaaggacaugcggagcugccucacagaagucgacacuguacugaccacccaggggacauccgccguccggccuguggucaccgcaucagcuaccaggccaccgaagcacagugaggaucucucagcucccaguacuccuaggcagccuguggacaccccagggcucagcacaguggcgucagugacagugucccaccaaguccagggugacauggcuggcagagggaaugaggagcagccacaugguaugagguuccuguccaucuucuucccuauugcacugguugcccuccuuguccuuggggccguccugcuguggaggaacuggcggcugaagaacaucacaaucaacagcauaaacuuugacaacccagucuaccagaagaccacagaggacgagcuccacauuugccgaagccaggauggcuauaccuaccccucaagacagauggucagccuggaggacgauguggcaugagcagccgggagagccgucucuuuccgggauccauugccaagcuuaggcagaaaagacacucucuccagaccuccccauccagcacugguccugccaccucccugggucuguguugcucaaagcaagauagagcaaagcugggcuggggggccaagcucagcuuccugucugccccagguucuguuuuauauauuuauugucugggacagaaaaggcuacuggcugugcuugaaauucga 175 U04354 Sequencebelow.accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcaccauggcgcaggagcugcagcaccccgaguucgcgcgcgcaggccagcaggcugggcugcagguguggagggucgagaagcuggaacugguaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaaguccagcaggggcuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucuuuacgguccagauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuugugggcuauuucaaaggcggucugaaguacaaggcuggagguguggcuucuggacuaaaccauguccucaccaaugaucugacugcgaaaagacuucugcacgugaagggucggagaguggucagagccacugaaguuccccucagcugggagagcuucaacaagggcgacugcuucaucauugaccuuggcaccgaaauuuaccaguggugugguuccuccugcaacaaauaugagcgucugaaagcaagccagguggccauuggcauccgggacaaugagaggaaaggaagaucucaacucauugugguggaagaaggaagugaaccaucagagcucaugaagguuuuagggagaaagccugagcuuccagauggggacaaugaugacgaugucguagcagacauaaguaacaggaagauggcgaagcucuacaugguuucagaugcaaguggguccaugaaaguaacacugguggcugaagaaaacccguucuccaugggaauguugcuuucugaagaaugcuucauuuuggaccauggugcugcaaaacaaauuuuuguauggaaagguaaaaaugcuaacccacaggagaggaagacugccaugaagacagcugaggaguuuuuacagaaaaugaaguauucuacuaauacucaaauucagguucuuccggaaggcggugaaacaccaauuuucaaacaguucuuuaaggacuggaaggauaaagaccagagugauggcuuugggaagguguacaucacggagaaaguggcucagauaaagcagauuccguuugaugccucaaaacugcacaguucuccgcagauggcagcccagcacaacaugguggacgauggcucuggcgggguggagaucuggcguguagagaacagugguagaguccagauugacccaagcuccuauggcgaguucuauggcggugacugcuacauuauccucuacacuuaucccagaggacagaucaucuacacauggcaaggagcaaaugcuaccagagaugaacugaccauguccgcguuucugacuguccaguuggaccggucccuuggagggcaggcugugcagguccgugucucucaaggcaaagagccugcucaccugcugaguuuguucaaagacaaaccacucauuauuuauaagaaugggacauccaagaaagaagggcaggcaccggcucccccuacacgccuuuuucaaguccggaggaaccuggcaucuaucaccagaauuguggagguugacguugaugcaaauucauuaaauucuaaugacacuuuuguccuaaaacugccacgaaacaauggcuucaucuggauaggaaaaggugcuagccaggaggaggagaaaggagcagaguauguggcugauguccucaagugcaaagcuucaagaauucaagaaggcaaggaaccagaggaauucuggaacucucuuggagggaggggagacuaccagacuucaccauugcuagaaacucgggcugaagaccauccaccucggcuuuaugguugcuccaacaaaacuggaagauucauuauugaagaaguuccgggagaguucacccaggaugaccuggcagaagaugaugucaugcuacuugaugcgugggaacagaucuuuauuuggauuggcaaagaugccaaugaaguugagaaaaaggaaucagugaagucugccaaaauguaccuggagacagacccuucuggaagagacaagaggacaccgauugucaucaucaagcaagggcacgagccccccacauucacaggcugguuucugggcugggacuccagcaggugguaaaaccagcaacuauccuggcugcauuggggcagcugccacuuuguuguuggggaauuguuuacuuuuuguuauuggcuuuugaagauaaacuccugccaaauggauauauaucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuaucuauaucuaaucuauaucuaucuaucuaucuaucuaucuaucuaucuaucuaucuaucuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuguauguuacuauacugaaauaaccuaaagcaaccauuuguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuugucauucagccacugcuagccaaacuugucuuuucccauagagaggaaggagagccacagugcuucuaagcauuuccccgucugcauacucuguuugcagugagcuuuacuuuauguauggcuuuaacaaugccuugcuguuucccaucucaagucaaugccacuucggaugccauucacucccaaguguccuuacauaggaugaacuucuuuagcuuuuuuagaaaacuaaaaucaugucuuuuaugauaaaacacauuuuauuucuauaaguuuaacuuuauauauuugauagcacaugcucaauagcauaaagaauaugcauugaaugauguuuuucauaauuaaaauauauccuuuugg 176 M35244 Sequence below.caggguugagagcaagaaggugcaggauguaggccagcagaauuaucagacccaguggcggcuucugccacuggaagaauuuccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauucagauugucugguguuuuccaaucacucgcgacuguaauuugaaguuggauucugagauaauacaaucgcugucgcucuaguuuauaaagcuguccaagaucugcccagucccagauguccuggguccucagggcggcuguggucugcgcccuucuccugcagcuggaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggccuggccuuggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccgaggauggcacccuggcuggagcaggaggaagcagaugacugggaacagcagacucauauagucacaauucaaggacagcugucugaaaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaggacugcgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugagcgaaaacccaaguuccuguacagugggaaacagcacuguaccucagaucucucagcaccuggagggccacugcucagaugugcugcagaaauaccuggaaaaagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucaccccagaccugaaggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcagaaggauggggaggagcugacccaagauguggaguuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugguggugccucuuggaaaggugcagaguuacacgugccauguggaccaugaggggcugccugagccccucacccugagaugggagccugcaugguaccaaaagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauuugucucuguguggcucgcagacccaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacucuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccacuccccaggaacuucaggaucaucugggagaugccccuuugaguggcugggcugugaggacagcaggccaguucuugccacccuggacagaaacacaucucaccuuucuggcucgaggaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacacaaagcucccuccucucacccacagcacucuggguccuacccccaaugcuucagggacauuuaaucaggucaaauugggaucaauggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaauaaaaaaaauaucuuuuu177 AW121930uuuuuuuuuuuuuuuuucaacuuuaaagacuggauuugagguucagucugggucucugggggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacgaccgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucaucaucucuccgguacccacuuccaaaugcccuucugccacugccuauccuggagucauagccucggucauagucucugcugccucggucaucauagcgaucccggcccccauagcgguccaugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaaucguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguggguagucaucacaacugucuguggugggacgggcccuccagucugugucuguuuug 178 AI852632uuuuuuuuuuuuuuuuuggcccccaggcucugucucaaggaugggaauagaucaagccaaacagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaaucagcagaggagaugcaaaugggguaacaaucacaguuagugggguaacaugagcaggcaggaaacccuugagacaacacccaagguccacgucuucgcaugugcagggcacaacuccagcagcaguuucugggcuuggaggcuuguuacucuuccuaccuuucccacccccuaaaagacaccaagauggagcccacgaagagauuacaucaagcucuucuggcuggg 179 U70475 Sequencebelow.ucuaggacagccagggcuacacagagaaacccugucucaacuaaaacaaagcaaaccccccgaauauuguuuuuuauuugcggaugucuguuuauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaaggggcgggggggggggugcgcuggagagguggcucagcaguuaagagcacugacuucucuuccagagguccugaguucaauucccagcaaccacaugguggcuuauaaccaucuauagugagaucugaugccuucuucuugccuguaggcagaccacuguauacauaauaaauaaaucuuaaaaggggggggaagguguggagcuaaaaguauggcaauaugcauaaguuuagcuauuucuguuguuuugcagucaucagugagccaaacuaauucgaauggguagcuagaucuuguugcuuuuagcgaauauauauugagugaauggaauugacagucuucuguauucucauucaguuuguuuguguucuuccccaucagugauaacauguagugaacuaacccguguggaccaucuuaaccauggcuucuccuuccuuuucuguuuuaaacauaggacauggauuugauugacauccuuuggaggcaagacauagaucuuggaguaagucgagaaguguuugacuuuagucagcgacagaaggacuaugagcuggaaaaacagaaaaaacucgaaaaggaaagacaagagcaacuccagaaggaacaggagaaggccuuuuucgcucaguuucaacuggaugaagaaacaggagaauuccucccaauucagccggcccagcauauccagacagacaccaguggauccgccagcuacucccagguacacucgucguggugggagcuaaggaaaacucuagugagaaagcagacucucuggaguugaguucuuggucugccauuuacugugucuuuugugaggaggagaaguucucaaacuucgcuucuugauaaucaggacacagaucacagggaggacuuugugaguucagaaacauccucuguggugaugaaacagcggcagaaauacuguugggaguaaaagaaguaggcauugcucauugugguaggcagggcccugauuguauggguaacugacuuaacuguguuaaguaugauucccauuuuauauucccaugucuaaacaacuaaagcauuugcccagaacacucagaaagaaaugaagggagguuauugccuagcacagagcccugguucagucccccacgcuguucguuaaaggggagggacuaauaauuugaacacaaucugguuugaaucuaugcaaaucgauuucugaaaugagaccauagguuauuuuaugaacaagucuuauugcucguugugacccugugcuuagaacauuucauaaaugaugcucucugugccuuuccccuuccuccagguugcccacauucccaaacaagaugccuuguacuuugaagacuguaugcagcuuuuggcagagacauucccauuuguagaugaccaugagguauaaaaauguuuguuuaacagcaaaacucccuuaucugauauuaguuccuuucaugugucuccaauuaagagaagaaaagaaaauuuuagaaggaaaaaauugaucaaagaaauugucaaguaaacuguaugagagcuauauaaugcuuaaaaauaagaccuguaugggcuggugagauggcucaguugguaagaguacccgacugcucuuccgaagguccagaguucaaaucccagcaaccacaagguggcucacaacauccauaacaagaucugacucccucuucuggagugucugaagacagcuacaguguacuuacauauaauaaauaaauaaaucuuuaaaaaaaaaaaauaaggccuguaaacuacaaguccauuuuacuguauagcuggaaacaggaaucagaauaauuuucccuggaaacuggauauagauauauaaaauauuuugacuaguaaagaacaacuauuaaucagcauuuggauuaaaaaaucuuaaucuguuguuugaagcauucugcuagauauuauggguacagauuaaguccuaaugaauguuuuuauccauuuugaagucugccuuuaaauacauggagugaaauaaccuaggaguguauuaauauggagucacugggaggaggaaauguuucauuuuauaaaagcagccugagagcuguaggcccugcugcugucuguucuucaugccuuggcucucacucacaugaaucaaugucacgucaaucuuggcuuucuucacuugcauuucagucgcuugcccuggauauccccagccacgcugaaaguucagucuucacugccccucaucaggcccagucccucaauagcucucuggaggcagccaugacugauuuaagcagcauagagcaggacauggagcaaguuuggcaggagcuauuuuccauucccgaauuacagguaagagagcucuaggagugugcuguuuucugcgggcccuuuuaaauuagucauccuaguuauuuauuauuuacaugcuaccuccucaaaggaagaaauugaugguguauuuaaauuacucaugagagcuucccagacucacuuaacacacauaguuuuuagguaaucagacugaauauuucuggauaaauucauucaaagacugaaagcuaauuuagaguucugacaaagauaaaauacuuaucuauugaaaaaugggaguugaaggaauuauugaaaagaacaccuuggauuuggggguagggaauugaucuaaaaugcacuuagccucugcucauacaaugugaccuucuuuccuagugucuuaauaccgaaaacaagcagcuggcugauacuaccgcuguucccagcccagaagccacacugacagaaauggacagcaauuaccauuuuuacucaucgaucuccucgcuggaaaaagaagugggcaacugugguccacauuuccuucaugguuuugaggauucuuucagcagcauccucuccacugaugaugccagccagcugaccuccuuagacucaaaucccaccuuaaacacagauuuuggcgaugaauuuuauucugcuuucauagcagagcccagugacgguggcagcaugccuuccuccgcugccaucagucagucacucucugaacuccuggacgggacuauugaaggcugugaccugucacuguguaaagcuuucaacccgaagcacgcugaaggcacaauggaauucaaugacucugacucuggcauuucacugaacacaagucccagccgagcguccccagagcacuccguggagucuuccauuuacggagacccaccgccuggguucagugacucggaaauggaggagcuagauagugccccuggaagugucaaacagaacggcccuaaagcacagccagcacauucuccuggagacacaguacagccucugucaccagcucaagggcacagugcuccuaugcgugaaucccaaugugaaaauacaacaaaaaaagaaguucccgugaguccuggucaucaaaagccccauucacaaaagacaaacauucaagccgcuuagaggcucaucucacacgagaugagcuuagggcaaaagcucuccauauuccauucccugucgaaaaaaucauuaaccucccuguugaugacuucaaugaaaugauguccaaggagcaauucaaugaagcucagcucgcauugauccgagauauacgcaggagagguaagaauaaagucgccgcccagaacuguaggaaaaggaagcuggagaacauugucgagcuggagcaagacuugggccacuuaaaagacgagagagaaaaacuacucagagaaaagggagaaaacgacagaaaccuccaucuacugaaaaggcggcucagcaccuuguaucuugaagucuucagcauguuacgugaugaggauggaaagccuuacucucccagugaauacucucugcagcaaaccagagauggcaauguguuccuuguucccaaaagcaagaagccagauacaaagaaaaacuagguucgggaggauggagccuuuucugagcuaguguuuguuuuguacugcuaaaacuuccuacugugaugugaaaugcagaaacacuuuauaaguaacuaugcagaauuauagccaaagcuaguauagcaauaauaugaaacuuuacaaagcauuaaagucucaauguugaaucaguuucauuuuaacucucaaguuaauuucuuaggcaccauuugggagaguuucuguuuaaguguaaauacuacagaacuuauuuauacuauucucacuuguuacagucauagacuuauaugacaucuggcuaaaagcaaacuauugaaaacuaaccagaccacuauacuuuuuuauauacuguaugaacaggaaaugacauuuuuauauuaaauuguuuagcucauaaaaauuaaaaggagcuagcacuaauaaagaauaucaugacuuaaacuacuuuggacuuuuugaauuuauucacacuauuuuccauaggacaaucacucauuuaccacauuugguuauuuuacauuuucaaaauggguuugaaaauacagaggcauuuuauagccauguguggcaguccaugauuuuuuauucccgacauucaggaggcagaagcaggcagaucccugggcuccaggacggccaaggcuacaugagagccugucucaagaaagacaaacccuuucuauacuaaacguuagcuaggauugucaaggagaugguauauauccacaaugguaugccugcuguacaguacuguggcacagagaacaaaaccuguaaccuccuguguucuuagaaguggcauucuaagaagggcuaggaaga 180 U09659ggccagcaggacucuccuugcagcagcggcccgaguucagaguccggagcugcggugguggcggcgaaggcgagagucauggcuggacaagcuuuuaggaaguuucuuccgcucuuugacagaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuuccagaaaagucucaaggaaaaguguugcaagcaacggucguggcuguggggucaggagggaaaggaaagaguggagagauugaaccugucagugugaaaguuggagauaaaguucuucucccagaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagugacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugccauuccacugaugucugaacuauuucaucauguaaauaauuu 181 AW124785uuuuuuuuuuuuuuuuucaggucucauuuucguuuauuugaaauucggugcucguguaaguuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauaccccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggaagucgucauagggaagagaacuaugggugggcuccugccugaggccuccaaucucagcccaguggacauaucacaggcagcuuaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuuaaauagguauucaagacagcuuuaaaaaaugcacccacucacaccccccucccuuuucuuuuuggaaaaaaaaauaggaaaaaaaaaaaaaccaaaccgaauucucgcuuggccucua 182 AF071315Sequence below.auuuggcuccgaggccaagaauucggauccaaggcgggcgcggggaaaauggcggcggcagcugcggcgggggcgaaugggagcggaggcagcagcggcauggaaguggaugcagcaguccccagcgugauggccuccggagugacugggaguguuuccgucgcucuucauccccuugucauccuuaacaucucagaccauuggauccgcaugcgcucccaggaggggcggccuaugcaggugauuggggcucugaucgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccguggaagagaagauuaucauugacaaagaauauuauuacaccaaggaggagcaguuuaaacagguuuucaaggagcuggaguuucuggguugguauaccacaggggggccaccugaccccucagacauccacguccauaagcaggugugugagauaauugagaguccgcucuuucugaaguugaacccuaugaccaagcacacagaucuuccugucagcguuuuugagucugucaucgauauaaucaauggagaggccacaaugcuguuugcugagcucacuuacacucuggccacugaggaagcugaacggaucgguguagaccacguggcccggaugacagcaacaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaagaugcugcacagccgugugaagcucauuuuagaauaugucaaggccucugaagcaggagagguucccuucaaccaugagauccugcgggaggccuaugcccuaugucacugucucccaguucucagcacugacaaguucaagacagacuuuuaugaucaaugcaaugacguggggcucauggccuaccucggcaccaucaccaaaacgugcaacacaaugaaccaguuugugaacaaguucaacguccucuacgaccgacaaggcauuggccggcgaaugcggggacuguuuuucugaugaugguucuggaagggaugguguguggggcucagacagcuguuccauggaccugaguaccacauucccuuuagagaaacucauuaauaaaagagcagccccuuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 183 D49733 Sequence below.aaaacccaauguuugguuuuaaagccaaaaauauaagggaagugcauagguuuggguuuuguuuuuuguuuuuucccgagguccuugaucuuugcccccaaauuugagggcauaaaguaaucccucaguuaccuaaaaacacagccauuccuuugccauuccacucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuacuacugaggaaaggggagccagugguggaaguggggugagucacugaugggcagcagcuucagcccuccccccaacuuccuuggcucucuggggaugccugauccucucccucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuuuggcucugcucuuuacuccagaaggccaaaggcaagcuuagaguugaguaggcaggaaccaacauugugaagccccaggccagaaagggguguucugcagagugaggguuggcaugcuggcuccuccucaccauaccugcccccgccccuuuggguacaggauggcuccuuuaagagcaguggauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcgggaacgcugccucagccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccaggagcgagcuucgccggcucgcugucccccugagcagccucuguccuucuguccaagucccgcgcccuucucgggaccccugcccagcgggcagcacugucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcucuaccccacugucgcccacucggaucacccggcugcaggagaaggaggaccugcaggagcucaaugaccgccuggccguguacaucgaucgcgugcguucccuggagaccgagaacgcggggcugcgccuucgcaucacugagucugaagagguggucagccgagagguguccggcaucaaggcggccuacgaggccgagcugggggaugcccgcaagacccuugauucuguggccaaggagcgcgcccgccuccagguagagcugagcaaagugcgugaggaguucaaggagcugaaggcucggugagugaggcccggccggccggcaccagggaggcagcagucgccuguaacuggccaucuaguccccucccuccccggaacugccucccgcgggugacuggcagugccaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngcuaggccagauauagaaagcuuucuguauuuaauacacaguacaugcaucauucaugucuacauaauuaagauaaaggaagcugcauuguuaaugggaaaaaaaauagggucugggaauguagugugccuagcauuuacgaacuucgggguuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguagaggccggaggauccgaaguuuaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucaugaauaaaaauaaauaauaaauaaaccaauaugggucuagguugagcagcagcuugggcaggguagggccggaaguuagccagguagaggguugcagucccaggaggacccuggcugggagcagcaccucaguccccugcccaaccacagggggccaccgggucuuuccggaacuccugagggcgcaaggccuugcucucucuggcccagccauggggaacgcggagggccggugaggcaggcggcaggcgggcgggcggggcgcgggccgucauccccuccugcuccuuauuuuuagcccaguguagagucugggccgccugucccucccccaggacagggggaggaaauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaugccaacaauccuaauguaaugaugcccucuucugacagcugcggggaccgcagagaggucccaucccagaugcacuccugaaaccugcuuuucuuuuucuagcaacaccaagaaggagggggacuuguuggcugcgcaggcccggcucaaggaccucgaggcucuucucaacuccaaggaagcugcccugagcacugcucucagugagaagcgcacauuggagggcgagcuccaugaccugcgggggcagguagccaagguaggccgcuguccugugaccccagugaccccaccugguccgacauaucauucggucccauuugccugcucaccuucacuucuccagucuagannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucuagauggggacagccaucaccucuccuuuggcauuuccugaacccccucccaccucuccaugaacuuggcuuucucccucucagcuugaggcggcccugggagaggcuaagaagcagcuucaggaugagaugcugaggcgaguggaugcugagaacaggcuacagacgcugaaggaggagcuugacuuccagaagaacauuuacagcgagguaagcgucccgcuguacaggucuuucuuacuguggacagcugggaggggucaccuaauaaugccaggcuaagcgagggcugcccgugccuggccgguggaguuacgacuucuggucucagcuucuaaggaaccauugcgauguucuaaucuaagugucuccccuuaaccuuucaggaacugcgugagaccaagcgccggcaugagacgcggcuuguggagaucgauaacgggaagcagcgagaguuugagagccggcuggcagaugcccugcaggagcugcgggcucagcaugaggaccagguggaacaguauaagaaggagcuagaaaagacauacuccgccaaggugcuggccucauccuguccucucccuggugcugcccuggggacgggugggugguggcagggggccagggaugccuuccucaggcccccagcuccagguuccugcucucauaacugugugcucccugcagcuggauaaugccaggcagucugcugagaggaacagcaaccucgugggggcugcccaugaggaacugcagcagucucgaauccgcauugacagccucucggcccagcucagccagcuccaaaagcaggugacccucaguuuaccccucccaccuuggcucuggucuaagcagauacugcagaagcccacugagaagggggugggggagggacuccaggaccacaugcuaugguucugaaucugaugccugucuggcuuuccagggcucuccuuuagcuagcccugauccucagagccucuauuuuacugugcaugaaggguuuuucauguuucuucugugccugccggagacugaaccagaggccucuugcuugguagauaggugcuuucucacugaguuacaaacccagccgcauucccuacuuggagauagagcuucccuuggacuggacauguagcucaguugguacagugcuugcuuauuauacacgauggccuggcuucuauccccaggaccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucuagagagagccuacagauccugagugucccucugccugccccugugccccucccucuucaucgacaucagcccuugggagcucaucagacccuuugucuuccccgccccaguuggcagccaaggaggcaaagcugcgugaccuggaggacucgcuggcccgugagcgcgauaccagccggcgccugcuggcugagaaagagcgagagauggcggagaugcgggcgaggaugcagcagcagcuggacgaguaccaggagcugcuggacaucaagcuggcccuggacauggagauccaugccuaucgaaagcugcuggagggcgaggaggagaggugaacuaggaggggucuacagaacuugucaggggccucuggccgcaacuaccaugacuaaccccgcaccgugucuccaccuuccccaggcugcgccugucccccagcccuaccucgcagcgcagccguggccgcgccuccucccacucaucccagucucaggguggaggcagcgucaccaaaaagcgcaagcuggagucuuccgagagccggagcagcuucucgcagcaugcucgcacuagcgggcguguggcgguagaggaagucgaugaagagggaaaguucgugcggcugcgcaacaaguccaacgaggugggccugugaaccaggguggucuuuucaguggcugggaguucuugguucucguggagcaucugucucccuaucugagaauuuggagugugugguaguccugucaucuuuaaauuguugggaagaugcaugauauagggaugggugacccuugagccaauagucuagguuugaugccagagguagugguggaagccugucuuucuuuucuuuuucuuuuucuuuuucuuuuucuuuuucucuuucuucucucuuuuuuuuuuuuccgauggggucuugcccagguuggcuuugaucucccuaguuaagcuguuccccugccucagccuccauaguagcuggaacugcaggngcacacuggcgnccagccuaccuaagcuccugagugagauaauccaagagucgguugaacucccuguccuccuuccuccuuccuccuuccuccacccuacuucaggaccaguccaugggcaacuggcagaucaggcgucagaauggugacgauccuuugaugaccuaucgcuucccaccgaaguucacccuaaaggcugggcagguggugacggugaguggaagggcacuugggacucuggcuggaguggagaaguuggccucaggacaggagcauuaaaaauaagcacaucucuuaaaccaucuuuucccagaucugggcuucaggagcuggggccacccauagccccccuacugacuugguguggaaggcgcagaacaccuggggcugugggagcagccuucgcaccgcucucaucaacuccacuggagaagugaguauguugcagccgguagcuugcuggacaaggcucccccgggugaccauaaugggaacuagcuaccuccaacccaagggaaccugccuuggguuuaggaucgcuuuccugagcccaagucccacccaguaagcaagccagaagucuccccaguagaauaauggguggaagucagccagugaguguuaauagcagacuccagcuuacagagcaccgagcucucaguuguguccuuuuugcgcgugcgugcgcgcgugugcacaugugcauguguuuauccuuaguccccagcaucagagguuggacaagguuguauaaaggcccgggacaguucuaagugguuacuauggguagacaggcugcacagcccucacccccugacucuugggccugggcuuauguccccacaggaaguggccaugcgcaagcuggugcgcucacugaccaugguugaggacaaugaggaugacgacgaggauggagaagagcuccuccaucaccaccgugugaguggcagccgccgcugaggcccagcccacaaggguagcccugccagccuagggcagcucucccaccuccaugccaaagucuuuucauuaaagaauguuuuggaaugccacuugcugcccuggccuuucuucucucuccucccucuaccuugaacagggaacccaggugucugguaaggaagggaguggggacuugcugaugccauggauacuccacgguggcaguggacaggguucuggauuuguguccugggaaggggcugggaggacagagguggccccagcccugccucucuuccucacucccauugcaugcacacuucucuccucucuccuuccacccuauugcaugcuucuccucagauuucccugcaacaauguucucuuuccuuccuguccccucacaaauuaagucucuccaucuuugcucuuccucuugauugccccauaagugucuaagauucaggagagaguuaaagccacagcucuuuauuucgaaggcuuccuggcuauuucccccaucaugcccuuccucccagccacaggucucccaaguccccaucacuugguugucuggguacagacagaggucaccuuccugcccaauggccaggaagcuccaagagcccacagccuaggugccgguccuaagaagucagucccaaacucgcugucccuccugagccuugucucccuucccaggguucccacugcagcggcucgggggaccccgcugaguacaaccugcgcucacgcaccgugcugugcgggacgugugggcagccugcugacaaggcugccgguggagcgggagcccaggugggcggauccaucuccucuggcucuucugccuccagugucacagucacucgaagcuuccgcaguguggggggcaguggggguggcagcuucggggacaaccuagucacccgcuccuaccuccugggcaacuccaguccccggagccaggugagucaucucugcccuacagcaggacacugcucacugagcagcagggcagggcagcccaagggaguggggucccccuccuugcagucccucuugcauccugccccuccugucugaaccccagacucgaggucagggcaaggcccagagugugaggguuggggagacaaccccuuuggggucagggagggagaggaagggccagccacugcugcucacaccucugccuucucuucucucuuagagcucccagaacugcagcaucauguaaucugggaccugccaggcagggcugggggcagaggccaccugcuccccccucaccacaugccaccuccugucugcuccuuaggagagcaggccugaagccaaagaaaaauuuauccccugccuuugguuuuuuuuuuucuucuauuuuuuuuucuuuuucuaagagaaguuauuuucuacagugguuuuauacugaaggaaaaacucaagcaaaaaaaaaaaucuuuaucucaauccuaaguccuuccccuuucuuuccuuguaucugccuuaaaaccaaagggcuucucuaggagcccagggaaaggacugcuuuuuauagagucuagauuuuuguccugcugccuuggcuuuacccucaucccaggacccugugacaauggugccugagaggcaggcauggaguucucuucaccagccuccuccaacagcuggcccacugccacgccagcugcagagaaauggggcgcagagaggaugacugagaaggucaagccccuccccggcacuacacgaggccgaggcuccucugccugccuuaccuucuuccugcccuucccuagccuggggcgaguggauucccagaggcaaaucugccgugcuugcuuuuucuauauuuuauuuagacaagagaugggaaugacggggaaggagaagggaagaucaguuugagccuaccuuuucccagcuucugagccuggugggcucugucucaaugauggagggcaaugucaagugggauacagggaagagugggggacgaaggcucccagagauggggagaaccugcuggggcuggugagaagucuagaggugcggcgauugguggcuacagcaaacacuaaggaacccuucaccccauuucccaucugcaccucugcucuccccuccaaaucaauacacuaguuguuuccaucccagaugcuguggugucucuuuguugggugugauguguguuuucaggggcagacacaugcacacagaggugccacacauucacuauauauucacuacccagcuauaaagguguguaugagggagacuucuagaaaggucagcauauguggggugagcgagggguguccuuccuaucccucauccauccagcaccuuuuaaaaggggccagcaauccacaugugcaucagacacaggagcacagagagacggaggguagaguagggcagaguagcagagcuuccuugcugcccuguagucgcaggcucuugaucgugugaucgcu 184 X80899 Sequence below.gcggugcgaagcgggccuccgccaacauguacuacaaguuuagcaguuucacgcagaaguuggcuggagcuugggcuucggaagccuacaccccgcagggguuaaagccaguuuccacagaagcaccaccuaucauauuugccacaccaaccaaacugaccuccagugugacagcauaugauuauucugggaagaacaaaguuccagagcugcagaaguuuuuccagaaggcugaugguuuccaccugaaacgaggccuuccagaccaaaugcuuuaccggaccaccauggcucugacacugggagggaccaucuacugccugaucgcccucuacauggccucgcagcccagaaacaaaugagcuugccuguggaggacugguucacuuuguggcacaaacccuuugaauccucacguuucauguuuuccacuuggauagucuacuuaacauuuugcaaacaaaggaaaagauaagaauacauuguuuugauuuguuuauggugugcagauggccugucagaugucagagcugguuugacaguuaaaacuauuguuuaaggaaaugucacugagccaucacugagcugugcuucugcuccugauuucccuggaguucugcaggaaaguugcucuccagcucauucguggccagccgugcucagggccucgggacucaggcggugucugagcgggaagcgaacgcggaagccuuuuggaguguaggugugauugaggaaggaaaacaaaagccagcggacagguggugaagugagggcugaguuagccacccuagggauucguccgccuugcagaaaacauugagaggaaugauagcaaccugccucuauuugugggcaguugguuucaaaggguugugugucucgcccagaaccuagggaaauggguguuuguuccaucgugggaggagcaccugucagugcugcacauuagacagcugugucaggacuucuccuuuaauaaugcuguggcuuuacguuaugauugaccggacugcggaauaaacacuggaaucaaaaaaaaaaaaaaaaaaaa185 D83203 Sequence below.cugagacagaacgaaacguccgcagauaacuacccguucuggcucuuguuaguucuauguguauggauaaugucuugggagguuuugaaaugccacaagccuugcuggcccagggugcagcugccucugccguucagaccucagauuauaaggacagaacacagcacggaaguggggggaucagaaccaugggagauccaggacgaaggguccugugcgcaggugcggcaccgaauccuauauuugacauugaagcugucgucagcccaacuaguguguuauuaacauggaagcacaaugacucaggcgcuucagaauguagaauagagaauaagauggagagcaaucugacguuuccuguuaaaaaccagacaucauguaacauuacaggcuuaagcccagguacuucguauacauucuccaucaucucuguaacaaccaaugagaccuugaacaaaacuaucacaacagagcccuggccagugucugaucuccaugucaccucugugggugugacacaggcucgucucaccuggagcaaugcaaauggcacugccuccuaccggaugcugauugaagaguugaccacacauuccucagucaauauuucaggucugaagccggggaccaauaauacguucgcuuucccagaaucaaaugagacacaggcugacuuugcaguugcagaggaggucccggaugccaaugguaccaagagaaucccagugaccaaccuaucccaaccacacaagaauucucuugccucuguggacccacccucuggccaggaucccucccucacagagaucuugcuuacugaccuaaagccugauacucaguacaaugccaccaucuauucucaagcagcaaauggcacugaaggacagcccaggaacaaaguguuuaaaacaaauuccacccagguuucugacguccgagcuaugaacaucagugccucaagcaugacccugaccuggaaaagcaauuacgaugggucccguacuucaauugucuacaaaauacacguggcugggggggaccacuccgucaaccaaacugucaauaagacugaggccaucauccucggacucagcuccagcaccuuguacaacaucacaguucauccuuuccugggucagacggagggcacaccaggcuuccuccaaguguacacuucccccgaucaggucucugacuuccgagugacaaaugucagcacaagggcaauugguuuggcuuggaggagcaaugacuccaaguccuucgagauuuucaucaagcaggacggaggugagaagcaucgaaaugcuucgacgggaaaccagagcuauaugguugaagauuuaaagccuggaaccaguuaccauuuugagauaauuccacgaggaccagacgggacagaagggcuguccaguacagugaaugggagcacugaccccagugccgugacugacauccggguggucaacauuagcaccacugaaaugcaguuggaguggcagaauacggacgaugccucuggauacacuuaccauuuaguucuagagucuaaaaguggcuccaucaucaggaccaacaguucucagaaguggaucacaguagggagccucaccccaggcaccuuauacaaugucacaaucuuuccagaaguggaccagauccagggaaucuccaacuccauuacccaguacacacggcccagcagugugucccacauugaaguaaacaccaccaccaccacggcagccauccgauggaagaacgaggacacagccucugcuuccuaugccuacuccguccuuaucuugaagacuggagauggcagcaauguaaccagcaacuucacaaaagacccuucuauucuaaucccugaguuaaucccuggcgucucuuacacagugaagauccuuacacaaguuggggaugguacaacaucacugguaccugguuggaagcuguucuguacggaaccugaaucagugaccuccuuccacugugaaguggucccuaaggagccagcauugguucucaagugggccugccccuuuggcauguacacaggcuucgagcugggggucaggagugauuccugggacaauaugacacgccuagagaacugcacaucggaugaugacacagagugcaggacggaagucgccuauuugaauuuuucuaccucguacaacaucagcaucgccaccuugucaugugggaagauggcgcuucccgcccagaacaucugcaccacuggcaucacagacccaccuacuccggauggauccccuaauauuacaucggucagucacaauucaguaaagguuaaguucagcggguuugaagccagccacggaccuaucaaagccuaugcugucauccucaccaccggggaagcugcccaaccuucugcagauguuuugaaguacacguaugaggauuucaaaaggggagccucggauacuuaugucacauaccucauaagaauagaagagaagggacagucucagggcuugucugaagucuugaacuaugaaauugauguggggaaccaauccacuacccucggcuacuacaacgggaggcuggagccucugggcuccuaccgggauuguguugcuggcuuuaccaauauuaccuacaaccuucagaaugacggccucaucaauggggaugagagcuaugugucuuucaguccauauucagaggccguguucuugccccaggauccaggugucaucugcggagcaguguuuggauguaucuuuggugcccuggccaucacagcugugggaggcuucaucuucuggagaaagaaaaggacagaugccaagaauaaugaaguguccuuuucucaaauuaaaccuaaaaaauccaaguuaauccgaguggagaauuuugaggccuacuuuaagaaacagcaagcugacucuaacuguggguuugcagaggaauaugaggaccugaagcugauugggauaaguuuaccuaaauacacagcugagauagccgagaacagagggaagaaccgcuacaacaauguucugcccuaugauauuucucgagucaaacuuucaguccagacccauucgacagaugacuacaucaaugccaacuauaugccuggcuaccauuccaagaaagauuucauugccacacaaggaccuuuacccaacacuuugaaagauuucuggcguaugguuugggagaaaaacguauaugccauuguuauguugaccaaaugcguggagcagggaaggaccaaaugugaggaguacuggccuuccaagcaggcucaggacuacggggacauaacuguggcgaugacaucagaagucguucuuccagaauggaccaucagagauuuuguggugaaaaauaugcagaauagcgagagccauccucugcggcaguuccauuucaccuccuggccugaccacgguguuccugacaccacugaccugcucaucaacuuucgguaccugguccgggauuacaugaagcagauaccccccgagucaccaauucuggugcauugcagugcugggguuggaaggacgggcacuuucaucgccaucgaucgccugaucuaucagauagagaaugagaacaccguggacguguaugggauugucuaugaccuucggaugcacaggccucugauggugcagacagaggaccaguauguuuuccucaaucaguguguuuuggauauuaucagagcccagaaagacucaaaaguugaucucaucuaucagaacacaacggcaaugacaaucuaugaaaaccucgagccaaguuccuugaaugugacuauguugcuucauccacagcugaacgauuuuggauguuggguucuagguccuggcuguugcuggucugcuaggauccagggccuuguugacaucugggaagauguaaauugucccgcugaaggccgcaguuuuagauguggccacuagauggagccagagcacugguaugaaggagcaccagggccguguaaggcaaaagaggacccagaaaaagaaacuuaacuuguucacuccugagaaaccugcaagucaacaagccaaggaagugccuuugcaugcauuugguagccuuuccaaucccgcuuauuacauaauauguucauguucauggcaaaaaaaaaaaaaauaaaauaaaauaaauaaaaaaggaaaacaaaauaaaaaaaaucuuagaacauu 186 Z20410gcccccucaagggcauccugggcuacacugagcaccagguggucuccucugacuucaacagcgacacccacuccuccaccugacgcuggggcuggcauugcccucaacgaccacuuugucaagcucauuuccugguaugacaacgaauuugcuacagcaacaggguguggaccucauggcccacauggccuccaagguaagccccuggaccaccagccccagcaaggcacaagaggaagg agagacccu187 AI839906 uuuuuuuuuuuuuuuuucauauuaaacuuguaguuuuauucagguuugauuuuuaacaaaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuucccagaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacagggguuugggaagagacacaggcagggaaggggcugguccccagucuguacaguggugcuugggggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaagggcacaagaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaaaggagaggggaaccuaaaccacaagcaguacccaacucccuuucccccaucagggcugc 188 AI843448uuuuuuuuuuuuuuuuuagggaagaggcugaugccagauaaguuuuuauuauauuaaaaaaaaaaaaaaaaccagugcaacuggaaaucagggugagucgcuggaggugagugagagucggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccuggucugauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaagagggcaagagagcccacggcuccuccauaccgcuugcuagggucuccuguguaguagccauaugcguaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcgggugguaaacaccucccaccguuaggaaaaa 189 AW125336cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacaucaguucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaaguccuuuugcauccucggaauuccaggggcugaccacuuuuaaaccugggcagugcccauaccaugcagcaaagcauugcgagugcugagcagcuacaccugcugaggcgccauugggcccccugaauacuaugggcaca 190 AW123802uuuuuuuuuuuuuuuuugaagggccauuggaguuuauuuacagacaaccuuaggugaggccuuuuccucuaggaucuacaugcuuuugaaguuacuugguuucaggcuucuugucuccagcuucgagcuugagacucucaggaggcuggcgauaggcagggaaagccucccaggggcuguucaggucaaacuugcggaauucuugugccagcuccacugguucagccacuacccgcuuuaccucaucgucguaacgaagcucaacauagccagugaggggaaagucuuuccggaaaggaugucccucgaagccauaaucugucaggauccuucuuaaaucagggugguuaaaaaaaaaaaaaaaaaaaaaa 191 AI835771uuuuuuuuuuuuuuuuuggggggcagcgaacuuuauugaugguauucaaaaaaauagggagggcucccuaggcccccccuguuauuaugggggucugggauggaaauuuugagggaaaugcucaauuuugggggcccauuugggaaaaggccccccuugcccaauguccuugcuggggugggugguccaagguuucuuacuccuuggaggccauuuuggccaagagguccaccacccuguugcuguagccguauucauugucaaaccaagaaaugagcuugacaaauuugucauugaaaaaaaugccaaccccggaaucaaagg 192 X53584 Sequence below.gcuccucaucucacucgggccuaugccaaagauguaaaauuuggugcggaugcucgagccuuaaugcuucaagguguagaccuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaagucccaaaguaacaaaagauggggucacuguugcaaagucaauugauuuaaaggauaaauacaaaaauaucggagcuaagcuuguucaggauguugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugccaaggagggcuuugagaagaucagcaaaggggcuaauccaguggaaauccggagaggugugauguuggcuguggaugcuguaauugcugaacuuaagaaacagucuaaaccugugacaaccccugaagaaauugcucagguugcuacaauuucugcaaacggagacaaagacauugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaaaacccugaaugaugagcuagaaauuauugaaggcaugaaguuugauagaggauauauuuccccauauuuuauuaacacaucaaaaggucaaaaaugugaauuccaagaugccuauguuuuguugagugaaaagaaauuuuccaguguucaguccauugucccugcucuugaaauugcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgcugguuuugaacaggcuaaaaguuggucuucagguuguagcagucaaagcuccaggguuuggggacaacaggaagaaccagcuuaaagauauggcuaucgcuacugguggugcgguguuuggagaagaggguuugaaucuaaaucuugaagauguucaagcucaugauuuagggaaaguuggagaggucaucgucaccaaagaugaugccaugcuuuugaaaggaaaaggugacaaagcucacauugaaaaacguauucaagaaaucacugagcagcuagacaucacaacuagugaauaugaaaaagaaaagcugaacgagcgacuugcuaaacuuucagauggaguagcuguguugaagguuggaggaacaagugauguugaagugaaugagaagaaagacagaguuacugaugcucucaaugcuacaagagcagcuguugaagaaggcauuguucuaggagggggcugcgcucugcuucggugcaucccagccuuggauucauuaaagccugcuaaugaagaccagaaaauagguauagaaauuauuaaaagagcacuuaaaauuccugcaaugacgauugcuaagaaugcagguguugaaggaucuuugauaguugagaaaauucugcagaguuccucagaaguugguuaugacgccaugcuuggagauuuugugaacaugguggaaaaagggaucauugauccaacaaagguugugagaacugccuuacuggaugcugcugggguggccuccuugcuaacuacagccgaagcuguagugacagaaauuccuaaagaagagaaggacccuggaaugggugcaauggguggcaugggaggggguaugggaggcggcauguucuaacuccuagaguagugcuuugcccuuaucaaugaacugugacaggaagcucaaggcagguuccucaccaauaacuucagagaagucaccuggagaaaaugacugaagagaaggcuggcugaccacuguaaucaucaguuacugguuuccuuugacgauauauaaugguuuacugcugucauuguccaugccuacagauaauuuauuuuguauuuuugaauaaagaacauuuguacauuccugaugcugguugcaagagccauauaccaguguccugcuuucaacuuaaaucacugaggcaucucuacucuucugugagucaucaggacuguagcgcugugucaacaaaacauagagaguucagaagacagccuuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaugugacaaccuuuguguaa193 M32599acagccgcaucuucuugugcagugccagccucgucccguagacaaaauggugaaggucggugugaacggauuuggccguauugggcgccuggucaccagggcugccauuugcaguggcaaaguggagauuguugccaucaacgaccccuucauugaccucaacuacauggucuacauguuccaguaugacuccacucacggcaaauucaacggcacagucaaggccgagaaugggaagcuugucaucaacgggaagcccaucaccaucuuccaggagcgagaccccacuaacaucaaauggggugaggccggugcugaguaugucguggagucuacuggugucuucaccaccauggagaaggccggggcccacuugaaggguggagccaaacgggucaucaucuccgccccuucugccgaugcccccauguuugugaugggugugaaccacgagaaauaugacaacucacucaagauugucagcaaugcauccugcaccaccaacugcuuagccccccuggccaaggucauccaugacaacuuuggcauuguggaagggcucaugaccacaguccaugccaucacugccacccagaagacuguggauggccccucuggaaagcuguggcgugauggccguggggcugcccagaacaucaucccugcauccacuggugcugccaaggcugugggcaaggucaucccagagcugaacgggaagcucacuggcauggccuuccguguuccuacccccaauguguccgucguggaucugacgugccgccuggagaaaccugccaaguaugaugacaucaagaagguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguugucuccugcgacuucaacagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuugucaagcucauuuccugguaugacaaugaauacggcuacagcaacagggugguggaccucauggccuacauggccuccaaggaguaagaaacccuggaccacccaccccagcaaggacacugagcaagagaggcccuaucccaacucggcccccaacacugagcaucucccucacaauuuccaucccagacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaauaaaguucgcugcacccac194 AF035644agaagcuuccuaaggaacaagcaaguugaauagagaaaauagugaucaauaauaggcauuuuaguggucuuuuuaauguuuucugcugcggaacauuucaagauuuauugauuuccuccuccccccauuuuuuucccaccacacucacacacgcacgcucacacuuuuuauuugccauaaugaaccguccagccccuguggagaucucuuaugagaacaugcguuuucugauaacucacaaccccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaacuuugguucgaguuugugaugcuacauaugauaaagcuccaguugaaaaagaaggaauccacguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauuggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauuguguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcggaaugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauuccaaacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauaccaaugggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagagg gaa 195Y00629 Sequence below.auucagguuccucacagacccagggggugaggauguugcuuuuugcccacuugcuucagcugcuggucagcgccacagucccgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagcgggaggguggugguggcggaggugcagcaccccaaguuccgccgcccuguccuagucccucccccgccuuuaccugggaccuugagccugggggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugcgguauuucaccaccgccgugucccggcccggccucggggagccccgguucaucauugucggcuacguggacgacacgcaguucgugcgcuucgacagcgacgcggaaaauccgaggauggagccucgggcgcgguggauugagcaggaggggccggaguauugggagcgggagacuuggaaagccagggacauggggaggaacuucagaguaaaccugaggacccugcucggcuacuacaaucagaguaacgacggugagugcggcugggaucacagcuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuucauccaaacgccuacccagaaccucagacaaaaaagcccccgcagaguucugcuuagguuugggguuguacuuuuguuucucuuuuguuuugagauaucuacuaacauugggcaaaguggccacagguggcgcucaucagcguaucccuuccagaaucucacacgcugcaguggauguacggcugcgacguggggcccgaugggcgccugcuccgcggguauugucaggaggccuacgauggccaggauuacaucucccugaacgaggaccugcguuccuggaccgcgaaugacauagccucacagaucucuaagcacaagucagaggcagucgaugaggcccaccaacagagggcauaccugcaagguccuugcguggaguggcuccauagauaccuacggcugggaaaugagacacugcagcgcucaggugcccuggagagcucuccucacuuuuccucugcgguuugggggaaauccuugagguauaaccucaggggcagaacgcuguucagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuuuuccccuguagggauucuaauccuuaacaaaagcagaucaggcucgacaauggcccuggacccauggggggagggggcucuuucucaggccucccuccuugcccuacucagugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccagcucaggaccagaagcccuucccaugagucugcagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaagagcagauccucccaggugcaggugcucuagcuggugucuagaugauggacaccauaaucccaccgcaguccuccuguccaccccaggacggucacaugaacacugcugaguccccagaagaaagcaagaugccucauccuuucaacucucucccucagacccuccaaaggcacaugugacccaucacccuagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugucguggugccucuugggaaggagcaguauuacacaugccauguguaccaugaggggcugccugagccccucacccugagaugggguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucugcagacccugaguuggucauggcucagagcugggaucauaacccucaccuucauuuccuguaccuguccuucccagagccuccuccauccacugucuccaacaugguaaucauagcuguucugguuguccuuggagcugugaucauccuuggagcugugguggcuuuugugaugaagaggaggagacacauagguaggaaagggcagggucugaguuuucucucagccuccuuuugcagugugcucugcuccuuaaugggaaacauagccacacccacauugcugcagucuccaacugggucagcugucaguuccgggaacucccuagggcugguguuucucuggucucucauggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuagguaagugcgagagaggggcaggggacacccuugucccugaggcucucaggauggagcugggauuuguuccagcccauaaucuccucuugccacauccucucugucuccucugugugccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucugacuggccucagaaggcaugaaaaucccugggggggcuggugagauggcucaguggguaagagcacugacugcucuucugaagguccagaguucaaaucccagcaaccacaugguggcucacaaccauccguaacgagaucugacucccucuucuggagugucugaagacagcuacaauguacuuacauauaauaaa196 AW125380uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguucuucucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcgaggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggcacgcucuggagggccugggcgaagguugcgguaccccgcaaggcagguaaccucagcagggccggcgagcggcgggugcgccucgugccg 197 U68564 Sequence below.ggugcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcggugcugcaaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguggccccccgaaggagcauuuccucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggcaucggcccagagcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcauguaagcuccaacgcugaugaggaggacauccgcaaugccaucauggccauccgccggaaccguguggcccugaagggcaacauugaaacaaaucauaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacgucauccacuguaagagccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcgaguacagcagccuggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcgcauugcugaauaugcuuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacugggugauggacucuuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagacaacacaacaaugcagcugguaucccggccucagcaguuugaugucauggugaugccuaaucucuaugguaacauugucaacaacgucugugcagggcuaguuggaggcccaggccuuguggcuggggccaacuauggccauguguaugcaguauucgagacagcuacaaggaacacaggcaaaaguauugccaauaagaacauugcuaacccgacugccacacugcuagcaagcugcaugaugcuagaccaccucaagcuccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcauaccccagauauuggaggccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuaauggacgggcuguggaggcuuagcuaucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuugggggacaggacccagaauaaagccacuucuguuccagaaaaaa 198 AW125346uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacuguaacauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauuucacacacuucugggcaggacgcacagcucugcccccacccccguguugacagucaacauuuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagcgugagcugaagucggacgcuugccaccucugaaugaauggucaccacagcaacagcacaugguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcugcacuuaucccuucaacauugu 199 X61232 See above (same Accession Number). 200D20333 gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguauuguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnnncugcccuuaacucugguauacaccaaaaagaaaucuuuacuuuccuuguuuuaucauuauaaaaauaaaguauuuugcuaguauggaaa 201 AB025218aguccgcgucccggcgucggcccgucccgcaccauggugacgcucgccgagcugcuggcgcugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgccgaggagugcuucuucgagcgggucaccuccggcaccaagaugggccucaucuucgagguggcggagggcggcuuccuggacaucgacguggagaucacaggaccagauaauaaaggaaucuauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggacauacaaguucugcuuuagcaauaggauguccacuaugacuccaaagauaguaauguucaccauugacauuggggaggcucccaaaggacaagacauggagacagaagcucaucagaacaagcuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggaguacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagugguccuuugguccuucuucgaagcucuuguucuaguugccaugacauugggacagaucuacuaccugaagagauuuuuugaaguccggaggguuguuuaaaaggccuuuuccuguugaucccaaauucaugauuuacu 202 U84411 Sequence below.gcauuggcucugggcugcggccggcucggcgacgcuccucgggcagcucacugcauggucgucuggugcccccgccgccugcauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguaugauuaggccacaaucuucaaugaguagacauauuccucaguucugugguguucucggucacacauuuauggaguuucugaagggcaguggagauuacugccaggcacagcacgaccucuaugcagacaagugaacuguagaaauucauuacuacuccaccaagaaacccccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcucagaccuggaugggguaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuuguuuaggagguucauuucauuggcccguuucucccaauuucauacucaagcacugagaauuucaaguggaguauaucgaauaucgaaguagacuucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugguuuaaaucauuucuguauucaauuuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacauggcucgaaugaaccgcccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcgaccuuaaacaaauuuauagaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacuacucuuguggagaaagaaggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaugacuggcuaagucuugugaagauuaaguuucgugaagaaccugguugcuguauugcuguccauugugucgcaggccuuggcagagcuccggugcuuguugcccuagcauuaauugaagguggaaugaaauaugaagaugcaguacaauucauaagacaaaagcggcguggagcuuuuaacagcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaauggucauagaaacaacuguuguauucaauaaaacuggggugccugaugccauugccuuggaaguggaacuucagaugggaccugauuugucaugcauauuacccaaugugucggcuuacugaauaagucuacugcagcuccacaggaauacugaaaaaccagucuuaccaggccacaaguuugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuuugcuguucagcauuuaaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaaauguacuccugugccagaauauuauuagucuauaaggaauuuagaaggauuaggugccaaaauacccagcacaauacuuguauauuuuuagcaucauacagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuucaaacacugcagggcuccucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguuugcuuagccauccuuuauuuuuuuuauuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucugucucauuuuguuuuguuuugggaaaccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaaagccuuauaguuaauuuaauguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuauuaaauauuuuuaguaauauguugccuuugucaugugcagaacauguagaguaugcucuuaauuuaguaaauauuuuuaagacauagagauacauguguagcuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguuuccagcuuguuugaauuauggcuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacugagcagaaauguuuuauaacgccuuuugagcuauguaacuuaauaauuggauacuugaucauuuguuuuauuauguaaucggauaaaauggugauguguauuaaaguuaguucaaccauauauuuauacugucugggaaugugugguuauaguucugugggagaaauaguuugucaguguucaccagcuuguaaaaacuuaguaugagagcuucaacauuuaaauaaaugaugaaccgcauucgucacugaggacacuuuugccuaaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuauggaaaaaauuguuaggguugccaagugcuuuuuauuaaaaguuucucuuuaaaggucuagauaauugugaaucaguugaauguugggcaccgaggggaaacaguuuguaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcucugcaauuuccagaccaguuuucucauuuuuaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugaguauuuggcacaugauggcuuaauaaauuuuaacuuuc 203 M62362 Sequence below.acgcuccccaaccuccaccuccccucgcucggccucuauaugcucccgggcucccuaguguuggcuggaagugggugacuuagaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcugcaagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccccacucaccgccuuggaaagucacaggagaaggcgggcucuaagacccagcaggcaccauccuacuggcgccuucgauccgagacccguuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagcugcgcgggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggcucgccaugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcggcccccgaugagcagucaccuccagagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagccccaccugccgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgccuucaacgacgaguuccuggccgaccucuuccagcacagccgacagcaggagaaggccaaggcggcggcgggccccgcggguggcggcggugacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccccucccggcuacggcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcgcuacggccgcuggugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuaccagccaccgccgccaccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgcgcacugcggccagaccaccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgcccgccuugggugcugcgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacgggaggcggcggcgguggcagcggugccggugcgggcaaagccaagaagucgguggacaagaacagcaacgaguaccggguacggcgggaacgcaacaacaucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcuggaguugaccagugacaaugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuuccgccagcugccugagagcuccuuggucaaggccauggcaacugcgcgugaggcgcgcggcugcgggaccgccuugggccggcccccuggcuggagacccagaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuaggagauuccgguguggccugaaagccuggccugcuccgcguguccccucccuuccucugagccggacucggugcgucuaagaugagggagucaggccguggugguuucuccuugagaccgagagacuuuuccgcggagcugagcugggggcccggcaguacuaguauuaaggaaguaaccuugugccuuggauacucaaaacucgcuccuuuuccuaccgaguagggggagcaaaaaugugccuugauauuuuauuuggaggauuccugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcaggcccagggcaggaggaagauacaggaagcugagaucccggcagugcccugagcugccccucagucccugucuuuagaggggagggacuuagguguuggggauuugagucuguguccucacccccagcuacagggagguggagggcuccuaaucccuugcuuuuugcaccuccaccuacauccccccccccccacucagcuuacaacaggccagguuuccugggugaguucauggagaaugggggcaccacccccagucagacagaaagcugaguugugaguuagccaugugguaggagacagagaccuagguuucugggcuuuguggggugggggauaggaggacacggggaccauuagccuuguguguacuguaugucgccagccgcuguugcugaaggaacuugaagcacaaucgauccaucccagagggacuggaguuaugacaagcuucccaaauauuuugcuuuaucauccgauaucaacacuuguaucuggucucugugucccagcggugccuugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauuuggucuuuuguuuuguuuugguuuugcucugauucuugccaaacugagacucuucacuaacggcugggggaaggagcugagugaggcucucauucuuuuugguuuagggauguuuggguuuuuucgucugccucccagaggaccaaugaaaugaagugggcuucccccucuccccuaguuguccaaggguguauguaguagugggucuuagcuuccuccggcuaagacuuaggcuuccccacccacccaaccccauccccaacggcccuggcucugggucuggaaagaaggccaccuccagccaguucauacacacaccccuguggcugggagcagggcuggaccgcuuccuucucuucuuuuuuuggggggggggacacaaaguuucaugcuagaugucguauguauuauaucuauaauauaaacauaucaaacucaa204 AA032310gaagcucagugucgugaaauggaaaccaaaccuuggagccaucgcugaguauaaaaaaaaggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagauaauuuuagacaagcauaugaagaucuucgaaaacaaaggcugaaugaauuuauggcugguuuuuacguaauaacaaauaaacuaaaagaaaacuaccagaugcucacauugggaggagaugcugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguucggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuuaguuccuggccuuaguguuug 205 M94087 Sequence below.gccgguuugaguugugcgcucgggugucccuuuccucuuccccucccgcagggcuugcggccaccauggcguauuagaggcagcagugccugcggcagcguuggccuuugcagcggcggcagcagcaccaggcucugcagcggcaacccccaccggccuaagccauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaauccagcaaagccccacaacaugaccgagaugagcuuccugaacagcgaaguguuggcgggggacuugaugucccccuucgaccagucggguuugggggcugaagaaagccuaggucucuuagaugacuaucuggagguggccaagcacuugaaaccucauggguucuccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaaggaggaugccuuuuccgggacagauuggauguuggagaaaauggaucugaaagaguuugacuucgaugcucuguuucgaauggaugaccuggaaaccaugccagaugagcucuugaccacguuggaugacacaugugaucuuuuugccccucuaguccaagagacuaauaaggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugcccccuuuacauucuugcagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuaggcagugaaguugauaucucugaaggagacaggaagccugacucugcugcuuacauuacucuaaucccuccauguguaaaggaggaagacacucccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuccaccuccagggccccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccuggaguuaguuugacagcuaaagugaagacugagaaauuggauaagaagcugaaaaagauggagcaaaacaagacagcagccacuagguaccgccagaagaagcgggcugagcaggaggcccucacuggcgaguguaaggagcuagaaaaaaagaaugaggcucugaaagagaaggcagauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaagggggaagaagagaguuccguaauaggguagucaggugcuuugugcuuguacauagucuuguguugcuguguuugcuguaauaaauuauuuuguagugaaagu 206 AI847609uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuuacaguugaauacaaguuaaaggccugcuugcacaccaaagccagguccuuugggugguucagucaaagaaguaaggccuccagcuggcucacaacagaagcggccacuccuuggcccugguuugggaacuuuuccagcuuugaguucaucaauaaucucuucaauauccuugggugucagauccucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuccacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa 207 AI853294uuuuuuuuuuuuuuuuuggggugaauauagccaaguauuccauuuauuaacaaaauagucuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaagccccagcgcugcugcguaagaccgggagggagggaagguguuggggagaagacuuguauuaagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauugcuggcucaggucugggacauggcgaagggagugcucugauccuagggcucccugaguccccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaagcuuuggagggauccaucaaggauuccccgaccccaccccuaucgccagggga 208 M33934Sequence below.ccucugcggcgcgguccucggagcggcgcgguucucggagccacgcgucugucuuccuccguggucauggcggacuaccugauuagcggaggcaccucuuacgugccggacgacgggcucacagcgcagcagcucuucaacugcggggacggccucaccuacaaugauuuucucauucuuccuggguauaucgacuucacugcagaucagguggacuugacgucugcucuaacuaagaagauuacacuaaagaccccauugguuuccucacccauggacacugucacagaggcuggaauggccaucgcgauggcgcuuacaggagguauugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacagggauucaucacugaccccgugguccuuagccccaaggaucguguacgcgauguuuuugaggccaaagccaggcauggcuucugugguauccccaucacagauacaggccggauggggagucgauuggugggcaucaucuccucaagggacauugauuuccucaaggaggaagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucacucugaaagaggcaaaugagauucugcagcgaaguaaaaagggaaaguugcccauugugaaugaaaaugaugagcugguagccaucauugcccggacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcaacugcuguguggggcagccauuggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuuggacucuucccagggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauuggaggcaauguagucacugcugcgcaagccaagaaccucauagaugcagguguagaugcuuugcgagucggcaugggaagugguuccaucugcaucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcccgucgcuuugguguuccuguuauugcugauggaggaauccaaaaugugggucauauugccaaagcuuuggcucuuggggcuuccacagucaugaugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggcugaagaaauaccgagguauggguucucuugaugccauggacaaacaucucagcagccagaaccgauacuucagugaagcugacaaaaucaaaguggcccaaggaguuucaggggcagugcaggacaaggggucuauccacaaguucguuccuuaccugauugcuggcauccagcauuccugucaagacauuggugccaagaguuuaacccaagucagagccaugacguacucgggggagcuuaaauuugagaagaggacauccucugcucagguggaagguggcguccacagccuccauucguacgagaaacggcuuuucugaaaacagauccaguauaugccuugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa209 X16202 gugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcucacggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagagccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcuuggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguaggaaagggcagagucugaguuuuu 210 AI661431acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacucggggucacccucaggaacaugcagucucugcacgugaggaaagaaacacgcagagauggacgagcacuuuuacacccuaauaaaauuagaugcacuaaccacagaccccccu 211 AI839109uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacacacugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucacccauaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacuuacauuuuauugucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaauagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaagcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauaguacuaaaagguagaagucagcuucaaaaacacacucuugcaauggacacugcucaugaugucuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccugagcauucgguuugac 212 AI849135uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuuuuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacgggaaguacgcaccuccauuccaccgggaaggggcagauucccaaaucaaacugguuuugauccuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucaguacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcagguguuuaaacauggccacgcgccacacgaaauucuaguuugugugggguagaagcaagaaaaaaaaaaaaccauggcgccucgugccg 213 M32459gguccggauaguaaacugcucccuuacaucuccuuaaauauaaaguaaggaaaaagaaaaaacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaaaaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuuaaugguaacaauguggcugaggaagcaauaguuaacaaagaggagcuaagcuaugcaacaaaccagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacuuccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucuauaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacgaagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaaggccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccgucccggcaccguggcgcugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgcaagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucuguuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggacauccagcuggcccgccguauccgcggcgagcgggcuuaauaggcacgcuuucuacacuggcacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaaguacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaaugugagcaccacccgacgaagcagucugag 214 AI841389uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacuggggggagggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagacacuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugauugcaaaacugggucuccagcagggauucugguggucagguguggaugccuaaggaagcagugacaugggaggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuagcagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaaggaccugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu acuu 215X03039 Sequence below.auucuaaggaucaugucugcgagucaggauucucgauccagagacaauggccccgacgggauggagccggaaggcgucaucgagaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccuaugguuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagcccagucugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuuugguucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucuugucaugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggguaccccuggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagcagaugaaauguuaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguaguuuuguugucugcuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaagaaggaagaauugacccuggaggguauccgccaauucuacaucaauguggaacgagaggaguggaagcuugacacauugugugacuuguaugagacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaagaugcaugcccgagauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagggaguuccggucuggcucuagcagaguauuaauuaccacugaccuguuggccagaggcauugaugugcagcaggucuccuuagucaucaacuaugaccuucccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggcuauuaacauggugaccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagagaugccccucaacguugcugaccucauuugaggggcuguccugcgaccuggcccuagcccaggguucaguccugggguggggcuaaggaagagcuggaggggggaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuguuucaguuuuuuuucucuaugaauaaaugucacuuuuugaggc 216 AW049795uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuuacccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuuccacagagugaguuuucguuuaaaacucauaaugaggagaaggcagggggcuccaccccuuuccuguucaaucugaagacugaauugggcuacacugggauggagauuucaggugcugcaggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaaggcuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucaucaucaaacgucugugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguuccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauugacacaguuuugagcuucgggacaacucuuaaucagguuguggaugguuggaugagaaaacccaaagaagucggcaccgcauga 217 D87691 Sequence below.auuguaacagaagaaggaaaggaaaagaaaguuaacauugacuuugaaccuuucaaaccaauuaauacaucauuguauuugugcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuauuguaauagacggaaguggugcucuuuuuggcacgcuccaaggaaacaccagagaaguccugcacaaauucacuguggaucucccaaagaaacacggcagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgagacugcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaacugaacuaagucaaucugacauguuugaccagagguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguggugaaaauggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauaggacgauauuuugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaugggagcuguacaaauucuaauagucuaugaaaaucuggauauaaugagauacguucuucauugccaaggcacagaagaggagaaaauucucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacugauagaaagcaugccucucuuggaaugguuugcuaacaacuauaaaaaauuuggagcuacacuagaaauugcacagauaagucacaagaaggaucacaguuugugaaaggauuugguggaauuggagguaucuugugguaccgaguagauuuccagggaauggaguaccaaggaggagaugaugaauuuuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccucacccuccagcauucaacccaaggagcauacccgugguggaguccaacagaucccugccuuacaauuggagcauuuccagaacuuaauccgugagcauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucguggugucagcgcagcagccgacaacuaagucucu 218 AI117211cagaggagucauuguugcugugguggcuuuugugaugaagaggaggagaaacacagcguaagccagcugccuggaguggacuaagugacagacaaugucuucacacaucuccugugacauccagagcccucaguuuucuuuagucaaguaucugauguucccugugagccuaugggucaaagugaagaacugugcagcccagccugcccugcacacagaacccugucccugcacugcccuggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcauccugccagcuccaugcugcccugagcugcagcuccucacuuccacacugagaguaagaaucugaaugggaccuugauucuuaacauccugaccgaggguugauuucuuguuaauuucauggauugagaauacuuagaguuuugguuugucuugauuuuuuuucaag 219 Y00520ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacugaacaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauuccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuagaucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaaaaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguuaacuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugggaauugaagaggggagaacgagcagacaucgaacgauuaauuucuauuucucguuaucguggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaaggacugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuucgcgcucaucccuugcuaaagcgcauacguuuucuugcuccuugguacuugucugaucaaucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaaucacguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcucacuucgcccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccucugacggcuucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcuu 220AA638002 uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugggcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugaugacagugaacagaguaug 221 Z22661 caugggccuccugagagauccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauugggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccgugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguccugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaagaugcuuggaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgaggagggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccaucccaccugccaggugccuuauuuuugugucaaagugggugcugaaggaggcaacucuguccagaaaagacgcaguaaccaaugaccuaggauaccacccuuuggaauuggcuaaucuuccuagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaauacccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcccaggcggccccggauuuguccggaacauuggagagcauaccggauaaacugaaggaguuugggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauuuugaccaagacccg 222 X99644 Sequence below.cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcggcugccuggccguuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcggcgugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcggccucugguagcccagggucgggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucguccccugcggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcgggauccucggcugcugcccugucuacauucggccugcagugccugccugggccccgcuacacccgccgcagcgaauaauucgggggauggcggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucguggagaauuauuuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaagauaaugccccagccacuagcuauuguguggagugcucugaaccacuuugugagaccuguguggaggcucaccagcgggugaaauacaccaaggaccacacugugcgcuccacaggaccugcuaagacucgagauggagagcgaacagucuacuguaaugugcacaagcaugagccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaaggaccaucaguaccaguuuuuggaagaugcagugaggaaccaacguaaacucuuggcuucacuggugaaacgucuuggggacaaacaugccacacuucagaaaaacaccaaggagguucgaagcucgauccgccaggugucugaugugcagaagcgagugcagguugaugucaagauggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccagaaggugaccgagggucagcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuuugcguuuugccucuugggcucuggagagugauaacaauacagcucucuugcucucuaagaagcugaucuauuuccagcugcaucgggcccucaaaaugauuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccuggaccaagagugcugaagccuuuggcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcuccuccaagagccccaggcccucuaagcaagcaagguucuggcaguagccagcccauggaaguacaagagggauauggcuuugggucagaugaucccuauucaagugcagagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaaguggccucuuaaggaaggugccacgugugagccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuucaaggucuuuccuggaagcacuacugaggacuacaaucugauuguuauugagcguggugcugcugcagcagcugcuggucaggcugggacugugccaccaggagccccuggugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcugcuauuggagcucccccggcugcccccgaggguccugaaaccaagccuguguugaugccucugacugaagguccuggugccgagggaccucgucuagcuucaccuaguggcaguaccagcucaggcuuggaggugguggcuccugagguuacuucagccccaguaagugggccagguauccuggaugacagugccacuaucugccgagucugccagaaaccaggugaccuggucauguguaaccagugcgaauuuugcuuccaccuggauugccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacucugccacgugcucccugaccuaaaggaggaagauggaagccucagccuggauggagcagauagcacugguguggugacuaaacucucaccagccaaccagcggaaaugugagcguguucuccuggcccuguucugccaugaaccaugccgucccuugcaucagcuggcuaccgacucuacauucuccauggagcagccuggugguacccuagaccugaccuugauucgugcucgccuccaagagaagcugucaccuccuuauagcucccccaggaguuugcucaagaugugggccgcauguucaaacaguucaacaagcugacugaggacaaggcagauguucaguccaucaucggcuugcagcgcuucuuugagacacgcaugaaugaugccuuuggugacaccaaguuuucugcugugcugguagaaccaccaccauugaaccuucccagugcuggccuaaguucucaggagcucucuggcccuggugauggccccugaagcuggggcucuuguggucagcccaguccagcucuggucucuguauuuucaccccauacccuguccuugguggccugacuccuguucuugcuggccccaucguccccucagucccucuucacaaaaugguuuuuacuucuguggauuuaauaaaaacuucacugagucaguuaaaaaaaaaaaa 223 AI843895uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaaccuaugaaaauaaaguuugcaaaagucaaaguaguacaugggccugcccuggagccaggcccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagccacuaaggugccuacagagcaagagggugccaucgggccagugcagccucugcaauuuccagaucugccacuagaggucggcaugguccugauugcuugucaggcucacccucuggaagaccacagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacgguggguccgccgcccaggcgcaggagcaucugcuggcaguccagcaguaaccggugaucgccaa 224 M38724uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaagguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaugaagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaaucucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugcucaugcaggacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggacuccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauccuccagggaauuguguuuugccacucccggcgaguucuucacagagacuugaaaccucaaaaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcguuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucuccagaaguguugcugggcucggcucguuacuccacuccgguugacaucuggaguauagggaccauauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccagcucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgagucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccacgucaagaaccuggacgagaacggcuuggauuugcucucaaaaaugcuagucuaugauccugccaaacgaaucucuggcaaauggcccugaagcacccguacuuugaugacuuggacaaucagauuaagaagauguagcccucuggauggaugucccugucugcuggucguaggggaaga ucg 225AW122989 uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauucccaggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaacugaaaagagcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagauccauaauaaacaaaaaaauuuuaaaaagcagucaugauauaaaauagcagcuccuguaauuucugcaaguaucaccuucuucagaaguugcuucaauucaguuugccucauucuuagaagccucaucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggggugcuuuuccauccacagauuguuugggcagagcuucagccagucuccuuaaacuagucaggcugucugcaccaagcugguugaggaugcugggaagcauuucugucagcugcuuuguc 226 AI844810uuuuuuuuuuuuuuuuuauucaugcuugccuagggauggggaauagaucauucaauaaaaacauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacuacaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaaaaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuuguagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaacguacauggacagccucaggacgagcugacgucucggaucagcucggcaggcaacaaaccauagugccaaauggaaagaagggcaguugcaaauaaacuuaaaacuaaguuaacuuuuauaauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaacacuucacuauaaagaaugaacaccaugacauccucgugccg 227 AA940430agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggcaugaaagaguaugaaggaggaagaggggacucaucuaaaagggacaagucuaagaagaaaaagaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagucuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugagagcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagaggagcuagccaguaccccuccaagcucagaggacucugccucgggaucugaugaauaaaggagggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccaucugaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag 228 M38381 Sequencebelow.aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguuggaaagaugagacauucaaagagaacuuacuguccugacugggaugaaagagacugggauuauggaacauggagaagcagcagcagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacagacagcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacuacaugggcuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggaguggaagaagcaguuacaaaaguaaacacaggagucgccaccacacaucgcagcaccauucacacgggaagagucaccgaaggaaaagaucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauaugaaauuguugauacuuuaggugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguagcaguaaaaauaguuaaaaauguggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaacagacccccauaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaacuucuggggcuuaguacuuaugauuucauuaaggaaaacaguuuucugccguuucgaauggaucauaucaggaagauggcauaucaaauaugcaaaucuguaaacuuuuugcauaguaauaaauugacucauacagacuugaagccugaaaacaucuuauuugugaagucugacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagugguggacuuuggaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaaguuauuuuagcccucggguggucacagccaugugaugucuggagcauaggauguauucuuaucgaguauuaucuuggauuuacaguuuuuucgacucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauacagaaaaccaggaaacgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucucggcgcuguaaaccucugaaggaguuuaugcuaucucaggaugccgaacaugagcuucucuuugaccucauugggaaaauguuggaguaugaucccgccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgugauuuauaaacacagugcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuuaauuuguaaaacauuuuauguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauagaaugauuuauuuggaauaaaauuugugcuuaugaauguaaaaaaa 229 AF014371ggacucgcgacaagcguccucagcgcgaagaggcggacucggaguccucgccuugagccuugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguguguuuucagcaccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuugugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugcccacgguguuugaaaacuauguggcggauaucgagguggaugggaagcagguagaguuggcuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccagacaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucccagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguugggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagcaggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuuggguacauggaguguucagcaaagaccaaagauggagugagagagguuuuugagauggccacgagagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagccuugugaacgcagccucaugcgguuaauuugaagugcuguuuauuaaucuuaguguaugauuacuggccuuucauuuaucuauaauuuaccuaaga 230 Z30939uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggacauccagcuggcccgucgcauucguggggagagggcguaaauuaggguagugagugaauuuggaccccaaaggcucuuuucagagccacccacauuuucuauaaaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc 231 U28208uuaugugauaaaaaaauucaacuugguauuaacuuaacuaagggccuuggugcuggugcuuugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauauaaaagauagccauaugcucuuuaucacagcagggauggguggugguacuggaacaggugcugcaccgguaauugcaaaagcagccagagaagcaagagcgguaguuaaagauaaaggagcaaaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugugcgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuuauugucauucccaaucaaaauuuauuuagaauugcuaacgagaaaacuacauuugcugacgcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaugaucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagauggguaaggcaaugauugguacuggagaagcagaaggagaagauagggcaauuagugcugcagaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaauauugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaauagagugcgugaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucaggcgauggagggaagaguuagaguuucuguucuugcaacuggcauugauagcuguaacgacaauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuauaaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag 232 AV218217ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccauaccacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccccugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggguggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu

indicates data missing or illegible when filed

Thus, the transcripts identified in this Example, the proteins theyencode, and the pathways in which the proteins participate contributesignificantly to HF stem cell activation. Accordingly, anagen can beinduced by activation of these transcripts, proteins, and pathways.

Example 9 Molecular Pathways Activated During Induction of EpidermalCells to Differentiate into HF Stem Cells

The gene expression pattern of HF stem cells was analyzed as describedin Example 8 and compared to non-bulge basal keratinocytes. 157 geneswere differentially expressed in the HF stem cells, as assessed bymicroarray analysis and quantitative polymerase chain reaction (qPCR). Agroup of selected genes with increased expression in HF stem cells isdepicted in Table 4. A group of selected genes with decreased expressionin HF stem cells is depicted in Table 5.

TABLE 4 Genes up-regulated in HF stem cells. Numbers in parentheses arethe fold increase as determined by quantitative real time PCR. GeneName/ Protein name/ Fold GenBk Acces #. Incr. Sequence SEQ ID No. Cellsurface proteins Cd34/Cd34 43uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauacacccaa 233 antigen (189)uccucucaucucuggaaaguuuuguuccuagccaucauuaagaucaggacccc AI847784,uguucuccccuuaaccccaggagaggaagcuuauagucuuuguagauauucug AI173145aaccucugaucacaaaggguuauaaaauagugaagggguuuggacuaggaaaggcacagacugaaaggaaucugccaggggacugaggccacagcucccccaggagucagaggaagggggaagucacguauuuuauagaaggccaagggccucagagcaagaguauuccuuugaagagcuca Calcium-related S100a4/S100A4 35ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggccugug 234 (mts) (144)gucuggucgccagcaaccugaaucucaaaccuggggaaugucucaaaguucgg X15986ggagagguggccucggacgccaagagcuuugugcugaaccugggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaaugcccauggagacgccaacaccauuguguguaacaccaaggaagaugggaccuggggaaccgaacaccgggaaccugccuuccccuuccagcccgggagcaucacagaggugucaucaccuuugaccaggcugaccugaccaucaagcugccagacggacaugaauucaaguuccccaaccgccucaacauggaggccaucaacuacauggcggcggauggagacuucaagauuaagugcguggccuuugagugaagccagccagccuguagcccucaauaa aggcagcugccucugcuTranscription Factors and related genes Id2 helix- 11gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauucucua 235 loop-helix(25) aacugcguuucucucccaaucuuuugcaggcauuuggggacuuuuucuuuucu proteinuuuuacuuucucuuuuucuuuugcacaagaagaagucuacaagaucuuuuaag AF077861acuuuuguuaucagccauuucaccaggagaacacguugaauggaccuuuuuaaaaagaaagcggaaggaaaacuaaggaugaucgucuugcccaggugucuuguucuccggccuggacugugauaccguuauuuaugagagacuuucagugcccuuucuacaguuggaagguuuucuuuauauacuauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaaucacaaggaauugcccaauguaagcagacuuugccuuuucacaaagguggagcgugaauuccaggaggacccaguauucgguuacuuaaaugaagucuucggucagaaauggccuuuuugacacgagccuacugaaugcuguguauauauuuauauauaaauauauauauauugagugaaccuuguggacucuuuaauuagaguuuucuuguauaguggcagaaauaaccuauuucugcauuaaaauguaaugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaaacuuaacccuuuuauacaaaauaaaucaaguguguuuauugaauguugauugcuugcuuuauuucagacaaccagugcuuugauuuuuuuuuaugcuauguuauaacugaacccaaauaaauaccaguucaaauuuauguagacuguauuaagauuauaauaaaaug ugucugacaucaa Id44 cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccgucgggc 236 AJ001972(12) ugcggcggcggggagcuggcgcuacgcugccuggcggagcacggccacagccuggguggcucggcagccgccgccgccgcugcggcggccgcgcgcugcaaggcggccgaggcggcggccgaugagccggcgcugugccugcagugcgauaugaacgacugcuacagucgccugcggaggcucgugccuaccaucccgcccaacaagaaagucagcaaaguggagauccugcagcacguuaucgacuacauccuggaccugcagcuggcgcuggagacucacccugcuuugcugagacagccgccaccgcccgcgccaccucuccacccggccggggcuuguccggucgcgccgccgcggaccccacucaccgcgcucaacacugacccggugagaagccuuggcgggcacccugggcaucgcgggaaagguggcggggcggcgagauacggguggucuugcuccucucagggaaugacagccgcuucucccgucuccaccgagagccgccugcugggcuuggugauccacuggucccugagccgagggcgguugggcuuggagcccugcgucuccggagugucccuugcaucacaggaggcuuccccagcuucgggcucggguggggacucugcucaugcgcacucuaaccgcuuuuccccuugguguuggguugcuguuccaggaugcgcacucuaaccgcuuuuccccuugguguuggguugcuguuccaggccggcgccgugaacaagcagggugacagcauucucugccgcu Peg3/ 12 Sequence below. 237Paternally expressed gene 3 zinc finger protein AF038939acuagucucgaccauguaccaucacggagacgacaccaacagugacaugaacagugacgacgacaugagccgaagugggagagaaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggagcgcaggggcagaagcagagauguggagccucgagaccgcuggccauacaccaggaaucccagaagcaggcugccucaacgggaucuuucucuuccugugaugucaagaccacauuuuggacuggacagagaugaugacagacguuccauggauuaugagucucgaucccaggaugccgagucauaccagaauguuguggaacucaaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgcugggaguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaagagagcugccuacccaagcaccagccgaggucucaaacccaugccugaggccaaaaagccaucccacaggcgugggaucugugaggacgagucuuucucauggagugauaauggaaaaauucaucaaggauguggcucgcaaccccaaauccggaagagcaagggagcugaacgagcguccuccuccaagguuccccaggccuaaugauaacuggaaggacaguuccuccagcagaagagagucagugauccaggagagggguuaugaagggagcgcauuuaggggcggcuuccgguucaacgcagaccuggcuuccagaagcagagcucuagaaaggaagaggcguuaccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugaggaagaagccuuuugaguguggugcugagaugagacaggcuaugagcaugggcaaccugaacagcccuuccuucucugagucgcagucaaucgauuuuggggccaacccauacgugugugaugagugcgggaggcaguucagugucaucucugaguuuguugagcaccagaucaugcacacuagggagaaccucuaugaauauggagaguccuuuauucauagcguggcugucaaugaggugcaaagaagucaggguggggggaaacgcuuugaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgccaaauccaugcuagagaauaucuugcagaauguagagaucaggaggaugaggagaccaucaugccuagcccgaccuuuagugagcugcagaagauguauggcaaagauaaguucuaugagugcaaggugugcaaggagaccuuucugcacaguuccgcccugauugagcaccagaaauccaugguagaggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcacgugcacgagagcagcgugagcgcgaacgugaacgggagcgugagcgugagcuuggggaacccuuucugaccuguccaaacuucaaugaguuucggaagauguacaggaaagacaaaaucuaugagugcaaaguguguggggagagcuuucuucaucucucaucccugagggagcaucagaaaauccauacuagaggaaacccauuugaaaauaagagcaggaugugcgaggagaccuuugucccuagucagucucuccgacggcgccagaaaacuuacagagagaagcuguucgacuuuaacaaugccagggaugcacugaugggaaacucagacuccagcgagcaucagaaaaaccguucccgaaggaacuucuuugagggcagaggauuugagaaacccuucguugaaucucagaagagucauacuauaacaagaccaccugaaaacaaagacgaugacaagccguucacaaucagugucaacccuaaugacaagcugaaacuccccaucauggaaaauggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgcagaagcucagaagagucaugguggacugggguucaguaaaccaagaccaguggcagagucuagcacccagagcucaagcagcauuuacuaccccagagcacacucuggaggcaacaccuaugaaggaaaagaauacaaggacucuaucauccauagcuugccagcuccucgaccucugaaacgucauagagcaaaugaccauauucaaugugaugaggggggagaauccuccauuuauaucccagauauuauuaauaagggaaggaagauuccugccagagaagaugcuuaugaaggaaguagcagcagcaacuaccacacaccaaauguaucccgugcugagccuccaagucuuucuggagagucccaugacucuaagcaggaugucacguuuucaguucccagcucaaguguucgugaacaccagaaagcucgugccaaaaagaaguacauugagcccaggaacaacgagaccucuguuauccacucccuaccuuuuggugaguugcuugcaggucaccguagggcaaaguucuuugagugucaggaaugcggggaggccuuugcucguaggucugagcucauugagcaccagaagauucaugauagagaaagaccuucuggaagccgacauuaugagcgcucugucauccgcagccuugcgcccagugacccucagaccaguuaugcccaagaacguuucauccaagaacaagugcguaaauucagagcguuuggacaacgcucaacuaccagcaacaaccucaguguacagaaaaucuaugcccaagagacauuuaaugccgaggagccccaugauaaagaaacucauggucaaaaaauucaugacaaagagccauaugguaaggagcccaguggcaaggagccccauggugaugagccccaggacaaagaaccccuuguucaggagaugcgcagugaagagccccaugaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccacggugaugagccccauggccaggagccccacggugaugagccccaugacaaggaacccauugaucaggagaugcgcagugaagagccccacagugaagagucucauggugaugagccccauggugaagagucccauggccaggagaaaguugaagaugcuaccauucaggccucaguuucugaagagcaucagaaagaugacgcuggugaugcaaucuaugaaugccaggacugugggcugggcuuuacugaucucaaugaccucacaagccaccaggacacccauagcagaaaggcucugguugacagucgugaauaugcacauucugaaguucaugcccacuccgucagcgaauuugagaaaaaaugcucuggagagaaacuauaugaauguccaaaauguggggagucuuucauucacagcucguuacuuuucgagcaccagagaguucacgaacaagaccagcuguauuccguaaaggccuguuaugacgcuuucaucgcucuguugcccguuagaccaaggagaaauugcacuguugaaaggaauccugccguuucugggucagccauucgaugccgucaguguggacaaggcuucauucacaguucugcccuaaaugagcacaugagacagcacagagauaaugaaauaauggaacagagugagcuuucagaugagauuuucauucaaggccuagcccucacugaguaucaggggagugaaacagaagagaagcuuuucgagugcacaaucuguggggaaugcuucuucacugccaaacagcucggggaccaccacaccaaaguucacaaggaugagcccuaugaguaugggcccuccuacacccaugccuccuuucucaccgagccccucaggaagcacaucccacuguacgaaugcaaagauugcggccaguccuuccuagacgacacugucaucgcugagcgcaugguguuucauccugagcgagaaggugggucagaaauaguagcugccacugcccaagaggucgaagccaauguccucaucccacaagaaguacugcgaauccaggggucaaaugcagaagcugcugagcccgaaguggaggcugcagagcccgagguggaggcugcagagccugagguggaggcugcagagccuauuggagaggcugaagggccagauggagaagcugcugagccugauggcgaggcugagcagcccaauggagaggcugaacagccaaacggugaugcugacgagccagacggagccgggaucgaagacccagaagagagagcugacgagccugaggaagacgucgaagagccagagggagaugcagaugagcccgauggugcagacauugaagacccagaagaggaaggagaagaucaagagauugagguugaagaaccauacuacaacugucaugaaugcgcagaaacguucgcuuccagcucagccuuuggcgagcaucugaaaagucacgccagugugaucaucuucgagccggccaaugcuccuggagagugcucuggcuacauugaacgggccagcaccagugcagguggugcggagcaggcagacgacaaguacuucaaaugugaugugugcgggcaacucuucaacgaccgccucucccuugccagacaccagaauucucacacugguugaguaaccaggcugaagaaaagaagagcaaagccaaaccuucuucccagaaccagacccuuaauaaaucacaaagagagccuaaaccaacccauaaugucuauaagaaauucaccuuccuguauacauaccggacuucacaucaaagacuuucacucucaucacagacugaaaaaagaaaagacauugaacgcagggacucuuucaguuuuagcuguucccuauggaacaucaguguauauuugggaaagcuagagugaacaucuacaucuuccauuucaucuaaguaacuagauugagggaaaccuagugacaauuccagaccacagagguugccccagucgacuguaaaugauaccccuuucauacccuauacauaaugauuccugccauguauauaaaugagcaaaucagugauacauauauuuggauuuagugugcuauagaauuuacaguuuacucuacagagcuaccuagccugguacucugauuuuuucccugaggaggaagagagcaacaauuuagcauauauuuguaaguauuguccaugcagaagcuuuucugugcaucauuugaaccccauuaguauccuuuccaguaauggaguguucuguccccuaccucuuagauaguccugugaaggugugggugugaaagaucgugugucuuugaauccuggcuguguggaaacaggcauuuuagcuucuacagccauuuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauauggauuugucucugugacccaaauacaacccaucccuacauuuauauaccuuacagugguuuucuugc Growth Factors, Receptors andRelated genes Fz2/ 9uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauaggaguccg 238 Frizzled 2(17) uagggugcacccuccccccuccugagugaaggagggcacggugcaguccggac AW123618cugggagaggggaaagcccggcaggcaggcgagaccgcuucacacaguggucucgccaugccggcuguuggugagacgaguguagaacuuccuccacgagugcagugucuugccggaccagauccagaagcccgacgugaugcccacgaugagcgucaugagguauuugaucauguagacugugaagucgggcgacaugcggggcguguagugggccgggcaggggauggcuaggcucuugcagugcuggcuuacccaggagcgcucccagugcucgcggaaggccugcucauagaaguagcaggcgaug Dkk3/ 6 Sequence below.239 Dickkopf3 (22) AJ243964ggccgcgucgacgccucuccagcugcucuguggcagcccagcuaccggucgugaccagauccagcuugcagcucagcuuuguucauucgaauugggcggcggccagcgcggaacaaacaugcagcggcucggggguauuuugcuguguacacugcuggcggcggcgguccccacugcuccugcuccuuccccgacggucacuuggacuccggcggagccgggcccagcucucaacuacccucaggaggaagcuacgcucaaugagauguuucgagagguggaggagcugauggaagacacucagcacaaacugcgcagugccguggaggagauggaggcggaagaagcagcugcuaaaacguccucugaggugaaccuggcaagcuuaccucccaacuaucacaaugagaccagcacggagaccagggugggaaauaacacaguccaugugcaccaggaaguucacaagauaaccaacaaccagaguggacagguggucuuuuucugagacagucauuacaucuguaggggaugaagaaggcaagaggagccaugaauguaucauugaugaagacugugggcccaccagguacugccaguucuccagcuucaaguacaccugccagccaugccgggaccagcagaugcuaugcacccgagacagugagugcuguggagaccagcugugugccuggggucacugcacccaaaaggccaccaaagguggcaaugggaccaucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggccugcuguuccccgugugcacaccccugcccguggagggagagcucugccaugaccccaccagccagcugcuggaucucaucaccugggaacuggagccugaaggagcuuuggaccgaugccccugcgccaguggccuccuaugccagccacacagccacagucugguguacaugugcaagccagccuucgugggcagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaagauguuggcuucauaggggaagugcgccaggagcuggaagaccuggagcggagccuagcccaggagauggcauuugaggggccugccccuguggagucacuaggcggagaggaggagauuuaggcccagacccagcugagucacugguagaugugcaauagaaauggcuaauuuauuuucccaggaguguccccaaguguggaauggccgcagcuccuucccaguagcuuuuccucuggcuugacaagguacagugcaguacauuucuuccagccgcccugcuucucuggcuugggaaagacaggcauggcggguaagggcagcggugagucgucccucgcuguugcuagaaacgcugucuuguucuucauggauggaagauuuguuugaagggagaggaugggaaggggugaagucugcucaugauggauuugggggauacagggaggaggaugccugccuugcagacguggacuuggcaaaauguaaccuuugcuuuugucuugcgccgcucccaugggcugaggcaguggcuacacaagagcuaugcugcucuguggccucccacauauucaucccuguguuucagcuccuaccucacugucagcacagcccuucauagccacgcccccucuugcucaccacagccuaggaggggaccagaggggacuucucucagagccccaugcucucucucucaaccccauaccagccucugugccagcgacagcccuuccaaauggagggagugaaauccuuugguuuuauuauuuucuccuucaaggcacgccugccacuaaggucaggcugacuugcaugucccucaacguucguagcagugugguggacacugucuuccaccgacugcuucaauaccucugaaagccagugcucggagugcaguucguguaaauuaauuugcaggaaguauacuuggcuaauuguagggcuaggauugugaaugaaauuugcaaagucgcuuagcaacaauggaaagccuuucucagucacaccgagaagucacaaccaagccagguuguguagaguacagcugugacauacagacagaagaaggcugggcuggaugucaggccucagaugacgguuucaggugccaggaacuauuaccauucuguaucuauccagaguuauuaaaauugaaaguugcacacauuuguauaagcaugccuuucuccugaguuuuaaauuauauguauacacaaacauguggcccucaaagaucaugcacaaaccacuacucuuugcuaauucuuggacuuuucucuuugauuuucaauaaauacaaauccccuucaugcaaaaaaaaaaaaaaaSfrp1/ 6 Sequence below. 240 Secreted frizzled-related protein 1 U88566gcacgagcagcccgcagcccgccgcgccugugcgagccgggacagcacucggccccgcgcgcuccccgccccgcgccagccccgccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgcgagccgacgggccccgacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgugggcagccccgacgucgccgagcaacaugggcgucgggcgcagcgcgcggggucgcggcggggccgccucgggagugcugcuggcguuggccgccgcucugcuggccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucagagcgggcgcuucuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugccacaacgugggcuacaagaagauggugcugcccaaccugcuggagcacgagaccauggcagaggugaagcagcaggccagcagcugggugccgcugcucaacaagaacugccacaugggcacccaggucuuccucuguucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcuggcucugcgaggccgugcgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugugacaaguuccccgagggcgacgucugcaucgccaugaccccgcccaauaccacggaagccucuaagccccaagguacaaccguguguccuccaugcgacaacgaguugaagucagaggccaucauugaacaucucugugcaagcgaguuugcacugaggaugaaaaucaaagaagugaagaaggaaaacggugacaagaagauuguccccaagaagaagaaacccuugaagcuggggcccaucaagaagaaggagcugaaggcgcuugugcuguuccugaagaacggugccgacugucccugccaccagcuggacaaccucagccacaacuuucucaucaugggccgcaaggugaagagccaguaccugcugacagccauucacaagugggacaagaaaaacaaggaguucaaaaacuucaugaagagaaugaaaaaccacgagugucccaccuuccagucuguuuuuaagugauacuggggcggacuggggaaggggaguguggcuuggggugagggugggggcgcguggaugacccuggcucuunggggcucacauauugcucucacccauacaguuguggcuuuugcauugcaccuggcucuguuccuacagcgaacccucucccuunccuccauagccacauccagcuaaggccacggccuuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugcaaaaggagaggcagaauccuuucacugagccuggggcacaaaaaacagaaaauguunnccgguuuggaaaaacaaaacaaaacggauuguaaagaacugcagacggacagcugcucagcucaacguuguucgggacaucauuaccaauugcuuguggagucuaagccucuacagguagaagagucugaucauugccaagccaggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauagaccaucgccaccuucaaaacacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaaguagccaggguaucccaguauagaacgggauagcuaaggguuugggugggaggccacugcuacucuaccuucagcuuuugaacuggccaccuuugauaggaaacugaggucucagauggacacuucuaccaguccaucgggauacaaggaugccaggcaagggucugcuuuugucugaaggagguacgugggcaugaagagacaugaggcauuucaggcugagaagcaacagcuacuaguuuucaacaauagaguggaagaaaugagcaaagguagaaaugucaagcaggucacaagucagggugauugggggaauccugugccaacagccucacuuuguaauuccaucugucacuuucaaaagaacagcagcauaagacagggauaaaagcccacauacccuccaaggcuugaguaaaaguccacacucagcauuucaaagacuaacgucguugacugcccaaggcugcccucuuaauacaccgccuaugcaugugcuguggaaggcaacucugugcaugugcuguggaggagaugggccucauggcugugcuggcugcccggaaucaguauagcguggaaggagacaguauccauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaauucagacaaauuuaaaaucgcugccugccugagcccuccaccuuuacuuuugcauucuccggucauauucuuuugaggcuaaagugcccuauccgaggagaugguuucaaaggcuaacuaaucugcagcuuuucccaagugcccagagguauuucucaaaguugguaugcuuaauaagugauguaaauauuccaguucucuuaggcagccuuacuccuguugucccug Dab2/Disabled 15 Sequence below. 241 homolog 2U18869aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcugcagccuugaggcuucgggcgcgggggaagucaugcuggcuccacagaagcacuagcuaguccguguacuuuguggguucuguccuuuugagaccugcccgccggggauuggcugguaucagugacugucuacugcuggauuuucugcuugccuucccgucaugucuaacgaaguagaaacaagcacaaccaauggccagccugaccaacaggcugccccgaaagcgccaucaaagaaggagaagaagaaagguucugaaaagacagacgaguacuuguuggccagguucaaaggugaugguguuaaauacaaggccaagcuaaucgguauugaugaugugccugaugcucgaggagacaaaaugagucaggauucuaugaugaaacucaagggaauggcagcagcuggucgcucucagggacaacacaagcaaagaaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaacauccaguaaauaagauuuccuucauugcucgugaugugacagacaacagagacauuugguuauguguguggaggugaaggccagcaucaauuuuuugcuauaaaaacagggcaacaggcugagccauuagucgucgaucuuaaagaccuuuuucaaguuaucuauaauguaaagaaaaaggaagaagauaagaaaaagguugaagaagccaacaaagcagaagagaauggaagugaggcccuaaugacccuugaugaucaagcuaacaaauugaagcuggguguugaccagauggauuuguuuggggacaugucuacaccuccugaccuaaauaguccaacagaaagcaaagauauccuguuaguggaucuaaacucugaaaucgacaccaaucagaacucuuuaagagaaaauccauucuuaacaaauggagucaccuccuguucucucccucgaccaaagccucaggcauccuucuugccugagaacgccuuuucugccaaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcacagccagaccaaucggcacccucuucguucgauucucucacaucuccagaucagaagaaagcgagucugaguagcucgucuacuccacagaguaaagggccccugaacgucgauacugauuacuuuggucagcaauuugaccagcucucuaaccggacuggcaaaccggaagcucagggaggcccguggcccuacccaaguucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagagaacagaacggcuuccauaucaaaucuuccccgaacccuuuugugggaagcccucccaaaggacuaucgguaccgaauggcguaaagcaggacuuggaaaguucuguccaguccucagcacugacuccauagccauuaucccaccuccacaaaguaccaaaccaggaagaggcagaaggacugcuaagucuucagcaaacgacuugccugcuucagacaucuuugccucagaaccuccaggccagaugucccccacaggacaaccugcagucccgcagucgaacuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccuuguaggucuagguacggucccaguaacacccccccaagcaggacccuggacgccuguugucuacaguccuucgacaacuguggucccaggagccauaauaaguggccagccucccaguuuucgccagccacucguuuuugguacaaccccagcaguacaagucuggaaucagucuccaucauuugcaaccccagcuuccccuccaccccccacaguuugguguccuaccacaucuguggcgcccaacgcuuggucauccacaagcccucuggggaauccuuuucagaguaauaauaucuuuccaccucccaccauguccacucaguccucuccucagccuaugauguccucuguucuggccacaccgccucaaccaccuccccgaaauggcccacuaaaggacauucccagugacgcuuucacuggcuuagacccccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcggcagccaccucuuguucccucaaggaagggggagacgccucccucugggacuucaagcgccuucuccaguuacuucaacaauaaaguuggcauuccucaggagcauguagaccaugaugauuuugaugccaaucaacuguugaacaagauuaaugaaccaccaaagccagccccgagacaagguguccucuuggguaccaagucugcugacaauucacucgagaacccuuucuccaaaggguucagcucaucaaaccccucugugguuucucagccugcaucuucugauccccacaggagcccuuucggaaauccuuuugccuagcuucugaaguuguaaugaugacuauccagaugagcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacauguugaccucuguccucgcuccagcuuugacguauuaucuguuacccuauuuguuuuggccucuuguacuuguaaaaugccuuucauuuuccugucuaggcuaaagcuaaacuuaaacuauggcuuuacguaaauuaagcuccuaaacucucuagcuccaauauaaaugaaguagcuucccuaucaaaucccugucuguugugcccccuugaaacuuccagaauauucuccauucuacccuccauuugggaggagcggcuaccuuuacccuuaauaucacacugccuugagucaauguccaaauacucauagcucucaaagucauuugggguuccuggugugcggccuaaaccuaaagcauccuauuaauagggaaguaagacaccuugcuuccuauguccacucagggagaauuuuauuuaauaaaaugaaagcaagacuaacuucucaaauccacccaaggaccauuuugagauggucguuucucagcuaacugcaccauuuaccaauccugccccaaguggugcuuacauuugacuugaagaagagaaagagcuaacucaaaacacaaggcauuauucaaagcuaauaaaacaauuucucccuggggccccacauuguuuucauuccagauacguugcagcuguuugacccugaugacauuaugcccuacauuuuccuugaagauccugauuuuauuucaugugauuuuuguuucucaauaaagaugauuauugugugcacggaauuc Cktsf1b1/ 12Augaaucgcaccgcauacacugugggagcguugcuucuccuccuggggacccu 242 Gremlin, (12)acugccaacagcugaggggaaaaagaaagguucccaaggagccauuccgccuc Cysteine knotcugacaaggcucagcacaaugacucugagcagacccaguccccaccacaaccu superfamily 1,ggcuccaggacccgggggcggggccaggggcggggcaccgccaugccuggaga BMP antagonist 1ggaggugcuugaguccagccaagaggcccugcacgugacagagcgcaaguauc AF045801ugaagcgagauuggugcaaaacucagccccugaagcagaccauccacgaggagggcugcaacagccgcacuaucaucaaccgcuucuguuauggccagugcaacuccuucuacauccccaggcacauccgaaaggaggaaggguccuuucagucuugcuccuucugcaagcccaagaaguucaccaccaugauggucacacucaacuguccugagcuacagccacccaccaagaagaaaagggucacacgcgugaagcagugccguugcauauccaucgacuuggauuaa Fgfr1/Fibroblast 10 Sequence below. 243 growthfactor receptor 1 U22324guggaauauccauggagguacggagccuuguuaccaaccuuuaaccgcagaacugggauguggggcuggaagugccuccucuucugggcugugcuggucacagccacucucugcacugccaggccagccccaaccuugcccgaacaagcucagcccuggggagucccuguggaaguggagucucuccugguccacccuggcgaccugcuacagcuucgcugucggcuucgcgaugaugugcagagcaucaacuggcugcgggauggggugcagcugguggagagcaaccguacccgcaucacaggggaggagguggaggugcgggacuccauccccgcugacucuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccgucaaugucucagaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggacaacaccaaaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugcaugcggugcccgcugccaagacggugaaguucaagugcccgucgagugggacacccaaccccacucugcgcugguugaaaaauggcaaagaguuuaagccugaccaccgaauuggaggcuacaagguucgcuaugccaccuggagcaucauaauggauucuguggugccuucugacaagggcaacuacaccugcaucguggagaaugaguaugggagcaucaaccacaccuaccagcuugacgucguggaacgaucuccgcaccgacccauccuucaggcagggcugccugccaacgagacaguggcccugggcagcaauguggaguucauguguaagguguacagcgauccgcagccucacauucaguggcugaagcacaucgaggugaacgggaguaagaucgggccagacaacuugccguauguccagauccugaagacugcuggaguuaauaccaccgacaaggaaauggaggugcuucaucuacggaaugucuccuuugaggaugcgggggaguauacgugcuuggcggguaacucuaucggacucucccaucacucugcaugguugaccguucuggaagcccuggaagagagaccagcugugaugaccucaccgcucuaccuggagaucauuaucuacugcaccggggccuuccugaucuccugcauguugggcucugucaucaucuauaagaugaagagcggcaccaagaagagcgacuuccauagccagauggcugugcacaagcuggccaagagcaucccucugcgcagacagguaacagugucagcugacuccagugcauccaugaacucugggguucuccugguucggcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauaugagcucccugaggauccccgcugggagcugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgggcaggugguguuggcugaggccaucgggcuggauaaggacaaacccaaccgugugaccaaaguggccgugaagauguugaaguccgacgcaacggagaaggaccugucggaucugaucucggagauggagaugaugaaaaugauugggaagcacaagaauaucaucaaccuucugggagcgugcacacaggaugguccucuuuaugucauuguggaguacgccuccaaaggcaaccuccgggaguaucuacaggcccggaggccuccugggcuggaguacugcuauaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauccugugccuaucagguggcucggggcauggaguaucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacguccuggugaccgaggauaacguaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacuacaagaaaaccaccaacggccggcugccugugaaguggauggccccugaggcguuguuugaccggaucuacacacaccagagcgauguguggucuuuuggagugcucuugugggagaucuucacucuggguggcuccccauaccccggugugccuguggaggaacuuuucaagcugcugaaggagggucaucgaauggacaagcccaguaacuguaccaaugagcuguacaugaugaugcgggacugcuggcaugcagugcccucucagagaccuacguucaagcaguugguggaagaccuggaccgcauuguggccuugaccuccagccaggaguaucuggaccuguccauaccgcuggaccaguacucacccagcuuucccgacacaggagcuccaccugcuccucaggggaggacucugucuucucucaugagccguuaccugaggagcccugucugccucgacaccccacccagcuugccaacaguggacucaaacggcgcugaFgf1/Fibroblast 10 auggcugaaggggagaucacaaccuucgcagcccugaccgagagguucaaccu244 growth factor 1gccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaacgggggcc M30641acuucuugaggauccuuccugauggcaccguggaugggacaagggacaggagcgaccagcacauucagcugcagcucagugcggaaagugcgggcgaaguguauauaaaggguacggagaccggccaguacuuggccauggacaccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugucuguuccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaagaagcaugcggagaagaacugguuugugggccucaagaagaacgggagcuguaagcgcgguccucggacucacuauggccagaaagccaucuuguuucugccccucccggugucuucugacuag Gpr49/G protein- 63Sequence below. 245 coupled receptor (377) 49 FEX AF110818auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcucaccgggaccagaugcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcucaggguggacugcucggaccuggggcucucggagcugcccuccaaccucagcgucuucaccuccuaccuggaccucaguaugaacaacaucagucagcuacccgccagucuccuacaucgccucugcuuccuagaagaguuacgucuugcuggaaaugcuuugacacacauucccaagggagcguucacgggccuucacagccucaaagugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacagaauuugagaagccuucaaucccugcgccuagaugccaaccacaucagcuacgugccacccagcuguuucagcggccugcacucccugaggcaccuguggcuagaugacaaugcucucacagacgucccuguccaggcuuucagaaguuuaucagcccugcaagccaugaccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagccucgugguucugcaucuccauaauaauagaauccacucccugggaaagaaaugcuuugauggacuccacagccuggagacuuuagauuuaaauuauaauaaccuugaugaauuccccacugcaaucaagacacucuccaaccuuaaggaacuaggauuccacagcaacaacaucaggucaauaccggagcgagcguucguaggcaacccuucucuuaucacaauacacuucuaugacaaccccauccaauuuguuggaguaucugcuuuucagcauuugccugaacuaagaacacugacuuugaauggugccucgcacauuacugaauuuccucacuugacaggaacugccacccuggagagucugacuuuaacuggagcaaagaucucaucucuuccccaggccgucugugaucaguuaccuaaucuccaagugcuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugccaaaaacuucagaaaauugaccugaggcauaacgagaucuaugaaauuaagggcagcacuuuucagcaguuguuuaaccuccgaucucugaacuuagcauggaauaaaauugcuaucauucaccccaaugcguuuucuacguugccgucucuaauaaaguuggaccuaucauccaaucuccugucguccuucccuguacuggguuacaugguuuaacucacuuaaaauuaacagggaaccgagccuuacagagccugauaccaucugcaaacuucccagagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggugugagaaugucuauaaaauuucuaaccaauggaauaaagacgacggcaacaguguggacgaccuucauaagaaagacgcuggguuauuucaaguucaagaugagcgggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcccuucacucggugcagugcucgccuuccccaggucccuucaagcccugugagcaccuauuugguagcuggcugauccgaaucgggguguggaccacggcaguacugacgcuuuccugcaangccuugguggcuuugaccguguucagaacuccccuguacaucucuuccauaaagcugcuaauugggguaaucgcgguaguggacauucucaugggggncuccagugcugugcuggcugccguggaugcauucacuuuuggccguuuugcucagcacggugcguggugggaagacggaaucggcugccaaaucguuggcuuccuguccauuuuugcuuccgaaucgucgaucuuccugcucacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagugaaagcuccccuuuuuagccngagagcgauguuuugcuauguguccuguuggcccugaccaungccacaauccccuugcuaggaggcaguaaguacaaugccucuccccucugccugcccuugcccuuuggggagcccagaccacgggcuacaugguggcucucguguugcucaacucucucuguuuccucauaaugaccauugccuacacaaagcucuacugcaguuuggagaaaggagagcuggagaaucuuugggauuguucgauggugaagcacauugcucuguugcucuucgccaacugcauccuuuacugccccguggcuuucuuauccuucuccucuuugcuaaaccucaccuuuaucaguccugacgucauuaaauuuauacuucucgugaucgucccacuuccuuccugucucaacccacuucucuacauugucuucaauccccauuuuaaggaggauaugggcagccugggaaagcauacccguuucuggaugagaucaaaacacgcgagucugcuguccauuaacucggacgaugnugagaaacgguccugugagucaacccaagccunaguauccuuuacccacgccagcauagccuaugacuugccuuccacuuccggggcaucaccagcuuaccccaugacugaaagcugucaucucucuucaguugcauuugucccaugucucuagugacuaugagagaggaacguuuuuaagaguuggaaaccugaaaagugauuucuaucagagcaguagcuaagaaaagcugagcuaaaaaccuaccuuaaaacccaagcaaacaucucnaaauugguguggaaacaguggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuuguucagcuaagaaggaaagccaucaagucacuuaggugaacccagaugagaaaagcagccugaaaugcucuucgcauuguagucucuucugacucaccagcauagucucccauagugagaagacncguuggaugacucaauggguguauuuaaauccacaaauuccuuguuuaaaagguuagaguuuuaagaaaaaaaaaaaaaaaaa Igfbp5/ 37 Sequencebelow. 246 insulin-like growth factor binding protein 5 L12447uuuuuuuucuucaccuccucccuuuucaaggccuccaagcuaauuauuucuguugcuuuggagugagcaauucugugguucucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuccgcucacucugcgugcaccuggcgcgccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgcaauugggacuugcgugcaggcaccugaauccuccuugccucauanuuugcaaguguuugggggagagcaccugcucuaccugcaagagauuuaaaaggaaaaaaaucuccaggcucccucuuucuccacacacucucgcucuccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcgugguccuccugcugcuggccgccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcucuguccauguguccccccagcccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugcgcccuggcggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccucccccggcaggaugaggagaagccgcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuacggcgagcaaaccaagauagagagagacucucgggaacacgaggaacccaccaccuccgagauggcugaagagaccuacucccccaaggucuuccggcccaagcacacucgcauuuccgagcugaaggcugaggcugugaagaaggaccgcagaaagaagcugacccaguccaaguuuguggggggugcagagaacacugcccaccccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcagacacauggaagcuucccuccaggaguucaaagccagcccacgcauggugccccgugcuguguaccugcccaacugugaccgcaaaggauucuacaagagaaagcaguguaagcccucccguggccgcaaacguggcaucugcugguguguggacaaguacggaaugaagcugccgggcauggaguacguggauggggacuuucagugccacgccuucgacagcaguaacguugagugacgcguccccucccuuccucccccuauccuacccccccagccccaacuccagccagcgccucccuccaccccaggacgucacuacauuucaucucauuuaggggaaauauauauacauauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaggagacacuccccaccaugaccccggaaauguauuccuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaagagggagcgagagauggaaagaaagcaaagcguuggaauagaggaaaagagggaaggacagauaggauuagagagagaagagagaaacagcaaggcagaaaggacuccacaaccaaggcugaaucugcccuuuugcuuucagcucuagccuggggucagaaaaaguguggcauucagugacacccaguuuagauuggucaaggggagaaaagaaacaaggugugucagugccucucgggucuguccccuccugcagccagcaguguggauggcuagaccccucacccuccucuccucuuacccaagugcagggugauuucauccccaaauuuacaaagacuaaaaugcauuccaucccucugaaaauaaacaaaagugagugauugaagauagguuuucccccagcagacaagugaacucagaaugugugcaaauuuuacucuuguuaaagauuuuuuuaagaagucaguacgcacccccaacacuggaaagacuugauucuccagggugacaagcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccggcagccucuguggaggaggaugagagguggagaaaaccaaggggcuuguacucacccacaagacuccauguagacuuuauaggcauauaaaucuauuuucuuuaccuuuuuuucccuuucccuuucuuucgaaguuuugcauuaccucuuuaaaguaguuuuuuuuaggacacugaagaucuuccucauucugggaaaaauccauauuucacaaauacaacccagaacgccagcuuggccugcguccaggcagccuuucucgugagcuacaaguguggcucuuuuguggggcaccgauuuggaucuucucaugauuccaaacguguguugaagugaauccaccaagccagguaacugccagcacccaagggugcaucaagugcauagcccaggucaccccauuucagccuuccaacccgcagaaaguaacugucucacaccacaccacauaaaccugccagauccaucuguaacccacuggccugcccagaccuuuuuuucccaucugcauuuuuuuuuuugaacugcauuuugaaagccucccucagaugccaggcugacagaucagagagaaacuaacaugagagaugacagaggaggaggaaguggagggugggggcagagacuuccacagagagacauagaagauggagcagaggucuggggguggggaggacaagaaagagacagagagaggaaaauaccaauagaauuuuccuuggugucucccaucuaaucaacucucugagauuugagaggaaaaagaaggcaggggaagaacuugagguagaaaugaggucaguucaagucacagggcccagaugguggguaacugaggcaggauccagacuugagacacacgguuggaaacaaggcugguuagccugacuggguauugaagggugaagaggaugccuuggaaagacagcacaacuucaguucaacuucaggcccccaaggaggaacugaggccaaagaauccuucaagugcuucaugagucuccucugcccgacucaaacauccuucccugugauggaggaugguagaaagcccaggacaacucaggcccggaucuucacgacuguugucauuugccagccugauuuugauccaagagaagcaucucauugcccacuggcuucuucaacaaagaggugcuuaacaaaaggcucaggacuaucuuugaagacugaagauaaccuuccaggagaggagacucggacauugguacaggaggccccuuuuggcgggggacacagcucuuugcgcucucuugauggcauggcauaguagaggcccccuccaacccggaacauggagcaacacaaagggagagcaaagaaacugacgugcgucgacucauaggacauggguggcugcgggcacagaaagggaugccuccuguugccuggacaggacaguuggcugggaaggaaagagaaaauugaucuucauaagacaaagggccugaugggauggcaauagaaggacuuaccagaccugcagggucaguauacccaucaccccgcacaacauccccagcccccaacucaaacuucaauauaucuuaggccaguauccuagaccuaagucucuccuuucugccauuauuucuccgcaucuugagcagucaucugacugagauuugccaaguggauacugggguaccacugccccccaagaaaagacugagccaggaacugccuacucgcucccccucccgagccuggagcuaacuccugugaggggugcucucuucaccccacaacuuacuagaccuugagugagccucugucccuuaugugggcucuucgcugugagccacagauggaggucauuguauagacaguuagccuuccccaggucagccuaccucccccaaacuugugagucuccccgcugcucauauggagaggcaugucuaagacagcaagucuucuagaggaagcuugccuuuaacagacagauggaacuaaaccuuccaaaugggagaucuggcugaacccaggauacagagaccauggacauggauggggucaucaagagaagagggauguccuucuccagguuagggagagagaaggcaaguuugcaacgaucccaucaugcccugagcaagaagcuuuuggcccaggcuagccuuuaacuccauuagaggccucucuguuggguuuauccacagcaguaggcccaaguauggccuguccccaccucuacuaucccguggaagguuucuucccaccccuuuuugacaaaugccucacucgagcaguggaaagauagcucucuucccccucuucugccagguaacaaagagaccuaaccaggaccuauucuccaccccagccagucuugaccagccagaacaaagcagggaaccuggagaauaaaagacucuacguuccucugacaaagacucuacguuucucugacggccaggccuaaacagacaaggcuugggaacaucugccccacaggauacggaggaggucagcugugcucacuccucuucuccuuccaagacccucuuccgaccaugacuuaucuccaugguaacauccucaccaucauucucccacuaccaaggguugccauggcaaccucccaaccaccugcccaucccaggcaggcagcuguccuucugcucagaacccuagaggacucuaggugaaauuuuacagcuuaagagaggagugagccaaggagaagagacccuguaguccucuggcuuucaagagaaagaaggcuaugauuuaaaacacaguagaagggaaagaggucucgucgaggucgaccucucccggggagcuuagggguuguacugucuuuauuuuuuaaaccacuaaagugcaaunuuuccugcacucuuguuaccccgccucucuucccuguuagguuuucauuuccuugagcagacuuucuugguuuuuuaauggaguauagacuuucaccacuucacagacucuggccuccucuccaagucucucuggauggggaaaaggaagguagagggucagaggggaaggggucccucgucaccccgcauccauucacccccacuucucuggucccuagucaccggcuucaccccnaucuccgacaccaucacugucacacaguagccugucacacggauaguacaguucagacaagacuccuucagauuccgagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuuguuuguuuguuuguuuuuuacaacagcaauaaccacaucacauauuacuguagcucucuauaguguuacguucagacaccguagcucuguccucucuuauuuuguugguuuugacuuaaaaaaaaauacuuaugcuuuuuacuggugaaacagauugaaaaaaaaauugaacaacaaaccaguuugugaaaaaaaaaaaaaaugugaaaaaaaaucaccccgauguggaagagcucggcuccucuuuagcauuuuguacuuaaggaaauaaaaaagaaaaaccuggaagaucucacauuuuauuacaaagugaaaaaaaaa Myoc/trabecular 111 Sequencebelow. 247 meshwork induced gluco-corticoid protein AF041335guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuuaauucaucaggauguggagcgcuagucuggguaggagagccagucacccugaggacagcugaaacaaucgcuggcaaguauggaguguggaugagagaccccaagcccacccaccccuacacccaggaaagcacauggaggauugacacgguuggcacagagauccgccagguguuugaguacagucagauaagccaguucgagcagggcuauccuuccaagguccaugugcucccucgggcacuggagagcacgggugcugugguguaugcggggagccucuauuuccagggggcugaguccagaacuguggucagguaugagcuagacacggagaccgugaaggcagagaaggaaauuccuggagcuggcuaccacggacacuucccguacgcgugggguggcuacacagacauugacuuagcuguggaugagagcggccucugggucaucuacagcacggaggaagccaagggggccauaguccucuccaaauugaacccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccuuuguuaucuguggcaucuuguacacggugagcagcuacucuucagcccaugcaaccgucaacuucgccuacgacacuaaaacggggaccaguaagacccugaccaucccauucacgaaucgcuacaaguacagcaguaugauugacuacaacccccuggagaggaagcuguuugccugggacaacuucaacauggucaccuaugauaucaagcucuuggagaugugaggagccucuaugccuaccagcaaaggccagaaaaggugaaguuccgggcucccgggugaagcagcugucagcagaggcagccagaugcauggaguuucuccuccugcuaaagauuuuguuuauccgggucaauguacagcuagcuccccucugacugacacguccuccaggcuuguauagucgcauagacucuguucucuucugucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug Itm2a/E25 30 Sequence below. 248 putative Integral membraneprotein 2A L38971gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcgcucaagcaagcgcgauccucuccucuuucaaccugcagcccaagauacugauucgagccgcgccuuaccgcgcagcccgaagauucaccauggugaagaucgccuucaacaccccuacggcggugcaaaaggaggaggcgcggcaagauauagaggcgcucgucagucgcacuguccgagcucaaauccugacuggcaaggagcucagaguugucccgcaggagaaagauggcucaucugggagaugcaugcuuacucuccuaggccucucauucaucuuggcaggacugauuguugguggagccugcauuuacaaguacuucaugcccaagagcaccauuuaccauggugagaugugcuucuuugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugaggaggcugauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgauccggcggcaauuauucacgacuuugagaagggaaugacugcuuaacuggacuugcuuuugggaaacuguuaucugaugccccucaauacuuccauuguuaugacuccaaagaaucugguggaacuuuuuggaaaacuggcaaguggcaaguauuugccucauacuuaugugguucgugaagaccugguugcuguggaagaaauucgugauguuaguaaccuugguauuuuuauuuaccaacuuugcaacaaccgaaaauccuuccgccuuagacgcagagaccuucugcuggguuucaacaagcgugccauugacaaaugcuggaagauuagacacuuccccaaugaauuuaucguugaaaccaagaucugucaggagugaaaugugacagauaaagaguauccuugauaauaagaagucaggaacuuaccgucugacuuggaaaauugaaauugaugggauacucaugcuauuuacucauacauuuacucuauugcuuauacuggaaaaggaaagggaaaggggggagaaaacuacuaaccacugcaagcgauuguccaauucuacuuuaauugacauugcuugcuguuuucaacaagucaaaugauuaucuuuucucuugaauuuauaggguuuagauuucugaaagcagcaugaaugugucaucuuaccauccugacaauaaagcccauccucugguuuuauuuaaagcaagcucuuuccaacaucacuuggcuagagcaugcuuuaaauuuaaaauauuugaaauuuguuuuugacauuuuuuugugugaaacaugucaaaucucuuaccauucuuugguuuucuucuuuauuauguucaacucuccugauuucagaaguuacauuuuugcauuucuaucaggugcuguguaacgaaucugacugauaugugaacaaucuucaugaggaagcaauuuuuuacucauguaaugauucuuucucacugauaucuguauugugaaauccacagaacuguacaggugcugaaugcuguaaggaguucugguuguaugaauucuacaacccuauaauaaaguuuaccguauucaauca Eps8/epidermal 15 Sequence below. 249 growth factorreceptor pathway substrate 8 L21671ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggcgcagggcgcggggcaagccccagcagcgugucugcaacggggcgcggcgggcgcuccagcuccgggaucuuucucccucggucaccucccucgcgucuagggaggucguggcacucccugaggagcgcggcugcucggagggcggauccuagaacagaggcgugagagccggcaugaauggucauaugucuaaccgcuccaguggguauggagucuacccuucucaacugaaugguuacggaucuucaccacccuauucccagauggacagagaacacagcucaagaacaagugcaaaggcccuuuaugaacaaaggaagaacuaugcccgagacagugucagcagugugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaaugaucacugucgaggacggaauaagaaagcugaaguugcuggaugccaagggcaaaguguggacucaagauaugauucuccaaguggaugaccgagcugugagccugauugacuuagagucaaagaaugaauuggagaauuuuccucuaaacacaaucucgcauugucaagcaguggugcaugcaugcagcuaugacuccauucucgccuugguaugcaaagagccaacgcagagcaagccagaccuucaccuuuuuccagugugaugagguuaaggcaaaccuaauuagugaagauaucgaaagugcaaucagugacaguaaaggugggaaacagaagaggcggccggaggcccugaggaugauugccaaagcagauccuggcaucccuccuccucccagagcuccugccccugugccaccggggacugucacacagguggacguuaggagucgcguagcagccuggucugccugggcagcugaccagggugacuucgagaagccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucgacagggaugugcaaaucuuaaaccauauuuuggaugacauugaauuuuuuaucaccaaacuccaaaaagccgccgaagcguuuucugagcuuucuaaaaggaagaaaaguaagaaaaguaaaaggaaaggaccuggagagggcguuuuaacacugagggcaaaaccgccaccuccugacgaguuuguugacuguuuccagaaguuuaaacauggauucaaccuucuggccaaguugaagucccauauccagaacccgagugcuucagaucugguucauuuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccugaacuggccaguucgguacucagcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugcggaggaacggaagcuguggaugucacugggagauaguugggugaaagugagagcagaguggccgaaagaacaguucaucccaccuuacgucccgagguuccgcaacggcugggagcccccgaugcugaacuucaugggcgcgcccacagagcaagacauguaucaacuggccgaguccguggccaacgcagaacaccagcgcaaacaggacagcaagaggcuguccacagagcauuccaauguguccgacuauccuccagccgacggauaugcguacaguagcagcauguaccacagaggaccacaugcagaccacggggaggcugccaugccuuucaagucaacuccuaaucaccaaguagauaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuuuguggcgaggaacagcagcgagcucucgguuaugaaagaugaugucuuagagauacucgacgaucgaaggcagugguggaaaguccggaaugccaguggagacucuggguuugugccaaauaacauucuggauaucaugagaacuccagaaucuggaguggggcgcgcugaccccccauacacacauaccauacagaaacaaaggacggaauacggccugagaucagcugacacuccuucugccccaucacccccuccaacgccagcacccguuccggucccccuuccaccuucuguaccagcacccguuucugugcccaagguuccagcagaugucacccgccagaacagcagcuccagugacagugggggcagcauugugcgggacagccagagauacaaacaacucccaguggaccgaaggaagucccagauggaagagguucaggaugagcucuuccagaggcugaccaucgggcgcagugcugcgcagaggaaguuccacgugccacggcagaacguuccagugaucaauaucacuuaugacuccucaccggaagaaguaaagacuuggcugcagucaaagggauucaaucccgugacugucaauagccucgggguguugaacggagcacaacucuuuucucucaacaaagacgaacugaggucugucugcccggaaggugccagagucuuuaaccaaaucacuguucagaaagcugcuuuggaggacaguaauggaagcuccgaguuacaagagaucaugcggagacggcaggagaagaucagcgccgcugcgagcgacucgggaguggagucuuuugaugaagggagcagccacugaguccaugaacuuccuuauucuugguguggucguugaacagugauggacaugcuuuguuuuaagaagccuugaagggaaugucaaagcugucgucuugguauauguaauuuaucgccauauaaggaaacaguauaugccugaguaagcagaggacccgcugcuucugugcacauuaguuugauuaaaacugagaagcggguaggugagauggcucagcaaguaaaggugcuugcugccaagcccaaugacccaaguucgagucccugggucuacaugguaggagagagcuggcuucugcaaguuguccucugaccaccacacauaaauaaauaacaaauguaauuuacaaacuuuuaaaagaaaauguaauuuaaaaaaccagacguucuagacuguucugggcuugggaauauuuuuuucacuuuccuaagguguacuuuccuuugcuacauuaauuauugcagccuuguucgaugaucuaaguggggauauuugacaauggcagauuuauucauugcaacaaggaaagacacagccauugaugaaaaaaaaaagaaagucucagcuuucagugacugggauaccugcuguccagggaggaggcucaguuagacuacccucugcuuacuugaggucugacaugcccaaugagaguguauuuagcuuuauuuaaaguucuuaaugccaacaguuuuaaaaaucacauuuaaaugaacuguacaagguagccagaccuugaauguaugaauagacuauauaauaugucccgagaaacuuuguuacucucagcucuguugauugcgaaaucuugcauagauuaugcuuugauuuaguuucuFyn/Fyn 10 Sequence below. 250 proto-oncogene M27266ccugggccccgccgcggacgcgcggagccgccugggccgcgccggaggagggcggggagaggaccaugugaaugugcuccggagcugagcgccaagccaagcaguguuugaaaggaacaggaugcugaucuaaucguggcaaaaagucaguccgaccgcugguuucgaagacaugugguguauauaaaguuugugauaguugguggaaauuugggagcuuggauaaugggcugugugcaauguaaggauaaagaagcagcgaaacugacagaggagagggacggcagccugaaccagagcucuggguaccgcuauggcacagaccccaccccucagcacuaccccagcuucggcgugaccuccaucccgaacuacaacaacuuccacgcagcugggggccagggacucaccgucuuugggggugugaacuccuccucucacacugggacccuacgcacgagaggagggacaggagugacacuguuuguggcgcuuuaugacuaugaagcacggacggaagaugaccugaguuuucacaaaggagaaaaauuucaaauauugaacagcucggaaggagauuggugggaagcccgcuccuugacaaccggggaaacugguuacauucccagcaauuacguggcuccaguugacuccauccaggcagaagagugguacuuuggaaaacuuggccgcaaagaugcugagagacagcuccuguccuuuggaaacccaagagguaccuuucuuauccgcgagagccaaaccaccaaaggugccuacucacuuuccauccgugauugggaugauaugaaaggggaccacgucaaacauuauaaaauccgcaagcuugacaaugguggauacuauaucacaacgcgggcccaguuugaaacacuucagcaacugguacagcauuacucagagaaagcugaugguuuguguuuuaacuuaacugugguuucaucaaguuguaccccacaaacuucuggauuggcuaaagaugcuugggaaguugcacgugacucguuguuucuggagaagaagcuggggcagggguguuucgcugaaguguggcuugguaccuggaauggaaauacaaaaguagccauaaagacccuuaagccaggcaccaugucuccggaguccuuccuggaggaggcgcagaucaugaagaagcugaagcaugacaagcuggugcagcucuacgcggucgugucugaggagcccauuuacaucgucacggaguacaugagcaaaggaaguuugcuugacuucuuaaaagauggugaaggaagagcucugaaguugccaaaccuuguggacauggcggcacagguugcugcaggaauggcuuacaucgagcgcaugaauuauauccacagagaucugcgaucagcaaacauucuaguggggaauggacuaauuugcaagauugcugacuuuggauuggcucgguugauugaagacaaugaauacacagcaagacaaggugcgaaguuucccauuaaguggacagcccccgaagcggcccuguauggaagguucacaaucaagucugacguauggucuuuuggaaucuuacucacagagcugguacaccaaaggaagagugccauacccaggcaugaacaaccgggaggugcuggagcagguggagagaggcuauaggaugcccugcccacaggacugcccgaucucccugcacgagcucaugauccacugcuggaaaaaggauccggaagagcgcccgaccuucgaguacuugcagggcuuccuggaggacuacuuuacggccacagagccccaguaucagcccggugaaaaccugugagagccugcgcuucagacgccucuucccgaggccucccuaccccuccccauuagcuuccaauucuguagccagcugccccagagcaggagaaccguccaggaucagauugcaugugacucuugaagcugaacuuccacggcccucauuaaugacacuugucccccaguccgaaccuccucugugaaccaucugagacagaacguguuauuucucagacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuguucaguguaaauagcugcuccugugccaacaaucccagugcuuuccuuuuuuaaaaaagaaaaagcaaauccuaugugauuuuaacucugauuucaccugauucaacuaaaaaaaaaaaaguauuauuuuccaaaaguggccucuuugucuaaaacaauaaaauuuuuuuucauguuuuaacaaaaaaaaaaaaaaaaaaaaaaaa Col6a1/ 36 Sequence below. 251 Procollagen, type VI, alpha 1 X66405cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucucgccuuucccagcgcccacccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggcccacgcucugcugccccugcugcuacaagccugcuggguggccacacaggacauccagggcuccaaagcgauugccuuccaagacugcccuguggaucuauucuucgugcucgacaccucggagaguguggccuugaggcugaaaccuuauggggccuugguggacaaggugaaguccuucacuaagcgcuucauugacaaccugagagacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacuacagugacgagguggagaucauccgagggcucacgcgcaugcccaguggccgcgaugagcucaaggccagcguggaugcggucaaguacuucgggaaaggcaccuacaccgacugcgccauuaagaaggggcuggaggagcugcucauagggggcucccaccugaaggagaacaaguacuugaucguggugaccgacgggcauccucuagagggcuacaaggaaccaugcgggggucuggaagaugcaguaaaugaggccaaacaccugggcaucaaggucuuuucuguggccaucacaccugaccaccuggagccacgucuaaguaucauugccacagaccacacauaccggcgcaauuucacggcagcugacugggggcauagccgcgaugcagaagaggucaucagccagaccauugacaccauuguggacaugauuaaaaauaacguggaacaaguguguuguucuuuugagugccaggcugccagaggaccuccagggccccgaggcgacccuggguaugagggggagcgaggaaagccaggucuuccgggagagaagggagaagcuggagacccuggacgaccuggggaucuuggaccagucggguaccaggguaugaagggagaaaaggggagccguggagagaaggguuccagaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucgacggcaugaagggagagacgggguacccaggacuaccgggcugcaagggcuccccaggauuugauggcauucaaggacccccgggucccaagggugaugcuggugccuuugggaugaagggagaaaagggugaagcuggagcagacggugaggcugggagaccagggaacucagggucaccuggagaugagggugauccuggagagccugguccccccggagaaaaaggagaggccggugaugaaggaaaugcuggcccagacggugccccuggagagagggguggcccuggugaaagaggaccucgggggaccccuggugugagaggaccaaggggagacccgggugaagcuggaccacagggugaccaaggaagagaggggcccgucggcaucccuggagacucgggugaggcuggccccauuggaccuaaaggauaccgaggugaugaggguccuccagguccugagggccucagaggagccccaggaccuguugguccuccuggagaccccggacugaugggugagagaggugaggauggaccaccaggaaacggcacggaagguuuccccggcuucccuggguauccaggcaacagaggcccuccugggcuaaauggcacaaaaggcuacccuggccucaagggggaugagggugaagugggagacccaggagaggauaacaacgacauuucaccccguggggucaaaggggcaaagggauaccgaggcccagaaggaccccagggaccuccaggacaugugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugcuccugcugugagugcacauguggacccauugacauccucuucgugcuggacagcucggagagcauuggccuacagaacuuugagauugccaaggacuucaucaucaaggucauugaccgguugagcaaggaugagcuggucaaauuugagccagggcagucucacgcgggcgugguacaguacagccacaaccagaugcaagagcacguggacaugcggagccccaacguccgcaacgcccaggacuucaaagaagcugucaagaagcuacaauggauggcugguggcacauucaccggagaagcgcugcaguacacccgggaccggcuacucccacccacacagaacaaccgaauugcccuggucauuacggauggacguucugacacucaacgggacacgacaccucucagugugcucuguggugcagacauucaggugaguuucugugggaaucaaggauguguuuggcuuuguggcgggcuccgaccagcucaaugucauuuccugccaaggcuuaucgcaaggucguccagguaucucccuggugaaggagaacuaugcagagcuucucgaugacggcuuucugaagaacauaacagcccagaucuguauagauaagaaguguccggauuauaccuguccaaucacauucuccuccccggcugacaucaccauccugcuagacagcucagccagugucggcagccacaacuucgaaaccaccaaggucuucgccaagcgccuagcugagcgauuccugucagcaggcagggcggauccuucccaggaugugcggguggccgugguacaguauaguggccaggggcagcaacagccaggucgggcggcucuucaguucuuacagaauuacacagugcuggccagcucuguggacagcauggauuucaucaacgacgccacagacgucaacgaugcucugagcuacgugacucguuucuaccgggaagccucgucaggugccaccaagaagagagugcuguuguuuucagacggcaacucucagggggccacagcagaggccauugagaaggcugugcaggaggcccagcgugcaggcauugagaucuuuguggugguggugggaccccaggugaacgagccccacauccgugugcuugucacuggcaagacugcagaguacgacguggccuuuggcgagcgccaccuauuccguguaccaaacuaccaggcccugcuacguggcguacucuaccagacagucuccaggaagguggcacugggcuagagggccacacacguggcuggacacacauggcauggagacacauuucaacaggccuucccgcccuucccacugacaaaacaggaauaggaaaugugacccaacuggucaacucaacugucuuaaagggaacgcugagaugcacacucuuugcuuuguguaauguccccuguggcucaccugagcuccuaucuagaucccgcccuugguuuguacaucaugguggccaucuugcugaccccucccccaucugggacuggauccagccaucucgucuuccuccucacugccccuaaccuauccguggugucuucacaccaucacugcaguuuccgucuguguucugucuuccaugcucaacaugaagcagaccuucucaugaguucagcuugcuggauuauggcuuuuaggaaauugaacacaggaggaguuccaaacacaaacuuggaggagaccccuccucuucaucaggugcuugucagugaccuacaugcaucuuggucugguccuuaguggcuaguccuuccacucugaaagcaaaggugcuaucuaucuguaagggcucucucuacacacccagaggcuuagcuuggacaguucacacucaaguguccugucagaaucaauccagagcuuucucccucaaaauagugacuugucucccccugguccccaaaggcuccccuuuaguuaguuucuucauggcucccccacauuccccguaaucugauccaagccagcuaucucugcuaauaaagguuuccauuuuucaaaaaaaaaaaaaaTnc/Tenascin C 17 accccaugccccacccccaccuucgauguuuugaacauuucuaacaacugaag252 AV230686 ccaguaaagucauauucuuuaaauuuccaggacauucauauuauucacauaauX56304 cauggucauggugaugauggaaacugaggacuuuaaaagagauuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuuguuuuguuuuguuuuuuaauaaaagcacaguacuuuucc Krt2-6a/Keratin 10 Sequence below. 253 complex2, basic gene 6a (keratin 6a) K02108gucugcccugccguuucucuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaaagucaaaccagccaccguggcuacagugccagcucagccagagugcuuggacucaaccgcucgggcuucagcaguguguccgugugccgcucccggggcagcgguggcuccagugcaauguguggaggagcuggcuuuggcagcaggagccucuaugguguggggagcuccaagaggaucuccaucggagggggcagcuguggcauuggaggaggcuauggcagccgauucggaggaagcuucggcauuggugguggagcugguaguggcuuuggcuucggugguggagcuggcuuuggugguggcuaugggggagcuggcuucccggugugcccacuuggaggcauccaagaggucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccauccagcgggucaggacugaggagagggagcagaucaagacccucaauaacaaguuugccuccuucaucgacaaggugcgguucauggagcagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacaccaagaccgugaggcagaacauggagcccauguuugagcaguacaucagcaaccuccgcagacagcuggacagcaucauuggagagaggggucgcaugaacucagagcugaggaacaugcaggaacucguagaagaacuacggaacaaauaugaagaugaaaucaacaagcgcacagacgcagagaaugaauucgugacccugaagaaggauguagaugcugccuacaugaacaaaguugaacugcaagccaaggcagacagucuaacagaugauaucaacuucuugagagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacacaucugugguccucuccauggucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugaggucauagcucagagaagucgggcugaagcugagucauuguaccagacuaaauaugaggagcugcaggucacagcuggcagacauggggacgaccugcgcaacaccaagcaggagauugcugagaucaaccgcaugauccagaggcugagaucugagaucgaccacguuaagaagcagugugccaaccugcaagcugcuauugcugaugcugagcaacguggggagauggcccugaaggaugcaaggggcaagcuggaagggcuggaggaugcccugcagaaggccaaacaggacauggccaugcugcugaaggaguaccaugaacucaugaaugucaagcuggcccuugauguggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggugaagguguuggaccagucaacaucucuguggugcaguccaccguguccagcggcuauggcagugccgggggugccagcagcagcuuaggcauggguggaggcagcagcuacuccuauagcagcagccauggccuuggagguggcuucagugcuggcaguggcagagccaucggagguggccucagcucuucugguggccucagcucuucuaccaucaaauacaccaccaccuccuccagcaagaagagcuacaggcagugaauucugucaccaagagcuugucucuggucccagaugucauggcugcagcugaaccacaugcuuugguucccggaagggaacgaaucccaaccucuggccuccccauggcucaguucuacauuuguguugcacgucagcaccuauacauguucuuuggugacccagaccccaaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccuaaauucugucaugguucugacuuccuccagagucuguaaaauaaaaugcccccacaacaaac Potassium 14uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuccaguuca 254 channel,caguuuauacgugguacaucccaccaugucagcuuccagaacggcuauucagg subfamily K,agauggguggagcuuucuuuguaaaggaacccgacauuuuaaaauuuugguua member 2gaaucuucauagguuuauaaaaguacucucugcaagcgaacuggauauauuua AI849601cauuuauagcuuaaauucaaauuuuggaaaauaggaaucuuuuuguguuuuuaaacauccuggguuuaugucuuaagacuuuacucugaaugccacaugaucacguaagcccaagccucccccagaagggaaaaaucaguuuugc Skd3/Supressor 4uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuuauuagaug 255 of K+transport uucagggcacagacagguggaugcuagaugguguagcacaccuucucagggug defect 3gaguggugccuggauguccaguuugcgggucuugcuguccuuaucaaugaucu AI837887ccagucgcaauguagguggacgcuucucagccuggggugagggcagcucacggcucuugaggaggugcuuguccgaauccuccacagugauacccagggugcaacc cccuggClic4/Chloride 3 uuuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuuacacaa256 intracellular uauuacaacucccccaguacauaaauguuccuauaccaugcacacagcaacauchannel 4 gggguccacugaugucgcaggcgacuuuucuaaugguggaacauagcaccuca(mito-chondrial) aguucugccaucuacacagugaagggacgugauggucggggcuccagagugacAI845237 agcaaacugccucuugggugacacgcuuguggcgaagugccucc Col18a1/ 5Sequence below. 257 Endostatin (alpha 1 (XVIII) collagen) L22545gagaauguugcugaggagguggggcugcugcagcuccuuggagacccccuaccugagaagaucucacaaaucgaugacccucacgucgggccggccuacaucuuuggaccagacuccaacaguggccagguggcccaguaucauuucccaaaacucuucuuccgggacuuuucgcugcuguuucauguccggccagccacagaggcagcaggggugcuauuugccaucacagaugcugcccaggugguagucucacugggcgugaagcucucagagguccgagauggacagcaaaacaucucauugcucuacacggagccuggggccagccagacccagacgggagccagcuuccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgacggaggcucuguggcucucuacguagacugugaagaauuccagagggugccauuugcucgggccucgcagggacuggagcuagagcguggcgcuggccucuuugugggucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagcugaagguacgcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgggcaucuggagauuuuggaaguggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuaccugggcucccucagccaccuccugucacuuccccaccccuggcuggaggcagcaccacagaagauccuagaacagaagaaacggaggaagacgccgcgguagauucuauaggagcugagacccuuccuggcacagguucaagcggugcaugggaugaggcuauccagaaccccggaaggggcuugauaaagggagguaugaaaggacaaaagggagaaccaggugcccagggcccaccuggcccagcuggcccccaggguccugccgguccagugguccagagccccaacucacaaccugucccuggagcacaaggacccccgggaccucaggggccaccagggaaggauggcacuccaggaagggauggugaaccgggugacccuggugaagaugggagaccgggugacacuggaccucaaggcuuuccagggaccccaggagaugugggcccuaagggcgagaagggagauccugguauugggccccgaggaccuccagggccuccagggccaccaggacccuccuucagacaagacaagcugaccuucauugacauggagggauccgguuucagcggagacauagagagccuuagaggcccacgaggcuucccuggccccccggggcccccuggugucccaggacuuccuggugagccaggacgcuuugggaucaaugguuccuaugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuuccaggucccccgggaccuccagguccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguuggugaugugggcaucccaggacccaaggggagcaaaggagaccuugggcccaucgguaugccuggcaagucuggcuuggcuggauccccugggccaguuggacccccaggaccuccagggccuccagggccaccaggaccaggauuugcugcuggauucgaugauauggaaggcucuggaauaccccucuggacaacagcccgaagcucugaugggcugcagggaccucccgggucgccgggacucaagggggauccuggaguggcaggccuaccuggagccaagggagaaguuggagcagauggagcccagggcaucccuggucccccaggaagagaaggugcagcuggaucuccggggccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggccggccgggccucccugggccuccaggaccuccagggcuggugaucuaugugucaagugaggauaaagcaauagugagcacgccaggaccugagggcaagccaggguacgcaggcuuuccuggaccugcuggaccgaagggugaccuggguuccaaaggcgagcagggucuuccgggguuuaagggugagaagggagagccaggcacuaucuuuaguccugauggcagacgucugggccauccccagaagggagccaagggagagccaggcuuucgaggacccccggguccuuauggacgaccugggcacaagggugaaauuggcuucccuggacggccgggucgaccuggaacgaauggcuuaaagggagagaagggagagccuggagaugccagccuuggguucagcaugaggggauugccuggccccccugggccuccaggacccccagguccuccugggaugcccaucuaugacagcaaugcauuuguggagucuggccgaccuggacuaccaggacagcagggugugcaggggccuucaggaccaaagggugacaaaggagagguggggccaccugggccaccagggcaauuccccauugaccucuuccaccuggaagcggaaaugaagggggacaagggagaccgaggggaugcuggacagaaaggagagaggggagaaccuggggcuccuggugguggauucuucagcucaaguguaccuggcccacccggcccaccuggauacccuggaauuccggguccaaagggagagagcauccgggggccaccuggcccuccuggcccgcagggaccuccuggcauuggcuaugagggucgccagggucccccaggaccuccaggaccuccaggaccucccuccuucccuggcccucacagacagacugucaguguuccugguccuccgggcccaccugguccuccaggucccccaggagccaugggugccucugcugggcaggugaggaucugggccacauaccagaccaugcuggacaagauccgggaggugccggagggcuggcucaucuuuguggccgagagggaagagcucuauguacgcguuagaaauggcuuccggaaggugcugcuggaggcccggacagcccuccugagaggcacgggcaaugagguggcugcuuuccagcccccauugguccagcuucaugagggcaguccauacacccggagggaguacuccuauuccacggcacgacccuggcgagcagaugacauccuggccaacccaccgcgccugccagaccgccagccuuacccuggaguuccacaucaccacaguuccuaugugcaccugccgccagcccgccccacccucucacuugcucauacucaucaggacuuucagccagugcuccaccugguggcacugaacaccccccugucuggaggcaugcgugguauccguggagcagauuuccagugcuuccagcaagcccgagccguggggcugucgggcaccuuccgggcuuuccuguccucuaggcugcaggaucucuauagcaucgugcgccgugcugaccgggggucugugcccaucgucaaccugaaggacgaggugcuaucucccagcugggacucccuguuuucuggcucccagggucaagugcaacccggggcccgcaucuuuucuuuugacggcagagauguccugagacacccagccuggccgcagaagagcguauggcacggcucggaccccagugggcggaggcugauggagaguuacugugagacauggcgaacugaaacuacuggggcuacaggucaggccuccucccugcugucaggcaggcuccuggaacagaaagcugcgagcugccacaacagcuacaucguccugugcauugagaauagcuucaugaccucuuucuccaaauaggccucugccagcuaggguggcagacagaggccaugcagaacuuugacacagcgcagggagcauucagucagcacccagggcucuggcugggauacaacuccuguauaguucccauuuuuauguaauccucaagaaauaaaaggaagccaaagaguaaaaaaaaa

TABLE 5 Gene Fold Name/Protein Decr Sequence SEQ ID No. Growth Factors,Receptors and Downstream genes GNA-14 32 Sequence below. 258 Mouse Gprotein alpha subunit (GNA-14) M80631aacugccuucgagaagcguuagccuagagauccgagccucuucuccauaccauaguugguucaggugguuuccucuucaaaccuugcgucugcggauaauccgcgcggccgggcguuaagcuccaggucccugucgcuccgucgagguggcaagccauggccggcugcugcuguuugucugcggaggagaaagagucucagcgcaucagcgcggagaucgagcggcacguucgccgcgacaagaaggacgcgcgccgggagcucaagcugcuguugcugggaaccggugagagugggaaaagcaccuuuaucaagcagaugaggauaauccaugggucuggcuacagugaugaagauagaaagggcuucacgaagcugguuuaccaaaacauauucacggccaugcaagccaugaucagagcaauggauacccugaggauacaauacaugugugagcagaauaaggaaaaugcccagaucaucagggaaguggaaguagacaaggucacugcacucucuagagaccagguggcagccaucaagcagcuguggcuggaucccggaauccaggaguguuacgacaggaggagggaguaccagcugucagacucugccaaauauuaccugacggacauugagcguaucgccaugcccucuuucgugccaacacaacaggaugugcuucguguuagagugcccaccacuggcaucauagaauauccauucgaccuggaaaacaucaucuuccgaaugguggauguugguggccagcgaucugaacgacggaaauggauucacugcuuugagagugucaccuccaucauuuucuugguugcucugagugaauaugaccagguucuggcugagugugacaaugagaaccgcauggaggagagcaaagcccuguuuagaaccaucaucaccuaccccugguuucugaacuccuccgugauucuguucuuaaacaagaaggaucuucuagaggagaaaaucauguacucucaucuaauuagcuacuucccagaguacacaggaccaaagcaagaugucaaagcggccagggacuuuauccugaagcuguaucaagaccagaauccugacaaagagaagguuaucuauucucacuucacuugugcuacagacaccgagaauauccgcuuuguguuugcugcugucaaagacacaauccuacagcuaaaccuacgggaguucaacuugguguaaauggagggccuacuccuccgagacagagggugaucugagcccuuccugccugaucuacaagugcuucuggaccaggaccuaaggacauuauguagcccacaggacagagauggguagugcaaugugaaaaauacuucaccaacccuuuuaagugucuuuaauucuucacugucuaacucuuuuucucgccuuuugguugaacgauuagguaucauuuuugagugguucccccucuccuauuuuuuuaaacuaguguucaacaguuauuaaaaaaucaugcLy6/Lymphocyte 12 gaauucccugcaaccuugucugagaggaagcaaggacuggugugagga 259antigen 6 complex gggagcugugagguuuuaucugugcagcccuucucugaggauggacacX04653 uucucacacuacaaaguccuguuugcugauucuucuuguggcccuacugugugcagaaagagcucagggacuggaguguuaccagugcuauggagucccauuugagacuucuugcccaucaauuaccugccccuacccugauggagucuguguuacucaggaggcagcaguuauuguggguucucaaacaaggaaaguaaagaacaaucuuugcuuacccaucugcccuccuaauauugaaaguauggagauccuggguacuaaggucaaugugaagacuuccuguugccaggaagaccucugcaaugcagcaguucccaauggaggcagcaccuggaccauggcaggggugcuucuguucagccugagcucaguccuccugcagaccuugcucugaugguccucccaaugaccuccacccuuguccuuuuauccucaugugcaacaauucuuccuggagcccucuagugaugaauuaugaguuauagaagcuccaaggugggaguagugugugaaauaccauguuuugccuuuauagcccugcuggguagguaggugcucuaauccucucuagggcuuucaagucuguacuuccuagaaugucauuuuguuguggauugcugcucaugacccuggaggcacacagccagcacagugaagaggcagaauuccaagguauuaugcuaucaccauccacacauaaguaucugggguccugcaauguucccacauguauccugaaugucccccuguugaguccaauaaacc cuuuguucuccc Bmp4/Bone11 Sequence below. 260 morphogenetic protein 4 L47480ggaagaaagagagggagggaaaagagaaggaagaguagaugugagaggguggugcugagggugggaaggcaagagcgcgaggccuggcccggaagcuaggugaguucggcauccgagcugagagaccccagccuaagacgccugcgcugcaacccagccugaguaucuggucuccgucccugaugggauucucgucuaaaccgucuuggagccugcagcgauccagucucuggcccucgaccagguucauugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaauggugagcagggcaaccuggagaggggcgcuauucugaggauucgaggugcacccguaguagaagcuggggauggggcucaggcuguaaccgaggcaaaaguuggccuauuccuccuuccuucuccaacaguguuggaggugggaugauggaggcuaaaaggcaccuccauauauguuacugcgucuaucaaccuacuuuagggaggugcgggccaggagaggcggaaggagagaaggccuuggaagagaggucauugggaagaacugugggguuugguggguuugcuuccacuuagacuauaagagugggagaggagggagucaacucuaaguuucaacaccagugggggacugaggacugcuucauuaggagagagaaccuagccagagcuagcuuugcaaaagaggcuguaguccugcuuugcucuaaagcgcgacccgggauagagaggcuuccuugagcggggugucaccuaaucuuguccccaacgcacccccucccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuauuuucuuagacaugggcacccaugauucugccuucugguacucuccccucccugggaaagggguguaagguuccgacggaaccguggccaggaugccgaaaggcuaccugugcgggucuucugccaugcugugucugugcggacaugccagcagggcuaaugaggagcuugcgauacuccaaaggguucgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgccacggcuuugguugauaguuuuuuuaguauccugguuuaugaacugaagguuuugugagauguugaaucacuagcagggucauauuuggcaaaccgaggcuacuauuaaauuuugguuuuagaagaagauucuggggagaaagugaaggguaacugccuccaggagcuguaucaaccccauuaagaaaaaaaaaaauaccaggagaugaaaauuuacuuugaucuguauuuuuuaauuaaaaaaaaucagggaagaaaggagugauuagaaagggauccugagcgucggcgguuccacggugcccucgcuccgcgugcgccagucgcuagcauaucgccaucucuuucccccuuaaaagcaaauaaacaaaucaacaauaagcccuuugcccuuuccagcgcuuucccaguuauucccagcggcgacgcgugucggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcggacugucgcucagggggcgcccgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgccaggaaggacgugacucuccauccuuuacacuucuuucucaaagguuucccgaaagugccccccgccucgaaaacuggggccggugcggggggggggagagguuagguugaaaaccagcuggacacgucgaguuccuaagugaggcaaagaggcgggguggagcgggcucuggagcgggggaguccugggacucgguccucggauggaccccgugcaaagaccuguuggaacaagaguucgcgcuuccgagguuagaacaggccaggcaucuuaggauagucaggucacccccccccccaaccccacccgaguuguguuggugaauuucuuggaggaaucuuagccgcgauucuguagcuggugcaaaaggaggaaaggggugggggaaggaaguggcngngcggggguggcgguggggguggaggugguuuaaaaaguaagccaagccagagggagaggucgagugcaggccgaaagcuguucucggguuuguagacgcuugggaucgcgcuuggggucuccuuucgugccggguaggaguuguaaagccuuugcaacucugagaucguaaaaaaaaugugaugcgcucuuucuuuggcgacgccuguuuuggaaucuguccggaguuagaagcucagacguccaccccccaccccccgcccacccccucugccuugaauggcaccgccgaccgguuucugaaggaucugcuuggcuggagcggacgcugagguuggcagacacgguguggggacucuggcggggcuacuagacaguacuucagaagccgcuccuucuaacuuucccacaccgcucaaaccccgacacccccgcggcggacugaguuggcgacggggucagagucuucuggcugaaaguuagauccgcuaggggucggcugccugucgcuagaagcauuauuuggccucucggagacccguguggaggaagugcuggagugugcgaguguguuugcgugugugugugugugugugugugugugugugugugugugugugugcgcgcgcccuuggagggucccuaugcgcuuuccuuuucauggaacgcugucgugaggcucccugauccucaggcuucagauaacccguccccgaaccuggccagaugcauugcacugcgcgccgcagguagagacgugccccacguccccugcgugcagcgacuacgaccgagagccgcgccaguguggugucccgccgagaguuccucagagcaggcggggacaacucccagacggcuggggcuccagcugcgggcgcggagguuggccucgcucgcaggggcuggacccagccggggugggaggauggaggaggggcgggcgggcucuucggugaguggggcggggccucuggguccacgugacuccuaggggcuggaagaaaaacagagccugucugcuccagagucucauuauaucaaauaucauuuuaggagccauuccguagugccauucggagcgacgcacugccgcagcuucucugagccuuuccagcaaguuuguucaagauuggcucccaagaaucauggacuguuauuaugccuuguuuucugucagugaguagacaccucuucuuucccuucuugggauuucacucuguccucccaucccugaccacugucugucccucccgucggacuuccauuucagugccccgcgcccuacucucaggcagcgcuaugguucucuuucuggucccugcaaggccagacacucgaaauguacgggcuccuuuuaaagcgcucccacuguuuucucugauccgcugcguugcaagaaagagggagcgcgagggaccaaauagaugaaagguccucagguuggggcugucccuugaagggcuaaccacucccuuaccagucccgauauauccacuagccugggaaggccaguuccuugccucauaaaaaaaaaaaaaaaaacaaaaaacaaacagucguuugggaacaagacucuuuagugagcauuuucaacgcagcgaccacaaugaaauaaaucacaaagucacuggggcagccccuugacuccuuuucccagucacuggaccuugcugcccgguccaagcccugccggcacagcucuguucuccccuccuccuguucuuaaccagcuggaaguuguggaaauugggcuggagggcggaggaagggcggggguggggggguggagaaggugggggggggggaggcugaagguccgaagugaagagcgauggcauuuuaauucucccuccnccuccccccuuuaccuccucaauguuaacuguuuauccuugaagaagccacgcugagaucauggcucagauagccguugggacaggauggaggcuaucunauuugggguuauuugaguguaaacaaguuagaccaaguaauuacagggcgauucuuacuuucgggccgugcauggcugcagcugguguguguguguguagggugugagggagaaaacacaaacuugaucuuucggaccuguuuuacaucuugaccgucgguugcuaccccuauaugcauaugcagagacaucucuauuucucgcuauugaucgguguuuauuuauucuuuaaccuuccaccccaacccccuccccagagacaccaugauuccugguaaccgaaugcugauggucguuuuauuaugccaaguccugcuaggaggcgcgagccaugcuaguuugauaccugagaccgggaagaaaaaagucgccgagauucagggccacgcgggaggacgccgcucagggcagagccaugagcuccugcgggacuucgaggcgacacuucuacagauguuugggcugcgccgccguccgcagccuagcaagagcgccgucauuccggauuacaugagggaucuuuaccggcuccagucuggggaggaggaggaggaagagcagagccagggaaccgggcuugaguacccggagcgucccgccagccgagccaacacugugaggaguuuccaucacgaaggucaguuucugcucuuaguccuggcgguguagggugggguagagcrccggggcagaggguggggggugggcagcuggcagggcaagcugaagggguuguggaagcccccggggaagaagaguucauguuacaucaaagcuccgaguccuggagacuguggaacagggccucuuaccuucaacuuuccagagcugccucugaggguacuuucuggagaccaaguagugguggugaugggggaggggguuacuuugggagaagcggacugacaccacucagacuncugcuaccncccagnggguguucuuuagcuauaccaaagncagggauucugcccguuuuguuccaaagcaccuacugaauuuaauauuacancuguguguuugucagguuuaucaauaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuuccaaaguaaaucugaguuauuaauccuccagcaucauuacuguguuggaauuuauuuucccuucuguaacaugaucaacaaggcgugcucuguguuucuaggaucgcuggggaauguuugguaacauacucaaaaguggagagggagagaggguggccccucuuuuucuuuacaaccacuuguaaagaaaacuguacacaaagccaagaggggcuuuaaaaggggaguccaagggugguggaguaaaagaguugacacauggaaauuauuaggcauauaaaggagguugggagauacuuucugucuuugguguuugacaaaugugagcuaaguuuugcugguuugcuagcugcuccacaacucugcuccuucaaauuaaaaggcacaguaauuuccuccccuuagguuucuacuauauaagcagaauucaaccaauucugcuauuuuuuguuuuuguuucuuguuuuuguuuuguuugguuuuuuuuuuuuuuuuuuuuuuuuugucucagaaaagcucaugggccuuuucuuuuccccuuucaacugugccuagaacaucuggagaacaucccagggaccagugagagcucugcuuuucguuuccucuucaaccucagcagcaucccagaaaaugaggugaucuccucggcagagcuccggcucuuucgggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuaugagguuaugaagcccccagcagaaaugguuccuggacaccucaucacacgacuacuggacaccagacuaguccaucacaaugugacacggugggaaacuuucgaugugagcccugcaguccuucgcuggacccgggaaaagcaacccaauuaugggcuggccauugaggugacucaccuccaccagacacggacccaccagggccagcaugucagaaucagccgaucguuaccucaagggaguggagauugggcccaacuccgcccccuccuggucacuuuuggccaugauggccggggccauaccuugacccgcaggagggccaaacguagucccaagcaucacccacagcgguccaggaagaagaauaagaacugccgucgccauucacuauacguggacuucagugacgugggcuggaaugauuggauuguggccccacccggcuaccaggccuucuacugccauggggacugucccuuuccacuggcugaucaccucaacucaaccaaccaugccauugugcagacccuagucaacucuguuaauucuaguaucccuaaggccuguuguguccccacugaacugagugccauuuccauguuguaccuggaugaguaugacaaggugguguugaaaaauuaucaggagauggugguagagggguguggaugccgcugagaucagacguccggagggcggacacacacacacacacacacacacacacacacacacacacacacaguucccauucaaccaccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuaaaaaaaaaaaaaagaaagaaagaaagaaagaaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacucaccuugaccuuauuuaugacuuuacgugcaaauguuuugaccauauugaucauauuuugacaaauauauuuauaacuacauauuaaaagaaaauaaaaugag Il1r2/Interleukin 11gaaucccacuuacaugcgagcaucucuauauacauccucaaucuaucc 261 1 receptor, typeccucgaauccacggacuuaucagucaaucaauacuacagucaaagaau IIuuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuucuaa AV223216ucaucuugguuguggggccaauauggaugcgcagacgguguaaacgca X59769gggcuggaaagacauauggacugaccaagcuacggacugacaaccaggacuucccuuccagcccaaacuaaauaaaggaaaugaa Wnt3a/wingless- 4 Sequence below.262 related MMTV integration site 3A X56842gaauucaugucuuacggucaaggcagagggcccagcgccacugcagccgcgccaccucccagggccgggccagcccaggcguccgcgcucucgggguggacuccccccgcugcgcgcucaagccggcgauggcuccucucggauaccucuuagugcucugcagccugaagcaggcucugggcagcuacccgaucuggugguccuuggcugugggaccccaguacuccucucugagcacucagcccauucucugugccagcaucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugcccagcguggcugagggugucaaagcgggcauccaggagugccagcaccaguuccgaggccggcguuggaacugcaccaccgucagcaacagccuggccaucuuuggcccuguucuggacaaagccacccgggagucagccuuuguccaugccaucgccuccgcuggaguagcuuucgcagugacacgcuccugugcagagggaucagcugcuaucugugggugcagcagccgccuccagggcuccccaggcgagggcuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggaguuugccgaugccagggagaaccggccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgccagucacaugcaccucaagugcaaaugccacgggcuaucuggcagcugugaagugaagaccugcugguggucgcagccggacuuccgcaccaucggggauuuccucaaggacaaguaugacagugccucggagauggugguagagaaacaccgagagucucguggcuggguggagacccugaggccacguuacacguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucacccaacuucugcgaaccuaaccccgaaaccggcuccuucgggacgcgugaccgcaccugcaaugugagcucgcauggcauagaugggugcgaccuguugugcugcgggcgcgggcauaacgcgcgcacugagcgacggagggagaaaugccacuguguuuuccauuggugcugcuacgucagcugccaggagugcacacgugucuaugacgugcacaccugcaaguaggagagcuccuaacacgggagcaggguucauuccgaggggcaagguuccuaccugggggcgggguuccuacuuggaggggucucuuacuuggggacucgguucuuacuugagggcggagauccuaccugugagggucucauaccuaaggacccgguuucugccuucagccugggcuccuauuugggaucuggguuccuuuuuaggggagaagcuccugucugggauacggguuucugcccgaggguggggcuccacuuggggauggaauuccaauuugggccggaaguccuaccucaauggcuuggacuccucucuugacccgacagggcucaaauggagacagguaagcuacucccucaacuaggugggguucgugcggaugggugggaggggagagauuagggucccuccucccagaggcacugcucuaucuagauacaugagagggugcuucagggugggcccuauuugggcuugaggaucccgugggggcggggcuucaccccgacuggguggaacuuuuggagacccccuuccacuggggcaaggcuucacugaagacucaugggauggagcuccacggaaggaggaguuccugagcgagccugggcucugagcaggccauccagcucccaucuggccccuuuccaguccugguguaagguucaaccugcaagccucaucugcgcagagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauaccaagaccuaacaaaccccgugccuggguaccucuuuuaaagcucugcaccccuucuucaagggcuuuccuagucuccuuggcagagcuuuccugaggaagauuugcagucccccagaguucaagugaacacccauagaacagaacagacucuauccugaguagagaggguucucuaggaaucucuauggggacugcuaggaaggauccugggcaugacagccucguaugauagccugcauccgcucugacacuuaauacucagaucucccgggaaacccagcucauccgguccgugauguccaugccccaaaugccucagagauguugccucacuuugaguuguaugaacuucggagacauggggacacagucaagccgcagagccaggguuguuucaggacccaucugauuccccagagccugcuguugaggcaauggucaccagauccguuggccaccacccugucccgagcuucucuagugucugucuggccuggaagugaggugcuacauacagcccaucugccacaagagcuuccugauugguaccacugugaaccgucccucccccuccagacaggggaggggauguggccauacaggagugugcccggagagcgcggaaagaggaagagaggcugcacacgcguggugacugacugucuucugccuggaacuuugcguucgcgcuuguaacuuuauuuucaaugcugcuauauccacccaccacuggauuuagacaaaagugauuuucuuuuuuuuuuuuucuuuucuuucuaugaaagaaauuauuuuaguuuauaguauguuuguuucaaauaauggggaaaguaaaaagagagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa Il12rb2/ 3 Sequence below. 263 Interleukin 12receptor, beta 2 U64199cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugccaggaucccucucugcguccugugcgcgggaagagcucuggagaaccagaguugcauucuggaguugaagacucauggcacagacuguuagagaaugcucauuggcacuucuuuuuuuguucauguggcugcugauuaaagcaaauauagaugugugcaagcuuggcacugugaccguccagccugccccugugauuccucuugggucagcugccaauauuuccugcuccuugaaucccaagcaaggcuguucacauuaucccaguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccauggcaagaaaguccaugaccacacuggucacuccuccacuuuucaagucaccaaccugucccuugguaugaccuuguuugucugcaagcuaaacuguagcaacucucaaaagaagccaccagucccaguaugugggguggagaucucaguugguguugcuccagagccaccucaaaacauaucauguguccaggaaggagaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaaccaauuacacuuuacaguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaaucgucagaauugcaaucgccuggaucuugggaucaaucuaagcccugauuuagcugaauccagguucauaguccguguuacugccaucaacgaucuuggaaauucuucuucacuuccgcauacguucacguucuuggacauagugaucccucuuccuccgugggacaucagaaucaacuuucuaaaugcuucugggagcagagguacacugcagugggaagaugaggggcaagugguacucaaucaacucagauaucagccucuuaacagcacguccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccugcgagaucugagaccguuuacagaauaugaauuucaaaucuccucuaagcuacaucucucuggaggaaguuggaguaauuggagugagucacugagaacacgaacaccagaggaagagccuguugggauauuagacaucugguacaugaaacaagacaugacuaugacagacagcagaucucucuuuucuggaagagucugaauccaucagaggcaagggggaagauccuccacuaucaggugacguuacaagaggugacaaagaaaacaacacugcagaauacuacaagacacaccuccuggaccagggucaucccccgaacuggggcuuggacggcaucagugucugcagccaacucaaaaggcgcuucugcacccacucacauuaacauaguggaccuauguggcacuggguugcuggcuccucaccaggucucugcaaagucggagaacauggacaacauucuagugaccuggcagccuccuaagaaagcugauucugcuguucgggaguacauaguggaauggagagcucuccaaccagggagcaucacgaaguuucccccacacuggcugcggauccccccggacaacaugucugcucugauuucagagaacauaaagcccuauaucuguuaugaaaucagggugcaugcacugucagagagccaaggagggugcagcuccauccggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucacagagaaaaaggaacgccuuuucauuuccuggacccacauuccauucccggagcaaaggggcugcauccuccauuacagaauauacuggaaagaacgagacucgacagcacaaccugagcucugcgaaauucaguaccgacgcucucaaaacucacauccaauaagcagccuacagcccagggugacauauguccuauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagggaauuuuguccacagggcaaagccaacuggaaagcauucgugauaucaagcauuugcaucgcuaucaucacggugggcacguucucaauucguuacuuccggcaaaaggcauuuacucuccugucuacucucaaaccucaaugguauagcagaaccauuccagauccagcaaacagcacuuggguaaagaaguaucccauucuggaggagaagauccagcuaccuacggauaaucuccugauggcauggcccacuccugaagagccugagccccugaucauccaugaaguccucuaccacaugaucccaguugucagacaaccauauuacuucaaaagaggccaaggauuccaaggcuacucuaccuccaagcaagaugcaauguauauugccaauccacaagcuacaggaacucucacagcugagaccagacaacuagugaaccuauacaaggugcuagaaagcagagacccugacucaaaacuggccaaccugaccagccccuugacagucaccccagugaacuaccuuccuagccaugaaggcuauuuacccuccaacauagaagaucugucaccacaugaggcugacccaacugauucuuuugaccuggagcaucaacauauuucucuuuccauuuuugcaucaaguucucuccgcccacucaucuucgguggugagcggcugacucuagaucgguuaaagaugggcuaugacucccucaugaguaaugaggcuugauacuagaaagccaacguaccucauuuuaucugcccaguuccuacuccaaaggucugugacagugaagacaagccagcugucucuggauaaaguuagcuucaccauagguacuuaagucuuauggauaagguggcaauacaccaacacugauaucauauagaaaggaccccaagauagucaugcucWnt10a/Wingless- 3 Sequence below. 264 related MMTV integration site 10aU61969ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccaguccaaagcggacucaguggccucggggacgggagcaugccaccuccuguggugacgucacuugggguagaacccuuagacacuacaugggggggggggguacagaacucccgagccaggacagucacucacucuucaggcgguggggcugggccagacaguaccgcccccaccgcgcccgccucgcacacccucggaagcgcaggcucgcagcgcggcgcuggggugggggguugcgccccagaacuucggccuccaguccccagcccgcugcaccuccuuacccucuagaggcccccucccccuuacccucuagaggcaccaggaguugucgcaaggggcccuugggaaauucccuggaccccugugccaggaggugcccgguucgcccgcuccccauccacccccccgagggcggugcccgggggcgcugccccauggagcggggaggcgggcgccgucugcugcgggagcugugaccugaguaggagcugugugucgcagccgccccaccccugccgaucaugcgccggcgacccugguucgccagucccacugggcugugagccccccacuccuggccugucacggcccgcgcgccaugggcagcgcccacccucgccccuggcugcggcucccacaagggccccagccgcggccugaguucugggcgcuccuguucuuccuacugcugcuggcugccgcugugcccaggucagcacccaacgacauccugggccuccgccuacccccagagcccgugcucaacgccaacacagugugccugacauugcccggccugagccggcggcagauggaggugugugugcgucacccugacguggccgccucugcuauccagggcauccagaucgccauccaugagugccagcaucaguuccgggaccagcgcuggaacugcuccagccuggagacucggaacaaaguccccuacgagagccccaucuucagccgagguuuucgagagagugcuuucgccuacgccauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucuggguaaacugaaggcuugcgguugcgacgccuccagacguggggacgaagaagcuuuccgcuggaagcugcaccgcuugcagcuggacgcgcugcagcgcggaaagggcuugagccacggggucccugaacacccggccauacuuccugccagcccaggucugcaggacuccugggagugggguggcugcaguccggaugugggcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagagacauccaugcucgaaugagacuccacaacaaccgugugggccggcaggcggugauggagaacaugcggcguaagugcaaaugccacggcaccucaggcagcugccagcucaagaccugcuggcaggugacgccugaguuccgcacaguaggggcgcugcugcgcaaccgcuuccaccgcgccacgcucauccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcacccucgccagcaccgggcacuccagggcugcgccgcagggccagccacuccgaccuggucuacuuugagaaaucucccgacuucugugagcgcgagccgcgccuggacucggcaggcacugugggccgccugugcaauaagagcagcacgggucccgauggcugcggcagcaugugcuguggccgcggccacaacauucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggugcugcuucguggucugcgaagaaugccgcaucaccgagugggucagcgucugcaagugagcagacccaagcuccucugggucucaagaaugguuguccucuuggugccuggcuucugccgcuagcggaucugagccaggcagcaagcagcagccuuggcuccugagagaggugguuggcucuuacagccccgagggucuacaauacaccagacaguccagaucugauugacauuccuccgcucaccucuguagguuccccucuuucuguuccuagcucagacagcugggggugauaguggagacuguuccacacccuaggacagguacaccaaagcagcccagccuggcaugccuaccuccugucaucucuucuucccuuccccaggagugauaggcaaugcacugaagcugaugggcaccggggaagaaaacuaaaaggcagaaauggccgucaucgggcugaagugacucuaagggcuccagaccucugcuccugucuuucacuuaacagauauuuauuuuugcgcucucuuugagacacucucugggaaaaagaagcuccggagucuacaggcugauuaagggacauggacaauaaaccaguaaacacacaaaaaaaaaaaaaaaaaa Ifngr2/Inter- 3 Sequence below. 265 feron-gammareceptor precursor M28233gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacgggcagcgcggguccccugucagaggugucccucgcgcaggaaugggcccgcaggcggcagcuggcaggaugauucugcuggugguccugaugcugucugcgaaggucgggaguggagcuuugacgagcaccgaggauccugagccucccucggugccuguaccgacgaauguucuaauuaagucuuauaacuugaacccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuacuguacagguaaagguguauucggguuccuggacugauuccugcaccaacauuucugaucauuguuguaauaucuaugaacaaauuauguauccugauguaucugccugggccagaguuaaagcuaagguuggacaaaaagaaucugacuaugcacggucaaaagaguuccuuaugugccuaaagggaaaggucgggcccccuggccuggagaucaggaggaagaaggaagaacagcucuccguccucguauuucacccugaagucguugugaauggagagagccagggaaccauguuuggugacgggagcaccuguuacacauucgacuauacuguguauguggagcauaaccggaguggggagauccuacauacgaaacauacggucgaaaaagaagaguguaaugagacucugugugaguuaaacaucucaguauccacacuggauuccagauauuguauuucaguagacggaaucucaucuuucuggcaaguuagaacagaaaaaucgaaagacgucuguaucccuccuuuccaugaugacagaaaggauucaauuuggauucuggugguugcuccucuuaccgucuuuacaguaguuauccugguauuugcguauugguauacuaagaagaauucauucaagagaaaaagcauaauguuaccuaaguccuugcucucugugguaaaaagugccacguuagagacaaaaccugaaucgaaguauucacuugucacaccgcaccagccagcuguccuagagagugagacggugaucugugaagagccccuguccacagugacagcuccagacagccccgaagcagcagaacaggaagaacuuucaaaagaaacaaaggcucuggaggcuggaggaagcacgucugccaugaccccagacagcccuccaacuccgacacaaagacgcagcuuuucccuguuaaguaguaaccagucaggcccuuguagccucaccgccuaucacucccgaaacggcucugacaguggccucgugggaucgggcagcuccauaucggacuuggaaucucucccaaaacaacaacucagaaacaaagauggcagagcacgacccuccacccgugagaaaggcccccauggccuccgguuaugacaaaccgcacauguugguggacgugcuuguggauguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguccuaaggucucccgaggccugcuggugguaaagaaacugaccuuuuaggcaguuuuucugcauugauuucaugaaagaagcuauacauuagcuaauacuaaccacauagaauaucagacuuagauacgugaauaaggauccugugggcacugcuggguccacucugcaaaugccaagacuaucaaaggaacguauugucgcuucuggcuccuucccaggugggcuagcaucugugaguuugccucggcuagccuugcuuccuacagccgccacugcuccuccacccugaucaucucacaggacaggguggaccggguuuuuuuuuuuuuuucacacaccuuuguauauguaaguucauguauauaauauguuuacauguuucacuuugaacugaaagcuacucaaagccagccguaagucuaugguagaaugugauggaacauguugguggaagcuuguacaauagaacacauuggugggagcuuguacauacuuuuuuauggagcauuacuuacgauuuuuuaaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc Fgfbp1/Fibroblast 3augagacuccacagccucauccugcucuccuuccuucuccuggcuacu 266 growth factorcaggcguucucagaaaaggucagaaagagagccaagaacgcaccacac binding protein 1agcacagcggaggaggggguagaggguucagcucccucguuagggaag AF065441gcccagaauaagcagagaagcaggacaucuaaaucucugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacugaggaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuuguguuuuugcuggugacccaacugacugccuuaaacacgacaaagaccagaucuacuggaaacagguugcccgcacgcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuugaagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaacgcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaacaagguccaagaagcugucuccacggagccaaacagggucaaagaagacaucacacucaauccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugugcucaaccagaggaagaccgcccuggaguucugugggaaucuuggagcuccauuugcacauucuuccucaacauguuacaggcgacaucaugcuaaTranscription Factors and Releated Genes Klf5/Kruppel- 5 267like factor 5 AA611766 Gata3/GATA 4 Sequence below. 268binding protein 3 X55123gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuugcucuccuuuucuauacccuuaacugcaaacaaaccauuaaacgaccccucuccugggccuccgacggcaggaguccgcggaccucccaggccgacagcccucccucuacccgcgagguuccgggccgggcgagagggcgcgagcacagccgaggacauggaggugacugcggaccagccgcgcugggugagccaccaucaccccgcgguccucaacggucagcacccagacacgcaccacccgggccucggccauucguacauggaagcucaguauccgcugacggaagagguggacguacuuuuuaacaucgauggucaaggcaaccacgucccguccuacuacggaaacuccgucagggcuacggugcagagguauccuccgacccaccacgggagccagguaugccgcccgccucugcugcacggaucucugcccuggcuggauggcggcaaagcccugagcagccaccacaccgccucgcccuggaaccucagccccuucuccaagacguccauccaccacggcucuccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacuccaguccucaucucuucaccuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguccaccccgggauccgccgggucggccaggcaagaugagaaagagugccucaaguaucaggugcagcugccagauagcaugaagcuggagacgucucacucucgaggcagcaugaccacccuggguggggccucauccucagcccaccaccccauuaccaccuauccgcccuaugugcccgaguacagcucuggacucuucccacccagcagccugcugggaggauccccuaccggguucggauguaagucgaggcccaaggcacgauccagcacagaaggcagggagugugugaacugcggggcaaccucuaccccacuguggcggcgagaugguaccgggcacuaccuuugcaaugccugcggacucuaccauaaaaugaaugggcagaaccggccccuuaucaagcccaagcgaaggcugucggcagcaaggagagcagggacauccugcgcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggacccggucugcaaugccugugggcuguacuacaagcuucauaauauuaacagaccccugacuaugaagaaagaaggcauccagacccgaaaccggaagaugucuagcaaaucgaaaaagugcaaaaaggugcaugacgcgcuggaggacuuccccaagagcagcuccuucaacccggccgcucucuccagacacaugucaucccugagccacaucucucccuucagccacuccagccacaugcugaccacaccgacgcccaugcauccgcccuccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagagaggcagagcccugcuccacaugcgugaggagucuccaagugugcgaagaguuccuccgaccccuucuacuugcguuuuucgcaggagcaguaucaugaagcccgaaagcgacagaucuguguuuuugaaggcagaaagcaaaauguuugcuucuuuuuucaaaggagcucgagguggugucugcauuccaaccacugaauccggaucccauuugugaauaagccauucagacucauauucccuauuuaacagggucucuagugcugugaaaaaaauauugcugaacauugcauauaacuuauauuguaagaaauacuguacauuugaggaagacuuuauuguaccuggauagcuguaagaaaggcaugaaggacgccaagaguuuuaaggaauauaggggnnuuaaaguauggagauacagaagaaaccacuaagucugauguccaaaugggcacacugucaguuuuguuucccuucaguuguuugaugcauuuaaaaaaaaaaaaaagaaagaa Stimulated by 3Sequence below. 269 retinoic acid 14, basic-helix- loop-helix proteinY07836caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugcccacauguaccaaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcugauugagaaaaagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacuuugggucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagcagcagcagaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaauguucugcucagguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuucccagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacucggcucccaaagccgucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugccagucauccagcggacuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggagaaaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacgugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacuucgcgggcagugaucugauggguuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggccacugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaacaccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagagagaucagcccacccugcagacccacagagaagauucagagugugugugagagugagugagugugcgugcgugcgugcuuguauguauguuuguauauguaggacaauaaguuccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggacuguagcacaucucugggcguuucccuacccagagaagagccMki67/antigen 4 Sequence below. 270 identified by monoclonalantibody Ki67 X82786agucaccgacguuguauaacgacggccagugaauuguaauacgacucacuauagggcgaauuggguaccggccccccccucgaggucgacgguaucgauaagcuugauaucgaauucucgnccgcgugcgggucuggucggggcggagcgaaggccgcggguggccguggucgguccuccgcggcuaaggagccgagggcuccgacgcgggcugcgcccggugagcggcggccagagcuaacuugcgcugacuggaccagcugaggagcggcccggcggggcgacugcgagcuucaccgagaggcuucuccgcccugguccgcagucccgacggccgggcggaccauggcguccucggcucaccuggucaccaucaagcggagcggcgaugacggcgcacacuucccgcugagccucagcuccugccuguuuggaaggaguauugaaugugacauucguauccagcugccuguagugucucaaagacauugcccaauuguaguccaagagcaagaggcgauauuauauaauuucaguucuaccaauccaacucaaguaaacgggguuacuauagaugagccugugaggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaagauggaaaucaugaggauggaagcaaaccaacagaauuuccaggaaagucccuuggaaaggaaccaucaaggcgagccucaagagauagcuucugugcugacccugauggggaaggucaagauaccaaagcuucaaaaaugacugcuucaagaagaucuuuuguguaugccaagggccuuucugcagauagcccugccucagauggcucaaagaacaguguuagccaagacucaucagggcauguagaacagcacacuggcagaaacauaguagagcccacuucugggggaucucuuuuaagaaguccaggucuacagggagcaguuacagggaaccgaagucuucuuccuacacagagccuuagcaauagcaacgaaaaggaaucucccuuugagaaacuuuaucaaucaaugaaggaagaguuggauguaaaaucccagaaaucuuguaggaaaucagaaccccaaccugaccgugcagcagaggaaucgcgggagacacagcuauuggugucaggcagggcaagagcaaagucuaguggaagcaccccuguuacugcagccucuucacccaaaguaggaaagaucuggacugagagauggcgcgguggaauggugccuguccagacuuccacagagacagcuaaaaugaagaccccugugcggcauucacagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucuggaugaagguggaagugcccaggcaguccauaaaacagucacuccugggaaacuggcgacuagaaaccaaacuccgguggaggcuggggauguuggcagccccgcugauacaccagaacauuccucuuccccccagagaaguauuccugcaaagguagaggcuccaucugcagagacacaaaaucggcucucuuuaacucagcgccuuguuccaggugaaaagaaaacucccaaggguuccuucagcaagccugagaaacuggccacagccgccgaacagacuugcucuggccuaccuggucuuaguuccguugauaucagcaacuuuggugauuccauuaacaagagugagggaaugccuaugaagagaagacguguauccuuugguggacaucuaagaccugaauuauuugaugaaaacuugccuccuaauacaccacugaaaagaggagaaacgccaaccaagaggaagucucuuggcacucacagcccagcuguccucaagacaaucaucaaggaacggccccagucuccagggaaacaagagucuccugggauaacgccaccgaggacaaaugaucaaagacgcagaucaggcaggacuuccaguggaagcaauuucuuaugugagacagacauucccaagaaagcaggcaggaagagcgguaaccugccugcgaagagagcauccaucagccggagucagcauggcauucuacagaugauuugcuccaaaaggcgaaguggagcuucugaagccaacuugauuguugcaaaaucaugggcugauguuguaaaacuuggcgugaaacaaacacaaacgaaaguugcgaaacaugucccuccaaagcagacgagcaagagacaaagaagacccagcacuccaaagaaacccacaagcaaucuucacaaucaauuuacuacaggccaugcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaaguaagugugccugcccgacccuacaaaaugcugaauaacuugaugcuaaaccgaaaaguggacuucagugaagaucugucaggacuaacugaaauguucaagacuccagugaaggagaagcagcagcagaugagugauacaggcuccguacuuuccaauucagcgaauuugucugaaagacaauugcaaguaacuaauucaggagacauaccugagcccaucaccacagagauuuugggagaaaaagugcuauccaguacucggaaugcagcaaagcagcagucugauagauauucugcaaguccuaccuuaagacggcggagcaucaaacaugaaaacacagugcaaacuccuaagaauguccauaacauuacugaccuugagaagaagacuccggucucugagacagagccccugaagacugcaucgagugugagcaaguuaagaagaucuagagagcucagacauacccuuguggaaacuaugaaugaaaaaacagaagcaguccuugcugagaacaccacagcaagacauuuaagggggacauuucgagaacaaaaaguagaucaacaggugcaggacaaugaaaacgcuccucaaagaugcaaggaaaguggugaauuaagugaagguucagaaaagacaucagcuaggagaucaagugccaggaagcagaagccgacaaaagacuuacuaggaagucagauggucacccaaacagcagacuaugcugaggaacuacuuagucaaggacaaggaaccauacaaaaccuagaggaauccaugcacaugcaaaacacaucaauaagugaggaucaaggaauuacagaaaagaaagugaacauaauaguauaugcaaccaaagagaagcacucgccaaagaccccuggcaaaaaggcacaaccucuagaagggccagcuggucucaaggaacacuuugaaacaccaaaccccaaagauaaaccuauaacggaagacagaacuagaguccuuugcaaaucaccacaagucacaacagagaauaucacaacaaacacaaagccacagacuagcacaucugggaagaaaguagacaugaaggaagaaagcucugccuugacaaaacguauacauaugccaggggaauccaggcauaaucccaaaauuuuaaaacuugagugugaggauaucaaagcuuugaagcaaucugaaaaugaaaugcugaccucaacaguaaauggaagcaagaggacuuuaggaaaaucuaaaaaaaaggcucagccccuggaagaccugacuuguuuccaggaacucuuuauaucaccaguuccuacuaacauaaucaaaaaaauucccagcaaaucuccacacacaaccagucagaaccccagcgagcacaaagagacucuccaagacaggucucaguaaaguggaugugagacaagaaccuucaacacuugggaaaagaacgaagucaccaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacugcacagccuacauggaaacuccaaagcagaaacuggagucuauagaaaauuuaacagggcuuaggaaacaguccagaacaccuaaagacaucacugguuuccaggauaguuuccaaauaccagaucaugcuaauggcccauuagugguugucaaaaccaaaaaaauguucuuuaauucuccacaaccagaaagugccauaacccgaaagagcagagagagacagucuagggcaaguauaaguaaaauagauguuaaagaagaacuuuuagaaucagaggaacaccuacaauuaggagaagguguagacacauuucagguauccaccaacaaagucauuagaucaucuaggaaaccugcaaagcguaaacuggauucaacagcugguaugccuaacagcaagaggaugcgcuguucuucaaaggauaacacaccaugccuagaagaccugaauggcuuccaagagcucuuccaaaugccaggcuaugcuaaugacucuuugaccacuggaaucucaacaaugcuugcuagaucaccacaauuaggaccaguuagaacccaaaucaacaaaaagagucugcccaagaucaucuugagaaaaauggaugugacagaagaaauuucaggucucuggaagcagucacugggcagaguccacaccacacaagagcaggaggauaaugcaaucaaagcaauuauggagauuccaaaggaaacacugcagacugcagcagauggaacuaggcuuaccagacagccacaaacaccuaaggaaaaaguucaaccgcuggaagaucacagugucuuccaagaacucuuccaaacaucacgcuacuguucugauccauuaauugguaacaaacaaacaagaauguccuugagaucuccacaaccaggauuuguuagaacuccacgaaccucaaagagacuggcuaagacaaguguugggaauauugcugugagagaaaagaucucuccagugagucugccacagugugcuacaggggagguuguacacauacccauagggccagaagaugacacagagaacaaaggugugaaggaauccacaccucagacacuggacucaucagcaagucgaacugucagcaagaggcagcaaggggcacaugaggaaaggccuc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Cks2/CDC28 4gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucug 271 protein kinasecgcgccggcaggauggcccacaagcagaucuacuacucagacaaguac regulatory subunituucgaugagcacuacgaguaccggcaugucauguuacccagagaacuc 2, sim to cdkucuaaacaaguacccaaaacucaucugauguccgaagaggaguggagg regulatoryagacuugguguccaacagagucuaggauggguucauuacaugauucau subunit 2gagccagaaccgcauauucuucucuuuagacgaccucuuccaaaagaa AA681998caacaaaaaugaagugcagcugggaucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucagugaauacuugaaaaguguacaaaccuuucauccauaccugugcaugcgcuguauucuucacagcaacagagcucagucaaaugcaacugcaaguagg Ccng2/Cyclin G2 3 Sequence below. 272U95826cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcuguccugagcucgaacgguccgacgcccccgccgcgccgguccgugacgccggggccgacacgaugaaggauuugggggccaagcacuuggcagguggcgaagggguucagcuuuucggauuguugaacuucuaccuggaacaagaacagagauaccaaccucgggaaaaagggcugaucuugauggaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaagauuuaagaaguuuaacuaacuucuuuggaucuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcccuuaugaaggugaaaccgaaacaccuguccugcauuggcgucugcugcuuuuugcuggccgccaggcuggcggaagaagaaggugacguuccccccacgcacgacgugauccgcaucagucaguguaaaugcacagcgucugacauuaaacgcauggagaaaaucaucucagagaaacugcacuaugagcuggaagcuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucacacuucagaaaggaaggagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguugucuucuccaaagcaagaccaucuguauuagcucugugccuucucaauuuggaaauagaaacgauaaaauccguggaacugcuggaaauucucuugcuuguuaaaaaacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaugucuagcagaguauucuucgccucgcugcugcaagccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaaccuccacagcagcuacuacaguguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagugaggacucuggugaagacaugaguuguggagaggagagucucagcagcuccccacccagcgaucaggagugcaccuucuucuuugacuuccaaguggcucagacacugugcuuuccaccauagaggaaucugacauuguucugugucagggaauuuauaaguguguguaccuagguuucaaagcaauaaacuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucaggPrc1/Protein 3 aacuaccuugggcagguucuauuaacugcaccuaacucagacgugagu 273regulator of aggacagaaggaagcugucccgggcgaacugaggucacaaagacuugccytokinesis 1 uuuugauucaagagagaccuuaaaggcuaguuaugauaguuaaguacaDNA segment, aguuuuaacaucugguagcuaacuuuuuuucucuaccccguaauucua Chr 7cuaugacugcucuucuagagguccugaguucaaaucccagcaaccaca AA856349ugguggcucacaaccaucuauaaugggaucugaugcccucuucuggug ugc

Thus, the transcripts identified in this Example, the proteins theyencode, and the pathways in which the proteins participate, contributesignificantly to induction of epidermal cells to differentiate into HFstem cells. Activation of the transcripts, proteins, and pathwaysdepicted in Table 4 is thus a method for enhancing EDIHN. In addition,inhibition of the transcripts, proteins, and pathways depicted in Table4 is thus a method for preventing EDIHN and eliminating hair follicles.In addition, inhibition of the transcripts, proteins, and pathwaysdepicted in Table 5 is a method for enhancing EDIHN. In addition,activation of the transcripts, proteins, and pathways depicted in Table5 is thus a method for enhancing EDIHN.

Example 10 Expression of Wnt-1 Inhibitors During the First Nine Daysafter Wounding Causes Pigmentation of New HF Materials and ExperimentalMethods

In this Example, doubly transgenic mice expressing both tetO-Dkk1 andK5-rtTA were utilized. When these mice are fed chow formulated with 1g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under thecontrol of the K5 promoter, in the basal epidermis. The control micealso received doxycycline, but they were K5-rtTA negative and thus didnot express Dkk1.

Results

A 1 cm² wound was induced on the lower back of the doubly transgenicmice at 21 days or 50 days old. Mice were placed ondoxycycline-containing chow immediately after wounding to induce Dkk1expression, and then doxycycline was discontinued after completion ofthe re-epithelialization at 9 days after wounding. Dkk1 expressioninhibits Wnt activity, which in turn induces follicle pigmentation. At22 days after wounding, pigmented HF were observed in the excised skinafter preparing the epidermal sheet (FIG. 23A-B). Control mice lackedpigmented HF (FIG. 24).

In other experiments, continued expression of Dkk1 after the 9-dayperiod inhibited formation of new HF.

The findings of this Example show that pigmented HF can be produced bysuppressing expression of Wnt1 or by inducing expression of Dkk1 duringthe period of re-epithelialization, then inducing expression of Wnt1. Inaddition, the findings of this Example show that factors that inhibitneonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thusfurther supporting the notion that hair follicles formed by EDIHN aresimilar to normal hair follicles.

Example 11 Inhibition of EDIHN by Epidermal Growth Factor Injection

21 day-old mice were wounded as described in previous Examples. Startingfrom day 11 after wounding, a time point corresponding to the point atwhich the wound had recently re-epithelialized, 10 μL of 1 μg/ml EGF wasinjected into the wound bed. EGF was injected once per day after thispoint for a total of 5 days. Three days later, the skin was collected,and whole-mount EDIHN assays were performed. EGF prevented HF formationas assessed by gross morphology. In addition, whole mounts of controland treated skin were analyzed with anti-K17 antibody immunostaining.All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25C-D).

In an additional experiment, recombinant EGF (1 microgram(mcg)/microliter (mcl)) was injected at days 11, 13 and 15 afterwounding. Skin was collected at 18 days after wounding and stained forK17 and alkaline phosphotase. Once again, administration of EGFinhibited EDIHN.

The findings of this Example show that EGF inhibits HF formation. Thus,inhibiting EGF, EGFR, or one of the pathways in which they participateincreases EDIHN-induced HF formation.

Example 12 Enhancement of EDIHN by Inhibition of EGF Receptor

To determine the effect of administration of EGF receptor inhibitors onDIHN, the inhibitor AG1478 (150 μM in 10 μL volume) was administered asa single injection 11 days after incisional wounding (1 cm²) to themiddle of the wound near the skin surface. EGF receptor inhibitoradministration led to generation of more and larger hair folliclescompared with control mice that were wounded only (FIG. 26A). As shownin FIG. 26B, large hair follicles developed in the wounded area in theAG1478-injected mice. Left panel: epidermis stained for K17, with threelarge hair follicles next to each other. Right panel: dermis stained forAP with large coalescing dermal papilla areas.

The findings of this Example confirm the results of the previousExample, and show that more and larger HF can be generated when EDIHNcomprises, or is followed by, administration of EGFR inhibitors, or withcompounds with a similar mechanism of action; e.g. Hedgehog protein andandrogen antagonists.

Example 13 Enhancement of EDIHN by Expression of a β-Catenin Activator

To determine the effect of administration of β-catenin activators onEDIHN, K14-Wnt7 transgenic mice, which overexpress the β-catenin pathwayactivator, Wnt7, in the epidermis, were subjected to EDIHN, then HFformation was measured 19 days after wounding. In each of 2 separateexperiments, with 4 week old and 3 week old mice, the transgenic micedeveloped significantly larger numbers of HF compared to control,non-transgenic littermate mice (FIG. 27 A-C).

Thus, administration of β-catenin activators leads to an increase inEDIHN. The findings of Examples 11-13 show that new HF can be generatedby (a) disrupting the epidermis; and (b) administering a factor thatpromotes a differentiation of an uncommitted epidermal cell into a HFcell.

Example 14 Enhancement of EDIHN by Administration of FGF

To determine the effect of fibroblast growth factor (FGF) on EDIHN,recombinant FGF is administered 11 days after incisional wounding, asdescribed in Example 11. FGF administration enhances HF formation,showing that new HF can be generated by (a) disrupting the epidermis;and (b) administering FGF, a nucleotide encoding FGF, or a factor thatincreases signaling by FGF.

Example 15 Enhancement of EDIHN by Administration of EDAR

To determine the effect of fibroblast growth factor (FGF) on EDIHN,K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1in the epidermis, are subjected to EDIHN, then HF formation is measured19 days after wounding as described in Example 13. The transgenic micedeveloped significantly larger numbers of HF compared to control,non-transgenic littermate mice, showing that new HF can be generated by(a) disrupting the epidermis; and (b) administering a factor thatenhances signaling by ectodysplasin.

Example 16 Enhancement of EDIHN by Administration of Minoxidil

To determine the effect of minoxidil on EDIHN, recombinant FGF isadministered 11 days after incisional wounding, as described in Example11. Minoxidil administration enhances HF formation, showing that new HFcan be generated by (a) disrupting the epidermis; and (b) administeringa minoxidil.

Example 17 Removal of HF by Abrasion and Administration of EGF

Hair-bearing regions of the epidermis of mice is abraded, as describedin Example 1, then administering recombinant EGF, as described inExample 1. This method prevents hair re-growth in the abraded areas,showing that hair can be removed by (a) disrupting the epidermal layer;and (b) administering EGF, a nucleotide encoding EGF, or a factor thatincreases signaling by EGF.

1-37. (canceled)
 38. A method of treating a scar in a subject, saidmethod comprising: (i) disrupting the epidermis or dermis on or around ascar of said subject; and (ii) administering to said subject a compoundselected from the group consisting of: a fibroblast growth factor (FGF)protein, a polynucleotide that encodes an FGF protein, an FGF receptorprotein, a polynucleotide that encodes an FGF receptor protein, and anactivator of an FGF protein; wherein said compound is administered in anamount effective to treat said scar in said subject.
 39. The method ofclaim 38, wherein said disrupting is performed using a light-basedmethod.
 40. The method of claim 38, wherein said disrupting is performedusing a laser.
 41. The method of claim 40, wherein said laser is a CO2laser, a fractional laser, or an excimer laser.
 42. The method of claim40, wherein said laser induces transepithelial injury.
 43. The method ofclaim 38, wherein said disrupting is performed by abrading.
 44. Themethod of claim 38, wherein said abrading comprises wearing away saidepidermis or dermis by friction.
 45. The method of claim 38, whereinsaid disrupting is performed using a mechanical method.
 46. The methodof claim 45, wherein said mechanical method comprises use of a tool thatcomprises sandpaper or a rotating felt wheel.
 47. The method of claim38, wherein said disrupting is performed by perforating.
 48. The methodof claim 47, wherein said perforating comprises use of a surgical tool.49. The method of claim 48, wherein said surgical tool induces punchwounds.
 50. The method of claim 38, wherein said disrupting is performedby freezing or cryoinjury.
 51. The method of claim 38, wherein the stepof administering is performed 3-12 days after the step of disrupting.52. The method of claim 38, wherein said subject is a human.
 53. Themethod of claim 38, wherein said compound is an FGF protein.
 54. Themethod of claim 38, wherein said compound is a polynucleotide thatencodes an FGF protein.
 55. The method of claim 38, wherein saidcompound is a polynucleotide that encodes an FGF receptor protein. 56.The method of claim 38, further comprising administering a lithiumcompound in an amount effective to treat said scar.